期刊文献+
共找到23篇文章
< 1 2 >
每页显示 20 50 100
CuAlSe_2在高压下结构、弹性、热学性质的第一性原理计算(英文) 被引量:1
1
作者 周梦 卢志鹏 +4 位作者 陶应奇 黄鳌 周乐 周晓云 胡翠娥 《四川大学学报(自然科学版)》 CAS CSCD 北大核心 2017年第4期771-780,共10页
本文中我们运用第一性原理平面赝势密度泛函理论,研究了四方晶体CuAlSe_2的结构、弹性性质以及热力学性质.首先通过状态方程拟合找到零温零压时的平衡体积、晶格常数、体弹模量B0以及其对压强的一阶导数B0′.接着分析了相对晶格常数a/a0... 本文中我们运用第一性原理平面赝势密度泛函理论,研究了四方晶体CuAlSe_2的结构、弹性性质以及热力学性质.首先通过状态方程拟合找到零温零压时的平衡体积、晶格常数、体弹模量B0以及其对压强的一阶导数B0′.接着分析了相对晶格常数a/a0、c/c0以及相对体积V/V0随压强的变化趋势.我们也研究了弹性常数随压强增大的变化趋势.计算也表明在15GPa以前CuAlSe2的弹性常数都满足力学稳定性,在15GPa以前都不发生相变,与实验结果相吻合.在零温零压下我们计算得到的弹性常数和体弹模量和其它理论值实验值都比较符合.然后根据准谐德拜模型,我们分析了热膨胀系数以及比热容随压强和温度的变化关系.最后我们分析了CuAlSe_2晶体在零温零压和高压下的态密度图,简单了解了一下电子结构的变化情况. 展开更多
关键词 密度泛函理论 高压性质 电子结构 CuAlSe2
下载PDF
新型超硬材料AlMgB_(14)高温高压物态方程和力学性质的第一性原理计算
2
作者 周梦 景素华 王彬彬 《原子与分子物理学报》 CAS 北大核心 2021年第3期106-115,共10页
新型三元超硬复合材料AlMgB_(14)由于具有硬度高、密度低、热稳定性好、导电性能好且制作成本低等一系列优良特性,而成为超硬材料领域的研究热点.本文基于密度泛函理论的第一性原理算法,运用计算机模拟技术,模拟实际实验中难以达到的高... 新型三元超硬复合材料AlMgB_(14)由于具有硬度高、密度低、热稳定性好、导电性能好且制作成本低等一系列优良特性,而成为超硬材料领域的研究热点.本文基于密度泛函理论的第一性原理算法,运用计算机模拟技术,模拟实际实验中难以达到的高温和高压条件,结合Kohn-Sham方程的自洽求解计算新型超硬材料AlMgB_(14)在高温高压下的力学性质、物态方程.从而对比获得其物理化学性质与高压弹性常数,并讨论其背后的物理本质.本文首先对AlMgB_(14)进行结构优化;其次,计算在不同原胞体积下所对应的晶格总能量,获得了AlMgB_(14)的状态方程参数、热力学性质及其随温度和压力的变化关系.同时也研究了常压及加压时,AlMgB_(14)晶体的弹性性质的特点及变化情况.研究结果不仅构建了微观结构AlMgB_(14)与其宏观物理特性之间的桥梁,同时为其材料的工程应用和基础理论研究提供良好的帮助,而且本论文采用的理论计算方法还可以应用到其它材料的物态方程研究中. 展开更多
关键词 超硬材料 AlMgB_(14) 第一性原理 高压性质
下载PDF
Fe_(50)Ti_(50)非晶合金的高温高压研究 被引量:1
3
作者 刘惠莲 刘永胜 +1 位作者 王佐成 华中 《吉林师范大学学报(自然科学版)》 2003年第3期10-11,14,共3页
对用机械合金化方法制备的Fe50Ti50非晶合金的高温高压性质进行分析,结果表明高温与高压均有利于非晶合金的晶化.
关键词 Fe50Ti50非晶合金 高温高压性质 机械合金化方法 非晶晶化温度 相转变温度
下载PDF
压力下NaN_3结构稳定性、力学性质和电子结构的理论研究
4
作者 余飞 《西南民族大学学报(自然科学版)》 CAS 2017年第3期314-320,共7页
采用基于密度泛函理论的从头算平面波超软贋势方法研究了压力对NaN_3结构稳定性、力学性能以及电子结构的影响.对能量和力学参量的计算结果表明,R-3m结构是NaN_3在零压下的稳定性结构.随着压力的增加,在5 GPa的压力范围内NaN_3会发生从R... 采用基于密度泛函理论的从头算平面波超软贋势方法研究了压力对NaN_3结构稳定性、力学性能以及电子结构的影响.对能量和力学参量的计算结果表明,R-3m结构是NaN_3在零压下的稳定性结构.随着压力的增加,在5 GPa的压力范围内NaN_3会发生从R-3m结构到C2/m结构的结构相变,而C2/m结构的NaN_3在压力超过20 GPa以后也不能够保持稳定.该结果与实验研究结果间取得了很好的一致.此外,对电子结构的研究表明,常压下两种结构NaN_3都表现出了绝缘体的性质.随着压力的增加,C2/m结构NaN_3的价带和导带宽度都略有增加,而带隙宽度略有减小. 展开更多
关键词 NA N3 平面波超软贋势 高压性质
下载PDF
C_(60)高压相变的拉曼光谱研究 被引量:1
5
作者 蓝国祥 林远坤 +2 位作者 王华馥 徐知三 盛蓉生 《光散射学报》 1992年第2期93-96,共4页
本文对非静水压淬火的 C_(60)样品进行了拉曼光谱研究。在14.8GPa 以上,C_(60)的1468cm^(-1)特征峰的频率和线宽保持不变,这是 fullerite 相己转变成“透明相”的拉曼光谱证据。在32GPa 以上,原 C_(60)的散射峰全部消失,只观察到两个新... 本文对非静水压淬火的 C_(60)样品进行了拉曼光谱研究。在14.8GPa 以上,C_(60)的1468cm^(-1)特征峰的频率和线宽保持不变,这是 fullerite 相己转变成“透明相”的拉曼光谱证据。在32GPa 以上,原 C_(60)的散射峰全部消失,只观察到两个新的弥散的弱散射峰。表明 C_(60)原子团簇已倒塌或严重畸变。 展开更多
关键词 C60 拉曼散射 光谱研究 相位变换 高压性质
全文增补中
Elasticity and Thermodynamic Properties of EuS Related to Phase Transition 被引量:1
6
作者 刘强 彭枫 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 2014年第4期387-393,J0001,共8页
First-principles calculations of the crystal structures, phase transition, and elastic properties of EuS have been carried out with the plane-wave pseudopotential density functional theory method. The calculated value... First-principles calculations of the crystal structures, phase transition, and elastic properties of EuS have been carried out with the plane-wave pseudopotential density functional theory method. The calculated values are in very good agreement with experimental data as well as some of the existing model calculations. The dependence of the elastic constants, the aggregate elastic modulus, and the elastic anisotropy on pressure have been investigated. Moreover, the variation of the Poisson's ratio, Debye temperature, and the compressional and shear elastic wave velocities with pressure have been investigated for the first time. Through the quasi-harmonic Debye model, the thermal expansions, heat capacities, Grneisen parameters and Debye temperatures dependence on the temperature and pressure are obtained in the pressure range from 0 GPa to 60 GPa and temperature range from 0 K to 800 K. 展开更多
关键词 EUS FIRST-PRINCIPLES Pressure effect Thermodynamic properties
下载PDF
Ground stability of underground gateroad with 1 km burial depth: A case study from Xingdong coal mine, China 被引量:13
7
作者 ZHANG Guang-chao HE Fu-lian +1 位作者 LAI Yong-hui JIA Hong-guo 《Journal of Central South University》 SCIE EI CAS CSCD 2018年第6期1386-1398,共13页
This paper presents an integrated investigation of the ground stability of a deep gateroad with a 1 km burial depth based on a field test, case studies, and numerical modelling. In situ stress measurements and mechani... This paper presents an integrated investigation of the ground stability of a deep gateroad with a 1 km burial depth based on a field test, case studies, and numerical modelling. In situ stress measurements and mechanical properties tests were first conducted in the test site. Then, the deformation behavior, stress and yield zone distributions, as well as the bolts load of the gateroad, were simulated using FLAC3D software. The model results demonstrated that the soft rock properties and high in situ stress were the main factors for the deep gateroad instability, and the shear slip failure induced by the high stress was the primary failure model for the deep rock mass. In addition, the unsuitable support patterns, especially the relatively short bolts/cables with low pre-tensions, the lack of high-strengthen secondary supports and the unsupported floor strata, also contributed to the gateroad instability. Subsequently, a new combined supporting strategy, incorporating longer bolts/cables, yielding ring supports, and grouting measures, was proposed for the deep gateroad, and its validity was verified via field monitoring. All these could be a reference for understanding the failure mechanism of the gateroad with 1 km burial depth. 展开更多
关键词 deep coal mine soft rock burial depth failure mechanism deformation behavior support strategy
下载PDF
Attenuation of portal hypertension by natural taurine in rats with liver cirrhosis 被引量:9
8
作者 Jian Liang Xin Deng +2 位作者 Zhi-Xiu Lin Li-Chun Zhao Xi-Liu Zhang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第36期4529-4537,共9页
AIM: To investigate the inhibitory effect of natural taurine (NTau) on portal hypertension (PHT) in rats with experimentally-induced liver cirrhosis (LC). METHODS: Experimentally-induced LC Wistar rats (20 ra... AIM: To investigate the inhibitory effect of natural taurine (NTau) on portal hypertension (PHT) in rats with experimentally-induced liver cirrhosis (LC). METHODS: Experimentally-induced LC Wistar rats (20 rats/group) were treated with either oral saline or oral NTau for 6 consecutive weeks. Evaluation parameters included portal venous pressure (PVP), portal venous resistance (PVR), portal venous flow (PVF), splanchnic vascular resistance (SVR) and mean arterial pressure (NAP). Vasoactive substance levels including nitric oxide (NO), nitric oxide synthase (NOS) and cyclic guanosine monophosphate (cGMP) were also measured. Histological investigation of type Ⅰ and Ⅲ collagen (COL Ⅰ and Ⅲ) and transforming growth factor-β1 (TGF-β1) was also performed. RESULTS: Treatment with NTau (1) significantly decreased PVP, PVR and PVF, and increased MAP and SVP; (2) markedly increased the vascular compliance and reduced the zero-stress of the portal vein; (3) markedly decreased the amount of NO and cGMP and activity of NOS; and (4) improved the pathological status of the liver tissue and reduced the expression of COL Ⅰ, COL Ⅲ and TGF-β1. CONCLUSION: NTau inhibited the LC-induced PHT by improving hyperdynamic circulation, morphology of liver and biomechanical properties of the portal vein in experimentally-induced LC rats. 展开更多
关键词 TAURINE Liver cirrhosis Portal hypertension RAT
下载PDF
Non-occupational lead exposure and hypertension in Pakistani adults 被引量:4
9
作者 RAHMAN Sohaila KHALID Nasir +2 位作者 ZAIDI Jamshed Hussain AHMAD Shujaat IQBAL Mohammad Zafar 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2006年第9期732-737,共6页
Hypertension is one of the most prevalent diseases in the developed and developing countries. Based on the long historical association and the provocative findings of blood pressure effects at low level of lead exposu... Hypertension is one of the most prevalent diseases in the developed and developing countries. Based on the long historical association and the provocative findings of blood pressure effects at low level of lead exposure a study was carried out to determine if an association existed between low blood lead concentration and hypertension. In this study the effects of low-level exposure to lead on blood pressure were examined among 244 adults using atomic absorption spectrometer. For quality assurance purpose certified reference materials i.e., Animal blood A-13, Bovine liver 1577 and cotton cellulose V-9 from IAEA (International Atomic Energy Agency) and NIST (National Institute of Standard Technology) were analyzed under identical experimental conditions. The mean age of hypertensive adults was 52 years (range 43-66). The mean values of systolic and diastolic blood pressure were (209±11.7) (range 170-250) and (117±3.9) (range 105-140) mmHg respectively. Blood lead concentration ranged from 78-201 μg/L with a mean of 139 μg/L and 165-497 μg/L with a mean of 255 μg/k in normal and hypertensive adults respectively. Increase in systolic blood pressure was significantly predictive with increase in blood lead levels. Body mass index (BMI) and lipid profile including total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol and triglyceride correlated with blood pressure. 展开更多
关键词 HYPERTENSION Lead exposure Biochemical parameters Body mass index
下载PDF
Experimental study on biaxial mechanical behavior of concrete suffered high temperature and constitutive model 被引量:1
10
作者 张众 宋玉普 覃丽坤 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2008年第5期679-685,共7页
Biaxial compression tests on plain concrete suffered high temperature ranging from 200 ℃ to 600 ℃ were carried out using the large-scale dynamic-static tri-axial concrete test system at the State Key Laboratory of C... Biaxial compression tests on plain concrete suffered high temperature ranging from 200 ℃ to 600 ℃ were carried out using the large-scale dynamic-static tri-axial concrete test system at the State Key Laboratory of Coastal and Offshore Engineering with designated stress ratios of 0, 0.25, 0.5, 0.75 and 1, respectively. The measured strength and strain were reported and the changes in both biaxial compressive failure envelopes and strains at peak stresses were analyzed. The regressive equation of initial elastic modulus in the biggest principal compressive stress direction was derived from test results. With the published results from previous biaxial tension-compression experiments, a three-parameter failure criterion has been proposed. A biaxial nonlinear elastic incremental constitutive model was developed for the compressive stress directions by using the equivalent uniaxial strain values deduced from test results. Analytical results obtained from the proposed biaxial constitutive model achieve good agreement with the experimental results. 展开更多
关键词 high temperature biaxial compression initial elastic modulus failure envelope constitutive model
下载PDF
Proteomic analysis of the serum in patients with idiopathic pulmonary arterial hypertension 被引量:3
11
作者 YU Min WANG Xing-xiang +4 位作者 ZHANG Fu-rong SHANG Yun-peng DU Yu-xi CHEN Hong-juan CHEN Jun-zhu 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2007年第4期221-227,共7页
Idiopathic pulmonary arterial hypertension(IPAH) is a rare disease of unknown etiology.The exact pathogenesis of pulmonary arterial hypertension is still not well known.In the past decades,many protein molecules have ... Idiopathic pulmonary arterial hypertension(IPAH) is a rare disease of unknown etiology.The exact pathogenesis of pulmonary arterial hypertension is still not well known.In the past decades,many protein molecules have been found to be in-volved in the development of IPAH.With proteomic techniques,profiling of human plasma proteome becomes more feasible in searching for disease-related markers.In present study,we showed the protein expression profiles of the serum of IPAH and healthy controls after depleting a few high-abundant proteins in serum.Thirteen spots had changed significantly in IPAH com-pared with healthy controls and were identified by LC-MS/MS.Alpha-1-antitrypsin and vitronectin were down-regulated in IPAH and may be valuable candidates for further explorations of their roles in the development of IPAH. 展开更多
关键词 Idiopathic pulmonary arterial hypertension Two-dimensional gel electrophoresis LC-MS/MS
下载PDF
Thermodynamic properties of San Carlos olivine at high temperature and high pressure
12
作者 Chang Su Yonggang Liu +3 位作者 Wei Song Dawei Fan Zhigang Wang Hongfeng Tang 《Acta Geochimica》 EI CAS CSCD 2018年第2期171-179,共9页
In this study, the thermal expansion and heat capacity of San Carlos olivine under high temperature and high pressure are reported. Combining accurate sound velocity data under different P–T conditions with density a... In this study, the thermal expansion and heat capacity of San Carlos olivine under high temperature and high pressure are reported. Combining accurate sound velocity data under different P–T conditions with density and heat capacity data at ambient pressure, the density,adiabatic bulk modulus, shear modulus, and most importantly, thermal expansion and heat capacity, of San Carlos are extracted to 14 GPa by a numerical procedure using classic thermodynamic relationships. These data are in agreement with published findings. To estimate the temperature gradient in the upper mantle, we also report the fitting equations of thermal expansion and heat capacity of San Carlos olivine as a function of both temperature and pressure to the P–T condition of the 410 km discontinuity,which provide the thermodynamic properties with increasing depth in the Earth's interior. 展开更多
关键词 San Carlos olivine Thermodynamic property Thermal expansion Heat capacity Temperature gradient
下载PDF
Performance of Structured Packing in High Pressure Distillation
13
作者 张鹏 刘春江 +2 位作者 王利东 唐忠利 余国琮 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2002年第6期635-638,共4页
Performance of Mellapak 250Y and 350Y corrugated structured packing in distillation applications at pressures ranging from 0.3 to 2.0MPa is analysed by using HTU-NTU method. These data are obtained in a distillation c... Performance of Mellapak 250Y and 350Y corrugated structured packing in distillation applications at pressures ranging from 0.3 to 2.0MPa is analysed by using HTU-NTU method. These data are obtained in a distillation column with 0.15 m diameter op-erated with n-butane/n-pentane system at total reflux. In considering the axial backmixing effects, the height of an overall gas phase transfer unit, HTUOG , is divided into two parts. One part represents the height of an overall gas phase transfer unit, without backmixing, designated as*OGHTU, and the other part, designated as the height of a backmixing unit (HBUO), accounts for the backmixing effects. The HTUOG is evaluated from the measured concentration profile of n-butane in liquid phase. The HBUO obtained experimentally is correlated in terms of the properties of the materials being separated and the equivalent diameter of the structured packing. Our result shows that HBUO varies from 0.12 to 0.34 m as pressure increases from 1.0 to 1.9 MPa. It indicates that the overall efficiency of the structured packing decreases gradually at high pressure, as a result of the vapor backmixing. 展开更多
关键词 mass transfer structured packing BACKMIXING height of a transfer unit high pressure
下载PDF
New pretreatment method for high-tension electrical separation of zircon from quartz 被引量:2
14
作者 Sivash NOURI Fatemeh Sadat HOSEINIAN +1 位作者 Bahram REZAI Kamal SABERYAN 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2019年第8期1737-1743,共7页
Electrostatic separation is one of the mineral processing methods based on mineral conductivity.This method has some significant problems such as being sensitive to humidity,high middling product,and impurity of non-c... Electrostatic separation is one of the mineral processing methods based on mineral conductivity.This method has some significant problems such as being sensitive to humidity,high middling product,and impurity of non-conductive minerals.In this study,a new pretreatment method was proposed for the separation of zircon from quartz before electrostatic separation to solve these disadvantages.In this regard,two stages of pretreatment were applied which involved using collector of sodium dodecyl sulfate(SDS)for adjusting wettability of the zircon surface and spraying electrolyte aqueous solution to increase conductivity of the quartz surface.The effects of important parameters including pH,collector concentration,conditioning time,and concentration and type of electrolyte on the process efficiency were evaluated.The results showed that the optimal conditions of high-tension electrical separation were pH of 4,SDS concentration of 1×10-4 mol/L,conditioning time of 4 min and NaCl as an electrolyte with concentration of 4.27 mol/L.Separation efficiency of 95.12% was achieved in optimum conditions.This pretreatment method can be successfully used before high-tension electrical separation to separate the conductive or non-conductive minerals with various compositions. 展开更多
关键词 ZIRCON QUARTZ COLLECTOR electrolyte aqueous solution conductivity high-tension electrical separation surface treatment
下载PDF
Ab initio Predictions of Structural and Thermodynamic Properties of Zr2AIC Under High Pressure and High Temperature 被引量:1
15
作者 Fen Luo Zhi-cheng Guo +2 位作者 Xiu-lu Zhang Chang-ying Yuan Ling-cang Cai 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 2015年第3期263-268,I0001,共7页
The structural and thermodynamic properties of Zr2A1C at high pressure and high temper- ature are investigated by first principles density functional theory method. The calculated lattice parameters of Zr2A1C are in g... The structural and thermodynamic properties of Zr2A1C at high pressure and high temper- ature are investigated by first principles density functional theory method. The calculated lattice parameters of Zr2A1C are in good agreement with the available theoretical data. The pressure dependences of the elastic constants, bulk modulus, shear modulus, Young's mod- ulus, and Vickers hardness of Zr2A1C are successfully obtained. The elastic anisotropy is examined through the computation of the direction dependence of Young's modulus. By using the quasiharmonic Debye model, the thermodynamic properties including the Debye temperature, heat capacity, volume thermal expansion coefficient, and Griineisen parameter at high pressure and temperature are predicted for the first time. 展开更多
关键词 Elastic property Thermodynamic property Density functional theory
下载PDF
Explore the direct and/or the synergistic antihypertensive effects of wind-dispelling herbs involving Fangfeng and Baizhi on hypertensive rats with liver-yang hyperactivity based on vasoactive substances
16
作者 Bo Liang Feng-Ying Luo Hui-Ling Liao 《TMR Modern Herbal Medicine》 2018年第1期19-28,共10页
Objective: To explore the direct and/or the enhancing antihypertensive effects of wind-dispelling herbs involvingFangfeng (Saposhnikoviae Radix) and Baizhi (Angelicae dahuricae Radix) using liver-yang hyperactivi... Objective: To explore the direct and/or the enhancing antihypertensive effects of wind-dispelling herbs involvingFangfeng (Saposhnikoviae Radix) and Baizhi (Angelicae dahuricae Radix) using liver-yang hyperactivity renalhypertension rat. Methods: Model rats with hyperactivity of liver-yang hyperactivity were prepared using male SD rats.Once successful, the rats were randomly divided into groups and given medicine by gavage for 4 weeks. Blood wascollected from the abdominal aorta to prepare serum. Serum nitric oxide (NO) concentration was determined bychemical colorimetry. The contents of ET, TXB2 and 6-K-PGF1a were determined by enzyme linked immunosorbentassay (ELISA). Results: Compared with the control model group, the blood pressure, serum ET and TXB2 of rats in thewind dispelling medicine group was not significantly reduced, while those of rats in captopril group, Tianma GoutengDecoction I group (TGD group) decreased significantly (P 〈0.05 for both). Interestingly, the blood pressure, serum ETand TXB2 of rats in the combination group (wind dispelling medicine & TGD) decreased significantly compared withboth wind dispelling medicine group and TGD group. Meanwhile, the levels of serum NO and 6- K-PGF1a in thecombination group was much higher than those in the wind dispelling medicine group or TGD group (P 〈0.05 for both).However, the levels of serum NO and 6- K-PGF1a in the wind dispelling medicine group was not significantly increasedcompared with the model group. Conclusion: There is no direct pressure lowering effects of wind dispelling medicinealone, while wind dispelling medicine could potentiates the antihypertensive effects of Tianma Gouteng Decoction I.Besides, the synergistic effects may be related to decreased ET and TXB2 levels and the increased NO and 6- K-PGF1alevels. 展开更多
关键词 Liver-yang hyperactivity renal hypertension Vasoactive substances Wind dispelling medicine (Fangfeng(Saposhnikoviae Radix) Baizhi (Angelicae dahuricae Radix)) Synergistic antihypertensive mechanism
下载PDF
Structural and Thermodynamic Properties of TiAl intermetallics under High Pressure
17
作者 LI Xu-Sheng WANG Hai-Yan +2 位作者 LI Chang-Yun MI Guo-Fa HU Qian-Ku 《Communications in Theoretical Physics》 SCIE CAS CSCD 2012年第1期141-144,共4页
The structural and thermodynamic properties of TiAI intermetallics under high pressure have been investigated by ab initio plane-wave pseudopotential density functional theory method. It is found that the ratio of lat... The structural and thermodynamic properties of TiAI intermetallics under high pressure have been investigated by ab initio plane-wave pseudopotential density functional theory method. It is found that the ratio of lattice parameter c to a keeps almost constant with a value of 1.02 under the pressure from 0 to 20 GPa, which agrees well with the experimental results. With the pressure increasing from 20 to 45 GPa the values of c/a decrease almost linearly from 1.02 to 0.99. These calculated results indicate under low pressure the variation rate for a-axis is almost the same to that for c-axis, but under higher pressure the variation for a-axis is smaller than along e-axis. Through the quasi-harmonic Debye model, the equation of state (EOS) of TiAI intermetallies, as well as the thermal expansion and heat capacity at various pressures and temperatures are also studied. 展开更多
关键词 density functional theory thermodynamic properties TIAL
下载PDF
Hub Genes of Astrocyte Involved in Glaucoma with Ocular Hypertension by Integrated Bioinformatics Analysis 被引量:1
18
作者 Yi-Jing YANG Yu XIANG +4 位作者 Ye TIAN Fei XIA Ya-Sha ZHOU Jun PENG Qing-Hua PENG 《Digital Chinese Medicine》 2018年第4期280-288,共9页
This study was conducted to elucidate the potential key candidate genes and pathways in role of astrocyte involved in glaucoma with ocular hypertension.Methods Expression profiles GSE2378 and GSE758 including 27 react... This study was conducted to elucidate the potential key candidate genes and pathways in role of astrocyte involved in glaucoma with ocular hypertension.Methods Expression profiles GSE2378 and GSE758 including 27 reactive optic nerve head astrocytes(ONHAs)by hypertensions and 26 normal controls,were integrated and deeply analyzed.Differentially expressed genes(DEGs)were sorted and candidate genes and pathways enrichment were analyzed.DEGs-associated protein-protein interaction network(PPI)was performed.Results A total of 119 consistently expressed genes were identified from 281 commonly changed DEGs,including 68 up-regulated genes and 51 down-regulated genes.PPI network complex filtered 75 DEGs(43 up-regulated and 32 down-regulated genes)of the 119 consistently altered DEGs and developed 117 edges,and 10 hub genes were identified.The most significant 3 modules were filtered from PPI,pathway enrichment analysis showed that module 1 was associated with extracellular exosome.Module 2 was mainly associated with antibody-dependent cellular cytotoxicity(ADCC)and module 3 was mainly associated with Hippo signaling pathway.Conclusion Taken above,using integrated bioinformatical analysis,we have identified DEGs candidate genes and pathways in role of astrocyte involved in glaucoma with ocular hypertension,which could improve our understanding of the cause and underlying molecular events,and these candidate genes and pathways could be therapeutic targets for glaucoma. 展开更多
关键词 GLAUCOMA Ocular hypertension Reactive optic nerve head astrocytes Hub gene Pathway enrichment
下载PDF
Effect of Huanglian Jiedu Decoction on cardiac endoplasmic reticulum stress in spontaneously hypertensive rats
19
作者 Xiaoming Zhang Shihui Zhu +3 位作者 Yiwen Gao Jianxiang Li Nan Zhang Guihua Yue 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2024年第7期609-619,共11页
Huanglian Jiedu Decoction(HLJDD)is a quintessential prescription renowned for its heat-clearing and detoxifying properties.It is primarily prescribed to counteract the syndrome characterized by the excessive heat of t... Huanglian Jiedu Decoction(HLJDD)is a quintessential prescription renowned for its heat-clearing and detoxifying properties.It is primarily prescribed to counteract the syndrome characterized by the excessive heat of the Sanjiao fire.Notably,the hyperactivity of liver fire is frequently linked with hypertension,where wind fire and wind toxicity emerge as pivotal pathogenic factors.This study aimed to investigate the impact of HLJDD on the endoplasmic reticulum in spontaneously hypertensive rats(SHR),further delving into the interplay between endoplasmic reticulum stress(ERS)and myocardial remodeling and damage.Fifty SHR rats were stratified randomly into five cohorts:model,low-dose HLJDD,medium-dose HLJDD,high-dose HLJDD,and captopril groups.For comparison,a set of Wistar-Kyoto(WKY)rats served as the baseline control group,with each group comprising 10 rats.While the model and control groups received equivalent volumes of normal saline via gavage,the other groups were administered the respective drug dosages through the same route daily for a span of 6 weeks.Upon the experiment’s conclusion,metrics such as the heart mass index(HWI)and left ventricular mass index(LVWI)were assessed.Cardiac tissue anomalies were identified using H&E staining,while ERS-related protein and mRNA expression levels were ascertained via Western blotting analysis and qPCR.Moreover,TUNEL staining was employed to detect cardiomyocyte apoptosis.The findings indicated that increasing HLJDD concentrations corresponded with escalated HWI and LVWI in rat hearts(P<0.05).There was a marked enhancement in myocardial structural integrity,accompanied by a notable reduction in collagen fibers.The mRNA and protein expressions of myocardial inositol-dependent enzyme 1α(IRE1α),X-box binding protein 1(XBP1),glycoregulatory protein 78(GRP78),and CCAAT enhancer binding protein homologous protein(CHOP)in the medium and high-dose groups saw significant declines(P<0.05).These effects mirrored those observed in the captopril group.The study underscored HLJDD’s efficacy in mitigating myocardial tissue damage in SHR.This therapeutic effect was potentially attributed to the downregulation of IRE1α,XBP1,GRP78,and CHOP,curbing excessive ERS,diminishing cardiomyocyte apoptosis,and thereby conferring cardioprotection. 展开更多
关键词 Huanglian Jiedu Decoction Spontaneous hypertension Endoplasmic reticulum stress Myocardial remodeling IRE1α XBP1 GRP78 CHOP
原文传递
Expression of adrenomedullin and its receptor in lungs of rats with hypoxic pulmonary hypertension
20
作者 程德云 田伟 +1 位作者 陈文彬 肖欣荣 《Chinese Medical Journal》 SCIE CAS CSCD 2002年第12期1806-1808,147-148,共3页
OBJECTIVE: To investigate the role of adrenomedullin (AM) in the development of hypoxic pulmonary hypertension (HPH), and to assess the expression of AM and adrenomedullin receptor (AMR) in the lungs of rats with HPH.... OBJECTIVE: To investigate the role of adrenomedullin (AM) in the development of hypoxic pulmonary hypertension (HPH), and to assess the expression of AM and adrenomedullin receptor (AMR) in the lungs of rats with HPH. METHODS: We exposed 10 rats to normobaric hypoxic conditions for 3 weeks to establish rat model of pulmonary hypertension; and 10 other rats were used as normoxic controls. Mean pulmonary arterial pressure (mPAP) was measured by a right cardiac catheterization. The thickness of pulmonary arterioles was measured by a computerized image analyzer. We used the reverse transcription-polymerase chain reaction (RT-PCR) to assess the change of expression of AM and AMR in lung of HPH rat model. RESULTS: Compared with the control group, hypoxic rats developed remarkable pulmonary hypertension, increment in the thickness of pulmonary arterioles and right ventricular hypertrophy (P 展开更多
关键词 Animals ANOXIA ARTERIOLES Gene Expression Hypertension Pulmonary Hypertrophy Right Ventricular Lung Male Peptides RATS Rats Wistar Receptors Peptide Reverse Transcriptase Polymerase Chain Reaction
原文传递
上一页 1 2 下一页 到第
使用帮助 返回顶部