高室压脉冲液体火箭发动机特性试验

为了研究高室压脉冲液体火箭发动机工作原理,增压规律以及脉冲特性,通过一系列冷热流试验对试验发动机进行了研究。冷流试验中使用水和氮气作为工质,试验发动机实现自主脉冲工作,验证了差动式可移动活塞应用在推力室中具有增压效果。热流试验中使用气氧/酒精为推进剂,使用传统挤压式推进剂供给系统。在可移动喷注器行程0.8mm条件下,获得9次连续脉冲,燃烧室峰值压强5.511MPa,高于推进剂供给压强(氧气路3.761MPa,酒精路4.424MPa),表明在相同的推进剂供给压强下,高室压脉冲液体火箭发动机能提高燃烧室压强。

高室压发动机系统适用性研究

应用Gibbs自由能法和喷管冻结流动模型,对双组元液体发动机推力室进行了热力气动计算;以系统总质量为目标函数,建立了姿轨控推进系统仿真模型,分析了推力室压强对系统性能参数的影响。结果表明:在空间尺寸受限条件下,提高推力室压强,可有效缩小推力室尺寸,增加喷管面积比,提高发动机比冲和系统总体性能。但当推力室压强较高时,这种效果减缓,同时推进系统总质量增幅较大,设计时应综合权衡。

燃烧室压力对440N空间发动机性能的影响

采用辐射冷却的铱一铼440N 推力轨道转移发动机,为增加比冲,提高燃烧室压力是最有希望的潜在途径。将燃烧室压力提高达3.5MPa(绝),不仅可以得到3283m/s 以上的比冲,而且可以显著降低发动机结构尺寸和重量。如果就利用现在使用的空间运载器上的贮籍,燃烧室压力提高到1.75MPa(绝)是切实可行的。如果把燃烧室压力提高到3,5MPa(绝),则只需增加一个用电力驱动的小型泵,便可以轻易地实现。推力室热试验采用四氧化二氮/肼,1.75MPa(绝)燃烧室压力试验采用铼材料推力室;3.5MPa(绝)燃烧室压力试验则采用铜材料推力室。在燃烧室压力为1.75MPa(绝),喷管面积比为300:1的条件下,实际比冲可以达到3263m/s。试验结果表明,铼燃烧室温度满足其长寿命极限要求,并且没有遇到稳定性,相容性和热的有关问题。

Losartan reduced connexin43 expression in left ventricular myocardium of spontaneously hypertensive rats

Objective:To assess the effect of angiotensin II type 1(AT1)receptor antagonist losartan on myocardium con- nexin43(Cx43)gap junction(GJ)expression in spontaneously hypertensive rats(SHRs)and investigate possible mechanisms. Methods:Sixteen 9-week-old male SHRs and 8 age-matched male Wistar-Kyoto(WKY)rats were included in this study.SHRs were randomly divided into two groups to receive losartan at 30 mg/(kg·d)by oral gavage once daily for 8 weeks(SHR-L)or vehicle(0.9%saline)to act as controls(SHR-V);WKY rats receiving vehicle for 8 weeks served as normotensive controls.At the end of the experiment,rats were sacrificed and the hearts were removed.Expressions of Cx43 and nuclear factor-kappaB p65 (NF-κB p65)proteins in all three groups were observed and further investigations on the effect of angiotensin II type 1 receptor antagonist losartan(30 mg/(kg·d),8 weeks)on Cx43 expression were conducted with Western blot and immunohistochemistry. NF-κB p65 protein in nuclear extracts was determined by Western blot.Results:Left ventricular(LV)hypertrophy was prominent in SHRs,Cx43 and NF-κB p65 protein expressions were obviously upregulated and Cx43 distribution was dispersed over the cell surface.Treatment with losarton reduced the over-expressions of Cx43 and NF-κB p65 in LV myocardium.The distribution of Cx43 gap junction also became much regular and confined to intercalated disk after losartan treatment.Conclu- sion:Cx43 level was upregulated in LV myocardium of SHR during early stage of hypertrophy.Angiotensin II type 1 receptor antagonist losartan prevented Cx43 gap junction remodeling in hypertrophied left ventricles,possibly through the NF-κB pathway.

Coefficients of earth pressure at rest in thick and deep soils

The effect of test methods and stress paths on the experimental value of the coefficient of earth pressure at rest, K0, was investigated under high pressures. The results indicate that the rigid pressure chamber and flexible lateral confining pressure medium method gives a stress ratio at the initial stage that is not the real K0. Moreover, K0 increases during the loading process becoming greater at high pressures. In the unloading process, however, K0 increases only at the initial stage but decreases thereafter. In addition, the incremental magnitude definition, K0=dσ3/dσ1, gives higher values than the total magnitude definition, K0=σ3/σ1, under loading. This is also true during initial stages of unloading. The experiment results also indicate that earth pressure at rest in deep and thick soils can be estimated by a power function of axial and confining pressures. It is necessary to choose the appropriate Kn to avoid some accidents.

Objects Obtained by y Quanta Irradiation with Threshold Energy of 10 MeV of Pure Gaseous He, under High Pressure, in CuBe2 Apparatus

A HeHPC （Helium high pressure chamber） filled up with pure gaseous helium at initial pressure about 1.1 bar was irradiated by braking γ-rays of 10 MeV threshold energy during 1.0 × 10^5 s at the electron beam current 22 - 24 μA. After irradiation, the residual pressure inside was equal to 430 bar. Synthesized foils of black color and other multiple objects were found inside the HeHPC mainly at the entrance window for γ-rays made from beryllium bronze as a plug of beryllium bronze HPC, at the inner surfaces of the reaction chamber made of high purity copper and at the copper collector. The element analysis, using SEM （Scanning electron microscopy） and MPRA （Microprobe roentgen analysis）, allowed us to establish that the foils consist predominantly of carbon and the smaller quantities of other elements from carbon to iron. An explanation for the observed elements is suggested on the basis of helium fusion reactions under the action of y-rays with the reactions taking place in giant stars （thermally activated）. The possible mechanism after 3α reaction is nα reactions and under barrier reactions. A second experiment with initial pressure of 3.05 kbar （with pressure drop by about 65 bar - after almost the same procedure of y-rays irradiation and with fully beryl bronze environment） suggests another possible nuclear reactions - He（Be, p）C, He（C, γ）O, and so on. The developed approach agrees well with a series of studies carried out by the authors where dense hydrogen and deuterium gases are acted on by γ-rays in the presence or absence of metals in the reaction chambers.

Longhole waterjet rotary cutting for in-seam cross panel methane drainage

In order to improve the efficiency of gas drainage before and during longwall extraction,a waterjet rotary cutting system has been developed for in-seam cross panel methane drainage.The purpose of the water rotary cutting system developed was to create artificial fractures along the gas drainage boreholes.During the design of the system,it was perceived that the nozzle geometry is one of the key factors,affecting cutting capacity.Therefore,we studied the structural and geometric parameters of the nozzle and optimized its performance during laboratory tests and numerical simulation.Underground trials conducted in a coal mine,indicate that production of gas drainage before and after cutting significantly increased by up to three times.The advantages of waterjet assisted gas drainage method has been identified as:1) increasing gas drainage efficiency,2) a possible development of a gas drainage fractured network within coal seams associated with panel extraction,and 3) reducing the risk of exceeding gas limits during longwalling.

IN PATIENTS WITH HYPERTENSIVE LEFT VENTRICULAR HYPERTROPHY AND CORONARY HEART DISEASE,CORONARY FLOW RESERVE IS SIMILARLY IMPAIRED

Coronary blood flow reserve (CFR) was assessed by transesophageal Doppler echocardiography in normal subjects (group A. n=20),hypertensive non-left ventricular hypertrophy (non-LVH)Patients (group B,n=22). hypertensive patients with LVH(group C.n=32)and coronary heart disease patients (group D. n=33) with the volume sample placed at the bifurcation of the left main and left main and left descending coronary artery. Coronary blood flow velocity (CBFV)was evaluated at rest.2 minutes after dipyridamole (0. 56mg/kg. i. v.) . and 2 minutes after aminophylline i.v. The ratio of dipyridamole to rest maximal diastolic velocity (D/R PDV) was considered the index of coronary blood flow reserve.It was found that D/R PDV was significantly less in groups C and D compared with that in groups A and B (D PDC,1.84±0. 57. 1. 57±0. 41 versus 2.59±0.70 and 2.22+0.58,respectively),with no difference in D/R PDV between groups C and D.Twenty-four out of 32 patients in group C with D/R PDV were less than 2.0 compared to 29 out of 33 patients in group D (P>0.05).Significant negative correlation was found between D/R PDV. D/R PSV and interseptal thickness. left ventricular mass index in hypertensive patients.These data show that impaired CFR in hypertensive patients with LVH is comparable to that in patients with coronary heart disease.

Inflammation and oxidative stress caused might lead to left ventricular diastolic and hypertension by nitric oxide synthase uncoupling systolic dysfunction in patients with

Objective To investigate the role of oxidative stress, inflammation, hypercoagulability and neuroendocrine activation in the transition of hypertensive heart disease to heart failure with preserved ejection fraction （HFPEF）. Methods We performed echocardiography for 112 patients （≥ 60 years old） with normal EF （18 controls and 94 with hypertension）, and determined protein carbonylation （PC）, and tetrahydrobiopterin （BH4）, C-reactive protein （CRP）, interleukin-6 （IL-6）, tumor necrosis factor-α （TNF-α）, fibrinogen, plasminogen activator inhibitor type-I （PAI-I）, von Willebrand factor, chromogranin A （cGA） and B-type natriuretic peptide （BNP） levels from their blood samples. Results We found that 40% （38/94） of the patients with hypertension （HT） had no diastolic dysfunction （HTDD-）, and 60% （56/94） had diastolic dysfunction （HTDD＋）. Compared to the controls, both patient groups had increased PC and BH4, TNF-α, PAI-I and BNP levels, while the HTDD＋ group had elevated cGA and CRP levels. Decreased atrial and longitudinal left ventficular （LV） systolic and diastolic myocardial deformation （strain and strain rate） was demonstrated in both patient groups versus the control. Patients whose LV diastolic function deteriorated during the follow-up had elevated PC and IL-6 level compared to their own baseline values, and to the respective values of patients whose LV diastolic function remained unchanged. Oxidative stress, inflammation, BNP and PAI-I levels inversely correlated with LV systolic, diastolic and atrial function. Conclusions In patients with HT and normal EF, the most common HFPEF precursor condition, oxidative stress and inflammation may be responsible for LV systolic, diastolic and atrial dysfunction, which are important determinants of the transition of liT to HFPEF.

Ventricular remodeling by Scutellarein treatment in spontaneously hypertensive rats

OBJECTIVE: To observe reversal of ventricular remodeling by the protein kinase C inhibitor Scutellarein in spontaneously hypertensive rats (SHRs). METHODS: Twelve SHRs were randomly divided into two groups. Scutellarein and saline (10 mg x kg(-1) x d(-1)) were given by intraperitoneal injection to two groups of rats separately. Systolic blood pressure (SBP) and ventricular weight index (LVW/BW, RVW/BW) were measured. A polarization microscope and an image analyzer system (IAS) were used to observe changes in cardiovascular structure and to count the content of cardiac muscle interstitial collagen. RESULTS: The pathologic changes in the left ventricle in the Scutellarein group rats (SHR(D)) improved to varying degrees, including hypertrophy of the cardiac muscle and collagen volume fraction. CONCLUSION: Scutellarein can reverse ventricular remodeling, improve myocardial stiffness and protect heart cardiac muscle.

Characteristics of coronary microvascular lesions in autopsied elderly with hypertensive left ventricular hypertrophy

OBJECTIVE: To observe the characteristics of coronary microvascular lesions (CML) in the autopsied elderly cases with hypertensive left ventricular hypertrophy (LVH) and the difference of CML among the groups of essential hypertension (EHT), coronary heart disease (CHD) and diabetes (NIDDM) also with LVH. METHODS: A retrospective study was performed in 206 cases > or = 60 years old of EHT, CHD and NIDDM with LVH and 30 normal cases as control, out of 3195 consecutive autopsied cases from 1954 to 1996 in our hospital. Arterioles with diameters of 10 - 60 microm and capillaries in the muscular layer were shown by the methods of HE, Elastic fiber + VG staining and immunohistochemistry of CD31. Quantitative measurements on the arteriole density (AD), the ratio of arteriolar wall and cavity (RWC), capillary density (CD) and the area of endothelial cell (AEC) were performed with light microscope observation and image analysis by computer. According to the thickness of the left ventricle free wall, the severity of LVH was divided into four degrees from 0 to III. LVH of degree 0-III was observed in EHT group, while only LVH of degree I was found in CHD, EHT + CHD, and NIDDM groups. SAS system was used for statistical analysis. RESULTS: AD and RWC increased while CD and AEC decreased significantly with the progression of LVH in EHT groups (P

A gravity heat pipe for high voltage vacuum interrupter

To enhance nominal current of high voltage vacuum circuit breakers （VCBs）, a gravity heat pipe was proposed to replace stationary conducting rod of a high voltage vacuum interrupter. The heat pipe is composed of two coaxis tubes： the external tube is made of oxygen-free copper and the inner tube is made of stainless steel. The bottom end of the inner stainless steel tube is connected to the external copper tube by holes. Transient and static thermal performance of the heat pipe was measured, and the thermal resistance of it was compared with that of a solid copper rod with the same dimensions. Experimental results showed that thermal resistance of the heat pipe was about 1/3 of that of the copper rod, and it decreased slightly with the rising of the input heat flux. 3D thermal simulation on a 126 kV/2000 A single break VCB was done to compare the thermal performance between the proposed gravity heat pipe and the copper rod serving as the stationary conducting rod of the vacuum interrupter. Simulation results revealed that in the heat pipe case, the maximum temperature between contacts was 67 ℃ lower than that in the copper rod case.

Experimental study on formation mechanism of compaction bands in weathered rocks with high porosity

Since Mollema and Antonellini observed compaction bands in the field in 1996,different patterns of compaction bands have been found in laboratory experiments.There are some discrepancies between the laboratory experiments and the field observations:compared to the field observation,the stress levels required to induce compaction bands in laboratory experiments are usually higher than the inferred in the field,and the grain crushing are more intense in the laboratory experiments.In this paper,compaction bands were observed at the maximal principal stresses below 8 MPa,which is lower than the stress level inferred in the field,and there was no severe comminution inside the compaction bands.Experimental results indicate that the porosity and confining pressure have great impacts on the types of localization bands.Lower porosity and confining pressure can promote the growth of shear bands and high-angle shear bands.Higher porosity and confining pressure can promote the growth of discrete compaction bands.Intermediate porosity and confining pressure are favorable for the growth of hybrid modes involving two of the three,i.e.,discrete compaction band,diffuse compaction band and high-angle shear band.The formation of discrete compaction bands is more unstable compared to diffuse compaction bands.The two types of compaction bands can appear in the same type rocks,and diffuse compaction bands are formed under lower confining pressure compared to discrete compaction bands.The reduction of permeability was within 2 orders of magnitude in this study,and it is 2 3 orders of magnitude lower than those obtained by other researchers.

Panda X-III： Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers

Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation experiments.Panda X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 bar.Fine pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the middle.Charge signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial resolution.The detector will be immersed in a large water tank to ensure～5 m of water shielding in all directions.The second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds.

Investigation on Temperature Separation and Flow Behaviour in Vortex Chamber

In the previous researches, it is known that the swirl flow in circular pipe causes the temperature separation. Recently, it is shown that the temperature separation occurs in a vortex chamber when compressed air are pumped into this device from the periphery. Especially, in a cavity installed in the periphery of the chamber, the highest temperature was observed. Therefore, it is expected that this device can be used as a heat source in the engineering field. In recent researches, the mechanism of temperature separation in vortex chamber has been investigated by some researchers. However, there are few researches for the effect of diameter and volume of vortex chamber, height of central rod and position of cavity on the temperature separation. Further, no detailed physical explanation has been made for the temperature separation phenomena in the vortex chamber. In the present study, the effects of chamber configuration and position of the cavity on temperature separation in the vortex chamber were investigated experimentally.