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骨炎康颗粒对膝骨性关节炎大鼠血清II型胶原、TGF-β1、IL-lβ作用的实验研究 被引量:5
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作者 付志媛 欧阳厚淦 《中国骨质疏松杂志》 CAS CSCD 北大核心 2013年第12期1275-1277,1310,共4页
目的通过对膝骨性关节炎(KOA)模型大鼠的实验,观察复方中药骨炎康颗粒对膝骨性关节炎的作用机制。方法选用SD大鼠,随机分为正常对照组(A组)、模型组(B组)、骨炎康颗粒治疗组(C组)、西药对照组(D组)。通过左膝关节腔内注入木瓜蛋白酶,造... 目的通过对膝骨性关节炎(KOA)模型大鼠的实验,观察复方中药骨炎康颗粒对膝骨性关节炎的作用机制。方法选用SD大鼠,随机分为正常对照组(A组)、模型组(B组)、骨炎康颗粒治疗组(C组)、西药对照组(D组)。通过左膝关节腔内注入木瓜蛋白酶,造成骨性关节炎病变模型。木瓜蛋白酶注射结束后2周,开始对C、D组分别予以药物骨炎康颗粒、布洛芬灌胃,8周后处死全部大鼠,取A组双侧膝关节及B、C、D组造模侧膝关节制作病理标本,分别行免疫组化(TGF-β1、IL-lβ)染色,观察血清II型胶原、关节软骨及白介素l(1L-lβ)、转移生长因子(TGF-β1)的改变。结果 (1)血清II型胶原结果:骨炎康颗粒能提高血清II型胶原含量;(2)TGF-β1、IL-lβ改变结果:各治疗组均能提高TGF-β1含量,并降低1L-lβ,其中以骨痹颗粒组效果最佳,布洛芬相对较弱。结论骨炎康颗粒可增进软骨基质的合成,抑制软骨基质的分解,促进受损关节软骨的修复。骨炎康颗粒的疗效机理可能在于通过对机体的细胞因子调节,提高血清II型胶原、关节软骨的TGF-β1含量,降低IL-lβ含量,从而直接或间接促进了损伤关节软骨的修复。 展开更多
关键词 骨性关节炎 骨炎康颗粒 血清II型胶原 TGF-Β1 IL-lβ
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骨炎康胶囊治疗慢性骨髓炎临床疗效观察 被引量:1
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作者 郭豪 郭德荣 《中国临床医生杂志》 2009年第4期42-43,共2页
目的观察骨炎康胶囊治疗慢性骨髓炎的疗效。方法将160例慢性骨髓炎病人随机分为治疗组(78例)和对照组(82例)。治疗组口服骨炎康胶囊,采用中西医结合疗法。结果治疗组有效率97.2%,复发率5.6%;对照组有效率85%,复发率17.5%,两者差异有显著... 目的观察骨炎康胶囊治疗慢性骨髓炎的疗效。方法将160例慢性骨髓炎病人随机分为治疗组(78例)和对照组(82例)。治疗组口服骨炎康胶囊,采用中西医结合疗法。结果治疗组有效率97.2%,复发率5.6%;对照组有效率85%,复发率17.5%,两者差异有显著性(P<0.05)。结论提示骨炎康胶囊有效消除局部症状体征,抑制局部细菌生长,改善骨质,且与对照组有明显差别。治疗组治疗后机体免疫系统有明显改善。其作用机制与其抗菌消炎、改善整体状况、提高机体免疫力、改善微循环、促使骨痂生长等作用有关。 展开更多
关键词 骨炎康胶囊 慢性骨髓炎 中医药疗法
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骨炎康热敷药治疗退行性骨关节病
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作者 崔树平 《中医正骨》 2002年第7期24-24,共1页
关键词 骨炎康 热敷药 治疗 退行性骨关节病
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“骨炎康”膏药治疗慢性化脓性骨髓炎159例
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作者 崔树平 张明华 《世界中医骨伤科杂志》 2000年第2期41-41,共1页
关键词 慢性化脓性骨髓炎 骨炎康 膏药
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Effect of Osteoarthritis Patients' Gender on Rehabilitation after Total Knee Arthroplasty 被引量:2
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作者 Jin Lin Bo Yang Xi-sheng Weng Jin Jin Qing Zhao Gui-xing Qiu 《Chinese Medical Sciences Journal》 CAS CSCD 2009年第2期102-106,共5页
Objective To investigate the influence of gender on osteoarthritic knee rehabilitation outcome of osteoarthritis patient undergoing total knee arthroplasty(TKA).Methods We prospectively studied thirty male and thirty ... Objective To investigate the influence of gender on osteoarthritic knee rehabilitation outcome of osteoarthritis patient undergoing total knee arthroplasty(TKA).Methods We prospectively studied thirty male and thirty female knee primary osteoarthritis patients receiving unilateral TKA with posterior stable-fixed plateau prosthesis at our hospital from March 2003 to March 2008.The age and body mass index of male and female patients were matched.The surgical and rehabilitation clinical factors were compared between two groups.Results There was no significant difference in postoperative hospitalization time,surgical tourniquet time,and wound drainage volume between two groups(P>0.05).The extension/flexion degrees of knee joint before operation,1-week,2-week and 1-year after operation for male patients were 6.0 ± 3.3 degrees/ 114.0 ± 10.0 degrees,2.0 ± 1.6 degrees/93.0 ± 7.4 degrees,0.6 ± 0.6 degrees/104.0 ± 9.9 degrees and 0.3 ± 0.5 degrees/125.0 ± 8.8 degrees,for female patients were 7.0 ± 3.4 degrees/112.0 ± 14.0 degrees,2.0 ± 1.3 degrees/89.0 ± 10.9 degrees,0.9 ± 0.8 degrees/101.0 ± 11.8 degrees,0.4 ± 0.5 degrees/124.0 ± 7.1 degrees.The range of motion before operation,1-week,2-week,and 1-year after operation for male patients was 108.0 ± 9.5 degrees,91.0 ± 7.1 degrees,103.0 ± 9.9 degrees,and 125.0 ± 8.9 degrees,for female patients was 105.0 ± 14.1 degrees,87.0 ± 11.4 degrees,100.0±11.9 degrees,and 124.0 ± 7.0 degrees.The preoperative and 1-year postoperative HSS scores were 55.8 ± 13.3 and 89.6 ± 6.7 for males and 54.5 ± 13.8 and 89.2 ± 4.1 for females.No significant statistical difference was observed between two gender groups in regards to degree of extension and flexion,range of motion and HSS score(P>0.05).Conclusions Gender does not influence postoperative knee function of osteoarthritis patients.TKA significantly improves knee joint function and relieve osteoarthritis-related pain. 展开更多
关键词 OSTEOARTHRITIS ARTHROPLASTY KNEE gender factor treatment outcome
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Efficacy observation on the treatment of knee osteoarthritis with warm needling and rehabilitation therapy 被引量:2
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作者 黄丽娟 罗文基 李月婵 《World Journal of Acupuncture-Moxibustion》 2011年第3期10-14,共5页
Objective To compare the clinical efficacies among the combined therapy of warm needling and rehabilitation, simple warm needling and rehabilitation therapy for knee osteoarthritis (OA). Methods Ninty cases of OA we... Objective To compare the clinical efficacies among the combined therapy of warm needling and rehabilitation, simple warm needling and rehabilitation therapy for knee osteoarthritis (OA). Methods Ninty cases of OA were divided randomly into three groups, 30 cases in each one. In an acupuncture and rehabilitation group, warm needling was applied at the acupoints such as Xuehai (血海SP 10), Neixiyan (内膝眼 EX-LE 4), Dubi (犊鼻 ST 35) and Zusanli(足三里ST 36) etc.. Additionally, rehabilitation therapy was combined such as joint gymnastics, isometric exercise, stretching exercise and endurance training. In the warm needling group, warm needling was given simply. In the rehabilitation group, rehabilitation therapy was only adopted. The joint pain scale and severity index scale of knee OA were taken as the efficacy assessment indices among the groups. Results The clinical cured rate was 36.7% (11/30) in acupuncture and rehabilitation group, which was superior to 13.3% (4/30) in warm needling group and 13.3% (4/30) in rehabilitation group (both P〈0.01) separately. The results of the joint pain scale and severity index scale of knee joint OA in three groups after 1 session and 2 sessions of treatment were reduced obviously as compared with those before treatment (P〈0.01, P〈0.05). After 2 sessions of treatment, every index in acupuncture and rehabilitation group was reduced much more obviously as compared with that in the other two groups (all P〈0,01). Conclusion Warm needling in combination with rehabilitation therapy has good efficacy on knee OA and relieves remarkably the symptoms of it, which is superior to those in either simple warm needling or rehabilitation training therapy. 展开更多
关键词 Knee Osteoarthritis Warm Needling Rehabilitation Therapy
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Adjunctive effects of acupressure therapy on pain and quality of life in patients with knee osteoarthritis:an interventional study
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作者 Meenu Rani Lokendra Sharma +1 位作者 Uma Advani Arun Sharma 《Journal of Acupuncture and Tuina Science》 CSCD 2021年第4期300-306,共7页
Objective To investigate the effect of acupressure therapy as an adjunctive therapy to pharmacological treatment on pain and health-related quality of life(QOL)among knee osteoarthritis(KOA)patients.Methods One hundre... Objective To investigate the effect of acupressure therapy as an adjunctive therapy to pharmacological treatment on pain and health-related quality of life(QOL)among knee osteoarthritis(KOA)patients.Methods One hundred KOA patients were recruited from the orthopedic out-patient clinic of the institute.The patients were allocated randomly(flipping-coin simple randomization method)into an intervention group(n=50)and a control group(n=50).Patients in the intervention group received acupressure therapy along with pharmacological treatment.Patients in the control group did not receive acupressure therapy but continued their pharmacological treatment.Changes in pain(visual analog scale,VAS)and QOL(short-form 36-item health survey,SF-36)scores at baseline(A0),during training session(A1),follow-up at the 3rd month after training(A2)and follow-up at the 6th month after training session(A3)were collected and examined.Multiple regression analysis was used to check the relationship between pain and SF-36 domains.Results The VAS score of participants in the intervention group decreased at A3(P=0.001).Scores of physical functioning(PF),role limitations due to emotional problems(RE)and mental health(MH)of SF-36 in the intervention group improved more as compared with the control group.Patients in the intervention group with improvement in VAS(pain)score showed greater changes in mean scores of all domains of SF-36 from baseline(all P<0.05).Except bodily pain(BP),the other domains of SF-36 were negatively correlated with pain score.Conclusion Acupressure therapy with pharmacological treatment can improve health-related QOL and pain among KOA patients. 展开更多
关键词 Acupoint Therapy Osteoarthritis Knee Quality of Life Short-form Health Survey Visual Analog Scale
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