温针灸联合透明质酸钠注射治疗骨关节炎的临床疗效分析

目的:研究温针灸联合透明质酸钠注射治疗骨关节炎的临床疗效。方法:选择到我院就诊的膝骨关节炎患者72例,随机分为对照组及治疗组,分别有36例。对照组接受透明质酸钠腔内注射,治疗组在此基础上加用温针灸,对各组患者VEGF、Ang-1、WOMAC评分、SF-36评分进行分析。结果:治疗组及对照组治疗后VEGF、Ang-1较治疗前均有显著下降(P<0.05),治疗组治疗后VEGF、Ang-1水较对照组均有显著改善(P<0.05)。治疗组及对照组治疗后疼痛、僵硬及关节功能评分较治疗前均有显著下降(P<0.05),治疗组治疗后疼痛、僵硬及关节功能评分较对照组均有显著改善(P<0.05)。治疗组功能因素、躯体疼痛、整体健康较对照组有显著性差异(P<0.05),心理因素未见显著性差异(P>0.05)。结论:温针灸联合透明质酸钠注射可显著改善膝骨关节炎临床症状及生活质量,该过程可能通过抑制新生血管形成来实现。

不同针灸方式对虚寒型膝骨关节炎患者WOMAC评分及疼痛症状的影响比较

目的:研究比较不同针灸方式对虚寒型膝骨关节炎(CTKO)患者骨性关节炎指数(WOMAC)评分及疼痛症状的影响。方法:选择CTKO患者162例,按数字表法为患者分成观察组及对照组各81例,观察组通过温针灸方式治疗,对照组不进行艾灸。对比两组疗效,WOMAC评分以及疼痛症状。结果:观察组显效率是62.96%,总有效率是98.77%,均分别明显高于对照组的46.91%及90.12%(P<0.05)。治疗后两组的WOMAC评分均分别较治疗前明显降低,且观察组的WOMAC评分明显较对照组更低(P<0.05)。治疗后两组的主诉疼痛分级(VRS)及数字评价量表(NRS)评分均分别较治疗前明显降低,且观察组明显较对照组更低(P<0.05)。结论:利用温针灸治疗CTKO患者可产生较好的疗效,还可有效降低其WOMAC评分及疼痛症状。

穴位敷贴联合自我管理治疗膝骨关节炎疗效观察

目的:观察穴位敷贴联合自我管理治疗膝骨关节炎的临床疗效。方法:70例患者随机分为治疗组和对照组,每组35例,对照组行基础治疗及自我管理,治疗组在对照组基础上给予穴位敷贴治疗,分别于治疗前、治疗6周后和治疗结束后6个月时采用WOMAC量表、SF-36问卷量表评定比较两组患者治疗前后的膝关节功能及生活质量。结果:治疗前、治疗6周后及治疗结束后6个月WOMAC评分、SF-36问卷评分比较:治疗6周后及治疗结束6个月后,两组患者WOMAC评分均显著低于治疗前(P<0.05),治疗组WOMAC评分显著低于对照组(P<0.05);治疗6周后及治疗结束6月后,两组患者SF-36问卷评分均明显高于治疗前(P<0.05),治疗组SF-36问卷评分显著高于对照组(P<0.05)。结论:穴位敷贴联合自我管理治疗膝骨关节炎疗效显著,可明显改善老年膝骨关节炎患者关节功能及生活质量。

Observation of therapeutic effect on senile osteoarthritis treated with both acupuncture and Chinese medicine

Objective To compare the therapeutic effect differences of senile osteoarthritis treated by the combined therapy of acupuncture and Chinese medicine and western medication.Methods Eightytwo cases of senile osteoarthritis were randomly divided into 2 groups.In observation group（42 cases）,puncture at Shènshū （肾俞 BL 23）,Yāoyángguān （腰阳关 GV 3）,Fēngchí（风池 GB 20） and Dàzhuī（大 椎 GV 14） etc.combining with Chinese medicine of Bushen Zhuanggu Decoction for oral administration was applied;in control group （40 cases）,routine western medicine was applied.Pain score and theraputic effect of both groups were observed before and after treatment.Results The total effective rate was 88.1%（37/42） in observation group,and 60.0%（24/40） in control group.The therapeutic effect in observation group was superior to that in control group （P0.01）.The pain score was improved by both therapies （P0.05,P0.01） after treatment,and the improvement in observation group was superior to that in control group （P0.05）.Conclusion The therapeutic effect of senile osteoarthritis by combined therapy of both acupuncture and Bushen Zhuanggu Decoction for oral administration is superior to that by western medication.

Knee osteoarthritis treated with acupuncture based on syndrome differentiation:a randomized controlled trial

Objective To compare the efficacy differences between acupuncture and western medicine in treating osteoarthritis of knee joints.Methods One hundred and twenty cases were randomly divided into an acupuncture group and a western medication group with 60 cases in each group.In the acupuncture group,acupuncture was applied mainly at Nèixīyǎn（内膝眼 EX-LE 4）,Dúbí（犊鼻 ST 35）,Yīnlíngquán（阴陵泉 SP 9） and Yánglíngquán（阳陵泉 GB 34） plus other acupoints selected according to syndrome differentiation.In the medication group,Glucosamine Hydrochloride capsules were orally given 3 times daily with 2 capsules each time.Western Ontario and McMaster Universities Osteoarthritis Index（WOMAC）,Medical Outcomes Study 36-Item Short Form Health Survey（SF-36,Chinese version） were used to assess therapeutic effects before treatment,after 4 weeks treatment and 9 weeks after treatment,respectively.Results After 4 weeks of treatment,the total effective rates were 86.7%（52/60） and 88.3%（53/60） in the acupuncture group and the western medication group,respectively,without significant difference（P〈0.05）.In 9 weeks after treatment,the total effective rates were 83.3%（50/60） and 61.7%（37/60） in the acupuncture group and the western medication group,respectively,with significant difference between the two groups（P〈0.05）.According to WOMAC and SF-36,the scores were all improved in both groups（P〈0.05,P〈0.01）,with significant difference in follow-up visit of 9 weeks after treatment between the two groups（P〈0.05,P〈0.01）,but not after 4 weeks of treatments（both P〈0.05）.Conclusion Short-term of therapeutic effects of acupuncture and oral administration of Glucosamine Hydrochloride on osteoarthritis of knee joints are similar,but long-term efficacy in the acupuncture group is better than that in the western medication group.

Clinical Observation on Treatment of Knee Osteoarthritis by Acupuncture and Tuina Therapy

Objective： To observe the effect of acupuncture and Chinese tuina manipulation therapy in treating knee osteoarthritis, and analyze the alteration of musculus quadriceps femoris strength. Methods： A total of 80 patients were randomly assigned to a treatment group receiving acupuncture combined Chinese tuina manipulation therapy （n=40） and a control group receiving Fenbid treatment （n=40）, curative effective score, Lequene ＆ Mery assessment tests, and isokinetic evaluation were recorded before and after the treatment course. Results： The total effective rate was 90.0 % in the treatment group and 87.5% in the control group, without a significant difference between the two groups. Lequene ＆ Mery assessment tests had no significant change. Musculus quadriceps femoris isokinetic evaluation improved significantly after the treatment course in the two groups （/9〈0.05）, and there was a significant difference between the two groups （P〈0.05）. Conclusion： Acupuncture combined with tuina manipulation therapy and Fenbid treatment both can reduce knee pain and joint disability in the short term, though no improvement was shown in the severity of the disease. Acupuncture combined with tuina manipulation therapy is better than Fenbid in improving the strength, total work and explosive force of the musculus quadriceps femoris.

Clinical Observation on Treatment of Knee Osteoarthritis by Warm Needling Method

Objective： To observe the therapeutic effect of warm needling method for knee osteoarthritis. Methods： Three hundred cases were randomly divided into treatment group and control group, 150 cases respectively in each group. The treatment group was treated by warm needling method, and the control group was treated by simple acupuncture. Their therapeutic effects were compared after 20 sessions of treatments. Results： The effective rate was 94.0% in the treatment group and 86.0% in the control group, with a significant difference between the two groups （P〈0.05）. Conclusion： The therapeutic effect is better in the warm needling group than in the control group in the treatment of knee osteoarthritis.

Clinical Study on Treatment of Knee Osteoarthritis with Combined Acupuncture and Medication

Objective： To observe the effect of treatment for proliferative knee osteoarthritis （KOA） using combined acupuncture and medicated compression. Method： All 328 cases were randomized into an observation and control group, 164 cases in each. Combined acupuncture and medicated compression were adopted in the observation group, while oral administration of Zhui Feng Tou Gu Wan （Wind-removing and Bone-penetrating Pills） were adopted in the control group. The clinical effects in the two groups were evaluated 40 days after the treatment. Result： There were significant differences in both marked and total effective rates （P〈0.05）. Conclusion Combined acupuncture and medicated compression can obtain better effect for KOA than oral administration of the Wind-Removing and Bone-Penetrating pills.

Clinical Observation on Treatment of Knee Osteoarthritis with Acupuncture plus Tuina

To investigate the efficacy of specific point acupuncture and manipulative adjustment on muscle strength of the knee osteoarthritis. Method： One hundred and five patients were randomly allocated to two groups. Sixty-eight cases in the treatment group were treated by specific point acupuncture and manipulative adjustment on muscle strength of the knee joint. While 37 cases in the control group were treated with specific point acupuncture alone. Result： The total effective rate was significantly higher in the treatment group than in the control group （P〈0.05）. Conclusion： Specific point acupuncture and manipulative adjustment on muscle strength of the knee joint has a satisfactory curative effect on knee osteoarthritis.

Efficacy and safety of acupuncture for the treatment of knee osteoarthritis:a systematic review and meta-analysis

Objective:To evaluate the efficacy and safety of acupuncture for the treatment of knee osteoarthritis and to provide evidence for its use in clinical practice.Methods:Eight databases were extensively searched up to March 2018.Randomized controlled trials(RCTs)comparing the efficacy of acupuncture with sham acupuncture or no acupuncture for knee osteoarthritis were included.Study selection,data extraction and quality assessment were independently conducted by two reviewers.The Cochrane Collaboration's tool was used for assessing the risk of bias.Results:A total of 18 RCTs were included,involving a total of 3522 participants.The results showed that acupuncture was superior to sham acupuncture in relieving pain(SMD=-0.34,95%CI:-0.57 to-0.11,I^2=85%,P=0.003)and improving physical function(SMD=-0.34,95%CI:-0.57 to-0.11,I^2=85%,P=0.003).In comparison to the no-acupuncture group,the acupuncture group also showed significant advantages in relieving pain(SMD=-0.79,95%CI:-1.15 to-0.43,I^2=87%,P<0.0001)and improving physical function(SMD=-0.75,95%CI:-1.19 to-0.31,I^2=91%,P=0.0008).Sensitivity analyses suggested that the results were robust,and Egger's test found no potential publication bias.Conclusion:In the treatment of knee osteoarthritis,the acupuncture group had significant advantages over sham acupuncture or no-acupuncture groups in relieving pain and improving physical function.

Effect of modified Qing Long Bai Wei needling on the levels of IL-1β, IL-6 and INF-α in synovial fluid of knee osteoarthritis patients

Objective:To compare the modified Qjng Long Bai Wei needling method and ordinary acupuncture method in the effects of improving the levels of interleukin (IL)-1β,IL-6 and tumor necrosis factor (TNF)-α in the treatment of knee osteoarthritis (KOA),and to determine the advantage of the modified Qing Long Bai Wei needling method for KOA.Methods:One hundred KOA patients were randomized into a treatment group and a control group by using the random number table,with 50 cases in each group.The treatment group was intervened by the modified Qing Long Bai Wei needling method,and the control group was given ordinary acupuncture.The two groups were observed before and after the treatment to determine the changes in the levels of IL-1β,IL-6 and TNF-α in synovial fluid,and the clinical efficacies were compared between the two groups.Results:The total effective rate and clinical recovery rate were 97.9％ and 52.1％ respectively in the treatment group,versus 85.1％ and 25.5％ in the control group,and the between-group differences were statistically significant (both P＜0.01).After the treatment,the levels of Ib1β,IL-6 and TNF-cα in synovial fluid changed significantly in both groups (all P＜0.01);there were significant differences in the levels of IL-1β,IL-6 and TNF-α in synovial fluid between the two groups (all P＜0.01).Conclusion:The modified Qjng Long Bai Wei needling is an effective method for KOA and it can significantly improve the levels of IL-1β,IL-6 and TNF-α in synovial fluid.