Objective To compare the postoperative outcomes of patients with the diagnostic univentricular heart undergoing lateral tunnel （LT） operation with extracardiac conduit （EC） operation. Methods- From June 1996 to Ju...Objective To compare the postoperative outcomes of patients with the diagnostic univentricular heart undergoing lateral tunnel （LT） operation with extracardiac conduit （EC） operation. Methods- From June 1996 to July 2007, 114 consecutive patients with a single ventricle underwent total cavopulmonary connection （TCPC） in Children＇s Heart Center, lAniversity Hospital Giessen and Marburg GmbH, Germany. A LT was performed in 19 （16.7%） patients, and an EC in 95 （83.3%） patients. The mean age of EC group was 50.8±31.6 （ranging from 22 to 212） months, and that of LT group was 61.5±41.2 （ranging from 30 to 168） months. Early and midterm outcomes of two groups were analyzed.Results One died in LT group （5.3%） and three in EC group （3.2%）. The overall mortality was 3.5%. There was no significant difference in mortality between EC-and-LT groups （P〉0.05）. The postoperative pulmonary arterial pressure, oxygen saturation, and effusion time of two groups had no significant difference （all P〉0.05）. No significant difference in the occurrences of complications （arrhythmias, enteropathy, and thrombosis） was found between two groups after operation （P〉0.05）. Conclusions There seems no difference between LT and EC in the clinical results in the early and middle postoperative stage. Glenn anastomosis followed by an EC seems to have some advantages.展开更多
AIM: To characterize the profiles of alveolar hypoventilation during colonoscopies performed under sedoanalgesia with a combination of alfentanil and either midazolam or propofol. METHODS: Consecutive patients undergo...AIM: To characterize the profiles of alveolar hypoventilation during colonoscopies performed under sedoanalgesia with a combination of alfentanil and either midazolam or propofol. METHODS: Consecutive patients undergoing routine colonoscopy were randomly assigned to sedation with either propofol or midazolam in an open-labeled design using a titration scheme. All patients received 4 μg/kg per body weight alfentanil for analgesia and 3 L of supplemental oxygen. Oxygen saturation (SpO 2 ) was measured by pulse oximetry (POX), and capnography (PcCO 2 ) was continuously measured using a combined dedicated sensor at the ear lobe. Instances of apnea resulting in measures such as stimulation of the patient, a chin lift, a mask maneuver, or withholding of sedation were recorded. PcCO 2 values (as a parameter of sedation-induced hypoventilation) were compared between groups at the following distinct time points: baseline, maximal rise, termination of the procedure and 5 min after termination of the procedure. The number of patients in both study groups who regained baseline PcCO 2 values (± 1.5 mmHg) five minutes after the procedure was determined.RESULTS: A total of 97 patients entered this study. The data from 14 patients were subsequently excluded for clinical procedure-related reasons or for technical problems. Therefore, 83 patients (mean age 62 ± 13 years) were successfully randomized to receive propofol (n = 42) or midazolam (n = 41) for sedation. Most of the patients were classified as American Society of Anesthesiologists (ASA) Ⅱ [16 (38%) in the midazolam group and 15 (32%) in the propofol group] and ASA Ⅲ [14 (33%) and 13 (32%) in the midazolam and propofol groups, respectively]. A mean dose of 5 (4-7) mg of Ⅳ midazolam and 131 (70-260) mg of Ⅳ propofol was used during the procedure in the corresponding study arms. The mean SpO 2 at baseline (%) was 99 ± 1 for the midazolam group and 99 ± 1 for the propofol group. No cases of hypoxemia (SpO 2 < 85%) or apnea were recorded. However, an increase in PcCO 2 that indicated alveolar hypoventilation occurred in both groups after administration of the first drug and was not detected with pulse oximetry alone. The mean interval between the initiation of sedation and the time when the PcCO 2 value increased to more than 2 mmHg was 2.8 ± 1.3 min for midazolam and 2.8 ± 1.1 min for propofol. The mean maximal rise was similar for both drugs: 8.6 ± 3.7 mmHg for midazolam and 7.4 ± 3.2 mmHg for propofol. Five minutes after the end of the procedure, the mean difference from the baseline values was significantly lower for the propofol treatment compared with midazolam (0.9 ± 3.0 mmHg vs 4.3 ± 3.7 mmHg, P = 0.0000169), and significantly more patients in the propofol group had regained their baseline value ± 1.5 mmHg (32 of 41vs 12 of 42,P = 0.0004). CONCLUSION: A significantly higher number of patients sedated with propofol had normalized PcCO 2 values five minutes after sedation when compared with patients sedated with midazolam.展开更多
Laboratory experiments were conducted to determine the effects of total dissolved gas （TDG） supersaturation on acute lethality and avoidance responses in juvenile rock carp （Procypris rabaudi Tchang）. The juvenile...Laboratory experiments were conducted to determine the effects of total dissolved gas （TDG） supersaturation on acute lethality and avoidance responses in juvenile rock carp （Procypris rabaudi Tchang）. The juvenile rock carp were exposed to water with different levels of supersaturation （105%, 115%, 120%, 125%, 130%, 135%, 140%, and 145%） and depth of 0.20 m at 25℃ for 60 h. Median lethal time （LT50） was used to assess the lethal responses corresponding to different levels of gas supersaturation. The results show that half of the juvenile rock carp died at the 120%, 125%, 130%, 135%, 140%, and 145% levels of supersaturation, and the LT50 corresponding to different levels of supersaturation was 18.7, 15.4, 8.2, 6.6, 3.5, and 1.7 h. When the level of supersaturated water is below 115%, the mortality is negligible. Avoidance responses were observed 5 min after the fish were put into equilibrated water （99%, 0.08 m deep） and water with different supersaturated levels （105%, 115%, 125%, 135%, and 145%, 0.08 m deep） at 25 ℃. The fish exhibited strong avoidance responses in supersaturated water when the gas supersaturation was above 135%. However, they exhibited an obvious preference to supersaturated water when the gas supersaturation was below 115%. Thus, the juvenile rock carp can likely survive in water with a supersaturated level of 115%.展开更多
We investigated the fatty acid profiles of muscle from large yellow croaker （Pseudosciaena crocea R.） of different age. One- and two-year-old fish were cultured in floating net cages and sampled randomly for analysi...We investigated the fatty acid profiles of muscle from large yellow croaker （Pseudosciaena crocea R.） of different age. One- and two-year-old fish were cultured in floating net cages and sampled randomly for analysis. Moisture, protein, lipid and ash contents were determined by methods of Association of Analytical Chemist （AOAC） International. Fatty acid profile was deter- mined by gas chromatography. Crude protein, fat, moisture and ash contents showed no significant differences between the two age groups. The contents of total polyunsaturated fatty acids and docosahexaenoic acid （DHA） were significantly higher and eicosapentaenoic acid （EPA） content was significantly lower in the two-year-old large yellow croaker than in the one-year-old （/＇〈0.05）. No significant differences were observed in the contents of total saturated fatty acids and monounsaturated fatty acids, or the ratio ofn-3/n-6 fatty acids among the large yellow croakers of the two age groups. We conclude that large yellow croakers are good food sources of EPA and DHA.展开更多
文摘Objective To compare the postoperative outcomes of patients with the diagnostic univentricular heart undergoing lateral tunnel （LT） operation with extracardiac conduit （EC） operation. Methods- From June 1996 to July 2007, 114 consecutive patients with a single ventricle underwent total cavopulmonary connection （TCPC） in Children＇s Heart Center, lAniversity Hospital Giessen and Marburg GmbH, Germany. A LT was performed in 19 （16.7%） patients, and an EC in 95 （83.3%） patients. The mean age of EC group was 50.8±31.6 （ranging from 22 to 212） months, and that of LT group was 61.5±41.2 （ranging from 30 to 168） months. Early and midterm outcomes of two groups were analyzed.Results One died in LT group （5.3%） and three in EC group （3.2%）. The overall mortality was 3.5%. There was no significant difference in mortality between EC-and-LT groups （P〉0.05）. The postoperative pulmonary arterial pressure, oxygen saturation, and effusion time of two groups had no significant difference （all P〉0.05）. No significant difference in the occurrences of complications （arrhythmias, enteropathy, and thrombosis） was found between two groups after operation （P〉0.05）. Conclusions There seems no difference between LT and EC in the clinical results in the early and middle postoperative stage. Glenn anastomosis followed by an EC seems to have some advantages.
文摘AIM: To characterize the profiles of alveolar hypoventilation during colonoscopies performed under sedoanalgesia with a combination of alfentanil and either midazolam or propofol. METHODS: Consecutive patients undergoing routine colonoscopy were randomly assigned to sedation with either propofol or midazolam in an open-labeled design using a titration scheme. All patients received 4 μg/kg per body weight alfentanil for analgesia and 3 L of supplemental oxygen. Oxygen saturation (SpO 2 ) was measured by pulse oximetry (POX), and capnography (PcCO 2 ) was continuously measured using a combined dedicated sensor at the ear lobe. Instances of apnea resulting in measures such as stimulation of the patient, a chin lift, a mask maneuver, or withholding of sedation were recorded. PcCO 2 values (as a parameter of sedation-induced hypoventilation) were compared between groups at the following distinct time points: baseline, maximal rise, termination of the procedure and 5 min after termination of the procedure. The number of patients in both study groups who regained baseline PcCO 2 values (± 1.5 mmHg) five minutes after the procedure was determined.RESULTS: A total of 97 patients entered this study. The data from 14 patients were subsequently excluded for clinical procedure-related reasons or for technical problems. Therefore, 83 patients (mean age 62 ± 13 years) were successfully randomized to receive propofol (n = 42) or midazolam (n = 41) for sedation. Most of the patients were classified as American Society of Anesthesiologists (ASA) Ⅱ [16 (38%) in the midazolam group and 15 (32%) in the propofol group] and ASA Ⅲ [14 (33%) and 13 (32%) in the midazolam and propofol groups, respectively]. A mean dose of 5 (4-7) mg of Ⅳ midazolam and 131 (70-260) mg of Ⅳ propofol was used during the procedure in the corresponding study arms. The mean SpO 2 at baseline (%) was 99 ± 1 for the midazolam group and 99 ± 1 for the propofol group. No cases of hypoxemia (SpO 2 < 85%) or apnea were recorded. However, an increase in PcCO 2 that indicated alveolar hypoventilation occurred in both groups after administration of the first drug and was not detected with pulse oximetry alone. The mean interval between the initiation of sedation and the time when the PcCO 2 value increased to more than 2 mmHg was 2.8 ± 1.3 min for midazolam and 2.8 ± 1.1 min for propofol. The mean maximal rise was similar for both drugs: 8.6 ± 3.7 mmHg for midazolam and 7.4 ± 3.2 mmHg for propofol. Five minutes after the end of the procedure, the mean difference from the baseline values was significantly lower for the propofol treatment compared with midazolam (0.9 ± 3.0 mmHg vs 4.3 ± 3.7 mmHg, P = 0.0000169), and significantly more patients in the propofol group had regained their baseline value ± 1.5 mmHg (32 of 41vs 12 of 42,P = 0.0004). CONCLUSION: A significantly higher number of patients sedated with propofol had normalized PcCO 2 values five minutes after sedation when compared with patients sedated with midazolam.
基金Project (No. 50979063) supported by the National Natural Science Foundation of China
文摘Laboratory experiments were conducted to determine the effects of total dissolved gas （TDG） supersaturation on acute lethality and avoidance responses in juvenile rock carp （Procypris rabaudi Tchang）. The juvenile rock carp were exposed to water with different levels of supersaturation （105%, 115%, 120%, 125%, 130%, 135%, 140%, and 145%） and depth of 0.20 m at 25℃ for 60 h. Median lethal time （LT50） was used to assess the lethal responses corresponding to different levels of gas supersaturation. The results show that half of the juvenile rock carp died at the 120%, 125%, 130%, 135%, 140%, and 145% levels of supersaturation, and the LT50 corresponding to different levels of supersaturation was 18.7, 15.4, 8.2, 6.6, 3.5, and 1.7 h. When the level of supersaturated water is below 115%, the mortality is negligible. Avoidance responses were observed 5 min after the fish were put into equilibrated water （99%, 0.08 m deep） and water with different supersaturated levels （105%, 115%, 125%, 135%, and 145%, 0.08 m deep） at 25 ℃. The fish exhibited strong avoidance responses in supersaturated water when the gas supersaturation was above 135%. However, they exhibited an obvious preference to supersaturated water when the gas supersaturation was below 115%. Thus, the juvenile rock carp can likely survive in water with a supersaturated level of 115%.
文摘We investigated the fatty acid profiles of muscle from large yellow croaker （Pseudosciaena crocea R.） of different age. One- and two-year-old fish were cultured in floating net cages and sampled randomly for analysis. Moisture, protein, lipid and ash contents were determined by methods of Association of Analytical Chemist （AOAC） International. Fatty acid profile was deter- mined by gas chromatography. Crude protein, fat, moisture and ash contents showed no significant differences between the two age groups. The contents of total polyunsaturated fatty acids and docosahexaenoic acid （DHA） were significantly higher and eicosapentaenoic acid （EPA） content was significantly lower in the two-year-old large yellow croaker than in the one-year-old （/＇〈0.05）. No significant differences were observed in the contents of total saturated fatty acids and monounsaturated fatty acids, or the ratio ofn-3/n-6 fatty acids among the large yellow croakers of the two age groups. We conclude that large yellow croakers are good food sources of EPA and DHA.
