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基于差分进化算法的MHC-I结合亲和力预测方法
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作者 丛春雨 王忠英 《电子技术与软件工程》 2015年第22期187-187,共1页
在细胞免疫反应中,抗原表位与MHCs的结合扮演着重要角色。预测多肽与MHC分子结合的准确率已有很大的进步,最近,MHC-多肽的结合预测模型趋向预测结合力亲和力的大小,代替了以前判断多肽是"结合"和"不结合"的预测结果... 在细胞免疫反应中,抗原表位与MHCs的结合扮演着重要角色。预测多肽与MHC分子结合的准确率已有很大的进步,最近,MHC-多肽的结合预测模型趋向预测结合力亲和力的大小,代替了以前判断多肽是"结合"和"不结合"的预测结果,在本文中,使用了差分进化算法与位置特异性得分矩阵相结合的方法来预测多肽与MHC-I的结合亲和力。 展开更多
关键词 主要组织相容性复合体(MHC) 预测结合力 差分进化算法(DE) 位置特异性得分矩阵(PSSM) 多肽
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TIME SERIES FORECASTING WITH MULTIPLE CANDIDATE MODELS:SELECTING OR COMBINING? 被引量:5
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作者 YULean WANGShouyang +1 位作者 K.K.Lai Y.Nakamori 《Journal of Systems Science & Complexity》 SCIE EI CSCD 2005年第1期1-18,共18页
Various mathematical models have been commonly used in time series analysis and forecasting. In these processes, academic researchers and business practitioners often come up against two important problems. One is whe... Various mathematical models have been commonly used in time series analysis and forecasting. In these processes, academic researchers and business practitioners often come up against two important problems. One is whether to select an appropriate modeling approach for prediction purposes or to combine these different individual approaches into a single forecast for the different/dissimilar modeling approaches. Another is whether to select the best candidate model for forecasting or to mix the various candidate models with different parameters into a new forecast for the same/similar modeling approaches. In this study, we propose a set of computational procedures to solve the above two issues via two judgmental criteria. Meanwhile, in view of the problems presented in the literature, a novel modeling technique is also proposed to overcome the drawbacks of existing combined forecasting methods. To verify the efficiency and reliability of the proposed procedure and modeling technique, the simulations and real data examples are conducted in this study.The results obtained reveal that the proposed procedure and modeling technique can be used as a feasible solution for time series forecasting with multiple candidate models. 展开更多
关键词 time series forecasting model selection STABILITY ROBUSTNESS combiningforecasts
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