AIM： To investigate whether red wine and green tea could exert anti-H pylori or anti-VacA activity in vivo in a mouse model of experimental infection. METHODS： Ethanol-free red wine and green tea concentrates were a...AIM： To investigate whether red wine and green tea could exert anti-H pylori or anti-VacA activity in vivo in a mouse model of experimental infection. METHODS： Ethanol-free red wine and green tea concentrates were administered orally as a mixture of the two beverages to H pylori infected mice, or separately to VacA-treated mice. Gastric colonization and gastric inflammation were quantified by microbiological, histopathological, and immunohistochemical analyses.RESULTS： In H pylori-infected mice, the red wine and green tea mixture significantly prevented gastritis and limited the localization of bacteria and VacA to the surface of the gastric epithelium. Similarly, both beverages significantly prevented gastric epithelium damage in VacA-treated mice; green tea, but not red wine, also altered the VacA localization in the gastric epithelium. CONCLUSION： Red wine and green tea are able to prevent H pylori-induced gastric epithelium damage, possibly involving VacA inhibition. This observation supports the possible relevance of diet on the pathological outcome of Hpylori infection.展开更多
Soft drinks have many potential health problems.The inherent acids and sugars have both acidogenic and cariogenic potential,resulting in dental caries and potential enamel erosion.In this report we present a 25-year-o...Soft drinks have many potential health problems.The inherent acids and sugars have both acidogenic and cariogenic potential,resulting in dental caries and potential enamel erosion.In this report we present a 25-year-old man complaining with the severe worn-out of the front teeth during the past 3 years.He had a history of drinking cola for more than 7 years and had a poor oral hygiene.Severe decays were present in the incisors and the canines,while less severe lesions were noted on the premolars and the molars.The review is to show the relationship between dental erosion and caries and soft drinks.Some efforts have been taken to reduce the harmful effect of soft drinks.展开更多
基金Supported partly by a CNR Target Project Biotechnology grantand a University of Padova Young Investigator grant
文摘AIM： To investigate whether red wine and green tea could exert anti-H pylori or anti-VacA activity in vivo in a mouse model of experimental infection. METHODS： Ethanol-free red wine and green tea concentrates were administered orally as a mixture of the two beverages to H pylori infected mice, or separately to VacA-treated mice. Gastric colonization and gastric inflammation were quantified by microbiological, histopathological, and immunohistochemical analyses.RESULTS： In H pylori-infected mice, the red wine and green tea mixture significantly prevented gastritis and limited the localization of bacteria and VacA to the surface of the gastric epithelium. Similarly, both beverages significantly prevented gastric epithelium damage in VacA-treated mice; green tea, but not red wine, also altered the VacA localization in the gastric epithelium. CONCLUSION： Red wine and green tea are able to prevent H pylori-induced gastric epithelium damage, possibly involving VacA inhibition. This observation supports the possible relevance of diet on the pathological outcome of Hpylori infection.
基金(No.NCET-05-0790) supported by the Program for New Century Excellent Talents in University,China
文摘Soft drinks have many potential health problems.The inherent acids and sugars have both acidogenic and cariogenic potential,resulting in dental caries and potential enamel erosion.In this report we present a 25-year-old man complaining with the severe worn-out of the front teeth during the past 3 years.He had a history of drinking cola for more than 7 years and had a poor oral hygiene.Severe decays were present in the incisors and the canines,while less severe lesions were noted on the premolars and the molars.The review is to show the relationship between dental erosion and caries and soft drinks.Some efforts have been taken to reduce the harmful effect of soft drinks.
