In this paper,the low and the high frequency noises of a laser diode have been analyzed. Based on the analysis a novel scheme that adapts analog and digital hybrid techniques is proposed to stabilize the output power ...In this paper,the low and the high frequency noises of a laser diode have been analyzed. Based on the analysis a novel scheme that adapts analog and digital hybrid techniques is proposed to stabilize the output power of a laser diode. With the hybrid controller,the low and the high frequency noises of a laser diode are conspicuously reduced.By accurate calculation,the short-term stability of the output power of laser diode reaches ±0.55‰, and the long-term stability is ±0.7‰.展开更多
The 21st century Maritime Silk Road(MSR) proposed by China strongly promotes the maritime industry. In this paper, we use wind and ocean wave datasets from 1979 to 2014 to analyze the spatial and temporal distribution...The 21st century Maritime Silk Road(MSR) proposed by China strongly promotes the maritime industry. In this paper, we use wind and ocean wave datasets from 1979 to 2014 to analyze the spatial and temporal distributions of the wind speed, significant wave height(SWH), mean wave direction(MWD), and mean wave period(MWP) in the MSR. The analysis results indicate that the Luzon Strait and Gulf of Aden have the most obvious seasonal variations and that the central Indian Ocean is relatively stable. We analyzed the distributions of the maximum wind speed and SWH in the MSR over this 36-year period. The results show that the distribution of the monthly average frequency for SWH exceeds 4 m(huge waves) and that of the corresponding wind speed exceeds 13.9 ms^(-1)(high wind speed). The occurrence frequencies of huge waves and high winds in regions east of the Gulf of Aden are as high as 56% and 80%, respectively. We also assessed the wave and wind energies in different seasons. Based on our analyses, we propose a risk factor(RF) for determining navigation safety levels, based on the wind speed and SWH. We determine the spatial and temporal RF distributions for different seasons and analyze the corresponding impact on four major sea routes. Finally, we determine the spatial distribution of tropical cyclones from 2000 to 2015 and analyze the corresponding impact on the four sea routes. The analysis of the dynamic characteristics of the MSR provides references for ship navigation as well as ocean engineering.展开更多
Objective To explore the clinicopathological features of non-familial colorectal cancer with high-frequency microsatellite instability (MSI-H). Methods One hundred and fifty patients with colorectal cancer who had no ...Objective To explore the clinicopathological features of non-familial colorectal cancer with high-frequency microsatellite instability (MSI-H). Methods One hundred and fifty patients with colorectal cancer who had no family history were enrolled in this study from June 2006 to June 2008. Five standard microsatellite loci including BAT25, BAT26, D2S123, D5S346, and D17S250 were amplified with immunofluorescent polymerase chain reaction. The patient information including age, sex, and tumor location was recorded. Pathological features including differentiation, mucinous differentiation, histological heterogeneity, and Crohn's-like reaction were observed under light microscope. The presence of tumor-infiltrating lymphocytes (TLs, CD4+ and CD8+) was detected by means of immunohistochemistry. A regression equation was obtained by stepwise logistic regression analysis to evaluate the relationship between MSI-H phenotype in colorectal cancer ands pathological features. Results MSI-H phenotype occurred in 13.33% of the 150 patients with non-familial colorectal cancer. Poor differentiation, histological heterogeneity, Crohn's-like reaction, and presence of TLs were found to be independent factors to identify MSI-H non-familial colorectal cancer. Logistic regression equation showed an overall sensitivity of 70.0%, specificity of 99.2%, and accuracy of 95.3% in identifying MSI-H non-familial colorectal cancer. Conclusion MSI-H non-familial colorectal cancer manifests specific pathological features, which may be relied upon for effective identification of that disease.展开更多
The scenario of bypass transition is generally described theoretically as follows: low-frequency disturbances in the free-stream would generate long stream-wise streaks in the boundary layer, which later would induce ...The scenario of bypass transition is generally described theoretically as follows: low-frequency disturbances in the free-stream would generate long stream-wise streaks in the boundary layer, which later would induce secondary instability, leading to rapid increase of high-frequency disturbances, then possibly turbulent spots would emerge, and through their merging, fully developed turbulence appears. This description, however, is insufficient in the sense that it does not provide the explanation on why during the breakdown stage, a large number of waves with different frequencies and wave numbers would appear almost simultaneously, leading to a swift change of the mean flow profile. In this paper, the mechanism leading to this phenomenon is found to be the change of the stability characteristics of mean flow profile, which has a positive feedback effect on the change of the profile itself. And another interesting finding is that, during the transition, the unstable disturbance waves which appear first belong to a branch of inviscid modes, while following the change of the stability characteristics of the mean flow profile, the disturbance waves will change to another branch of inviscid modes, and the latter play the key role in bypass transition.展开更多
LES (Large-Eddy Simulation) computations were preformed to investigate the mechanisms of a kind of spanwisegroove for the passive control of laminar separation bubble on the suction surface of a low-speed highly loade...LES (Large-Eddy Simulation) computations were preformed to investigate the mechanisms of a kind of spanwisegroove for the passive control of laminar separation bubble on the suction surface of a low-speed highly loadedlow-pressure turbine blade at Re = 50,000 (Reynolds number, based on inlet velocity and axial chord length).Compared with the smooth suction surface, the numerical results indicate that: (1) the groove is effective toshorten and thin the separation bubble, which contributes the flow loss reduction on the groove surface, by thinningthe boundary layer behind the groove and promoting earlier transition inception in the separation bubble; (2)upstream movement of the transition inception location on the grooved surface is suggested being the result of thelower frequency at which the highest amplification rate of instability waves occurs, and the larger initial amplitudeof the disturbance at the most unstable frequency before transition; and (3) the viscous instability mode ispromoted on the grooved surface, due to the thinning of the boundary layer behind the groove.展开更多
基金Supported by the National Natural Science Foundation of China(Grant No.F600077007)Youth Science Foundation of Hei-longjiang University(Grant No.QL200410)
文摘In this paper,the low and the high frequency noises of a laser diode have been analyzed. Based on the analysis a novel scheme that adapts analog and digital hybrid techniques is proposed to stabilize the output power of a laser diode. With the hybrid controller,the low and the high frequency noises of a laser diode are conspicuously reduced.By accurate calculation,the short-term stability of the output power of laser diode reaches ±0.55‰, and the long-term stability is ±0.7‰.
基金supported by the National Key R&D Program of China under contract No. 2016YFC1402703the National Youth Natural Science Foundation under contract No. 61501130supported by the Fundamental Research Funds for the Central Universities under contract No. 16CX02033A
文摘The 21st century Maritime Silk Road(MSR) proposed by China strongly promotes the maritime industry. In this paper, we use wind and ocean wave datasets from 1979 to 2014 to analyze the spatial and temporal distributions of the wind speed, significant wave height(SWH), mean wave direction(MWD), and mean wave period(MWP) in the MSR. The analysis results indicate that the Luzon Strait and Gulf of Aden have the most obvious seasonal variations and that the central Indian Ocean is relatively stable. We analyzed the distributions of the maximum wind speed and SWH in the MSR over this 36-year period. The results show that the distribution of the monthly average frequency for SWH exceeds 4 m(huge waves) and that of the corresponding wind speed exceeds 13.9 ms^(-1)(high wind speed). The occurrence frequencies of huge waves and high winds in regions east of the Gulf of Aden are as high as 56% and 80%, respectively. We also assessed the wave and wind energies in different seasons. Based on our analyses, we propose a risk factor(RF) for determining navigation safety levels, based on the wind speed and SWH. We determine the spatial and temporal RF distributions for different seasons and analyze the corresponding impact on four major sea routes. Finally, we determine the spatial distribution of tropical cyclones from 2000 to 2015 and analyze the corresponding impact on the four sea routes. The analysis of the dynamic characteristics of the MSR provides references for ship navigation as well as ocean engineering.
基金Supported by National Natural Science Foundation of China (30940086)
文摘Objective To explore the clinicopathological features of non-familial colorectal cancer with high-frequency microsatellite instability (MSI-H). Methods One hundred and fifty patients with colorectal cancer who had no family history were enrolled in this study from June 2006 to June 2008. Five standard microsatellite loci including BAT25, BAT26, D2S123, D5S346, and D17S250 were amplified with immunofluorescent polymerase chain reaction. The patient information including age, sex, and tumor location was recorded. Pathological features including differentiation, mucinous differentiation, histological heterogeneity, and Crohn's-like reaction were observed under light microscope. The presence of tumor-infiltrating lymphocytes (TLs, CD4+ and CD8+) was detected by means of immunohistochemistry. A regression equation was obtained by stepwise logistic regression analysis to evaluate the relationship between MSI-H phenotype in colorectal cancer ands pathological features. Results MSI-H phenotype occurred in 13.33% of the 150 patients with non-familial colorectal cancer. Poor differentiation, histological heterogeneity, Crohn's-like reaction, and presence of TLs were found to be independent factors to identify MSI-H non-familial colorectal cancer. Logistic regression equation showed an overall sensitivity of 70.0%, specificity of 99.2%, and accuracy of 95.3% in identifying MSI-H non-familial colorectal cancer. Conclusion MSI-H non-familial colorectal cancer manifests specific pathological features, which may be relied upon for effective identification of that disease.
基金supported by the National Natural Science Foundation of China (Grant No. 11102131)the National Basic Research Program of China (Grant No. 2009CB724103)+1 种基金the National Aeronautics Basic Science Foundation of China (Grant No. 2010ZA48002)the Doctoral fund of Ministry of Education of China (Grant No. 20110032120003)
文摘The scenario of bypass transition is generally described theoretically as follows: low-frequency disturbances in the free-stream would generate long stream-wise streaks in the boundary layer, which later would induce secondary instability, leading to rapid increase of high-frequency disturbances, then possibly turbulent spots would emerge, and through their merging, fully developed turbulence appears. This description, however, is insufficient in the sense that it does not provide the explanation on why during the breakdown stage, a large number of waves with different frequencies and wave numbers would appear almost simultaneously, leading to a swift change of the mean flow profile. In this paper, the mechanism leading to this phenomenon is found to be the change of the stability characteristics of mean flow profile, which has a positive feedback effect on the change of the profile itself. And another interesting finding is that, during the transition, the unstable disturbance waves which appear first belong to a branch of inviscid modes, while following the change of the stability characteristics of the mean flow profile, the disturbance waves will change to another branch of inviscid modes, and the latter play the key role in bypass transition.
文摘LES (Large-Eddy Simulation) computations were preformed to investigate the mechanisms of a kind of spanwisegroove for the passive control of laminar separation bubble on the suction surface of a low-speed highly loadedlow-pressure turbine blade at Re = 50,000 (Reynolds number, based on inlet velocity and axial chord length).Compared with the smooth suction surface, the numerical results indicate that: (1) the groove is effective toshorten and thin the separation bubble, which contributes the flow loss reduction on the groove surface, by thinningthe boundary layer behind the groove and promoting earlier transition inception in the separation bubble; (2)upstream movement of the transition inception location on the grooved surface is suggested being the result of thelower frequency at which the highest amplification rate of instability waves occurs, and the larger initial amplitudeof the disturbance at the most unstable frequency before transition; and (3) the viscous instability mode ispromoted on the grooved surface, due to the thinning of the boundary layer behind the groove.