AIM: To explore the association between single nucleotide polymorphisms (SNPs) at 8q24 and gastric cancer risk. METHODS: A case-control investigation including 212 gastric cancer patients and 377 healthy controls was ...AIM: To explore the association between single nucleotide polymorphisms (SNPs) at 8q24 and gastric cancer risk. METHODS: A case-control investigation including 212 gastric cancer patients and 377 healthy controls was conducted. The genotypes of SNPs (rs6983267, rs7008482 and rs10808555) were examined and established through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Multivariate logistic regression models were used to evaluate the association between SNPs and gastric cancer. RESULTS: The genotype frequencies of rs6983267 in gastric cancer patients were obviously different from those in the control (P = 0.005). GT genotype of rs6983267 was associated with an increased risk of gastric cancer compared with GG genotype (adjusted odds ratio = 2.01, 95% confidence interval: 1.28-3.14). Further stratified analysis indicated that rs6983267 GT genotype facilitated the risk of gastric cancer of non-cardiac and intestinal type (OR: 2.638, 95% CI: 1.464-4.753; OR: 1.916, 95% CI: 1.166-3.150, respectively). CONCLUSION: This study demonstrates for the first time that rs6983267 is involved in susceptibility to gastric cancer, although further large-sample investigations are still needed.展开更多
To avoid dangerous climate change impact, the Paris Agreement sets out two ambitious goals: to limit the global warming to be well below 2 ℃ and to pursue effort for the global warming to be below 1.5 ℃ above the ...To avoid dangerous climate change impact, the Paris Agreement sets out two ambitious goals: to limit the global warming to be well below 2 ℃ and to pursue effort for the global warming to be below 1.5 ℃ above the pre-industrial level. As climate change risks may be region-dependent, changes in magnitude and probability of extreme precipitation over China are investigated under those two global warming levels based on simulations from the Coupled Model Inter-Comparison Projects Phase 5. The focus is on the added changes due to the additional half a degree warming from 1.5 ℃ to 2 ℃ . Results show that regional average changes in the magnitude do not depend on the return periods with a relative increase around 7% and 11% at the 1.5 ℃ and 2 ℃ global warming levels, respectively. The additional half a degree global warming adds an additional increase in the magnitude by nearly 4%. The regional average changes in term of occurrence probabilities show dependence on the return periods, with rarer events(longer return periods) having larger increase of risk. For the 100-year historical event, the probability is projected to increase by a factor of 1.6 and 2.4 at the 1.5 ℃ and 2 ℃ global warming levels, respectively.The projected changes in extreme precipitation are independent of the RCP scenarios.展开更多
基金Supported by Shanghai "Phosphor" Science Foundation, China, No. 09QB1403100the National High Technology Researchand Development Program of China, No. 2006AA020704 and 2006AA02A407the Funds for Key Programs of Ministry ofHealth of China, No.2008ZX10002-017
文摘AIM: To explore the association between single nucleotide polymorphisms (SNPs) at 8q24 and gastric cancer risk. METHODS: A case-control investigation including 212 gastric cancer patients and 377 healthy controls was conducted. The genotypes of SNPs (rs6983267, rs7008482 and rs10808555) were examined and established through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Multivariate logistic regression models were used to evaluate the association between SNPs and gastric cancer. RESULTS: The genotype frequencies of rs6983267 in gastric cancer patients were obviously different from those in the control (P = 0.005). GT genotype of rs6983267 was associated with an increased risk of gastric cancer compared with GG genotype (adjusted odds ratio = 2.01, 95% confidence interval: 1.28-3.14). Further stratified analysis indicated that rs6983267 GT genotype facilitated the risk of gastric cancer of non-cardiac and intestinal type (OR: 2.638, 95% CI: 1.464-4.753; OR: 1.916, 95% CI: 1.166-3.150, respectively). CONCLUSION: This study demonstrates for the first time that rs6983267 is involved in susceptibility to gastric cancer, although further large-sample investigations are still needed.
基金supported by the National Key R&D Program of China(Grant 2017YFA0603804)the State Key Program of National Natural Science Foundation of China(41230528)+1 种基金the China Scholarship Council(CSC)under the State Scholarship Fundsupported by the French ANR Project China-Trend-Stream
文摘To avoid dangerous climate change impact, the Paris Agreement sets out two ambitious goals: to limit the global warming to be well below 2 ℃ and to pursue effort for the global warming to be below 1.5 ℃ above the pre-industrial level. As climate change risks may be region-dependent, changes in magnitude and probability of extreme precipitation over China are investigated under those two global warming levels based on simulations from the Coupled Model Inter-Comparison Projects Phase 5. The focus is on the added changes due to the additional half a degree warming from 1.5 ℃ to 2 ℃ . Results show that regional average changes in the magnitude do not depend on the return periods with a relative increase around 7% and 11% at the 1.5 ℃ and 2 ℃ global warming levels, respectively. The additional half a degree global warming adds an additional increase in the magnitude by nearly 4%. The regional average changes in term of occurrence probabilities show dependence on the return periods, with rarer events(longer return periods) having larger increase of risk. For the 100-year historical event, the probability is projected to increase by a factor of 1.6 and 2.4 at the 1.5 ℃ and 2 ℃ global warming levels, respectively.The projected changes in extreme precipitation are independent of the RCP scenarios.
