G_(b)-(p,r)E-半预不变凸多目标规划的最优性条件

为了丰富广义凸函数类,扩大多目标规划的应用范围,运用Clark广义梯度,借助αE半预不变凸函数和G B(p,r,α)不变凸函数,进一步给出了一类新的广义凸函数的定义:G_(b)(p,r)E半预不变凸函数。对于涉及这类函数的多目标规划问题,得到了其可行解是弱有效解的若干最优性条件。

B位氧化物预合成法制备(1-x)Pb(Fe_(1/4)Sc_(1/4)Nb_(1/2))O_3-xPbTiO_3铁电陶瓷及其性能研究

利用传统的陶瓷工艺、通过B位氧化物预合成法制备了高质量、钙钛矿结构的(1-x)Pb(Fe1/4Sc1/4Nb1/2)O3-xPbTiO3(PFSN-PT)铁电陶瓷。结构测定和性能测试表明,1180℃烧结2h制备的PFSN-PT陶瓷呈现相当均匀的显微结构和良好的电学性能,同时具有较高的致密度(约95%),只有PbTiO3(PT)物质的量分数为40%、60%的陶瓷致密度略低(约91%)。随着PT含量的增加,PFSN-PT从三方相结构转变为四方相结构,并伴随着晶胞体积的减小(从PFSN的6.6676×10-2nm3下降到0.2PFSN-0.8PT的6.3555×10-2nm3)和钙钛矿结构四方性的增大(从0.6PFSN-0.4PT的1.0242增加到0.2PFSN-0.8PT的1.0488)。PFSN-PT陶瓷的介电常数最大值(εm)及其峰值温度(Tm)也随着PT含量的增加呈线性增大。介电性能测试和热滞行为研究表明,随着PT含量的增加,PFSN-PT的铁电-顺电相变从弛豫铁电体的弥散型铁电相变向正常铁电体的一级铁电相变转变。

82B钢4道次预精轧过程的计算机模拟和分析

采用非线性有限元分析软件ABAQUS,通过建立的线材与轧辊的3维热机耦合模型,对钢厂82B钢(/%:0.79～0.86C、0.15～0.35Si、0.60～0.90Mn、≤0.030S、≤0.030P)φ20mm至φ16.5mm 4道次预精轧过程中轧件的温度场、应力-应变场和轧制力进行数值模拟和分析。结果表明,数值模拟结果与实测结果相符;预精轧过程轧件心部温度和表面温度的差值为～130℃;运用该模型对现场轧制过程中的前滑进行了分析,得出了影响前滑的因素主要有延伸系数、轧制孔型尺寸、轧制速度以及辊径与轧件厚度比值。

B-C-半预不变凸函数的择一定理与优化条件

利用凸集分离定理,讨论了B-C-半预不变凸函数的择一性定理,并利用择一性定理,给出了带约束条件的向量优化问题解的优化条件。

大型综合医院基于BIM技术的机电预留预埋实施重难点分析

大型综合医院机电系统复杂、管线密集,人防区、辐射屏蔽区等特殊区域较多,管线预留预埋要求高,难度大,所以预留预埋是后期机电管线系统成功实施的重要基础。本文结合四川大学华西天府医院项目,分析了基于BIM技术的机电预留预埋在辐射区域、人防区域医疗专业管线、外墙结构的机电管线预留预埋施工关键技术,可为其他类似项目提供一定的参考。

全国足球甲级联赛期间部分足球运动员赛中重度损伤的原因及预防措施

对足球甲级联赛赛中重度损伤的成因进行追踪 ,通过对部分损伤实例的报道及对其机制的分析发现 :加强足球运动员全面身体素质的平衡发展及技术动作的合理应用 ,开展对运动员的职业道德和文明精神教育 ,提高球队医务人员的业务素质和专业技术水平是防止足球运动员重度损伤的重要因素。

半严格-(B,G)-半预不变凸规划的Wolfe对偶问题

讨论了与半严格-(B,G)-半预不变凸函数有关的可微多目标规划问题(TP),及其相对应的Wolfe型对偶问题(TW)之间可行解与弱Pareto解的关系。给出了目标函数和约束函数均为可微的半严格-(B,G)-半预不变凸函数的多目标规划问题的弱对偶、强对偶和逆对偶定理。其结果拓展了已有文献中与广义凸规划相关的Wolfe对偶结论,具有一般性。

B/S架构小溶江水库预/测报系统研究

针对小溶江水库预/测报系统的总体开发目标,介绍了基于B/S架构的洪水预报系统,论述开发中的关键技术,展示了水库预/测报系统的总体拓扑结构。基于B/S架构的小溶江水库预/测报系统,在分析了预/测报功能模块设计、数据库、数图交互展示和系统结构性等核心问题的基础上,探讨小溶江水库预/测报系统的各项功能。

带空气穿刺法对B超引导下经外周置入中心静脉导管穿刺的影响

目的探讨带空气穿刺法对B超引导下经外周置入中心静脉导管(peripherally inserted central catheter,PICC)穿刺的影响,以期为临床PICC准备提供参考依据。方法 2014年1月至2015年6月,便利抽样法选取在安徽省立医院肿瘤科治疗的266例肿瘤患者为研究对象,所有患者均在B超引导下行PICC。按随机数字表法将其分为观察组和对照组,每组133例。观察组患者采用肝素液预冲穿刺针后弃去肝素液(带空气穿刺法),对照组采用肝素液预冲后穿刺针内保留肝素液(带液穿刺法),比较两组患者的PICC穿刺一次成功率及置管时间。结果观察组患者PICC一次穿刺成功率为92.48%(123/133),高于对照组的84.21%(112/133),差异有统计学意义(P<0.05)。观察组患者置管所需时间为(19.98±2.12)min,少于对照组的(23.45士2.05)min,差异有统计学意义(P<0.05)。结论 PICC操作中,带空气穿刺法优于带液穿刺法,能提高PICC一次穿刺成功率,缩短穿刺置管时间,值得推广。

The Prediction of B Cell Epitopes for VP73 Protein of African Fever Virus

[Objective] The B cell epitopes for VP73 protein of African swine fever virus was predicted. [ Method] Based on the analysis of the amino acid sequence and the flexible regions of VP73 protein, the B cell epitopes for VP73 protein of African swine fever virus were predicted by method of Kyte-Doolittie, Emini and Jameson-Wolf. [Result] The B cell epitopes were located at or adjacent to the N-terminal No. 11 - 18,26 -48,73 -82,136 - 150,159 - 174,181 - 189,191 - 210,247 - 276,279 - 295,313 - 323 and 382 - 392. [Conclusion] The multi-parameters analytic method was adopted to predict the B cell epitopes for VP73 protein of African swine fever virus, which laid solid foundation for further characterizing the protein of VP73 and researching epitope vaccine.

高居里温度铁电体0.20Pb(Fe_(1/2)Nb_(1/2))O_3-0.32PbZrO_3-0.48PbTiO_3的性能

用传统的陶瓷工艺、通过B位氧化物预合成法制备了高质量、钙钛矿结构的0.20Pb(Fe1/2Nb1/2)O3-0.32PbZrO3-0.48PbTiO3(PFN20-PZ32-PT48)铁电陶瓷,该条件下制备的铁电陶瓷呈现相当均匀的微结构和良好的电学性能。PFN20-PZ32-PT48具有较大的室温介电常数(~410)、高的居里温度(TC,~350℃),在295K<T<525K温度区间,具有较小的介电常数温度梯度/εT=2.8/℃,并且介电常数与频率无关,特别适合高温电容器工业的应用。虽然PFN20-PZ32-PT48呈现较为典型的一级铁电相变,其介电性能在顺电相区呈现明显的频率色散现象,并伴随着介电常数和损耗的反常增加。该反常现象的产生可能与陶瓷烧结过程中Fe3+被部分还原成Fe2+离子所诱导产生的热激发的空穴导电机制有关。PFN20-PZ32-PT48的剩余极化(Pr)与频率的关系可以很好地用随机场模型模拟,表明其弛豫行为的产生与短程化学有序所诱导产生的极性簇和/或纳米尺寸的非均匀性有关。

Overexpression of metastasis-associated in colon cancer 1 predicts a poor outcome of hepatitis B virus-related hepatocellular carcinoma

AIM: To investigate the intratumoral expression of metastasis-associated in colon cancer 1 (MACC1) and c-Met and determine their clinical values associated with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). METHODS: A retrospective study admitted three hundred fifty-four patients with HBV-related HCC. The expression and distribution of MACC1 and c-Met were assessed by quantitative real-time polymerase chain reaction and immunohistochemistry staining. Prognostic factors influencing survival, metastasis and recurrence were assessed. RESULTS: Intratumoral MACC1 level was found to be associated with HCC disease progression. Both median tumor-free survival (TFS) and overall survival (OS) were significantly shorter in the postoperative HCC patients with high intratumoral MACC1 expression, as compared to those with low intratumoral MACC1 levels (TFS: 34 mo vs 48.0 mo, P < 0.001; OS: 40 mo vs 48 mo, P < 0.01). Multivariable analysis indicated that high MACC1 expression or co-expression with c-Met were independent predictors for HCC clinic outcome (P < 0.001). CONCLUSION: High intratumoral MACC1 expression can be associated with enhanced tumor progression and poor outcome of HBV-related HCC. MACC1 may serve as a prognostic biomarker for postoperative HCC.

Survival and prognostic factors in hepatitis B virus-related acute-on-chronic liver failure

AIM:To investigate the survival rates and prognostic factors in patients with hepatitis B virus-related acuteon-chronic liver failure(HBV-ACLF).METHODS:Clinical data in hospitalized patients with HBV-ACLF admitted from 2006 to 2009 were retrospectively analyzed.Their general conditions and survival were analyzed by survival analysis and Cox regression analysis.RESULTS:A total of 190 patients were included in this study.The overall 1-year survival rate was 57.6%.Patients not treated with antiviral drugs had a significantly higher mortality[relative risk(RR)=0.609,P=0.014].The highest risk of death in patients with ACLF was associated with hepatorenal syndrome(HRS)(RR=2.084,P=0.026),while other significant factors were electrolyte disturbances(RR=2.062,P=0.010),and hepatic encephalopathy(HE)(RR=1.879,P<0.001).CONCLUSION:Antiviral therapy has a strong effect on the prognosis of the patients with HBV-ACLF by improving their 1-year survival rate.HRS,electrolyte disturbances,and HE also affect patient survival.

Non-alcoholic fatty liver disease and metabolic syndrome in obese children

I read with great interest the article of Fu et al who investigated whether non-alcoholic fatty liver disease(NAFLD)is an early mediator for prediction of metabolic syndrome,and whether liver B-ultrasound could be used for its diagnosis,in a study involving 861 obese children(6-16 years old).In this study,it was reported that NAFLD is not only a liver disease,but also an early mediator that reflects metabolic disorder,and that liver B-ultrasound can be a useful tool for metabolic syndrome(MS)screening.The authors reported that NAFLD and MS were present in 68.18%and 25.67%of obese children,respectively.Moreover,they observed that the prevalence of MS in NAFLD children was 37.64%,which was much higher than that in the non-NAFLD group.Criteria analogous to those of the Adult Treatment PanelⅢdefinition for MS were used for children in this study.The reported prevalence data on MS in the young has varied markedly,in large part because of disagreement among the variously proposed definitions of MS.Therefore,in my opinion,a study aiming to assess the association between MS components and NAFLD in obese children has to take into account a simple,easy-to-apply clinical definition proposed by the international diabetes federation for MS.Interpretation of the results of the Fu et al study are limited byanother major caveat:that the diagnosis or exclusion of NAFLD was based on liver enzymes and ultrasound imaging,but was not confirmed by liver biopsy.Indeed,it is known that liver enzymes may be within the reference interval in up to 70%of patients with diagnosed NAFLD and that the full histopathological spectrum of NAFLD may be present in patients with normal liver enzymes,which therefore cannot be reliably used to exclude the presence of NAFLD.

Impact of smoking habit on surgical outcomes in non-B non-C patients with curative resection for hepatocellular carcinoma

To analyzed the correlation between smoking status and surgical outcomes in patients with non-B non-C hepatocellular carcinoma (NBNC-HCC), and we investigated the patients’ clinicopathological characteristics according to smoking status.METHODSWe retrospectively analyzed the consecutive cases of 83 NBNC-HCC patients who underwent curative surgical treatment for the primary lesion at Saga University Hospital between 1984 and December 2012. We collected information about possibly carcinogenic factors such as alcohol abuse, diabetes mellitus, obesity and smoking habit from medical records. Smoking habits were subcategorized as never, ex- and current smoker at the time of surgery. The diagnosis of non-alcoholic steatohepatitis (NASH) was based on both clinical information and pathological confirmation.RESULTSAlcohol abuse, diabetes mellitus, obesity and NASH had no significant effect on the surgical outcomes. Current smoking status was strongly correlated with both overall survival (P = 0.0058) and disease-specific survival (P = 0.0105) by multivariate analyses. Subset analyses revealed that the current smokers were significantly younger at the time of surgery (P = 0.0002) and more likely to abuse alcohol (P = 0.0188) and to have multiple tumors (P = 0.023).CONCLUSIONCurrent smoking habit at the time of surgical treatment is a risk factor for poor long-term survival in NBNC-HCC patients. Current smokers tend to have multiple HCCs at a younger age than other patients.

Advances of Bioinformatics Tools Applied in Virus Epitopes Prediction

In recent years,the in silico epitopes prediction tools have facilitated the progress of vaccines development significantly and many have been applied to predict epitopes in viruses successfully. Herein,a general overview of different tools currently available,including T cell and B cell epitopes prediction tools,is presented. And the principles of different prediction algorithms are reviewed briefly. Finally,several examples are present to illustrate the application of the prediction tools.

N-terminal pro-B-type natriuretic peptide as prognostic marker for patients of non ST-segment elevation myocardial infarction

In this work, we analyzed only the patients of the NSTEMI (non ST-segment elevation myocardial infarction) who arrived at the hospital within 12 h after symptoms started. Using NSTEMI follow-up data within, the characteristics of the clinical data, the risk factor, and the blood tested in the hospital visit were analyzed for MACE (major adverse cardiac events) patients. MACE includes cardiac death, MI (myocardial infarction), Re-PCI, and CABG (coronary artery bypass graft). As a result, from the NSTEMI patients which can be followed up for over 12 m, NT-ProBNP (p=0.014) and age (p=0.045) are found to be the independent risk factors related to MACE. Accordingly, they can be useful for the diagnosis and prognosis for NSTEMI patients as a biomarker.

Admission white blood cell count predicts short-term clinical outcomes in patients with uncomplicated Stanford type B acute aortic dissection

Objectives Inflammation has been shown to be related with acute aortic dissection （AAD）. The present study aimed to evaluate the association of white blood cell counts （WI3Cc） on admission with both in-hospital and long-term all-cause mortality in patients with uncom- plicated Stanford type B AAD. Methods From 2008 to 2010, a total of 377 consecutive patients with uncomplicated type B AAD were enrolled and then followed up. Clinical data and WBCc on admission were collected. The primary end points were in-hospital death and long-term all-cause death. Results The in-hospital death rate was 4.2%, and the long-term all-cause mortality rate was 6.9% during a median follow-up of 18.9 months. WBCc on admission was identified as a risk factor for in-hospital death by univariate Cox regression analysis as both a continuous variable and a categorical variable using a cut off of 11.0 × 109 cell/L （all P 〈 0.05）. After adjusting for age, sex and other risk factors, elevated admission WBCc was still a significant predictor for in-hospital death as both a continuous variable [hazard ratio （HR）： 1.052, 95% CI： 1.024-1.336, P = 0.002] and a categorical variable using a cut off of 11.0 × 109 cell/L （HR： 2.056, 95% CI： 1.673-5.253, P = 0.034）. No relationship was observed between WBCc on admission and long-term all-cause death. Conclusions Our results indicate that elevated WBCc upon admission might be used as a predictor for increased risk of in-hospital death in uncomplicated type B AAD. There might be no predictive value of WBCc for the long-term survival of type B AAD.

Laboratory investigation on relationship between degree of saturation, B-value and P-wave velocity

Laboratory tests were performed on Toyoura sand specimens to investigate the relationship between degree of saturation Sr, B-value and P-wave velocity Vp. Different types of pore water （de-aired water or tap water） and pore gas （air or CO2） as well as different magnitudes of back pressure were used to achieve different Sr （or B-value）. The measured relationship between B-value and Vp was not consistent with the theoretical prediction. The measurement shows that the Vp value in the specimen flushed with de-aired water is independent of B-value （or St） and is always around the one in fully saturated condition. However, the Vp value in the specimen flushed with tap water increases with B-value, but the shape of the relationship between Vp and B-value is quite different from the theoretical prediction. The possible explanation for the discrepancy between laboratory measurement and theoretical prediction lies in that the air exists in the water as air bubbles and therefore the pore fluid （air-water mixture） is heterogeneous instead of homogenous assumed in the theoretical prediction.

Expression profile of CD10, Bcl-6, CD138, Bcl-2 and MUM1 and their prognostic value in 136 patients with diffuse large B-cell lymphoma

Objective： We evaluated the value of using a panel of GC B-cell （CD10 and Bcl-6） and activation （MUM1, CD138 and Bcl-2） markers by immunohistochemistry to define prognosis in patients with diffuse large B-cell lymphoma （DLBCL）. Methods： Two different models （Hans＇ and modified Chang＇s model） were applied on 136 de hove DLBCL patients. Median follow-up in all patients was 39 months （range 5-80 months）. Results： According to Hans＇ model, patients with GCB had much better overall survival （5-year OS, 75%） than those with non-GCB （5-year OS, 52%） （Kaplan-Meier survival analysis, P 〈 0.05, log rank test）. According to modified Chang＇s model, patients with group 1 had much better overall survival （5-year OS, 78%） than those with group 3 （5-year OS, 44%） while group 2 had no significant value compared with group 1 and group 3 in prognosis （Kaplan-Meier survival analysis, P 〈 0.05, log-rank test）. Using multivariate Cox proportional hazards regression analysis, the international prognostic index scores （IPI）, expression of CD138 and the expression pattern of modified Chang＇s model were independent prognostic indicators. Conclusion： Our results suggest that the expression patterns of the panel of GCB-cell and activation markers by immunohistochemistry correlate with prognosis of patients with DLBCL and both models can be used well in ordinary work.