部级贪官高严的腐败之路

2004年6月23日，国家审计署李金华审计长所作的审计报告公开，“审计风暴”使畏罪潜逃的原“国电”领导人、前云南省委书记高严进入了公众视线。据公安部近日称，高严目前潜逃在国内的可能性要远远大于国外。

MYB通过调控细胞周期促进胃癌细胞的增殖

目的探讨MYB基因在胃癌细胞增殖过程中的作用及机制。方法应用免疫组化实验在200对胃癌配对组织中检测MYB的表达;利用MTT和克隆形成实验检测MYB对胃癌细胞增殖的影响;采用流式细胞术研究MYB对细胞周期的影响;应用TCGA转录组数据分析MYB对细胞周期相关基因表达的影响。结果MYB在胃癌组织表达显著增加,且与患者预后负相关;MYB通过调控细胞周期促进胃癌细胞的增殖,并且MYB的表达与周期素CYCLIN A2 mRNA的表达正相关。结论MYB可作为胃癌的诊治靶点。

高新元牵出电力腐败系列案

身为原国电力公司总经理高严之子，高新元在电力系统内谋取么益可谓顺风顺水。

中国十大“诡秘高管”

经过考究公司文档与咨询国内知名商学专家，《董事会》杂志评出自20OO年4月1日至2005年4月1曰五年间中国最为“诡秘”的十名高级管理人员。这份名单主观色彩浓厚，但不影响其代表性。这些高管的“离奇”故事，在某个层面造成了中国公司的“短命”，也说明了《董事会》杂志提出的“公司高管通透化”对于公司健康发展的重要性。

Impact of Organic Soil Amendments on the Physical Characteristics and Yield Components of Potato （Solanum tuberosurn L.） in the Highlands of Cameroon

A field experiment was conducted in the Western Highlands of Cameroon to study the effects of Calliandra calothyrsus, sterilized compost, non-sterilized compost and mineral fertilizers （NPK 11：11：22） on physical characteristics, yield components and late blight disease severity of potato （Solanum tuberosum）. A two factorial treatment combination made up of fertilization schemes and sanitary measures were laid out in a randomized complete block design （RCBD） with four replicates and 10 treatments. Data collected were subjected to a multivariate ANOVA and means separated with the Dunnett t-test with Calliandra calothyrsus considered as the main treatment. Mineral fertilizers and Calliandra calothyrsus significantly augmented stem diameter, plant height and plant vigor, total and marketable yields, despite the fact that late blight severity was high in the two treatments. The correlation matrix showed that total yield had significant and positive correlation with stem diameter （r = 0.74）, plant height （r = 0.61）, plant vigor （r = 0.61） and marketable yield （r = 0.99） and negative correlation （r = -37） with late blight severity. The increase observed is attributed to the nutrient contents of the treatments applied. Leafy prunings of C. calothyrsus increase soil organic matter which probably improves moisture retention and biological activity. The highest late blight severity recorded between the 45 and 60 coincides with active development of plant canopy which influences disease severity and create a canopy microclimate conducive to disease development. This study suggests that Calliandra calothyrsus has the potential of improving potato production provided appropriate fungicide is used.

Value of adipokines in predicting the severity of acute pancreatitis:Comprehensive review

AIM:To analyze the prognostic value of adipokines in predicting the course,complications and fatal outcome of acute pancreatitis(AP).METHODS:We performed the search of PubMed database and the systemic analysis of the literature for both experimental and human studies on prognostic value of adipokines in AP for period 2002-2012.Only the papers that described the use of adipokines for prediction of severity and/or complications of AP were selected for further analysis.Each article had to contain information about the levels of measured adipokines,diagnosis and verification of AP,to specify presence of pancreatic necrosis,organ dysfunction and/or mortality rates.From the very beginning,study was carried out adhering to the PRISMA checklist and flowchart for systemic reviews.To assess quality of all included human studies,the Quality Assessment of Diagnostic Accuracy Studies tool was used.Because of the high heterogeneity between the studies,it was decided to refrain from the statistical processing or meta-analysis of the available data.RESULTS:Nine human and three experimental studies were included into review.In experimental studies significant differences between leptin concentrations at 24 and 48 h in control,acute edematous and acute necrotizing pancreatitis groups were found(P = 0.027 and P < 0.001).In human studies significant differences between leptin and resitin concentrations in control and acute pancreatitis groups were found.1-3 d serum adiponectin threshold of 4.5 μg/mL correctly classified the severity of 81% of patients with AP.This threshold yielded a sensitivity of 70%,specificity 85%,positive predictive value 64%,negative predictive value88%(area under curve 0.75).Resistin and visfatin concentrations differ significantly between mild and severe acute pancreatitis groups,they correlate with severity of disease,need for interventions and outcome.Both adipokines are good markers for parapancreatic necrosis and the cut-off values of 11.9 ng/mL and 1.8 ng/mL respectively predict the high ranges of radiological scores.However,the review revealed that all nine human studies with adipokines are very different in terms of methodology and objectives,so it is difficult to generalize their results.It seems that concentrations of the leptin and resistin increases significantly in patients with acute pancreatitis compared with controls.Serum levels of adiponectin,visfatin and especially resitin(positive correlation with Acute Physiology and Chronic Health Evaluation Ⅱ,Ranson and C-reactive protein) are significantly different in mild acute pancreatitis and severe acute pancreatitis patients,so,they can serve as a markers for the disease severity prediction.Resistin and visfatin can also be used for pancreatic and parapancreatic necrosis prediction,interventions needs and possible,outcome.CONCLUSION:High levels of adipokines could allow for prediction of a severe disease course and outcome even in small pancreatic lesions on computed tomography scans.

Analysis of Pb-Bi Vessel Wall Ablation Experiment with High Temperature Liquid by MPS Method

In a severe accident of a light water reactor, ablation of the RPV （reactor pressure vessel） lower head by corium is a key phenomenon, which affects progression of the accident. The MPS （moving particle semi-implicit） method is one of particle methods that calculate behavior of incompressible fluid by semi-implicit method. In preceding studies, the MPS method has been extensively studied and developed for simulations of different phenomena involved in severe accident of nuclear reactors. This paper aims to investigate whether the MPS method is capable of analyzing the lower head ablation phenomenon. The small-scale experiment carried out at CRIEPI （Central Research Institute of Electric Power Industry） using Pb-Bi vessel and silicone oil was analyzed for the validation of the MPS method. The MPS analysis well reproduced the experimental phenomena qualitatively. However, with respect to some quantitative results, more investigation such as influence of the calculation particle size is necessary.

COSMIC GPS observations of topographic gravity waves in the stratosphere around the Tibetan Plateau

Temperature profiles provided by the Constellation Observing System for Meteorology, Ionosphere and Climate （COSMIC） global positioning system （GPS） satellite constellation were used to study an eight-year series （2007 to 2015） of gravity wave （GW） potential energy in the stratosphere （18-30 kin） around the Tibetan Plateau （TP）. We found that with increasing altitude, the GW potential energy （Ep） values in the stratosphere caused by convection decreases. The importance of GWs that are stimulated by topography is enhanced in this area. In the TP, which was considered to lack strong topographical GW activity, clear activity existed in the spring and winter of all studied years. Based on the latitudinal zone of the TP, the distribution of GW potential energy is highly consistent with the elevation of the local topography. The activities of topographical GWs are strongly filtered as they propagate upward to the area of zero speed wind. The analysis indicates that in the TP, clear orographic GW excitation exists and propagates upward to the upper stratosphere, where it is greatly influenced by the wind.

Improving Gravity Anomalies Over China Marginal Sea from Retracked Geosat and ERS-1 Data

The quality of altimeter data and ocean tide model is critical to the recovery of coastal gravity anomalies. In this contribution, three retracking methods (threshold, improved threshold and Beta-5) are investigated with the aim of improving the altimeter data over a shallow water area. Comparison indicates that the improved threshold is the best retracking method over China Sea. Two ocean tide models, NAO99b and CSR4.0, are analyzed. Results show that different tide models used in the processing of altimeter data may result in differences more than 10 mGal in recovered coastal gravity anomalies. Also, NAO99b is more suitable than CSR4.0 over the shallow water area of China Sea. Finally, gravity anomalies over China Sea are calculated from retracked Geosat/GM and ERS-1/GM data by least squares collocation. Comparison with shipborne gravimetry data demonstrates that gravity anomalies from retracked data are significantly superior to those from non-retracked data. Our results have the same order as the other two altimeter-derived gravity models: Sandwell&Smith(V16) and DNSC08.