AIM： To asses the expression of myeloid dendritic cells （CD11c＋） subset during acute HCV hepatitis and its possible involvement in natural history of the infection.METHODS： We enrolled 11 patients with acute hepa...AIM： To asses the expression of myeloid dendritic cells （CD11c＋） subset during acute HCV hepatitis and its possible involvement in natural history of the infection.METHODS： We enrolled 11 patients with acute hepatitis C （AHC） （Group A）, 10 patients with acute hepatitis A （AHA） （as infective control-Group B） and 10 healthy donors （group C） in this study. All patients underwent selective flow cytometry gating strategies to assess the peripheral number of the myeloid dendritic cells （mDCs） to understand the possible role and differences during acute hepatitis.RESULTS： Eight of 11 patients with acute HCV hepatitis did not show any increase of mDCs compared to healthy individuals, while a significant decrease of mDCs was found in absolute cell count （z=-2.37, P〈0.05） and percentage （z=-2.30; P〈 0.05） as compared with AHA. On the contrary, The remaining three patients of the group A had a higher mDCs number and percentage as occur in group B. Interestingly, after six months, those patients did not show any increase of mDCs subset were chronically infected, while the three subjects with an increase of peripheral mDCs, as in HAV acute infection, resolved the illness.CONCLUSION： The lack of increase of mDCs during acute hepatitis C might be an important factor involved in chronicization of the infection.展开更多
In order to expand the engineering application of recycle aggregate mortars （RAM） with aggregates from demolished concretes, the models for the properties of RAM and the replacement rate of these recycled fine aggre...In order to expand the engineering application of recycle aggregate mortars （RAM） with aggregates from demolished concretes, the models for the properties of RAM and the replacement rate of these recycled fine aggregates were proposed. First, different kinds of mathematical models for the basic properties （compressive strength, water retention rate, and consistency loss） of RAM with two kinds of admixtures, thickening powders （TP） and self-made powdery admixtures （SSCT） designed for RAM, and the replacement rates were established, while the average relative errors and relative standard errors of these models were calculated. Additionally, the models and their error analyses for the curves of drying shrinkage and curing time of RAM ＋ SSCT at different replacement rates were put forward. The results show that polynomial functions should be used to calculate the basic properties of RAM ＋ TP and RAM ＋ SSCT at different replacement rates. In addition, polynonfial functions are the most optimal models for the sharp shrinkage sections in the curves of drying shrinkage-curing time of RAM ＋ SSCT, while exponential functions should be used as the models for the slow shrinkage sections and steady shrinkage sections.展开更多
The aim of the present study was to develop and validate a new marker model for optoelectronic systems adapted to wearable devices, in order to have an analysis tool for kinematic gait evaluation of reproduced pattern...The aim of the present study was to develop and validate a new marker model for optoelectronic systems adapted to wearable devices, in order to have an analysis tool for kinematic gait evaluation of reproduced patterns by exoskeletons. The marker model has a total of 36 retro-reflective markers attached bilaterally to anatomical landmarks during the static measures （without exoskeleton） and 28 markers at the dynamics measures （with exoskeleton）. The main difference between others kinematic models and the described adapted model was the placement of the three markers in the back thigh and the other three in the back calf, what allowed removing the hip, thigh, knee, tibia and ankle markers. The proposed adapted marker model could be an effective tool to validate the joint movement and velocities of those wearable exoskeletons that at present have been developing.展开更多
The most commonly accepted system of classification for tibia plateau fractures is that of Schatzker. Increasingly, both high energy injuries and atypical osteoporotic fragility failures have led to more complex, unus...The most commonly accepted system of classification for tibia plateau fractures is that of Schatzker. Increasingly, both high energy injuries and atypical osteoporotic fragility failures have led to more complex, unusual and previously undescribed fracture patterns being recognized. We present a case of a patient with a previously unreported pattern of tibia plateau fracture and knee dislocation. We highlight the challenges confronted and present the management and the outcomes of his injury. A 28-year old male motorcyclist was involved in a head on collision with a truck and was transferred by helicopter to our level I major trauma centre emergency department. His injuries were a circumferential degloving injury to his left leg and a right lateral tibial plateau fracture/knee dislocation. The pattern of the lateral tibial plateau fracture was unique and did not fit any recognised classification system. The patient received a spanning external fixator initially and after latency of 12 days for soft tissue resuscitation he underwent definite fixation through an antero-lateral approach to the proximal tibia with two cannulated 6.5 mm partially threaded screws and an additional lateral proximal tibia plate in buttress mode. A hinged knee brace was applied with unrestricted range of motion post-operatively and free weight bearing were permitted post operatively. At the 6 months follow up, the patient walks without aids and with no limp. Examination revealed a stable joint and full range of motion. Plain radiographs revealed that the fracture healed with good alignment and the fixation remained stable. High energy injuries can lead to more complicated fracture patterns, which challenge the orthopaedic surgeons in their management. It is crucial to understand the individual fracture pattern and the possible challenges that may occur. This study reports a lateral tibia plateau fracture/dislocation which perhaps is best described as a reverse Schatzker IV type fracture.展开更多
The purpose of this study was to establish a method for measuring the knee valgus angle from the ana- tomical and mechanical axes on three-dimensional reconstruction imaging models, and to use this method for estimati...The purpose of this study was to establish a method for measuring the knee valgus angle from the ana- tomical and mechanical axes on three-dimensional reconstruction imaging models, and to use this method for estimating an average knee valgus angle value for northern Chinese adults. Computed tomographic angiography data in DICOM format for 128 normal femurs from 64 adult subjects were chosen for analysis. After the femur images were subjected to three-dimensional reconstruction, the deepest point in the intercondylar notch （point A）, the midpoint of the medullary cavity 20 cm above the knee-joint line （point B）, and the landmark of the femoral head rotation center （point C） were identified on each three-dimensional model. The knee valgus angle was defined as the angle enclosed by the distal femoral anatomical axis （line AB） and the femoral mechanical axis （line AC）. The average （mean＋SD） of knee valgus angle for the 128 femurs was 6.20°±1.20° （range, 3.05° to 10.64°）. Significant positive correlations were found between the knee valgus angles of the right and left sides and between the knee valgus angle and age. During total knee arthroplasty, choosing a valgus cut angle of approximately 6° may achieve a good result in reestablishing the natural mechanical alignment of the lower extremity for patients of northern Chinese ethnicity. Larger valgus cut angles should be chosen for older patients.展开更多
文摘AIM： To asses the expression of myeloid dendritic cells （CD11c＋） subset during acute HCV hepatitis and its possible involvement in natural history of the infection.METHODS： We enrolled 11 patients with acute hepatitis C （AHC） （Group A）, 10 patients with acute hepatitis A （AHA） （as infective control-Group B） and 10 healthy donors （group C） in this study. All patients underwent selective flow cytometry gating strategies to assess the peripheral number of the myeloid dendritic cells （mDCs） to understand the possible role and differences during acute hepatitis.RESULTS： Eight of 11 patients with acute HCV hepatitis did not show any increase of mDCs compared to healthy individuals, while a significant decrease of mDCs was found in absolute cell count （z=-2.37, P〈0.05） and percentage （z=-2.30; P〈 0.05） as compared with AHA. On the contrary, The remaining three patients of the group A had a higher mDCs number and percentage as occur in group B. Interestingly, after six months, those patients did not show any increase of mDCs subset were chronically infected, while the three subjects with an increase of peripheral mDCs, as in HAV acute infection, resolved the illness.CONCLUSION： The lack of increase of mDCs during acute hepatitis C might be an important factor involved in chronicization of the infection.
基金The National Key Research and Development Program of China(No.2017YFC0703100)Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.KYCX18_0081)
文摘In order to expand the engineering application of recycle aggregate mortars （RAM） with aggregates from demolished concretes, the models for the properties of RAM and the replacement rate of these recycled fine aggregates were proposed. First, different kinds of mathematical models for the basic properties （compressive strength, water retention rate, and consistency loss） of RAM with two kinds of admixtures, thickening powders （TP） and self-made powdery admixtures （SSCT） designed for RAM, and the replacement rates were established, while the average relative errors and relative standard errors of these models were calculated. Additionally, the models and their error analyses for the curves of drying shrinkage and curing time of RAM ＋ SSCT at different replacement rates were put forward. The results show that polynomial functions should be used to calculate the basic properties of RAM ＋ TP and RAM ＋ SSCT at different replacement rates. In addition, polynonfial functions are the most optimal models for the sharp shrinkage sections in the curves of drying shrinkage-curing time of RAM ＋ SSCT, while exponential functions should be used as the models for the slow shrinkage sections and steady shrinkage sections.
文摘The aim of the present study was to develop and validate a new marker model for optoelectronic systems adapted to wearable devices, in order to have an analysis tool for kinematic gait evaluation of reproduced patterns by exoskeletons. The marker model has a total of 36 retro-reflective markers attached bilaterally to anatomical landmarks during the static measures （without exoskeleton） and 28 markers at the dynamics measures （with exoskeleton）. The main difference between others kinematic models and the described adapted model was the placement of the three markers in the back thigh and the other three in the back calf, what allowed removing the hip, thigh, knee, tibia and ankle markers. The proposed adapted marker model could be an effective tool to validate the joint movement and velocities of those wearable exoskeletons that at present have been developing.
文摘The most commonly accepted system of classification for tibia plateau fractures is that of Schatzker. Increasingly, both high energy injuries and atypical osteoporotic fragility failures have led to more complex, unusual and previously undescribed fracture patterns being recognized. We present a case of a patient with a previously unreported pattern of tibia plateau fracture and knee dislocation. We highlight the challenges confronted and present the management and the outcomes of his injury. A 28-year old male motorcyclist was involved in a head on collision with a truck and was transferred by helicopter to our level I major trauma centre emergency department. His injuries were a circumferential degloving injury to his left leg and a right lateral tibial plateau fracture/knee dislocation. The pattern of the lateral tibial plateau fracture was unique and did not fit any recognised classification system. The patient received a spanning external fixator initially and after latency of 12 days for soft tissue resuscitation he underwent definite fixation through an antero-lateral approach to the proximal tibia with two cannulated 6.5 mm partially threaded screws and an additional lateral proximal tibia plate in buttress mode. A hinged knee brace was applied with unrestricted range of motion post-operatively and free weight bearing were permitted post operatively. At the 6 months follow up, the patient walks without aids and with no limp. Examination revealed a stable joint and full range of motion. Plain radiographs revealed that the fracture healed with good alignment and the fixation remained stable. High energy injuries can lead to more complicated fracture patterns, which challenge the orthopaedic surgeons in their management. It is crucial to understand the individual fracture pattern and the possible challenges that may occur. This study reports a lateral tibia plateau fracture/dislocation which perhaps is best described as a reverse Schatzker IV type fracture.
基金supported by the Norman Bethune B Program of Jilin University(No.2012216)the Science and Technology Development Program of Jilin Province(No.20100750),China
文摘The purpose of this study was to establish a method for measuring the knee valgus angle from the ana- tomical and mechanical axes on three-dimensional reconstruction imaging models, and to use this method for estimating an average knee valgus angle value for northern Chinese adults. Computed tomographic angiography data in DICOM format for 128 normal femurs from 64 adult subjects were chosen for analysis. After the femur images were subjected to three-dimensional reconstruction, the deepest point in the intercondylar notch （point A）, the midpoint of the medullary cavity 20 cm above the knee-joint line （point B）, and the landmark of the femoral head rotation center （point C） were identified on each three-dimensional model. The knee valgus angle was defined as the angle enclosed by the distal femoral anatomical axis （line AB） and the femoral mechanical axis （line AC）. The average （mean＋SD） of knee valgus angle for the 128 femurs was 6.20°±1.20° （range, 3.05° to 10.64°）. Significant positive correlations were found between the knee valgus angles of the right and left sides and between the knee valgus angle and age. During total knee arthroplasty, choosing a valgus cut angle of approximately 6° may achieve a good result in reestablishing the natural mechanical alignment of the lower extremity for patients of northern Chinese ethnicity. Larger valgus cut angles should be chosen for older patients.
