AIM: To investigate the pathological characteristics of non-thermal damage induced by pulsed high intensity focused ultrasound (PHIFU) combined with ultrasound contrast agent (UCA), SonoVue (Bracco SpA, Milan, I...AIM: To investigate the pathological characteristics of non-thermal damage induced by pulsed high intensity focused ultrasound (PHIFU) combined with ultrasound contrast agent (UCA), SonoVue (Bracco SpA, Milan, Italy) in rabbit liver VX2 tumor. METHODS: Liver VX2 tumor models were established in 20 rabbits, which were divided randomly into PHIFU combined with ultrasound contrast agent group (PHIFU + UCA group) and sham group. In the PHIFU + UCA group, 0.2 mL of SonoVue was injected intravenously into the tumor, followed by ultrasound exposure of Isp 5900 W/cm^2. The rabbits were sacrificed one day after ultrasound exposure. Specimens of the exposed tumor tissues were obtained and observed pathologically under light microscope and transmission electron microscope. The remaining tumor tissues were sent for 2,3,5-Triphenyltetrazolium chloride (TTC) staining. RESULTS: Before Trc staining, tumor tissues in both the sham and the PHIFU + UCA groups resembled gray fish meat, After TIC staining, the tumor tissues were uniformly stained red, with a clear boundary between tumor tissue and normal tissue, Histological examination showed signs of tumor cell injury in PHIFU + UCA group, with cytoplasmic vacuoles of various sizes, chromatin margination and karyopyknosis. Electron microscopic examination revealed tumor cell volume reduction, karyopyknosis, chromatin margination, intercellular space widening, the presence of high electro'n-density apoptotic bodies and vacuoles in cytoplasm. CONCLUSION: The non-thermal effects of PHIFU combined with UCA can be used to ablate rabbit liver VX2 tumors.展开更多
The high-temperature oxidation resistance behavior of 7% (mass fraction) Y203-ZrO2 thermal barrier coatings (TBCs) irradiated by high-intensity pulsed ion beam (HIPIB) was investigated under the cyclic oxidation...The high-temperature oxidation resistance behavior of 7% (mass fraction) Y203-ZrO2 thermal barrier coatings (TBCs) irradiated by high-intensity pulsed ion beam (HIPIB) was investigated under the cyclic oxidation condition of 1 050 ℃ and 1 h. The columnar grains in the TBCs disappear after the HIPIB irradiation at ion current densities of 100-200 A/cm^2 and the irradiated surface becomes smooth and densified after remelting and ablation due to the HIPIB irradiation. The thermally grown oxide (TGO) layer thickness of the irradiated TBCs is smaller than that of the original TBCs. After 15 cycles, the mass gains of the original TBCs and those irradiated by ion current densities of 100 and 200 A/cm^2 due to the oxidation are found to be 0.8-0.9, 0.6-0.7, and 0.3-0.4 mg/cm^2, respectively. The inward diffusion of oxygen through the irradiated TBCs is significantly impeded by the densified top layer formed due to irradiation, which is the main reason for the improved overall oxidation resistance of the irradiated TBCs.展开更多
A wide range of events observed at the giant pulses (high energy density, observed localization of giant pulses GPs relative to the average pulse, fine structure of GPs with duration up to some nanoseconds, observed ...A wide range of events observed at the giant pulses (high energy density, observed localization of giant pulses GPs relative to the average pulse, fine structure of GPs with duration up to some nanoseconds, observed circular polarization of GPs, correlation between the GP phase and the phase of the hard pulsar emission X-ray and gamma) can be explained from the viewpoint that the internal polar gap is a cavity-resonator stimulated by discharges and radiating through the breaks in the magnetosphere. The new results in this field [the electromagnetic (era) waves generation in the gap in the process of longitudinal acceleration in the electric field vanishing on the star surface, high frequency break in the spectrum as a result of switching off this generation, formation in this process a power-low spectrum with a high frequency (hf) break, the possibility determination of pulsar magnetic field by the hf break position, the difference between main pulse and inter pulse mechanism generation, quantization of em tornado rotation in the gap and appearance of the bands in the inter pulse spectrum, influence the high energy density in the gap on pair generation and position of the dead line in pulsars] are added in the intermediate epilogue.展开更多
Highly adhesive cold cathodes with high field emission performance are fabricated by using a screen-print- ing method. The emission density of carbon nanotube (CNT) cold cathode reaches 207.0 mA cm-2 at an electric ...Highly adhesive cold cathodes with high field emission performance are fabricated by using a screen-print- ing method. The emission density of carbon nanotube (CNT) cold cathode reaches 207.0 mA cm-2 at an electric field of 4.5 Vμm-1 under continuous driving mode, and high peak current emission of 315.8 mA corresponding to 4.5 A cm 2 at the electric field of 10.3 V μm-1 under pulsed driving mode. The emission patterns of the cold cathodes are of excellent uniformity that was revealed by vivid luminescent patterns of phosphor coated transparent indium tin oxide (ITO) an- ode. The cold cathodes also exhibit highly stable emission under continuous and pulsed driving modes. The high adhe- sion of CNTs to molybdenum substrates results in robust cold cathodes and is responsible for the high field emission performance. This robust CNT emitter could meet the operating requirements of continuous and pulsed electron sources, and it provides promising applications in various vacuum- micro/nanoelectronic devices.展开更多
基金Supported by Key Project of National Natural Science Foundation of China,No.30830040Outstanding Youth Funding Project of China,No.30325027Key Project of Natural Science Foundation of CQ CSTS,No.CSTC2006BA5020
文摘AIM: To investigate the pathological characteristics of non-thermal damage induced by pulsed high intensity focused ultrasound (PHIFU) combined with ultrasound contrast agent (UCA), SonoVue (Bracco SpA, Milan, Italy) in rabbit liver VX2 tumor. METHODS: Liver VX2 tumor models were established in 20 rabbits, which were divided randomly into PHIFU combined with ultrasound contrast agent group (PHIFU + UCA group) and sham group. In the PHIFU + UCA group, 0.2 mL of SonoVue was injected intravenously into the tumor, followed by ultrasound exposure of Isp 5900 W/cm^2. The rabbits were sacrificed one day after ultrasound exposure. Specimens of the exposed tumor tissues were obtained and observed pathologically under light microscope and transmission electron microscope. The remaining tumor tissues were sent for 2,3,5-Triphenyltetrazolium chloride (TTC) staining. RESULTS: Before Trc staining, tumor tissues in both the sham and the PHIFU + UCA groups resembled gray fish meat, After TIC staining, the tumor tissues were uniformly stained red, with a clear boundary between tumor tissue and normal tissue, Histological examination showed signs of tumor cell injury in PHIFU + UCA group, with cytoplasmic vacuoles of various sizes, chromatin margination and karyopyknosis. Electron microscopic examination revealed tumor cell volume reduction, karyopyknosis, chromatin margination, intercellular space widening, the presence of high electro'n-density apoptotic bodies and vacuoles in cytoplasm. CONCLUSION: The non-thermal effects of PHIFU combined with UCA can be used to ablate rabbit liver VX2 tumors.
基金Projects supported by The 2nd Stage of Brain Korea and Korea Research Foundation
文摘The high-temperature oxidation resistance behavior of 7% (mass fraction) Y203-ZrO2 thermal barrier coatings (TBCs) irradiated by high-intensity pulsed ion beam (HIPIB) was investigated under the cyclic oxidation condition of 1 050 ℃ and 1 h. The columnar grains in the TBCs disappear after the HIPIB irradiation at ion current densities of 100-200 A/cm^2 and the irradiated surface becomes smooth and densified after remelting and ablation due to the HIPIB irradiation. The thermally grown oxide (TGO) layer thickness of the irradiated TBCs is smaller than that of the original TBCs. After 15 cycles, the mass gains of the original TBCs and those irradiated by ion current densities of 100 and 200 A/cm^2 due to the oxidation are found to be 0.8-0.9, 0.6-0.7, and 0.3-0.4 mg/cm^2, respectively. The inward diffusion of oxygen through the irradiated TBCs is significantly impeded by the densified top layer formed due to irradiation, which is the main reason for the improved overall oxidation resistance of the irradiated TBCs.
文摘A wide range of events observed at the giant pulses (high energy density, observed localization of giant pulses GPs relative to the average pulse, fine structure of GPs with duration up to some nanoseconds, observed circular polarization of GPs, correlation between the GP phase and the phase of the hard pulsar emission X-ray and gamma) can be explained from the viewpoint that the internal polar gap is a cavity-resonator stimulated by discharges and radiating through the breaks in the magnetosphere. The new results in this field [the electromagnetic (era) waves generation in the gap in the process of longitudinal acceleration in the electric field vanishing on the star surface, high frequency break in the spectrum as a result of switching off this generation, formation in this process a power-low spectrum with a high frequency (hf) break, the possibility determination of pulsar magnetic field by the hf break position, the difference between main pulse and inter pulse mechanism generation, quantization of em tornado rotation in the gap and appearance of the bands in the inter pulse spectrum, influence the high energy density in the gap on pair generation and position of the dead line in pulsars] are added in the intermediate epilogue.
基金supported by the National Natural Science Foundation of China(51002161)One-Three-Five Strategic Planning of Chinese Academy of Sciences
文摘Highly adhesive cold cathodes with high field emission performance are fabricated by using a screen-print- ing method. The emission density of carbon nanotube (CNT) cold cathode reaches 207.0 mA cm-2 at an electric field of 4.5 Vμm-1 under continuous driving mode, and high peak current emission of 315.8 mA corresponding to 4.5 A cm 2 at the electric field of 10.3 V μm-1 under pulsed driving mode. The emission patterns of the cold cathodes are of excellent uniformity that was revealed by vivid luminescent patterns of phosphor coated transparent indium tin oxide (ITO) an- ode. The cold cathodes also exhibit highly stable emission under continuous and pulsed driving modes. The high adhe- sion of CNTs to molybdenum substrates results in robust cold cathodes and is responsible for the high field emission performance. This robust CNT emitter could meet the operating requirements of continuous and pulsed electron sources, and it provides promising applications in various vacuum- micro/nanoelectronic devices.