AIM： TO assess the early predictability of the soluble CD40L （sCD40L） in pancreatitis severity. METHODS： Between February 2000 and February 2003, 279 consecutive patients with acute pancreatitis were prospectively...AIM： TO assess the early predictability of the soluble CD40L （sCD40L） in pancreatitis severity. METHODS： Between February 2000 and February 2003, 279 consecutive patients with acute pancreatitis were prospectively enrolled in our study. In this report, 40 patients with mild and 40 patients with severe pancreatitis were randomly studied, sCD40L concentrations were measured 48 hours after admission. RESULTS： sCD40L levels were significantly higher 48 hours after admission in severe pancreatitis than in mild pancreatitis. Using a cutoff of 1000 pg/L, the sensitivity and specificity of sCD40L to detect a severe course of the disease were 78% and 62% respectively compared to 72% and 81% for CRP. Logistic regression analysis found that CRP was the only statistically significant marker able to detect a severe course of the disease. CONCLUSION： These findings indicate that CRP remains a valuable marker to determine the severity and prognosis of acute pancreatitis whereas sCD40L levels should be assessed in further studies.展开更多
As the fifth most common cancer and the third most comxnon cause of cancer deaths worldwide, gastric cancer remains a significant public health concern and an economic burden in developed and developing countries. Gas...As the fifth most common cancer and the third most comxnon cause of cancer deaths worldwide, gastric cancer remains a significant public health concern and an economic burden in developed and developing countries. Gastric inflammation induced by Helicobacter pylori may initiate superficial gastritis, which then progresses to atrophic gastritis, gastric epithelial dysplasia, and finally gastric cancer. The pathogenesis of AT. pylori infection is related to its virulence factors, including urease, flagella, vacuolating cytotoxin A and cytotoxin-associated gene antigen. The relevant mechanisms of H. pylori-induced inflammation include activation of nuclear factor-r,B, mitogen-acfivated protein kinase pathway, and oxidative stress. To date, therapeutic strategies and results in this infection remain undesirable. Complicated treatment issues include antibiotic resistance, adverse effects of chemical drugs, and recurrence after operation. Therefore, chemoprevention has been regarded as an important measure, and Chinese medicinal herbs have been the research hotspot. This review aimed to summarize the effects of Chinese medicinal herbs on the prevention of gastric cancer, mechanism of action and the treatment prospects, with emphasis H. pylori-induced effects.展开更多
基金Supported by a grant from the Fonds de Perequation des Hopitaux Universitaires de Geneve (to JLF) and Fondation Schmiedheiny
文摘AIM： TO assess the early predictability of the soluble CD40L （sCD40L） in pancreatitis severity. METHODS： Between February 2000 and February 2003, 279 consecutive patients with acute pancreatitis were prospectively enrolled in our study. In this report, 40 patients with mild and 40 patients with severe pancreatitis were randomly studied, sCD40L concentrations were measured 48 hours after admission. RESULTS： sCD40L levels were significantly higher 48 hours after admission in severe pancreatitis than in mild pancreatitis. Using a cutoff of 1000 pg/L, the sensitivity and specificity of sCD40L to detect a severe course of the disease were 78% and 62% respectively compared to 72% and 81% for CRP. Logistic regression analysis found that CRP was the only statistically significant marker able to detect a severe course of the disease. CONCLUSION： These findings indicate that CRP remains a valuable marker to determine the severity and prognosis of acute pancreatitis whereas sCD40L levels should be assessed in further studies.
基金Natural Science Foundation of China(Grant No.81120108025)the Science and Technology Department of Guangzhou City(Grant No.201509010004)
文摘As the fifth most common cancer and the third most comxnon cause of cancer deaths worldwide, gastric cancer remains a significant public health concern and an economic burden in developed and developing countries. Gastric inflammation induced by Helicobacter pylori may initiate superficial gastritis, which then progresses to atrophic gastritis, gastric epithelial dysplasia, and finally gastric cancer. The pathogenesis of AT. pylori infection is related to its virulence factors, including urease, flagella, vacuolating cytotoxin A and cytotoxin-associated gene antigen. The relevant mechanisms of H. pylori-induced inflammation include activation of nuclear factor-r,B, mitogen-acfivated protein kinase pathway, and oxidative stress. To date, therapeutic strategies and results in this infection remain undesirable. Complicated treatment issues include antibiotic resistance, adverse effects of chemical drugs, and recurrence after operation. Therefore, chemoprevention has been regarded as an important measure, and Chinese medicinal herbs have been the research hotspot. This review aimed to summarize the effects of Chinese medicinal herbs on the prevention of gastric cancer, mechanism of action and the treatment prospects, with emphasis H. pylori-induced effects.
