中西医结合治疗新型冠状病毒肺炎验案二则

新型冠状病毒肺炎属于中医疫病范畴,病因为感受疫戾之气,病位在肺,基本病机为“湿、热、毒、瘀”,临床初期以湿邪郁肺型较为多见,对于此型运用新型冠状病毒感染的肺炎诊疗方案(试行第三版)麻杏石甘汤、达原饮加减治疗二则,取得显著疗效。

Study on Inactivated Vaccine in Oil Emulsion Against Newcastle Disease and Fowl Cholera IV——Field Test of Vaccine

[ Objective] The aim of this study was to evaluate the clinical effect of the inactivated vaccine in oil emulsion against Newcastle disease and Fowl cholera, and provide conditions for combined prevention and control of Newcastle disease and Fowl cholera. [ Method] The mixture of avian pasteurella multocida （type A） virulent strain 1502 and Newcastle disease virus attenuated strain La Sota was prepared into five batches of the inactivated vaccine in oil emulsion to use in the field test for assessing its safety and effects on immune protection of chicken, duck and goose. [ Result] The field safety test showed that there was no adverse reaction in the vaccinated chickens, ducks and geese. The field test of immune effect for chickens suggested that the titers of hemagglutination inhibition antibody for Nescastle disease virus （ ND-HI ） in 7 - 14 day- old chickens and 60 -90 day-old young chickens were 2 -3 log2 higher than the control group after being vaccinated for 3 weeks, which could last for more than 4 months. The protection rate against avian pasteurella multocida was over 75.0% and its immune effect could last for 6 months. The field test of immune effect for duck and goose indicated that the titers of ND-HI antibody were all higher than 4.2 log2 in vaccinated ducks and geese while lower than 2 log2 in the control group after being vaccinated for 3 weeks. The protection rate against avian pasteurella multocida in vaccinated ducks and geese was higher than 75.0% and 62.5% respectively. [ Conclusion] The binary vaccine is safe for poultry and has good immune effects.

Research on the Jilin Oilfield Field Trials of Microbial Enhanced Oil Recovery

This paper describes the experience of Jilin oilfield trials for Microbial Enhanced Oil Recovery (MEOR). A new technique to identify microbes with DNA for MEOR has been established, and useful microbes selected for use in field trials. Behaviors of bacteria activated in the reservoir, oil recovery and water cut, and the viscosity of crude oil produced through huff & puff testing and flooding with molasses-injection tests, have been investigated in situ. CJF-002, which produces biopolysaccharide, is the best among the microbes used for field trials, as it can use molasses as nutrient and produce a small quantity of CO2 and a mass of water-insoluble biopolymer. The metabolic behavior in the reservoir showed that CJF-002 had a good potentiality for MEOR.

PROGRESS OF MARINE METEOROLOGICAL OBSERVATION EXPERIMENT AT MAOMING OF SOUTH CHINA

The coastal area of southern China is frequently affected by marine meteorological disasters,and is also one of the key areas that influence the short-term climate change of China.Due to a lack of observational facilities and techniques,little has been done in this area in terms of operational weather monitoring and scientific research on atmospheric and marine environment.With the support of China Meteorological Administration (CMA) and Guangdong Meteorological Bureau (GMB),the Marine Meteorological Science Experiment Base (MMSEB) at Bohe,Maoming has been jointly established by Guangzhou Institute of Tropical and Marine Meteorology (GITMM) and Maoming Meteorological Bureau (MMB) of Guangdong Province after three years of hard work.It has become an integrated coastal observation base that is equipped with a complete set of sophisticated instruments.Equipment maintenance and data quality control procedures have been implemented to ensure the long-term,steady operation of the instruments and the availability of high quality data.Preliminary observations show that the data obtained by the MMSEB reveal many interesting features in the boundary layer structure and air-sea interaction in such disastrous weather as typhoons and sea fog.The MMSEB is expected to play an important role in the scientific research of disastrous weather related to marine meteorology.

Prestiction friction compensation in direct-drive mechatronics systems

LuGre model has been widely used in friction modeling and compensation.However,the new friction regime,named prestiction regime,cannot be accurately characterized by LuGre model in the latest research.With the extensive experimental observations of friction behaviors in the prestiction,some variables were abstracted to depict the rules in the prestiction regime.Based upon the knowledge of friction modeling,a novel friction model including the presliding regime,the gross sliding regime and the prestiction regime was then presented to overcome the shortcomings of the LuGre model.The reason that LuGre model cannot estimate the prestiction friction was analyzed in theory.Feasibility analysis of the proposed model in modeling the prestiction friction was also addressed.A parameter identification method for the proposed model based on multilevel coordinate search algorithm was presented.The proposed friction compensation strategy was composed of a nonlinear friction observer and a feedforward mechanism.The friction observer was designed to estimate the friction force in the presliding and the gross sliding regimes.And the friction force was estimated based on the model in the prestiction regime.The comparative trajectory tracking experiments were conducted on a simulator of inertially stabilization platforms among three control schemes:the single proportional–derivative(PD)control,the PD with LuGre model-based compensation and the PD with compensator based on the presented model.The experimental results reveal that the control scheme based on the proposed model has the best tracking performance.It reduces the peak-to-peak value(PPV)of tracking error to 0.2 mrad,which is improved almost 50%compared with the PD with LuGre model-based compensation.Compared to the single PD control,it reduces the PPV of error by 66.7%.

Effect of temperature and heating rate on mechanical properties of magnesium alloy AZ31

Effects of temperature and heating rate on the mechanical properties of the tensile specimens of magnesium alloy AZ31 were experimentally investigated using a Gleeble-1500 thermo-mechanical material testing system.The metallurgraphs of the fracture section of the specimens were also experimentally observed and analyzed for exploring their failure mechanism under different temperatures and heating rates.The results show that the higher the temperature,the lower the ultimate strength of the specimens.And the higher the heating rate,the higher the ultimate strength of the specimens.The high temperatures and high heating rates will induce microvoids in the specimens which make the specimens failure under relatively low loads.

Accurate level set method for simulations of liquid atomization

Computational fluid dynamics is an efficient numerical approach for spray atomization study, but it is challenging to accurately capture the gas-liquid interface. In this work, an accurate conservative level set method is intro- duced to accurately track the gas-liquid interfaces in liquid atomization. To validate the capability of this method, binary drop collision and drop impacting on liquid film are investigated. The results are in good agreement with experiment observations. In addition, primary atomization （swirling sheet atomization） is studied using this method. To the swirling sheet atomization, it is found that Rayleigh-Taylor instability in the azimuthal direction causes the primary breakup of liquid sheet and complex vortex structures are clustered around the rim of the liq- uid sheet. The effects of central gas velocity and liquid-gas density ratio on atomization are also investigated. This work lays a solid foundation for further studvin~ the mechanism of s^rav atomization.

Longitudinal Magnetoresistance and ＂Chirar＇ Coupling in Silver Chalcogenides

A complex longitudinal magnetoresistance （MR//） effect in the non-stoichiometric silver chaJcogenides （include the silver selenide and telluride） has been found, however the mechanism for the MR// effect is not clear now. In this work, a new random resistor network for MR// effect is proposed based on the experimental observation. The network is constructed from six-terminal resistor units and the mobility of carries within the network has a Gaussian distribution. Considering the non-zero transverse-longitudinal coupling in materials, the resistance matrix of the six- terminal resistor unit is modified. It is found that the material has the ＂chiral＂ transverse-longitudinal couplings, which is suggested a main reason for the complex MR//effect. The model predictions are compared with the experimental results. A three dimension （3D） visualization of current flow within the network demonstrates the ＂current jets＂ phenomenon in the thickness of materials dearly.

Numerical model and experimental observation for distribution of SiC_p in electromagnetic-centrifugally cast composites

A two-phase numerical model coupled with heat transfer was presented to describe the radial distribution of SiC particles on centrifugally-cast metal matrix composite,and a transverse static magnetic field was concurrently imposed to induce electromagnetic stirring of the melt as it revolved with the mold.Meanwhile,experimental observations were also carried out to examine the radial distribution of SiC particles in pure aluminum.The effects of the imposed magnetic field,particle size and the matrix metals were discussed.The computational results show that the particles tend to be congregated by the centrifugal force,and both increasing the imposed magnetic field and decreasing the particle size tend to result in even distribution of the particles.With the magnetic field varying from 0 to 1 T and the particle size from 550 to 180 μm,a uniform distribution of the particles in the aluminum matrix can be obtained among the computational results.The matrix metal can also influence the particle distributions due to the difference in physical properties of metals.Experimental observation shows similar tendency of particle distributions in aluminum matrix influenced by magnetic field and particle size.However,the chilling effect from the mold wall results in an outer particle-free zone,which is not involved in the numerical model.

Numerical simulation of solidification morphologies of Cu-0.6Cr casting alloy using modified cellular automaton model

The purpose of this study is to predict the morphologies in the solidification process for Cu-0.6Cr(mass fraction,%)alloy by vacuum continuous casting(VCC)and verify its accuracy by the observed experimental results.In numerical simulation aspect, finite difference(FD)method and modified cellular automaton(MCA)model were used to simulate the macro-temperature field, micro-concentration field,nucleation and grain growth of Cu-0.6Cr alloy using real data from actual casting operations.From the observed casting experiment,the preliminary grain morphologies are the directional columnar grains by the VCC process.The solidification morphologies by MCAFD model are in agreement with the result of actual casting experiment well.

EFFECTS OF ACUPUNCTURE ON THE PITUITARYTHYROID AXIS IN RABBITS WITH FRACTURE

PURPOSE: To observe the effects of acupuncture on the pituitary-thyroid axis in rabbits with fracture. METHOD: 36 male rabbits with a 3-mm width experimental defect in the middle segment of the left radius were randomly divided into the treatment group and control group, and the changes in serum T3, T4 and TSH contents in different weeks were investigated. RESULTS: Serum T3, T4 and TSH contents in the treatment group all were higher than those in the control group, with statistically significant differences in the contents of T4 and TSH in the second week and T3 content in the fourth week (P

Effect of probiotics on growth performance, development of small intestinal tract and microbial populations in broilers

The experiment was conducted using a total of 1392 one-day-old, Cobb commercial male broilers to investigate the effects of a commercial probiotic addition in diet on growth, the development of the small intestine and microbial populations of broilers. Broilers were randomly allotted by BW to 1 of 6 replicate cages （29 chicks per cage） for each of 8 treatments in a randomized block design involving one factorial arrangement of treatments. Dietary treatments included the basal diet （including corn, soybean, rapeseed, cottonseed meal） added with 100 mg/kg antibiotic, 0%, 0.05%, 0.1%, 0.15%, 0.2%, 0.25% or 0.3%. The experiment last 42 d and divided into the starter period （1-21 d） and the finisher period （22-42 d）. The results showed that there were significant differences in broiler body weight （BW） （P〈0.001）, average daily feed intake （ADFI） （P=0.033）, relative length of the duodenum （P〈0.001）, jejunum （P=0.008）, ileum （P〈0.001） and the populations of lactobacillus （P〈0.001） and coliform （P〈0.001） in the rectum between the probiotics treatments and the control treatment only in the starter period of the trails. No significant differences were observed in intestinal morphology parameters in two periods of the experiment. Our results indicated that the probiotic was able to improve the performance of broiler chickens, and it was better in the starter period to be used than in the finisher period.

Traffic Flow States in a Freeway with Bottleneck

The system of mixture of single lane and double lane is studied by a cellular automata model, which is developed by us based on the Nagel and Schreckenberg＇s models. We justify that the model can reach a stable states quickly. The density distributions of the stable state is presented for several cases, which illustrate the manner of the congestion. The relationship between the outflow rate and the total number of vehicles and that between the outflow rate and the density just before the bottleneck are both given. Comparing with the relationship that occurring in the granular flow, we conclude that the transition from the free traffic flow to the congested traffic flow can also be attributed to the abrupt variation through unstable flow state, which can naturally explain the discontinuities and the complex time variation behavior observed in the traffic flow experiments.

An Experimental Study on Major Element Release from the Sediments in the Changjiang(Yangtze River) Estuary

With the enhanced warming and acidification of global ocean, whether and to what extent the naturally-weathered flu- vial sediment into the sea can release elements and thus influence the geochemical process and ecosystem of global ocean remain to be resolved. In this contribution, an experimental study was carried out to examine the release rates of major elements （Ca, K, Mg and AI） from the surface sediments in the Changjiang （Yangtze River） Estuary under the pH values of 4.0, 6.0 and 7.0. The two stud- ied sediments consist primarily of quartz, plagioclase, calcite and clay minerals, with the BET （Brunauer, Emmett and Teller） surface areas of 61.7m2g-1 and 23.1 m2g-1. Major elements of Ca, K, Mg and A1 show different release rates under different solution pH values. With the decreasing solution pH, the release rates of Ca and K increase obviously, while the release rates of Mg and A1 in- crease with the initial solution pH varying from 6.0 to 7.0. The different release rates of these elements are closely related to the original mineral composition of the sediments and the reaction kinetics. Based on the experimental observation, quartz and clay min- erals that have low dissolution rates may dominate the major element release to the aqueous phase. This study reveals that the en- hancing ocean acidification could cause considerable release of major elements from natural terrigenous sediments into the ambient marine environment, which has to be considered carefully in the future study on global change.

Meeting with the Depicted Other

The main aim of this article is to describe the intersubjective relationship between the observer and the subject depicted in a work of art. More precisely, I am interested in the observer＇s imagination as it is manifested in this relationship. I argue that every act of empathy involves the imagination, but the act of imagination is never understood as an act of empathy. This article will take a new approach towards the perception of a work of art and challenges the traditional notion of empathy as ＂looking into,＂ ＂looking in,＂ or ＂seeing-in.＂ I describe the experience of empathy as a lived experience, where I understand it as a type of intentional act that is distinct from imagination; meanwhile, I show that the imagination plays a role in the empathetic experience of the work of art. How？ I understand this situation as one that brings the observer into a new reality, an intersubjective mode of being where she finds a better understanding of her own （as an observer） inner world. I wish to argue that empathy gives a new dimension to experience, where being ＂here＂ becomes being ＂there.＂ Empathy is in fact a special form of meeting the Other. In the case of a work of art, we do not meet the Other as a person who lives their daily life like everyone else; instead we have an independent empathetic experience of the world, taking place within the work of art, in relation to the depicted subject. The nature of empathy is that it enables the observer to enter the deepest intimacy of the work of art and dwell inside it. This depends solely on the observer on how open they are to this world and how much it coincides with the observer＇s will, as she always retains limitless freedom when interpreting a work of art.

Analyzing Dynamics of a Bright Soliton in Bose-Einstein Condensates with Time-Dependent Atomic Scattering Length

We analyze the dynamics of a bright soliton in atomic scattering length in an expulsive parabolic potential. Bose-Einstein condensates （BECs） with time-dependent Under a safe ravage of parameters in which the Gross-Pitaevskii （GP） equation is effective in one dimension, our results show that, the dynamics of the bright soliton can be classed into two phases, depending on the value of the scattering length. Meanwhile, there exists a critical value of the absolute value of the atomic scattering length, below which, the dynamics of the bright soliton is very regular. Those phenomena can be useful for developing concrete applications of the nonlinear matter waves. We also obtain the orbital equation of the bright soliton and get some interesting data which may be useful for the experimental observation of the bright soliton and the application of the atom laser with manipulated intensity.

Effect of Water Salinity on the Spatial Variability of Soil and Plant Parameters

Spatial pattern and interdependence of different soil and plant parameters were examined in green bean field experiment carried out at the Mediterranean Agronomic Institute of Bari （MAIB）, Italy. The study aimed to identify the spatial distribution of soil and plant parameters and their relationship at transects scale. The experiment consisted of three transects of 30 m length and 4.2 m width, irrigated with three different salinity levels （1 dSm＂1, 3 dSm1, 6 dSml）. Soil measurements （electrical conductivity and soil water content） were monitored along each transect in 24 sites, using TDR probe installed vertically at soil surface. Water storage was measured by using Diviner sensor for calculating directly the evapotranspiration fluxes along the whole soil profile under the different salinity levels imposed during the experiment. In the same 24 sites, crop monitoring involved measurements of Leaf Area Index （LAI）, Osmotic Potential （OP）, Root length Density （RID） and Evapotranspiration fluxes （ET）. Soil and plant properties were analyzed using both classical and geostatistical methods which included descriptive statistics, semivariograms and cross-semivariograms. Results indicated that moderate to large spatial variability existed across the field for soil and plant parameters, especially under the 6 dSm1 salinity treatment. A relatively satisfactory fit of the experimental cross-semivariogram was obtained for the 6 dS1, thus indicating similar spatial structures of the pairs of compared variables. By contrast, the experimental cross-semivariograms observed under the 3 dS~ treatment indicated no significant correlation structure between the compared variables. Overall, the results observed in the 3 dSm-1 were not significantly different from those obtained in the 1 dSm-1 transect and suggested a general insensitivity of the crop response to those levels of salinity.

Combined inhibitors of angiogenesis and histone deacetylase:Efficacy in rat hepatoma

AIM:To evaluate the antitumoral effect of combined inhibitors of angiogenesis and histone deacetylases in an experimental rat hepatoma model.METHODS:MH7777A hepatoma cells were injected into the liver of male Buffalo rats.After 7 d treatment with the vascular endothelial growth factor receptor antagonist PTK787/ZK222584(PTK/ZK),the histone deacetylase inhibitor MS-275,tamoxifen(TAM) and/or retinoic acid was initiated(n ≥ 8 animals/group).Natural tumor development was shown in untreated control groups(control 1 with n = 12,control 2 with n = 8).The control groups were initiated at different time points to demonstrate the stability of the hepatoma model.For documentation of possible side effects,we documented any change in body weight,loss of fur and diarrhea.After 21 d treatment,the rats were euthanized.Main target parameters were tumor size and metastasis rate.Additionally,immunohistochemistry for the proliferating cell nuclear antigen(PCNA) and TdT-mediated dUTP-biotin nick end labeling(TUNEL) assay were performed.RESULTS:The control groups developed large tumor nodules with extrahepatic tumor burden in the lung and abdominal organs(control 1:6.18 cm3 ± 4.14 cm3 and control 2:8.0 cm3 ± 4.44 cm3 28 d after tumor cell injection).The tumor volume did not differ significantly in the control groups(P = 0.13).As single agents MS-275 and PTK/ZK reduced tumor volume by 58.6% ± 2.6% and 48.7% ± 3.2% vs control group 1,which was significant only for MS-275(P = 0.025).The combination of MS-275 and PTK/ZK induced a nearly complete and highly significant tumor shrinkage by 90.3% ± 1%(P = 0.005).Addition of TAM showed no further efficacy,while quadruple therapy with retinoic acid increased antitumoral efficacy(tumor reduction by 93 ± 1%) and side effects.PCNA positive cells were not significantly reduced by the single agents,while dual therapy(MS-275 and PTK/ZK) and quadruple therapy reduced the PCNA-positive cell fraction significantly by 9.1 and 20.6% vs control 1(P < 0.05).The number of TUNEL-positive cells,markers for ongoing apoptosis,was increased significantly by the single agents(control 1:6.9%,PTK/ZK:11.4%,MS-275:12.2% with P < 0.05 vs control 1).The fraction of TUNEL-positive cells was upregulated highly significantly by dual therapy(18.4%) and quadruple therapy(24.8%,P < 0.01 vs control 1).For the proliferating(PCNA positive) and apoptotic cell fraction,quadruple therapy was significantly superior to dual therapy(P = 0.01).CONCLUSION:Combined PTK/ZK and MS-275 were highly effective in this hepatoma model.Quadruple therapy enhanced the effects microscopically,but not macroscopically.These results should be investigated further.

Post-Fertilization Development of Seed in French Bean Genotypes： Changes in Seed Quality

An experiment was conducted to evaluate physiological maturity of French bean genotypes at District Seed Farm ＂D＂ Block, Bidhan Chandra Krishi Viswavidyalaya, Kalyani, Nadia, West Bengal during winter season of both 2012-2013 and 2013-2014. All the five genotypes were grown with sufficient population in three replications following randomized block design （RBD） for the purpose of developmental studies. Developing pods were harvested at different stages, starting from 7 days after anthesis （7 DAA） to 49 DAA with an interval of 7 d, including the field maturity stage, thus leading to study on maximum seven different stages. Harvested pods and seeds were utilized for this development programme through dry seed weight, germination and vigour index. Enhancement in dry matter accumulation in seed continued till 42 DAA for Selection 9 and Victoria in both the years; it was 49 and 42 DAA for Sonali in respective years; it was 49 DAA for Abhay in both the years; and for Deepali, it was 42 DAA along with statistically similar magnitude at 49 DAA. Significant enhancement in germination potential of developing seeds continued till 42 DAA for Selection 9 and Deepali, while it was 49 DAA for the other three genotypes. Enhancement in vigour index continued till 49 DAA for all the genotypes except for Selection 9, for which it continued till 42 DAA and then declined.

Study of soil and water conservation Function on Slope with Different Planting Patterns for a Typical Small Watershed in Karst Region of Guizhou Province

Ten runoff plots with different planting patterns were established for experimental observation in Yangjichong small watershed of Longli County in Karst region of Guizhou Province. Results show that under the same rainfall condition, shrub land, natural grassland and abandoned land presented the best function of soil and water conservation. The function of soil and water conservation was poor for arbor planting pattern, because the shrub layer, herb layer and forest floor were not formed. Because of no-tillage, surface crust and other effects, the function of soil and water conservation in slope farmland was better than that in runoffplots with arbor planting pattern.