目的：研究骨疼静胶囊对热板法致小鼠疼痛及对尾部加压法致小鼠疼痛的影响。方法取体重19～22 g雌性小鼠，随机分组；分别灌服大中小剂量骨疼静胶囊混悬液，颈复康颗粒混悬液和同体积的0,．5％CMC。按热板法及尾部加压法测定小鼠痛阈，...目的：研究骨疼静胶囊对热板法致小鼠疼痛及对尾部加压法致小鼠疼痛的影响。方法取体重19～22 g雌性小鼠，随机分组；分别灌服大中小剂量骨疼静胶囊混悬液，颈复康颗粒混悬液和同体积的0,．5％CMC。按热板法及尾部加压法测定小鼠痛阈，并计算痛阈提高值。结果骨疼静胶囊组和颈复康颗粒组可显著提高小鼠痛阈（ P ＜0．01）；骨疼静胶囊组和颈复康颗粒组可显著提高在小鼠30 min和60min 的压痛痛阈（ P ＜0．01）。结论骨疼静胶囊有显著的镇痛作用。展开更多
Objective：To investigate the effect of injecting a compound of Bupivacaine and Fentanyl into sacral spinal space to treat chronic pelvic pain syndrome （CPPS）. Methods： A total of 36 men with recalcitrant （TPPS re...Objective：To investigate the effect of injecting a compound of Bupivacaine and Fentanyl into sacral spinal space to treat chronic pelvic pain syndrome （CPPS）. Methods： A total of 36 men with recalcitrant （TPPS refractory to multiple prior therapies were treated with the injection of a compound of Bupivacaine and Fentanyl （10 ml of 0. 125% Bupivacaine, 0.05 mg Fentanyl, 5 mg Dexamethasone, 100 mg Vitamin B1 and 1 mg Vitamin B12） into sacral space once a week for 4 weeks. The National Institute of Heahh Chronic Prostatitis Symptom Index （NIH-CPSI）, maximum and average flow rate were performed al the start and the end of 4 weeks＇ therapy. Results：Mean NIH-CPSI total score was decreased from 26. 5±1.6 to 13.4±2.0 （p〈0.001）. Significant improvement was seen in each subscore domain. A total of 32 patients （89%） had at least 25% improvement on NIH-CPSI and 22 （61%） had at least 50% improvement. Maximal and average flow rate were increased from 19. 5±3. 8 to 23. 6±4. 2 and 10. 9±2.6 to 14.3±2.4 respectively. Conclusion： Injection of this compound of Bupivacaine, Fentanyl and Dexamethasone into sacred spinal space is an effective and safe approach for recalcitrant CPPS. Further study of the mechanisms and prospective placebo controlled trials are warranted.展开更多
Pelvic osteotomy is commonly used to adjust acetabula dysplasia for congenital dislocation of the hip, whereas congenital insensitivity to pain with anhidrosis(CIPA) is a rare hereditary disease that often has the cha...Pelvic osteotomy is commonly used to adjust acetabula dysplasia for congenital dislocation of the hip, whereas congenital insensitivity to pain with anhidrosis(CIPA) is a rare hereditary disease that often has the characteristics of joint development deformity and easy fracture. This article reports the case involving a CIPA patient who was surgically treated by Chiari pelvic osteotomy and proximal femoral rotation osteotomy for congenital dislocation of the left hip joint and was provided long-term follow-up for redislocation and bilateral femoral head absorption.展开更多
文摘目的：研究骨疼静胶囊对热板法致小鼠疼痛及对尾部加压法致小鼠疼痛的影响。方法取体重19～22 g雌性小鼠，随机分组；分别灌服大中小剂量骨疼静胶囊混悬液，颈复康颗粒混悬液和同体积的0,．5％CMC。按热板法及尾部加压法测定小鼠痛阈，并计算痛阈提高值。结果骨疼静胶囊组和颈复康颗粒组可显著提高小鼠痛阈（ P ＜0．01）；骨疼静胶囊组和颈复康颗粒组可显著提高在小鼠30 min和60min 的压痛痛阈（ P ＜0．01）。结论骨疼静胶囊有显著的镇痛作用。
文摘Objective：To investigate the effect of injecting a compound of Bupivacaine and Fentanyl into sacral spinal space to treat chronic pelvic pain syndrome （CPPS）. Methods： A total of 36 men with recalcitrant （TPPS refractory to multiple prior therapies were treated with the injection of a compound of Bupivacaine and Fentanyl （10 ml of 0. 125% Bupivacaine, 0.05 mg Fentanyl, 5 mg Dexamethasone, 100 mg Vitamin B1 and 1 mg Vitamin B12） into sacral space once a week for 4 weeks. The National Institute of Heahh Chronic Prostatitis Symptom Index （NIH-CPSI）, maximum and average flow rate were performed al the start and the end of 4 weeks＇ therapy. Results：Mean NIH-CPSI total score was decreased from 26. 5±1.6 to 13.4±2.0 （p〈0.001）. Significant improvement was seen in each subscore domain. A total of 32 patients （89%） had at least 25% improvement on NIH-CPSI and 22 （61%） had at least 50% improvement. Maximal and average flow rate were increased from 19. 5±3. 8 to 23. 6±4. 2 and 10. 9±2.6 to 14.3±2.4 respectively. Conclusion： Injection of this compound of Bupivacaine, Fentanyl and Dexamethasone into sacred spinal space is an effective and safe approach for recalcitrant CPPS. Further study of the mechanisms and prospective placebo controlled trials are warranted.
文摘Pelvic osteotomy is commonly used to adjust acetabula dysplasia for congenital dislocation of the hip, whereas congenital insensitivity to pain with anhidrosis(CIPA) is a rare hereditary disease that often has the characteristics of joint development deformity and easy fracture. This article reports the case involving a CIPA patient who was surgically treated by Chiari pelvic osteotomy and proximal femoral rotation osteotomy for congenital dislocation of the left hip joint and was provided long-term follow-up for redislocation and bilateral femoral head absorption.
