The expression of BAX in carotid atherosclerosis and its regulation is far from defined. Objectives To investigate BAX expression in stable/fibrous and instable/vulnerable carotid plaque and its clinical significance....The expression of BAX in carotid atherosclerosis and its regulation is far from defined. Objectives To investigate BAX expression in stable/fibrous and instable/vulnerable carotid plaque and its clinical significance. Methods 25 cases of carotid plaque specimens obtained from endarterectomy were divided into two groups, stable/fibrous 14 cases, vulnerable/instable 11 cases; aortic artery and its branches from hepatic transplantation donors 6 case as control The expression of proapoptotic BAX was detected by immunohistochemistry （IHC）, in situ hybridization （ISH） and in situ TdT dUTP nick end labeling （TUNEL）. Results 5 cases of BAX （ ＋ ） were detected by ICH and ISH, 4 case of TUNEL （ ＋ ） were detected by TUNEL in stable/fibrous carotid plaque , while 10 cases were BAX （ ＋ ）by IHC（P 〈 0.05 ） , 11 case by ISH and 9 case by TUNEL were detected in instable/vulnerable carotid plaque （P 〈0.01 ）, respectively. The intensity of BAX （ ＋ ） cells by IHC and ISH was 8.63±2.62 and 10.32 ± 3.12 in fibrous plaques,whereas 122 ±21.64 and 152 ± 23.35 in vulnerable plaques, respectively. No expression of BAX was found in controlled group. Conclusion The higher expression of Bax in vulnerable carotid plaque may be one mechanisms in molecular pathogenesis of carotid atherosclerosis which affect plaque stability and be the cause of higher incidence of stroke than fibrous carotid plaques, the regulation of BAX expression in different stage of atherosclerosis may provide targets in gene therapy for carotid atherosclerosis.展开更多
Absence of the common carotid artery(CCA) and/or internal carotid artery (ICA ) is a kind of rare congenital anomaly. This paper reports one patient with bilateral absence of the CCA and ICA who suffered from cerebral...Absence of the common carotid artery(CCA) and/or internal carotid artery (ICA ) is a kind of rare congenital anomaly. This paper reports one patient with bilateral absence of the CCA and ICA who suffered from cerebral infarction. And the relative literatures of the possible cause and collateral circulation were reviewed.展开更多
To evaluate the effects of carotid endoarterectomy in the treatment of extracranial cerebrovascular disease, 26 cases with internal carotid stenosis were performed by three different kinds of surgical endoarterectomy....To evaluate the effects of carotid endoarterectomy in the treatment of extracranial cerebrovascular disease, 26 cases with internal carotid stenosis were performed by three different kinds of surgical endoarterectomy. The satisfactory results were achieved in all the patients, with no complications and mortality occurring. Endoarterectomy is the effective way to treat the extracranial cerebrovascular disease.展开更多
文摘The expression of BAX in carotid atherosclerosis and its regulation is far from defined. Objectives To investigate BAX expression in stable/fibrous and instable/vulnerable carotid plaque and its clinical significance. Methods 25 cases of carotid plaque specimens obtained from endarterectomy were divided into two groups, stable/fibrous 14 cases, vulnerable/instable 11 cases; aortic artery and its branches from hepatic transplantation donors 6 case as control The expression of proapoptotic BAX was detected by immunohistochemistry （IHC）, in situ hybridization （ISH） and in situ TdT dUTP nick end labeling （TUNEL）. Results 5 cases of BAX （ ＋ ） were detected by ICH and ISH, 4 case of TUNEL （ ＋ ） were detected by TUNEL in stable/fibrous carotid plaque , while 10 cases were BAX （ ＋ ）by IHC（P 〈 0.05 ） , 11 case by ISH and 9 case by TUNEL were detected in instable/vulnerable carotid plaque （P 〈0.01 ）, respectively. The intensity of BAX （ ＋ ） cells by IHC and ISH was 8.63±2.62 and 10.32 ± 3.12 in fibrous plaques,whereas 122 ±21.64 and 152 ± 23.35 in vulnerable plaques, respectively. No expression of BAX was found in controlled group. Conclusion The higher expression of Bax in vulnerable carotid plaque may be one mechanisms in molecular pathogenesis of carotid atherosclerosis which affect plaque stability and be the cause of higher incidence of stroke than fibrous carotid plaques, the regulation of BAX expression in different stage of atherosclerosis may provide targets in gene therapy for carotid atherosclerosis.
文摘Absence of the common carotid artery(CCA) and/or internal carotid artery (ICA ) is a kind of rare congenital anomaly. This paper reports one patient with bilateral absence of the CCA and ICA who suffered from cerebral infarction. And the relative literatures of the possible cause and collateral circulation were reviewed.
文摘To evaluate the effects of carotid endoarterectomy in the treatment of extracranial cerebrovascular disease, 26 cases with internal carotid stenosis were performed by three different kinds of surgical endoarterectomy. The satisfactory results were achieved in all the patients, with no complications and mortality occurring. Endoarterectomy is the effective way to treat the extracranial cerebrovascular disease.
