AIM: To investigate whether in the prefrontal cortical(PFC) pyramidal eells, focal glutamate application tothe apical dendrite induces bursting and whether theeffect of glutamate involves activation of both NMDAand no...AIM: To investigate whether in the prefrontal cortical(PFC) pyramidal eells, focal glutamate application tothe apical dendrite induces bursting and whether theeffect of glutamate involves activation of both NMDAand non-NMDA receptors. METHODS: Pyramidalcells in layers Ⅴ and Ⅵ of the PFC were visualized inrat brain slices using infrared videomicroscopy andrecorded with whole-cell electrodes. Glutamate and itsagonists were focally applied to the apical dendrite andthe soma using microiontophoresis. RESULTS:Dendritic glutamate application (0--20 nA, 10 mmol/L) induced repetitive bursts in most cells tested (12/展开更多
基金Scottish Rite Benevolent Foundation's Schizophrenia Research Program (Shi WX)a NASARD Young Investigator Award (Shi WX)an USPHS grant MH52686(shi WX)
文摘AIM: To investigate whether in the prefrontal cortical(PFC) pyramidal eells, focal glutamate application tothe apical dendrite induces bursting and whether theeffect of glutamate involves activation of both NMDAand non-NMDA receptors. METHODS: Pyramidalcells in layers Ⅴ and Ⅵ of the PFC were visualized inrat brain slices using infrared videomicroscopy andrecorded with whole-cell electrodes. Glutamate and itsagonists were focally applied to the apical dendrite andthe soma using microiontophoresis. RESULTS:Dendritic glutamate application (0--20 nA, 10 mmol/L) induced repetitive bursts in most cells tested (12/
