风湿性湿关节炎患者中医临床治疗的疗效观察与分析

观察用中医临床治疗方法治疗风湿性湿关节炎患者的效果,并分析是否具备临床推广价值。方法 选择2023年上半年在本院诊疗的116例风湿性湿关节炎患者,按照入院时间对他们编号,其中编号为单数的患者为对照组,对他们进行日常调理,借助抗炎镇痛药等常规方法进行治疗;编号为双数的患者为实验组,对他们在采用常规治疗方法的同时,也配合针灸治疗等方法。观察二组患者的治疗效果、生活质量变化情况,进行横向对比。结果 和对照组相比,实验组患者在治疗前的相关指数差异不大,而治疗后的指数明显偏低,晨僵延续时间同样更短;实验组的治愈人数、治愈率、显效人数、显效率、无效人数、无效率分别为17、29.31%、41、70.69%、2、3.45%,表示非常满意的人数及占比、表示满意的人数及占比、表示不满意的人数及占比分别是23、39.66%、34、58.62%、3、51.72%。对照组的治愈人数、治愈率、显效人数、显效率、无效人数、无效率分别为9、15.52%、34、58.62%、15、25.86%,表示非常满意的人数及占比、表示满意的人数及占比、表示不满意的人数及占比分别是12、20.69%、24、41.38%、22、37.93%。两组的相关数据比较差异大,具备统计价值,P<0.05。结论 在对风湿性湿关节炎患者治疗期间,在应用中药临床治疗方法的情况下,可形成更为显著的疗效,可更好地改善临床症状,更能提高患者的生活质量,具有较大的临床推广价值。

外用清热利湿通络中药治疗湿热痹阻型类风湿性关节炎患者的临床效果及中药学探讨

观察外用清热利湿通络中药治疗湿热痹阻型类风湿性关节炎患者的临床效果及中药学。方法 选取我院湿热痹阻型类风湿性关节炎患者84例(2021年8月至2022年10月),随机分为外用清热利湿通络中药治疗的观察组(42例)与常规治疗的对照组(42例)。结果 与对照组相比,观察组临床症状评分低,炎性因子水平低,P<0.05。结论 给予湿热痹阻型类风湿性关节炎患者外用清热利湿通络中药治疗效果显著,值得借鉴。

自拟蠲痹通络汤治疗早期类风湿性关节炎湿热痹阻证的疗效及对脂肪因子的影响

目的:观察自拟蠲痹通络汤治疗早期类风湿性关节炎(rheumatoid arthritis,RA)湿热痹阻证的临床疗效及对脂肪因子(内酯素、脂联蛋白、抵抗素)的影响。方法:将RA患者72例按随机数字表法分为观察组与对照组各36例。对照组予甲氨蝶呤片和柳氮磺吡啶肠溶片治疗,观察组在此基础上予自拟蠲痹通络汤治疗。治疗4周后观察两组患者治疗前后主要症状(关节疼痛、肿胀及屈伸不利)评分,检测红细胞沉降率(erythrocyte sedimentation rate,ESR)、C-反应蛋白(C-reactive protein,CRP)、类风湿因子(rheumatoid factors,RF)及血清内酯素、脂联蛋白、抵抗素等指标水平,并评价临床疗效。结果:总有效率观察组为91.7%(33/36),高于对照组的75.0%(27/36),差异有统计学意义(P<0.05);治疗后两组患者关节疼痛、肿胀及屈伸不利等主要症状评分,ESR、CRP、RF水平及血清内酯素、脂联蛋白、抵抗素等脂肪因子水平较治疗前下降(P<0.05),观察组下降更明显(P<0.05)。结论:甲氨蝶呤片和柳氮磺吡啶肠溶片联合自拟蠲痹通络汤能缓解早期RA湿热痹阻证患者主要临床症状,改善实验室理化指标,其机制可能与降低脂肪因子水平,调节炎症免疫反应有关。

中西医结合疗法治疗湿热痹阻型类风湿性关节炎的效果探析

目的评价并研究选择采用中西医结合疗法对于湿热痹阻型类风湿性关节炎患者进行治疗的临床治疗效果,以便为临床治疗工作提供有价值的参考依据。方法本研究当中所选择的患者均来自我院在2016年4月至2017年8月收治的湿热痹阻型类风湿性关节炎患者,选择50例患者作为本研究的对照组,对于所有患者选择采用常规的西医治疗方法进行治疗,同时选择同期收治的50例患者作为本研究的观察组,对所有患者选择采用中西医结合的方法进行治疗,评价两种患者的临床治疗效果,并且对两组患者治疗后的中医症候评分的改善情况进行比较。结果对于两组患者的临床治疗总有效率情况进行比较,在治疗以后,观察组患者的临床中治疗有效率明显高于对照组,两组患者之间存在差异性,P <0.05,具有统计学意义;对于本研究两组患者治疗以后,患者的中医证侯的评分的改善情况进行比较,观察组也明显优于对照组,两组之间比较,P <0.05,差异明显,具有统计学意义。结论临床上对于湿热痹阻型类风湿性关节炎患者在治疗的时候为患者选择采用中西医结合治疗的疗法进行治疗能有效的改善患者临床症状,提高患者的临床治疗有效率,改善患者的中医综合评分,具有推广使用的价值。

６４例风寒湿阻型类风湿性关节炎患者应用温针灸治疗效果探究

目的 探讨研究风寒湿阻型类风湿性关节炎患者应用温针灸的治疗效果.方法 将自２０１３年１２月至２０１５年１１月之间在我院治疗的６４例风寒湿阻型类风湿性关节炎患者为研究对象,对患者采用温针灸术进行治疗,并在治疗后对患者的评价指标进行统计分析.结果 ６４例患者有６１例患者达到有效标准,总有效率达９５??３１％,显效例数达４７例占７３??４４％.结论 采用温针灸治疗风寒湿阻型类风湿性关节炎,具有较好的临床疗效,安全性高,同时治疗费用较为低廉,具有较高的临床推广应用价值.

外用清热利湿通络中药治疗湿热痹阻型类风湿性关节炎的效果研究

目的分析外用清热利湿通络中药治疗湿热痹阻型类风湿性关节炎的效果。方法66例湿热痹阻型类风湿性关节炎患者,采用随机数字表法分为对照组和观察组,每组33例,对照组采用常规治疗,观察组在常规治疗基础上加用清热利湿通络中药外敷治疗。对比两组患者治疗效果和临床症状积分。结果实验组患者治疗总有效率为78.79%,高于对照组的54.55%,差异有统计学意义(P<0.05)。治疗后,实验组患者关节肿胀、晨僵和疼痛积分均低于对照组,差异有统计学意义(P<0.05)。结论对湿热痹阻型类风湿性关节炎进行外用清热利湿通络中药方法治疗,可以有效提高治疗效果,改善患者的临床症状,值得广泛应用。

MODIFICATION OF TRYPTOPHAN RESIDUES OF IgGRF AND ITS EFFECT ON THE ADSORPTION CAPACITY

Tryptophan residues of IgGRF from rheumatoid arthritis patient were modified with N-Bromosuccinimide (NBS) and the product of modification was characterized by UV-spectrum、Fluorescence emission spectrum and CD-spectrum. The corresponding adsorption capacity of immobilized ssDNA immunoadsorbent for IgGRF was enhanced from 46% to 86%, This result indicates the tryptophan residue is essential for the interaction between ssDNA and IgGRF .and ionic-bonding plays an important role in adsorption.

Clinical Observation on Treatment of Rheumatoid Arthritis with Fengshi Xiandan in 53 Cases

We have successfully developed Fengshi Xiandan (风湿仙丹) and used it to treat 53 cases of rheumatoid arthritis (RA),with indomethacin used to treat another 53 cases of RA as the controls.The results showed that the rate of cure and obvious effect was 54.7% and the total effective rate was 92.4% in the treatment group,as compared to 26.4% and 66.0% respectively in the control group,with an obvious difference in curative effect between the two groups (P<0.01).The improvement of all the main clinical symptoms and signs except arthralgia in the treatment group was superior to that in the control group (P<0.05 or P<0.01). The improvement of erythrocyte sedimentation rate (ESR),rheumatoid factor (RF),C-reaction protein (CRP), immunoglobulin (Ig),T-lymphocyte subgroups,micro-circulation in nail fold,and red blood cell (RBC) and hemoglobin (Hb) of anemia patients in the treatment group was superior to that in the control group (P<0.05 or P<0.01).There was an obvious difference (P<0.05 or P<0.01) in superoxide dismutase (SOD) of RBC and lipid peroxide (LPO) of plasma before treatment in the two groups as compared to normal group (P<0.05 or P<0.01).The level of SOD and LPO after treatment in the treatment group obviously tended to normal as compared to that befbre treatment (P<0.05 or P<0.01).The reduction of LPO in the treatment group was obviously superior to that in the control group (P<0.01).The result shows that Fengshi Xiandan (风湿仙丹) with an obvious curative effect on RA can not only control the symptoms of RA but also improve its pathologic damage and prevent its development.

A DOUBLE BLIND OBSERVATION FOR THERAPEUTIC EFFECTS OF THE TONG LUO KAI BI TABLETS ON RHEUMATOID ARTHRITIS

The therapeutic effects of the Tong Luo Kai Bi Tablets [symbol: see text] in 120 patients with rheumatoid arthritis were observed in this clinical trial by the randomized double blind method. Both the observed group and the control group each had 60 patients. In the observed group treated with the Tong Luo Kai Bi Tablets, 1 case (1.7%) was cured clinically, 27 cases (45.0%) improved markedly, 26 cases (43.3%) improved, with a total effective rate of 90.0%. In the control group treated with Rheumatic Semen Strychni Tablets [symbol: see text], no case was cured, 16 cases (26.7%) improved markedly, 33 cases (55.0%) improved, with a total effective rate of 81.7%. Statistical data showed the Tong Luo Kai Bi Tablets had much better therapeutic effectiveness clinically than the Rheumatic Semen Strychni Tablets (P

Effect of methotrexate combined with Sanhuang Yilong decoction on serum and synovial fluid aquaporin levels in rheumatoid arthritis dampness-heat blockage syndrome

OBJECTIVE:To study the effect of methotrexate(MTX) combined with Sanhuang Yilong decoction(SYD) on aquaporin(AQP) expression,and to explore the role of AQPs in the pathogenesis of rheumatoid arthritis(RA).METHODS:A total of 118 dampness-heat blockage type RA patients who were hospitalized in the General Chengdu Military Hospital between January2014 and December 2016 were selected as subjects in this study(30 patient of these patients with knee joint effusion were assigned to the RA synovial fluid group).For the pre-treatment controlgroups,30 healthy volunteers were recruited as the healthy control group and 30 osteoarthritis(OA) patients with knee joint effusion were included as OA synovial fluid control group.The RA dampnessheat blockage syndrome treatment groups were divided into 45 cases in the combined group and 45 cases in the MTX group.The combined group received MTX combined with SYD treatment while the MTX group received MTX alone.AQP1,AQP2 and AQP3 expressions were detected in the serum and synovial fluid.RESULTS:AQP1 had the highest expression,followed by AQP3,and AQP2.The serum levels of AQP1,AQP2 and AQP3 were all significantly lower than those in the healthy volunteers(P < 0.05),while the synovial fluid AQP1,AQP2 and AQP3 expression in the RA group were comparable to these in the OA groups(P > 0.05).After treatment for2 weeks,serum AQP1,AQP2,AQP3 were significantly increased and erythrocyte sedimentation rate,C-reactive protein,disease activity score of 28 joints were decreased in the combined group(P < 0.05).CONCLUSION:Abnormal expression of AQPs inhibits water metabolism in RA dampness-heat blockage syndrome,so liquid is accumulated at the joint,which may play an important role in the pathogenesis of RA.MTX combined with SYD for the treatment of RA can effectively increase AQP expression.