颈髓损伤对颈髓细胞线粒体膜流动性与线粒体呼吸功能的影响

目的 探讨颈髓损伤后颈髓细胞线粒体膜流动性变化与线粒体呼吸功能的关系。 方法 30只猫随机分成假手术组 (对照组 )和颈髓损伤后 2 ,6 ,2 4,72h组 ,每组 6只。采用Allen打击法造成猫颈髓损伤 ,观察颈髓损伤后线粒体膜流动性、磷脂酶A2 (PLA2 )活性、线粒体呼吸控制率 (RCR)、磷氧比值 (P/O)、氧化磷酸化效率 (OPR)的变化。 结果 颈髓损伤后 2～ 72h线粒体膜PLA2 活性较假手术对照组明显增高 (P <0 .0 5 ) ,而线粒体膜流动性、RCR、P/O比值、OPR均较假手术对照组明显降低 (P <0 .0 5 )。 结论 颈髓损伤后 ,PLA2 激活与膜流动性降低密切相关 ,颈髓线粒体膜流动性降低在颈髓损伤后线粒体呼吸功能损害的病理过程中起重要作用。

Diagnosis and treatment of intramedullary hemangioblastoma of cervical spinal cord

OBJECTIVE: To investigate the diagnosis and surgical techniques of intramedullary hemangioblastoma of the cervical spinal cord. METHODS: MR imaging and the methods and results of surgery were analyzed in 21 patients. RESULTS: The tumors were divided into three types on MR imaging. Syringeal type, where the tumor varied in size and was accompanied by syringobulbia and syringomyelia; Cystic type, where the tumor presented as a cyst with a small mural node; and Solid type, where the tumor was revealed as a huge solid mass. All tumors were totally removed and diagnosis was confirmed by histological study. Post-operative neurological status was improved in 20 patients and aggravated in 1. CONCLUSIONS: The localization and the nature diagnosis of the tumor can be made by cervical MR imaging. Operative methods vary with tumor types. It is the most important that the tumor is dissected along the right interface and removed after devascularization.