目的评价高效抗逆转录病毒疗法(highly active antiretroviral therapy,HAART)对HIV/AIDS患者的疗效。方法采用HAART治疗73例HIV/AIDS患者,流式细胞仪测定治疗前后HIV/AIDS患者体内CD4+,CD8+T淋巴细胞数量,定量ELISA法检测血浆细胞因子I...目的评价高效抗逆转录病毒疗法(highly active antiretroviral therapy,HAART)对HIV/AIDS患者的疗效。方法采用HAART治疗73例HIV/AIDS患者,流式细胞仪测定治疗前后HIV/AIDS患者体内CD4+,CD8+T淋巴细胞数量,定量ELISA法检测血浆细胞因子IL-2,IL-10和TGF-β1水平。结果经HAART治疗后,CD4+T细胞数量显著回升(P(0.01),但CD8+T细胞变化不大(P(0.05)。血浆IL-10水平较治疗前明显下降(P(0.05),IL-2水平较治疗前升高(P(0.05),TGF-β1的水平显著降低(P(0.01)。结论HAART治疗HIV/AIDS患者疗效显著,对于重建免疫功能、改善体内细胞因子失调有明显效果。展开更多
【目的】评价艾可清胶囊联合高效抗病毒逆转录疗法(highly active antiretroviral therapy,HAART)治疗艾滋病(AIDS)患者的有效性和安全性。【方法】将18例患者随机分为2组,每组9例。治疗组在HAART治疗的同时加用中药艾可清胶囊,对照组...【目的】评价艾可清胶囊联合高效抗病毒逆转录疗法(highly active antiretroviral therapy,HAART)治疗艾滋病(AIDS)患者的有效性和安全性。【方法】将18例患者随机分为2组,每组9例。治疗组在HAART治疗的同时加用中药艾可清胶囊,对照组只给予HAART治疗。分别在治疗前、治疗3个月和治疗6个月检测T淋巴细胞亚群,记录症状体征积分(积分1)和症状舌脉积分(积分2),观察体质量和生存质量(卡洛夫斯基积分,Karnovsky Score),检测血常规、肝功能、肾功能及血清淀粉酶以评价艾可清胶囊的安全性。【结果】两组T淋巴细胞亚群各项指标在治疗后均有所改善(P<0.05或P<0.01),但各评价点两组间比较无显著性差异(P>0.05)。治疗组治疗后各评价点证候、体征积分均较对照组下降(P<0.05),卡洛夫斯基积分及体质量较对照组增加(P<0.05或P<0.01)。加用艾可清胶囊未见血常规、肝肾功能及血清淀粉酶异常变化。【结论】艾可清胶囊可有效、安全地缓解因HAART引起的不良反应。展开更多
Objective.-To evaluate Quality of life(QoL)of HIV-infected children under highly active antiretroviral therapies,and its change over 18 months.Material s and methods.-QoL was evaluated by self-administred questionnair...Objective.-To evaluate Quality of life(QoL)of HIV-infected children under highly active antiretroviral therapies,and its change over 18 months.Material s and methods.-QoL was evaluated by self-administred questionnaires(french v ersions of AUQUEI,OK-ado,and compilation of both)in 23 young living with HIV /AIDS(6-15 yrs),under antiretroviral multitherapies,and re-evaluated 18 mon ths later in 19 of them.Results.-At baseline,QoL in HIV-infected children-adolescents was relatively good.The answers given to each items and the mean sc ore from infected children were similar to those obtained in uninfected healthy children.Moreover,infected adolescents distinguished definitly from healthy ad olescents,describing higher QoL.The mean satisfaction score from the whole gro up decreased between M0 and M18(mainly in the youngests)-,and mainly concerne d 3 fields(self-esteem,health and school)while their somatic health remained stable or improved.An effect of the familial context was also observed for the se 3 fields.Conclusion.-The progressive decline of QoL in HIV-infected child ren,and the surprising high and steady level of satisfaction over-time provide d by the adolescents,underlined the frailty of this population and the need for a psychologic management associated to the medical follow-up.Such a multidisc iplinary approach should take into account the preoccupations and difficulties o f each age-class,those linked to the diagnosis itself,and to the familial or scolar contexts,in order to preserve QoL of this pediatric population,as far a s possible,in a long term.展开更多
文摘目的评价高效抗逆转录病毒疗法(highly active antiretroviral therapy,HAART)对HIV/AIDS患者的疗效。方法采用HAART治疗73例HIV/AIDS患者,流式细胞仪测定治疗前后HIV/AIDS患者体内CD4+,CD8+T淋巴细胞数量,定量ELISA法检测血浆细胞因子IL-2,IL-10和TGF-β1水平。结果经HAART治疗后,CD4+T细胞数量显著回升(P(0.01),但CD8+T细胞变化不大(P(0.05)。血浆IL-10水平较治疗前明显下降(P(0.05),IL-2水平较治疗前升高(P(0.05),TGF-β1的水平显著降低(P(0.01)。结论HAART治疗HIV/AIDS患者疗效显著,对于重建免疫功能、改善体内细胞因子失调有明显效果。
文摘【目的】评价艾可清胶囊联合高效抗病毒逆转录疗法(highly active antiretroviral therapy,HAART)治疗艾滋病(AIDS)患者的有效性和安全性。【方法】将18例患者随机分为2组,每组9例。治疗组在HAART治疗的同时加用中药艾可清胶囊,对照组只给予HAART治疗。分别在治疗前、治疗3个月和治疗6个月检测T淋巴细胞亚群,记录症状体征积分(积分1)和症状舌脉积分(积分2),观察体质量和生存质量(卡洛夫斯基积分,Karnovsky Score),检测血常规、肝功能、肾功能及血清淀粉酶以评价艾可清胶囊的安全性。【结果】两组T淋巴细胞亚群各项指标在治疗后均有所改善(P<0.05或P<0.01),但各评价点两组间比较无显著性差异(P>0.05)。治疗组治疗后各评价点证候、体征积分均较对照组下降(P<0.05),卡洛夫斯基积分及体质量较对照组增加(P<0.05或P<0.01)。加用艾可清胶囊未见血常规、肝肾功能及血清淀粉酶异常变化。【结论】艾可清胶囊可有效、安全地缓解因HAART引起的不良反应。
文摘Objective.-To evaluate Quality of life(QoL)of HIV-infected children under highly active antiretroviral therapies,and its change over 18 months.Material s and methods.-QoL was evaluated by self-administred questionnaires(french v ersions of AUQUEI,OK-ado,and compilation of both)in 23 young living with HIV /AIDS(6-15 yrs),under antiretroviral multitherapies,and re-evaluated 18 mon ths later in 19 of them.Results.-At baseline,QoL in HIV-infected children-adolescents was relatively good.The answers given to each items and the mean sc ore from infected children were similar to those obtained in uninfected healthy children.Moreover,infected adolescents distinguished definitly from healthy ad olescents,describing higher QoL.The mean satisfaction score from the whole gro up decreased between M0 and M18(mainly in the youngests)-,and mainly concerne d 3 fields(self-esteem,health and school)while their somatic health remained stable or improved.An effect of the familial context was also observed for the se 3 fields.Conclusion.-The progressive decline of QoL in HIV-infected child ren,and the surprising high and steady level of satisfaction over-time provide d by the adolescents,underlined the frailty of this population and the need for a psychologic management associated to the medical follow-up.Such a multidisc iplinary approach should take into account the preoccupations and difficulties o f each age-class,those linked to the diagnosis itself,and to the familial or scolar contexts,in order to preserve QoL of this pediatric population,as far a s possible,in a long term.
