High performance liquid chromatography with column switching has been developed for the determination of lansoprazole in plasma. The plasma samples were injected onto a pretreatment column packed with LiChromprep RP2 ...High performance liquid chromatography with column switching has been developed for the determination of lansoprazole in plasma. The plasma samples were injected onto a pretreatment column packed with LiChromprep RP2 (25～40 mm) after simple dilution with distilled water. Distilled water was used to wash out protein and other polar components in plasma. After switching, the concentrated lansoprazole was eluted in the backflush mode onto a Shimpack CLC ODS column with methanol 0 2 mol·L 1 ammonium acetate (65:35) as mobile phase. Purge solutions were used for clean up and for regenerating the pretreatment column. The method showed good precision and recovery. The detection limit was 0 005 mg·L -1 plasma. The RSD’s (intra and interday) were less than 2 5% and 5 3% respectively. The method has been successfully used to determine pharmacokinetics of lansoprazole in Chinese volunteers.展开更多
The effects of Ca and Sr addition on the microstructure and creep properties of Mg-4Al-2Sn alloys were examined. Tensile tests at 25 ℃ and 200 ℃ and creep tests at 150 ℃ and 200 ℃ were carried out to estimate the ...The effects of Ca and Sr addition on the microstructure and creep properties of Mg-4Al-2Sn alloys were examined. Tensile tests at 25 ℃ and 200 ℃ and creep tests at 150 ℃ and 200 ℃ were carried out to estimate the room temperature and high temperature mechanical properties of these alloys. The microstrueture of the Mg-4Al-2Sn alloy showed dendritic a-Mg, Mg17Al12 and Mg2Sn phases. The latter two phases precipitated along the grain boundaries. The addition of Ca and Sr resulted in the formation of ternary CaMgSn and SrMgSn phases within the grain. The grain size was reduced slightly with the addition of Sr and Ca. The tensile strength was decreased by the addition of Ca and Sr at room temperature. However, the high temperature tensile strength was increased. The creep strength was improved by the addition of Ca and Sr.展开更多
The core-disk phenomenon has been observed generally in the drilling process under high-stress conditions.This paper presents the in-situ experimental study of the coring-disking failure mechanism of marble in an unde...The core-disk phenomenon has been observed generally in the drilling process under high-stress conditions.This paper presents the in-situ experimental study of the coring-disking failure mechanism of marble in an underground cavens with 2400 m depth.Based on the disk samples in several boreholes with different diameters,both macro-and micro-morphological characteristics of core-disks’break surface were analysis,using 3D optical scanning and electron microscope scanning.Moreover,the numerical back analysis was also used to simulate the drilling process for demonstrating the development of core disking.The in-situ experiment results showed that the failure types of core disking consisted of tensile break and shear break,i.e.,the shear break usually appears in the edge part of break surface,and tensile break appears in the central part.What’s more,the ration of core-disks thickness to borehole diameter is in a relatively stable range.Numerical back analysis indicated this micro asynchronous break of hard marble is induced by high geostress and unloading drill.展开更多
In this paper, the high speed tension experiments have been performed on ultra high strength bulletproof steel. The specimen were cut from B-grade bulletproof steel sheet after hard-module quenching with thickness of ...In this paper, the high speed tension experiments have been performed on ultra high strength bulletproof steel. The specimen were cut from B-grade bulletproof steel sheet after hard-module quenching with thickness of 2.3 mm. The mechanical properties at strain rates of 0.001 s^-1, 0.01 s^-1, 0.1 s^-1 and 1 s^-1 were carried out on MTSS10, while those at higher strain rates of 200 s^-1, 500 s^-1 and i 000 s^-1 were tested on HTM5020 high speed tension tester and Hopkinson bar. The data from the high speed tension experiments were fitted via Johnson-Cook constitutive equation, and the fracture surface of each specimen was analyzed by scanning electron microscope （SEM）. The results indicate that, the shoot resistance capability of bulletproof steel is closely related to its strength, thickness and flow behaviors under high strain rate. The shoot resistance will be improved in the case of higher strength and better matching between strength and elongation. The Johnson-Cook constitutive equation fitted via experimental data provides fundament to numerical simulation. With the increase of strain rate, the size and depth of dimple trend to decrease and the depth of dimple changes less in steel with lower strength and higher elongation. The SEM analysis of fracture aspect is of benefit for further understanding of deformation and fracture mode under high strain rate.展开更多
Simulations of bubble entrainment into a stationary Gaussian vortex are performed by using the combined particle tracking method(PTM)and boundary element method(BEM).Before the bubble is captured by the vortex core,os...Simulations of bubble entrainment into a stationary Gaussian vortex are performed by using the combined particle tracking method(PTM)and boundary element method(BEM).Before the bubble is captured by the vortex core,oscillation and migration of the quasi-spherical nucleus are solved by using improved RP equation and the momentum theorem in the Lagrangian reference frame simultaneously,and the trajectory of the nucleus presents a kind of reduced helix shape.After captured by the vortex core,the bubble grows immediately and moves and deforms along the vortex core axis.The non-spherical evolution and deformation of the bubble is simulated by adopting a mixed Eulerian-Lagrangian method.The output of quasi-spherical stage is taken as the input of non-spherical stage,and all the behaviors of the entrained bubble can be simulated such as inception,motion,deformation and split.Numerical results agree well with published experimental data.On this basis,the influences of various factors such as viscosity,surface tension,buoyancy are studied systemically.Hopefully the results from this paper would provide some insight into the control on vortex bubble entrainment.展开更多
文摘High performance liquid chromatography with column switching has been developed for the determination of lansoprazole in plasma. The plasma samples were injected onto a pretreatment column packed with LiChromprep RP2 (25～40 mm) after simple dilution with distilled water. Distilled water was used to wash out protein and other polar components in plasma. After switching, the concentrated lansoprazole was eluted in the backflush mode onto a Shimpack CLC ODS column with methanol 0 2 mol·L 1 ammonium acetate (65:35) as mobile phase. Purge solutions were used for clean up and for regenerating the pretreatment column. The method showed good precision and recovery. The detection limit was 0 005 mg·L -1 plasma. The RSD’s (intra and interday) were less than 2 5% and 5 3% respectively. The method has been successfully used to determine pharmacokinetics of lansoprazole in Chinese volunteers.
基金supported by a grant from the Metals Bank by the Ministry of Knowledge Economy and a grant-in-aid for the National Core Research Center Program (No.R15-2006-022-02001-0)
文摘The effects of Ca and Sr addition on the microstructure and creep properties of Mg-4Al-2Sn alloys were examined. Tensile tests at 25 ℃ and 200 ℃ and creep tests at 150 ℃ and 200 ℃ were carried out to estimate the room temperature and high temperature mechanical properties of these alloys. The microstrueture of the Mg-4Al-2Sn alloy showed dendritic a-Mg, Mg17Al12 and Mg2Sn phases. The latter two phases precipitated along the grain boundaries. The addition of Ca and Sr resulted in the formation of ternary CaMgSn and SrMgSn phases within the grain. The grain size was reduced slightly with the addition of Sr and Ca. The tensile strength was decreased by the addition of Ca and Sr at room temperature. However, the high temperature tensile strength was increased. The creep strength was improved by the addition of Ca and Sr.
基金Projects(U1965205,51779251,41672314)supported by the National Natural Science Foundation of China。
文摘The core-disk phenomenon has been observed generally in the drilling process under high-stress conditions.This paper presents the in-situ experimental study of the coring-disking failure mechanism of marble in an underground cavens with 2400 m depth.Based on the disk samples in several boreholes with different diameters,both macro-and micro-morphological characteristics of core-disks’break surface were analysis,using 3D optical scanning and electron microscope scanning.Moreover,the numerical back analysis was also used to simulate the drilling process for demonstrating the development of core disking.The in-situ experiment results showed that the failure types of core disking consisted of tensile break and shear break,i.e.,the shear break usually appears in the edge part of break surface,and tensile break appears in the central part.What’s more,the ration of core-disks thickness to borehole diameter is in a relatively stable range.Numerical back analysis indicated this micro asynchronous break of hard marble is induced by high geostress and unloading drill.
文摘In this paper, the high speed tension experiments have been performed on ultra high strength bulletproof steel. The specimen were cut from B-grade bulletproof steel sheet after hard-module quenching with thickness of 2.3 mm. The mechanical properties at strain rates of 0.001 s^-1, 0.01 s^-1, 0.1 s^-1 and 1 s^-1 were carried out on MTSS10, while those at higher strain rates of 200 s^-1, 500 s^-1 and i 000 s^-1 were tested on HTM5020 high speed tension tester and Hopkinson bar. The data from the high speed tension experiments were fitted via Johnson-Cook constitutive equation, and the fracture surface of each specimen was analyzed by scanning electron microscope （SEM）. The results indicate that, the shoot resistance capability of bulletproof steel is closely related to its strength, thickness and flow behaviors under high strain rate. The shoot resistance will be improved in the case of higher strength and better matching between strength and elongation. The Johnson-Cook constitutive equation fitted via experimental data provides fundament to numerical simulation. With the increase of strain rate, the size and depth of dimple trend to decrease and the depth of dimple changes less in steel with lower strength and higher elongation. The SEM analysis of fracture aspect is of benefit for further understanding of deformation and fracture mode under high strain rate.
基金supported by the Excellent Young Scientists Fund(Grant No.51222904)the national natural science foundation of China(Grant No.11302056)
文摘Simulations of bubble entrainment into a stationary Gaussian vortex are performed by using the combined particle tracking method(PTM)and boundary element method(BEM).Before the bubble is captured by the vortex core,oscillation and migration of the quasi-spherical nucleus are solved by using improved RP equation and the momentum theorem in the Lagrangian reference frame simultaneously,and the trajectory of the nucleus presents a kind of reduced helix shape.After captured by the vortex core,the bubble grows immediately and moves and deforms along the vortex core axis.The non-spherical evolution and deformation of the bubble is simulated by adopting a mixed Eulerian-Lagrangian method.The output of quasi-spherical stage is taken as the input of non-spherical stage,and all the behaviors of the entrained bubble can be simulated such as inception,motion,deformation and split.Numerical results agree well with published experimental data.On this basis,the influences of various factors such as viscosity,surface tension,buoyancy are studied systemically.Hopefully the results from this paper would provide some insight into the control on vortex bubble entrainment.
