Objective: To examine the association between chronic infection and cumulative burden of infection and acute coronary syndrome. Design: The 5C(Cork coronary care case-control)-study was a community based case-control ...Objective: To examine the association between chronic infection and cumulative burden of infection and acute coronary syndrome. Design: The 5C(Cork coronary care case-control)-study was a community based case-control study. Patients and controls underwent a standard physical examination and had blood samples taken for serological analysis for Helicobacter pylori(IgG), Chlamydia pneumoniae(IgA, IgM, and IgG), cytomegalovirus(IgG), and herpes simplex virus types 1 and 2(IgG). Setting: Patients were recruited from four hospitals in Cork City and Mal lowTown, Controls, individually matched on age and sex, were selected by incident density sampling from the same general practices as the referent case. Main outcome measures: Age and sex adjusted and fully adjusted odds ratios for acute coronary syndrome by seropositivity and by increasing number of infections. Results: Cases and controls did not differ significantly in seropositivity to C pneumoniae, cytomegalovirus, herpes simplex viruses, and H pylori. In unconditional logistic regression analysis adjusted for age, sex, waist to hip ratio, smoking, physical activity, alcohol consumption, and social class there was no evidence of an increasing risk for acute coronary syndrome with increasing burden of infection. Conclusions: The findings do not support an association between specific infectious agents and acute coronary syndrome and do not provide evidence of a burden of infection effect.展开更多
目的评价低温等离子射频消融术切除扁桃体的安全性及可行性。方法计算机检索Medline数据库、P u b m e d、中国生物医学数据库(C BM)、C N K I及万方数据库国内外关于低温等离子射频消融术与传统扁桃体剥除术的随机对照试验及临床对照...目的评价低温等离子射频消融术切除扁桃体的安全性及可行性。方法计算机检索Medline数据库、P u b m e d、中国生物医学数据库(C BM)、C N K I及万方数据库国内外关于低温等离子射频消融术与传统扁桃体剥除术的随机对照试验及临床对照试验。运用Rev Man 5.1软件对两种手术方式在术中、术后指标进行Meta分析。结果共纳入20个随机对照试验和5个临床对照试验,共4162例患者。低温等离子射频消融术与传统扁桃体剥除术相比,显著缩短了手术时间[MD=-16.04,95%CI(-20.24,-11.84),P<0.0 0 0 01],减少了术中出血量[M D=-50.07,95%CI(-6 6.0 3,-3 4.11),P<0.0 0 0 01],缩短了住院时间[MD=-3.18,95%CI(-5.72,-0.63),P=0.01],加快了恢复饮食时间[MD=-1.98,95%CI(-3.11,-0.85),P=0.0006],减轻了患者疼痛程度(术后6、24、48、72 h)(VAS评分)(P<0.05),减少了术后并发症发生率[MD=0.65,95%CI(0.46,0.93),P=0.02],同时延长了白膜脱落时间[MD=1.84,95%CI(0.24,3.44),P=0.02],而平均疼痛时间无显著差别。结论现有的研究表明,低温等离子射频消融术切除扁桃体在应用价值上具有创伤小、恢复快,更加安全和有效,但是由于数量少,期待更多高质量的试验提供高质量的证据。展开更多
文摘Objective: To examine the association between chronic infection and cumulative burden of infection and acute coronary syndrome. Design: The 5C(Cork coronary care case-control)-study was a community based case-control study. Patients and controls underwent a standard physical examination and had blood samples taken for serological analysis for Helicobacter pylori(IgG), Chlamydia pneumoniae(IgA, IgM, and IgG), cytomegalovirus(IgG), and herpes simplex virus types 1 and 2(IgG). Setting: Patients were recruited from four hospitals in Cork City and Mal lowTown, Controls, individually matched on age and sex, were selected by incident density sampling from the same general practices as the referent case. Main outcome measures: Age and sex adjusted and fully adjusted odds ratios for acute coronary syndrome by seropositivity and by increasing number of infections. Results: Cases and controls did not differ significantly in seropositivity to C pneumoniae, cytomegalovirus, herpes simplex viruses, and H pylori. In unconditional logistic regression analysis adjusted for age, sex, waist to hip ratio, smoking, physical activity, alcohol consumption, and social class there was no evidence of an increasing risk for acute coronary syndrome with increasing burden of infection. Conclusions: The findings do not support an association between specific infectious agents and acute coronary syndrome and do not provide evidence of a burden of infection effect.
文摘目的评价低温等离子射频消融术切除扁桃体的安全性及可行性。方法计算机检索Medline数据库、P u b m e d、中国生物医学数据库(C BM)、C N K I及万方数据库国内外关于低温等离子射频消融术与传统扁桃体剥除术的随机对照试验及临床对照试验。运用Rev Man 5.1软件对两种手术方式在术中、术后指标进行Meta分析。结果共纳入20个随机对照试验和5个临床对照试验,共4162例患者。低温等离子射频消融术与传统扁桃体剥除术相比,显著缩短了手术时间[MD=-16.04,95%CI(-20.24,-11.84),P<0.0 0 0 01],减少了术中出血量[M D=-50.07,95%CI(-6 6.0 3,-3 4.11),P<0.0 0 0 01],缩短了住院时间[MD=-3.18,95%CI(-5.72,-0.63),P=0.01],加快了恢复饮食时间[MD=-1.98,95%CI(-3.11,-0.85),P=0.0006],减轻了患者疼痛程度(术后6、24、48、72 h)(VAS评分)(P<0.05),减少了术后并发症发生率[MD=0.65,95%CI(0.46,0.93),P=0.02],同时延长了白膜脱落时间[MD=1.84,95%CI(0.24,3.44),P=0.02],而平均疼痛时间无显著差别。结论现有的研究表明,低温等离子射频消融术切除扁桃体在应用价值上具有创伤小、恢复快,更加安全和有效,但是由于数量少,期待更多高质量的试验提供高质量的证据。
