目的:研究膳食纤维Fibersol?-2对人体餐后血糖、胰岛素水平和胰岛素敏感性的影响。方法:研究招募30~39岁的健康成年人为受试者,采用随机对照交叉试验设计,根据进食米饭种类不同随机分为混合米饭组(添加Fibersol■-2)和普通米饭组,间隔1...目的:研究膳食纤维Fibersol?-2对人体餐后血糖、胰岛素水平和胰岛素敏感性的影响。方法:研究招募30~39岁的健康成年人为受试者,采用随机对照交叉试验设计,根据进食米饭种类不同随机分为混合米饭组(添加Fibersol■-2)和普通米饭组,间隔1周后进行第2次的交叉试验。每次试验分别采集空腹(2次,间隔5 min)、餐后15、30、45、60、90、120 min 7个时间点的血液,分离血清,测定各时间点的血糖和胰岛素水平,分别计算曲线下面积,用胰岛素与血糖应答曲线下面积比(Ins/Glu)评估机体对胰岛素的敏感性。结果:在餐后45、60、90、120 min时,混合米饭组的血糖水平均显著低于同时点普通米饭组(P<0.05);在餐后45、60、120 min时,混合米饭组的血清胰岛素水平均显著低于普通米饭组(P<0.05)。同时,混合米饭组餐后2 h血糖和胰岛素曲线下面积均显著低于普通米饭组(P<0.05)。混合米饭组Ins/Glu值在餐后30、45、60 min 3个时间点均显著高于普通米饭组(P<0.05)。结论:添加膳食纤维Fibersol■-2具有降低餐后血糖和胰岛素水平、提高胰岛素敏感性的作用。展开更多
Ultra rapid lispro(URLi)is a novel formulation of insulin lispro designed to more closely match the physiological insulin response to a meal,with the aim of improving postprandial glucose(PPG)control.We conducted a mu...Ultra rapid lispro(URLi)is a novel formulation of insulin lispro designed to more closely match the physiological insulin response to a meal,with the aim of improving postprandial glucose(PPG)control.We conducted a multinational,multicenter,randomized,double-blind,treat-to-target,26-week,phase 3 trial to evaluate the efficacy and safety of URLi in adults with type 2 diabetes(T2D).After an 8-week lead-in period during which basal insulin glargine or degludec was optimized,adults with T2D were randomized(2:1)to prandial URLi(n=395)or lispro(n=200).The primary endpoint was non-inferiority of URLi versus lispro in glycated hemoglobin A1c(HbA_(1c))change from baseline to week 26.Multiplicity-adjusted analyses were performed to assess the superiority of URLi in 1-and 2-h PPG excursions during a mixed-meal tolerance test(MMTT)and HbA_(1c) change at week 26.URLi showed non-inferiority for Hb Achange at week 26 versus lispro(least-squares mean[LSM]difference,0.07%;95%confidence interval:-0.07,0.21).HbA_(1c) was reduced by 0.56%and 0.63%with URLi and lispro,respectively,with no significant treatment difference(P=0.321).URLi provided superior PPG excursion control versus lispro at1 h(LSM difference:-14.6 mg/d L,P<0.001)and 2 h(LSM difference:-21.8 mg/d L,P<0.001)as well as other time points(30–240 min)during the MMTT.Incremental area under the glucose curve during the MMTT was also significantly lower with URLi versus lispro.The safety profiles were generally similar between treatment groups.In conclusion,URLi was superior to lispro for PPG control,with noninferiority in HbA_(1c) improvement,in adults with T2D.展开更多
文摘目的:研究膳食纤维Fibersol?-2对人体餐后血糖、胰岛素水平和胰岛素敏感性的影响。方法:研究招募30~39岁的健康成年人为受试者,采用随机对照交叉试验设计,根据进食米饭种类不同随机分为混合米饭组(添加Fibersol■-2)和普通米饭组,间隔1周后进行第2次的交叉试验。每次试验分别采集空腹(2次,间隔5 min)、餐后15、30、45、60、90、120 min 7个时间点的血液,分离血清,测定各时间点的血糖和胰岛素水平,分别计算曲线下面积,用胰岛素与血糖应答曲线下面积比(Ins/Glu)评估机体对胰岛素的敏感性。结果:在餐后45、60、90、120 min时,混合米饭组的血糖水平均显著低于同时点普通米饭组(P<0.05);在餐后45、60、120 min时,混合米饭组的血清胰岛素水平均显著低于普通米饭组(P<0.05)。同时,混合米饭组餐后2 h血糖和胰岛素曲线下面积均显著低于普通米饭组(P<0.05)。混合米饭组Ins/Glu值在餐后30、45、60 min 3个时间点均显著高于普通米饭组(P<0.05)。结论:添加膳食纤维Fibersol■-2具有降低餐后血糖和胰岛素水平、提高胰岛素敏感性的作用。
文摘Ultra rapid lispro(URLi)is a novel formulation of insulin lispro designed to more closely match the physiological insulin response to a meal,with the aim of improving postprandial glucose(PPG)control.We conducted a multinational,multicenter,randomized,double-blind,treat-to-target,26-week,phase 3 trial to evaluate the efficacy and safety of URLi in adults with type 2 diabetes(T2D).After an 8-week lead-in period during which basal insulin glargine or degludec was optimized,adults with T2D were randomized(2:1)to prandial URLi(n=395)or lispro(n=200).The primary endpoint was non-inferiority of URLi versus lispro in glycated hemoglobin A1c(HbA_(1c))change from baseline to week 26.Multiplicity-adjusted analyses were performed to assess the superiority of URLi in 1-and 2-h PPG excursions during a mixed-meal tolerance test(MMTT)and HbA_(1c) change at week 26.URLi showed non-inferiority for Hb Achange at week 26 versus lispro(least-squares mean[LSM]difference,0.07%;95%confidence interval:-0.07,0.21).HbA_(1c) was reduced by 0.56%and 0.63%with URLi and lispro,respectively,with no significant treatment difference(P=0.321).URLi provided superior PPG excursion control versus lispro at1 h(LSM difference:-14.6 mg/d L,P<0.001)and 2 h(LSM difference:-21.8 mg/d L,P<0.001)as well as other time points(30–240 min)during the MMTT.Incremental area under the glucose curve during the MMTT was also significantly lower with URLi versus lispro.The safety profiles were generally similar between treatment groups.In conclusion,URLi was superior to lispro for PPG control,with noninferiority in HbA_(1c) improvement,in adults with T2D.
