Background/Aims: The role of coffee in the development of hepatocellular carci noma (HCC) is debated. The aim of this study was to investigate the role of coff ee in HCC, taking the main risk factors into account. Met...Background/Aims: The role of coffee in the development of hepatocellular carci noma (HCC) is debated. The aim of this study was to investigate the role of coff ee in HCC, taking the main risk factors into account. Methods: A hospital-based case-control study was conducted in an area of northern Italy.We recruited 250 HCC cases and 500 controls hospitalized for any reasons other than neoplasms, a nd liver and alcohol-related diseases. Subjects were interviewed on their lifet ime history of coffee consumption using a standardized questionnaire. Results:Co ffee consumption in the decade before the interview was associated with a decrea sing risk of HCC with a clear dose-effect relation. With respect to non-drinki ng subjects, the odds ratios (ORs) were: 0.8, (95%CI 0.4-1.3) for 1-2 cups/da y,0.4 (95%CI 0.2-0.8) for 3-4 cups/day and 0.3 (95%CI 0.1-0.7) for 5 or mor e cups/day. The ORs for HCC decreased for drinking >2, compared to 0-2 cups/day of coffee, for an alcohol intake >80 g/day (OR from 5.7 to 3.3), for presence o f hepatitis B virus infection (OR from 16.4 to 7.3) or hepatitis C virus infecti on (OR from 38.2 to 9.0). Conclusions: Coffee drinking was inversely associated with HCC regardless of its aetiology.展开更多
在美国农业部2000年开展的个人食物摄入量持续调查（CSFII）中，饮用水（非食物来源水）方面的资料仅限于24h内的摄人总量。而对于各时间段内的饮用量并未详述。为此，Barraj等在美国全国范围内开展了饮用水摄入调查（drinking water co...在美国农业部2000年开展的个人食物摄入量持续调查（CSFII）中，饮用水（非食物来源水）方面的资料仅限于24h内的摄人总量。而对于各时间段内的饮用量并未详述。为此，Barraj等在美国全国范围内开展了饮用水摄入调查（drinking water consumptions survey，DWCS），以了解一天之中的饮水次数、饮用时间及饮水量。展开更多
文摘Background/Aims: The role of coffee in the development of hepatocellular carci noma (HCC) is debated. The aim of this study was to investigate the role of coff ee in HCC, taking the main risk factors into account. Methods: A hospital-based case-control study was conducted in an area of northern Italy.We recruited 250 HCC cases and 500 controls hospitalized for any reasons other than neoplasms, a nd liver and alcohol-related diseases. Subjects were interviewed on their lifet ime history of coffee consumption using a standardized questionnaire. Results:Co ffee consumption in the decade before the interview was associated with a decrea sing risk of HCC with a clear dose-effect relation. With respect to non-drinki ng subjects, the odds ratios (ORs) were: 0.8, (95%CI 0.4-1.3) for 1-2 cups/da y,0.4 (95%CI 0.2-0.8) for 3-4 cups/day and 0.3 (95%CI 0.1-0.7) for 5 or mor e cups/day. The ORs for HCC decreased for drinking >2, compared to 0-2 cups/day of coffee, for an alcohol intake >80 g/day (OR from 5.7 to 3.3), for presence o f hepatitis B virus infection (OR from 16.4 to 7.3) or hepatitis C virus infecti on (OR from 38.2 to 9.0). Conclusions: Coffee drinking was inversely associated with HCC regardless of its aetiology.
文摘在美国农业部2000年开展的个人食物摄入量持续调查（CSFII）中，饮用水（非食物来源水）方面的资料仅限于24h内的摄人总量。而对于各时间段内的饮用量并未详述。为此，Barraj等在美国全国范围内开展了饮用水摄入调查（drinking water consumptions survey，DWCS），以了解一天之中的饮水次数、饮用时间及饮水量。
