目的观察重症加强护理病房(Intensive Care Unit,ICU)重症患者肺部真菌感染预防性给药效果。方法采用随机数字表法将我院2016年1月~2017年1月收治的80例ICU重症患者分为对照组(西药给药)及观察组(痰热清静脉滴注给药)各40例,对两组效果...目的观察重症加强护理病房(Intensive Care Unit,ICU)重症患者肺部真菌感染预防性给药效果。方法采用随机数字表法将我院2016年1月~2017年1月收治的80例ICU重症患者分为对照组(西药给药)及观察组(痰热清静脉滴注给药)各40例,对两组效果进行观察和比较。结果观察组肺部真菌感染发生率5%、对照组肺部真菌感染发生率7.5%,差异无统计学意义(P>0.05);给药前两组患者干扰素-γ、白细胞介素-4、白细胞介素-10无明显差异,给药结束后差异无统计学意义(P>0.05)。结论无论是西药还是中药预防性给药均能够在ICU重症患者肺部真菌感染中取得理想的效果,临床可灵活运用。展开更多
Objectives: We assessed the impact of intravenous fluconazole prophylaxis (FP) in extremely low birthweight (ELBW[<1000 g]) infants on the incidence of and ou tcome from invasive candidiasis (IC) in all infants adm...Objectives: We assessed the impact of intravenous fluconazole prophylaxis (FP) in extremely low birthweight (ELBW[<1000 g]) infants on the incidence of and ou tcome from invasive candidiasis (IC) in all infants admitted to a neonatal inten sive care unit (NICU). Study design: Beginning April 1, 2002, FP was given to EL BW infants aged < 5 days admitted to the NICU of Woman’s Hospital of Texas. Inf ants in NICU in whom IC developed during the first 2 years of FP (FP period) wer e compared with those with IC during 2000-2001. Results: During 2000-2001 and the FP period, the incidence of IC in ELBW infants decreased from 7%(15 of 206) to 2%(5 of 240) (P = .01), and the IC-related mortality rate decreased from 1 2%(4 of 33) to 0 (0 of 40) (P = .04); the incidence of IC increased from 0.1%( 4 of 2806) to 0.2%(8 of 3372) in infants of birth weight ≥1000 g (P = .06), an d no IC-related deaths occurred. During the FP period, IC developed in older in fants (24 vs 12 days; P = .12) who had similar risk factors for IC. Conclusion: Invasive candidiasis occurred in our NICU in spite of FP and shifted to bigger,m ore mature infants who had a better outcome.展开更多
文摘目的观察重症加强护理病房(Intensive Care Unit,ICU)重症患者肺部真菌感染预防性给药效果。方法采用随机数字表法将我院2016年1月~2017年1月收治的80例ICU重症患者分为对照组(西药给药)及观察组(痰热清静脉滴注给药)各40例,对两组效果进行观察和比较。结果观察组肺部真菌感染发生率5%、对照组肺部真菌感染发生率7.5%,差异无统计学意义(P>0.05);给药前两组患者干扰素-γ、白细胞介素-4、白细胞介素-10无明显差异,给药结束后差异无统计学意义(P>0.05)。结论无论是西药还是中药预防性给药均能够在ICU重症患者肺部真菌感染中取得理想的效果,临床可灵活运用。
文摘Objectives: We assessed the impact of intravenous fluconazole prophylaxis (FP) in extremely low birthweight (ELBW[<1000 g]) infants on the incidence of and ou tcome from invasive candidiasis (IC) in all infants admitted to a neonatal inten sive care unit (NICU). Study design: Beginning April 1, 2002, FP was given to EL BW infants aged < 5 days admitted to the NICU of Woman’s Hospital of Texas. Inf ants in NICU in whom IC developed during the first 2 years of FP (FP period) wer e compared with those with IC during 2000-2001. Results: During 2000-2001 and the FP period, the incidence of IC in ELBW infants decreased from 7%(15 of 206) to 2%(5 of 240) (P = .01), and the IC-related mortality rate decreased from 1 2%(4 of 33) to 0 (0 of 40) (P = .04); the incidence of IC increased from 0.1%( 4 of 2806) to 0.2%(8 of 3372) in infants of birth weight ≥1000 g (P = .06), an d no IC-related deaths occurred. During the FP period, IC developed in older in fants (24 vs 12 days; P = .12) who had similar risk factors for IC. Conclusion: Invasive candidiasis occurred in our NICU in spite of FP and shifted to bigger,m ore mature infants who had a better outcome.
