宋诗东传与异域阐释——四种宋人诗集日本古注本考论

宋诗是随着朱子学东传到日本的,在日本中世时期就产生了不少关于东坡诗、山谷诗、宋代禅僧诗的“抄物”,即对诗歌的注释、讲解之作。江户时期中期,以市河宽斋、大窪诗佛、山本北山、柏木如亭为代表的“江湖诗社”诗人开始提倡学习“清新”的宋诗,反对“古文辞学派”倡导的唐诗、明诗,他们特别推崇陆游、杨万里、范成大等南宋中兴“三大家”的诗,编纂了很多“三大家”诗歌的选本与注本。本文从日本汉文学史的脉络出发,对日本中世、近世时期四部宋集注本《冠注祖英集》《宋三大家绝句笺解》《感兴诗考注》《中兴禅林风月集注》进行了考证,考察其学术背景与阐释特色。

GM1 stabilizes expression of NMDA receptor subunit 1 in the ischemic hemisphere of MCAo/reperfusion rat

Objective: To determine the protective effect of monosialoganglionside (GM1) and evaluate the influence of GM1 on expression of N-methyl-D-aspartate receptor subunit 1 (NMDAR1) in Sprague-Dawley (SD) rats with focal cerebral ische- mia-reperfusion (I/R). Methods: Left middle cerebral artery (MCA) was occluded by an intraluminal suture for 1 h and the brain was reperfused for 72 h in SD rats when infarct volume was measured, GM1 (10 mg/kg) was given ip (intraperitoneally) at 5 min (group A), 1 h (group B) and 2 h (group C) after MCA occlusion (MCAo). Expression of NMDAR1 was detected by Western blot at various time after reperfusion (4 h, 6 h, 24 h, 48 h and 72 h) in ischemic hemispheres of the rats with or without GM1 admin- istered. Results: (1) Adjusted relative infarct volumes of groups A and B were significantly smaller than that of group C and the control group (P<0.01 and P<0.05, respectively). (2) Expression level of NMDAR1 was temporally high at 6 h after reperfusion, and dipped below the normal level at 72 h after reperfusion. GM1 at 5 min after MCAo significantly suppressed the expression of NMDAR1 at 6 h after reperfusion (P<0.05 vs the control). At 72 h after reperfusion, the NMDAR1 expression level of rats treated with GM1 administered (at 5 min or 2 h after MCAo) was significantly higher than that of the control (P<0.05). Conclusion: GM1 can time-dependently reduce infarct volume in rats with focal cerebral I/R partly through stabilizing the expression of NMDAR1.

Protective effects of apocynin and allopurinol on ischemia/reperfusion-induced liver injury in mice

AIM: To determine the effects of allopurinol, an inhibitor of xanthine oxidase, and apocynin, an inhibitor of NADPH oxidase, on oxidant stress and liver injury caused by hepatic ischemia/reperfusion (I/R) procedure in mice. METHODS: Mice were pretreated with a xanthine oxidase inhibitor, allopurinol, or NADPH oxidase (NOX) inhibitor, apocynin before the hepatic I/R procedure. Then treated or untreated mice underwent the hepatic I/R procedure. The effects on hepatic injury and superoxide anions were determined after starting reperfusion. RESULTS: A standard warm hepatic I/R procedure led to a marked increase in superoxide anion production as indicated by a superoxide anion tracer, MCLA. At the same time, the procedure caused profound acute liver injury, as indicated by elevated serum alanine aminotransferase and tumor necrosis factor-α levels, reduced liver glutathione levels and elevated malondialdehyde contents, as well as a high apoptotic cell count. All these changes were reversed by the use of apocynin or allopurinol prior to the hepatic I/R procedure. CONCLUSION: Allopurinol and apocynin exerted protective effects on hepatic ischemia/reperfusion injury. The protection is associated with blocking the generationof superoxide anions during the hepatic I/R procedure by inhibiting xanthine oxidase and NADPH oxidase activity.

Somatostatin adjunctive therapy for non-variceal upper gastrointestinal rebleeding after endoscopic therapy

AIM:To evaluate the effect of pantoprazole with a somatostatin adjunct in patients with acute non-variceal upper gastrointestinal bleeding(NVUGIB).METHODS:We performed a retrospective analysis of a prospective database in a tertiary care university hospital.From October 2006 to October 2008,we enrolled 101 patients with NVUGIB that had a high-risk stigma on endoscopy.Within 24 h of hospital admission,all patients underwent endoscopic therapy.After successful endoscopic hemostasis,all patients received an 80-mg bolus of pantoprazole followed by continuous intravenous infusion(8 mg/h for 72 h).The somatostatin adjunct group(n=49)also received a 250-μg bolus of somatostatin,followed by continuous infusion (250μg/h for 72 h).Early rebleeding rates,disappearance of endoscopic stigma and risk factors associated with early rebleeding were examined.RESULTS:Early rebleeding rates were not significantly different between treatment groups(12.2%vs 14.3%,P=0.766).Disappearance of endoscopic stigma on the second endoscopy was not significantly different between treatment groups(94.2%vs 95.9%,P=0.696).Multivariate analysis showed that the complete Rockall score was a significant risk factor for early rebleeding(P =0.044,OR:9.080,95%CI:1.062-77.595).CONCLUSION:The adjunctive use of somatostatin was not superior to pantoprazole monotherapy after successful endoscopic hemostasis in patients with NVUGIB.

Hepatitis C virus in Pakistan:A systematic review of prevalence,genotypes and risk factors

In Pakistan more than 10 million people are living with Hepatitis C virus (HCV), with high morbidity and mortality. This article reviews the prevalence, genotypes and factors associated with HCV infection in the Pakistani population. A literature search was performed by using the keywords; HCV prevalence, genotypes and risk factors in a Pakistani population, in Pubmed, PakMediNet and Google scholar. Ninetyone different studies dating from 1994 to May 2009 were included in this study, and weighted mean and standard error of each population group was calculated. Percentage prevalence of HCV was 4.95% ± 0.53% in the general adult population, 1.72% ± 0.24% in the pediatric population and 3.64% ± 0.31% in a young population applying for recruitment, whereas a very high 57% ± 17.7% prevalence was observed in injecting drug users and 48.67% ± 1.75% in a multi-transfused population. Most prevalent genotype of HCV was 3a. HCV prevalence was moderate in the general population but very high in injecting drug users and multi-transfused populations. This data suggests that the major contributing factors towards increased HCV prevalence include unchecked blood transfusions and reuse of injection syringes. Awareness programs are required to decrease the future burden of HCV in the Pakistani population.

Conceptual Design and Aerodynamic Study of Joined-Wing Business Jet Aircraft

The concept of joined-wing aircraft with nonplanar wings as conceived and patented by Wolkovitch is attractive due to various advantages such as light weight, high stiffness, low induced drag, high trimmed CLmax, reduced wetted area and parasite drag and good stability and control, which have been supported by independent analyses, design studies and wind tunnel tests. With such foreseen advantages, the present work is carried out to design joined-wing business-jet aircraft and study and investigate its advantages and benefits as compared to the current available conventional business jet of similar size, passenger and payload capacity. In particular, the work searches for a conceptual design of joined-wing configured business-jet aircraft that possesses more superior characteristics and better aerodynamic performance in terms of increased lift and reduced drag, and lighter than the conventional business jet of similar size. Another significant objective of this work is to prove that the added rigidity possessed by the joined wing configuration can contribute to weight reduction.

Effects of electroacupuncture at Fengchi(GB20)on motor function and GFAP/NeuN expression around the ischemic tissue of the motor cortex in MCAO rats

Objective:To investigate the potential mechanism of electroacupuncture(EA)at bilateral Fengchi(GB20)in treating cerebral ischemia-reperfusion injury and to provide a scientific basis for future experimental research and clinical applications.Methods:Forty male specific-pathogen-free Sprague-Dawley rats were randomly divided into four groups:a normal group,a normal with EA group,a model group,and a model with EA group,with 10 rats in each group.The normal group received no intervention.The normal with EA group received EA at bilateral Fengchi(GB20).The model group underwent middle cerebral artery occlusion(MCAO)using the suture.The model with EA group underwent MCAO and received EA at bilateral Fengchi(GB20).Cerebral blood flow was monitored using a laser Doppler cerebral blood flow meter.Neurologic damage was assessed using the neurologic deficit score,and motor ability was observed using the CatWalk gait system.The expression of glial fibrillary acidic protein(GFAP)and neuronal nuclei(NeuN)protein,the neuron markers,was detected by Western blotting.The protein expression levels of GFAP and NeuN,as well as the number of positive cells in the motor cortex,were detected using immunofluorescence.Results:Compared to the normal group,the cerebral blood flow values in the model group and the model with EA group decreased by more than 50%during the modeling process(P<0.01)and returned to pre-modeling levels after reperfusion(P>0.05).The neurologic deficit score increased(P<0.05),the average motor velocity decreased(P<0.05),GFAP protein expression and the number of positive cells in the motor cortex increased(P<0.05),and the NeuN protein expression and the number of positive cells decreased(P<0.05)in the model group.Compared to the model group,the neurologic deficit score decreased(P<0.05),the average motor velocity accelerated(P<0.05),GFAP and NeuN protein expression and the number of positive cells in the motor cortex increased(P<0.01)in the model with EA group.Conclusion:EA at bilateral Fengchi(GB20)can reduce neuronal loss and increase GFAP and NeuN protein expression in the motor cortex of rats after ischemia-reperfusion,improve the motor function after ischemic stroke,and accelerate the recovery of balance and stability of the affected limbs.

干祖望对舌部杂病的临证思辨方法

口舌部疾病在古代隶属喉科范畴，本篇选取干祖望医案中治疗舌部疾病的几则记录，进行分析探讨，由于这几个疾病缺乏系统的现代医学名称，故将其综合起来共同讨论，分别以飞扬喉、风注、舌根痛、弄舌症等命名进行讨论。

UP GIFT

Christofle Palm系列项链美国艺术家Michele Oka Doner为Christofle设计的纯银首饰——Palm棕榈系列,将源于自然的灵感注入其中,使海贝、荆棘乃至植物的根系、枝条优雅呈现于这一套自然主义味道极浓的首饰中,幻化出藤蔓及谷穗的形象,缠绕于女士优美的曲线。

腊字·腊八·腊月

＂腊＂的先字 ＂腊＂字,繁体为＂腊＂。远古时期,腊是一种祭礼。先人习在冬季将尽时,用猎获的禽兽举行大祭,是为＂猎祭＂,以祈福求寿,避灾迎祥。后来,每年农历十二月被定为＂腊月＂,即如《礼记·月令》所记：＂是月也,大饮蒸。天子乃祈来年于天宗。＂故而,＂猎祭＂遂更称＂腊祭＂。这也是＂猎＂字与＂腊＂字相通的原因。《风俗通》里就说：＂腊,猎也。＂可见,＂腊＂源于＂猎＂,即＂猎＂字在先,＂腊＂字后出。

Effects of Electroacupuncture on the Ability of Learning and Memory in Rats with Ischemia-reperfusion Injury

Objective： To observe the effects of pretreatment and treatment with electroacupuncture on the ability of learning and memory in rats with ischemia-reperfusion injury, and to provide the research basis for preventing and treating the disorder of learning and memory in patients with apoplectic sequelae. Methods： Seventy-two SD rats, clean class, were randomly divided into sham operation group, model group, pretreatment group, and treatment group. The step-through latency and number of errors, nerve injury score, and the number of cholinoceptor in the affected hippocampus were recorded to analyze the effects of pretreatment and treatment with electroacupuncture on the ability of learning and memory in rats with ischemia-reperfusion injury. Results： 1） The rats with ischemia had various signs of nerve injury. Compared with that in the sham operation rats, the nerve injury score in the model rats was lower, the step-through latency and number of errors were increased, and the content of special mAchR was decreased （P〈0.05）; 2） Electroacupuncture could decrease the nerve injury score of the model rats. Compared with those in the model group, the step-through latency and number of errors all had significant difference in the pretreatment and treatment groups （P〈0.05）; 3） Compared with that in the model group, the content of mAchR was increased in the pretreatment group （P〈0.05）, and increased a little in the treatment group. Conclusion： Pretreatment and treatment with electroacupuncture can prolong step-through latency, and

Improving Film Cooling Performance by Using One-Inlet and Double-Outlet Hole

The film cooling performance of a trunk-branch hole is investigated by numerical simulation in this paper. The geometry of the hole is a novel cooling concept, which controls the vortices-pair existing at the mink hole outlet using the injection of the branch hole. The trunk-branch holes require easily machinable round hole as compared to the shaped holes. The flow cases were considered at the blowing ratios of 0.5, 0.75, 1.0, 1.5 and 2.0. At the low blowing ratio of 0.5, the vortices-pair at the outlet of the trunk hole is reduced and the laterally coverage of the film is improved. At the high blowing ratio of 2.0, the vortices-pair is killed by the vortex which is produced by the injection of the branch hole. The flow rate of the two outlets becomes more significantly different when the blowing ratio increases from 0.75 to 2.0. The discharge coefficients increase 0.15 and the laterally averaged film effectiveness improve 0.2 as compared to the cylindrical holes. The optimal blowing ratios occur at M=1.0 or M= 1.5 according to the various locations downstream of the holes.