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透明质酸钠治疗膝骨关节炎疗效及对血清肿瘤坏死因子-α白细胞介素-1β水平的影响 被引量:2
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作者 张乾 付战利 《山西医药杂志》 CAS 2021年第8期1315-1317,共3页
随着我国人口老龄化趋势的加重,膝骨关节炎(knee osteoarthritis,KOA)的发病率也出现逐年增长的趋势[1]。KOA的病因复杂,目前尚未完全明确,一般认为其发病是由多方面的因素如老龄化、超重或肥胖、创伤、长期疲劳损伤、关节异常畸形(先... 随着我国人口老龄化趋势的加重,膝骨关节炎(knee osteoarthritis,KOA)的发病率也出现逐年增长的趋势[1]。KOA的病因复杂,目前尚未完全明确,一般认为其发病是由多方面的因素如老龄化、超重或肥胖、创伤、长期疲劳损伤、关节异常畸形(先天或后天性)等共同参与引起的[2]。近年来,关于KOA发病机制有了更加深入的认识,肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)等炎症因子对关节软骨细胞的破坏作用越来越受到临床重视[3]。 展开更多
关键词 骨关节炎 透明质酸钠 关节软骨细胞 超重或肥胖 骨关节炎疗效 炎症因子 KOA 人口老龄化趋势
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有限元分析全膝关节置换股骨假体置入定位参数及临床优化验证 被引量:9
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作者 徐高伟 董斌 +1 位作者 崔海勇 马强 《中国组织工程研究》 CAS 北大核心 2016年第17期2451-2458,共8页
背景:三维有限元仿真分析在生物力学中有着广泛应用,但在膝关节置换中的研究不多,对股骨假体的研究也比较少。目的:有限元分析膝关节置换股骨假体置入的优化定位参数,并对Gemini-PS膝关节假体全膝关节置换进行临床验证。方法:1构建全膝... 背景:三维有限元仿真分析在生物力学中有着广泛应用,但在膝关节置换中的研究不多,对股骨假体的研究也比较少。目的:有限元分析膝关节置换股骨假体置入的优化定位参数,并对Gemini-PS膝关节假体全膝关节置换进行临床验证。方法:1构建全膝关节置换膝关节有限元模型,对股骨假体截骨定位参数进行正交实验,选择股骨假体的平移量A、外旋度数B、外翻度数C 3个参数作为正交实验的相关因素,每个参数取3个值建立正交表,创建9个实验组合的全膝关节置换膝关节的有限元模型,对9个模型进行有限元分析,通过优化处理进行方差和极差分析。2纳入42例(47膝)中老年膝骨关节炎患者,采用Gemini-PS膝关节假体进行全膝关节置换,采用美国特种外科医院膝关节评分及美国膝关节协会评分评价置换前后膝关节功能,以疼痛目测类比评分评估置换前后膝关节疼痛程度。结果与结论:1聚乙烯衬底表面压应力峰值最小的为平移0 mm,外旋3°,外翻6°组合,压应力峰值为15.9 MPa;聚乙烯衬垫表面压应力的影响因素中,内外平移的影响大于外旋角度的影响大于外翻角度的影响;通过极差分析和方差分析发现股骨假体置入的最佳定位参数组合为平移0 mm,外旋3°,外翻6°;通过仿真计算证明正交实验是有效的;242例患者均得到随访,随访时间12-36个月,1例发生术口下段皮下脂肪液化;置换后末次随访患膝美国特种外科医院膝关节评分及美国膝关节协会评分均较置换前显著提高(P<0.05);置换后疼痛目测类比评分较置换前显著降低(P<0.05)。X射线检查未发现骨溶解、假体脱位及松动等并发症,置换后膝关节功能恢复良好;3结果提示,股骨假体置入位置的微小变化都会引起聚乙烯衬垫表面压应力峰值的异常分布,全膝关节置换术中对股骨假体进行准确定位可以取得良好的置换效果。 展开更多
关键词 关节成形术 置换 假体植入 有限元分析 骨关节炎 组织工程 骨科植入物 人工假体 全膝关节置换 股骨假体 定位 正交实验 关节 骨关节炎 临床疗效
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Observations on Curative Effect of High-frequency Electric Sparkle and Point-injection Therapy on Knee Osteoarthritis 被引量:5
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作者 梅志刚 程传国 郑俊峰 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2011年第4期311-315,共5页
Objective: To observe the curative effect of high-frequency electric sparkle and point-injection therapy (HESPT) on knee osteoarthritis (KOA). Methods: Two hundred and five patients were randomly divided into a warmin... Objective: To observe the curative effect of high-frequency electric sparkle and point-injection therapy (HESPT) on knee osteoarthritis (KOA). Methods: Two hundred and five patients were randomly divided into a warming needle moxibustion group (68 cases), a HESPT group (68 cases) and a point-injection group (69 cases). In the warming needle moxibustion group, the main points of Xuehai (SP 10), Neixiyan (EX-LE4), Waixiyan (EX-LE5), Dubi (ST 35), Zusanli (ST 36) and Yanglingquan (GB 34), and the adjunct points of Yinlingquan (SP 9) and Sanyinjiao (SP 6), on the affected side, were chosen for stimulation. In the HESPT group, tenderness points, the main points of Liangqiu (ST 34), Xuehai (SP 10), Neixiyan (EX-LE4), Waixiyan (EX-LE5) and Zusanli (ST 36), and the adjunct points of Yinlingquan (SP 9), Weizhong (BL 40) and Chengshan (BL 57), were chosen. After proper manipulation, Corydalis decumbens Pers. liquid was injected into the points and a high-frequency electric sparkle was applied to stimulate the needles for 30 seconds. In the point-injection group, point injection was performed with the same method, but the patients did not receive electric stimulation. The Western Ontario and McMaster University Osteoarthritis Index (WOMAC), the Lysholm Knee Score Scale (LKSS) and the ROM (Range of Motion) scale were used to evaluate the severity of KOA and the function of knee joints before treatment and 4 weeks after treatment. Finally, the Nimodipine method was used to assess the total curative effect. Results: After HESPT treatment, the scores for pain, morning stiffness and swelling were significantly lower (P<0.01) and LKSS index and ROM were much higher (P<0.01 and P<0.05 respectively) compared to the two other groups. The obviously effective rate and total effective rate were also significantly higher in the HESPT group than in the two other groups (P<0.01 or P<0.05). Conclusion: HESPT can improve joint function in KOA patients, and the curative effect is better than for warming needle moxibustion or point-injection only. 展开更多
关键词 high-frequency electric sparkle and point-injection therapy knee osteoarthritis
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Clinical Observation on Curative Effect of Dissolving Phlegm-Stasis on 50 Cases of Knee Osteoarthritis 被引量:21
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作者 李西海 梁文娜 +1 位作者 刘献祥 段树民 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2010年第2期108-112,共5页
Objective: To observe the curative effect of dissolving phlegm-stasis on knee osteoarthritis. Methods: The 100 patients with knee osteoarthritis were randomly divided into two groups. The 50 patients in the treatmen... Objective: To observe the curative effect of dissolving phlegm-stasis on knee osteoarthritis. Methods: The 100 patients with knee osteoarthritis were randomly divided into two groups. The 50 patients in the treatment group orally took Chinese medicine while the other 50 patients in the control groups orally took Votalin and Vitamin C for one week as a course of treatment. At the end of 2-week treatment, analytic comparison was carried in evaluate the curative effect and the changes in total score of symptoms before and after treatment between the two groups. Results: The total score of symptoms after treatment was significantly lower than that before treatment in both groups (P〈0.01, P〈0.05). The total score after treatment of patients with X-ray grade I and II in the treatment group was more obviously reduced as compared to the control group (P〈0.05). The remarkably effective rate after treatment of patients with X-ray grade I and It in the treatment group was also higher than that in the control group (P〈0.05). Conclusion: The treatment of knee osteoarthritis with dissolving phlegm-stasis can effectively improve the clinical symptoms. 展开更多
关键词 dissolving phlegm-stasis OSTEOARTHRITIS knee joint Chinese herbal therapy
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