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家蚕高蛋白血症模型建立及其丝腺细胞凋亡的特点研究
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作者 王璐 王玉龙 +2 位作者 陶卉 司马杨虎 徐世清 《蚕业科学》 CAS CSCD 北大核心 2015年第5期879-886,共8页
以阻止熟蚕吐丝的方法建立家蚕高蛋白血症模型,研究模型家蚕丝腺退化过程中细胞程序性死亡的特点,探索家蚕高蛋白血症模型的发病机制。形态解剖学观察显示,模型家蚕的丝腺退化过程延长了2倍时间;组织切片HE染色显示,模型家蚕的中部丝腺... 以阻止熟蚕吐丝的方法建立家蚕高蛋白血症模型,研究模型家蚕丝腺退化过程中细胞程序性死亡的特点,探索家蚕高蛋白血症模型的发病机制。形态解剖学观察显示,模型家蚕的丝腺退化过程延长了2倍时间;组织切片HE染色显示,模型家蚕的中部丝腺和后部丝腺都出现了退化启动推迟的现象。对家蚕组织解体退化信号通路相关基因表达水平的检测显示,模型家蚕丝腺细胞中自噬信号基因Atg6和Atg8的转录水平显著低于对照组家蚕,而凋亡信号基因Dronc的转录水平则显著高于对照组家蚕。免疫组化染色显示,模型家蚕丝腺细胞中凋亡启动蛋白Caspase-3在丝腺退化过程中持续表达。研究结果表明高蛋白血症模型家蚕丝腺细胞的凋亡活动增强,而丝腺退化延缓与自噬作用启动延迟有关。 展开更多
关键词 家蚕 高蛋白血症 疾病模型 丝腺 细胞程序性死亡
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山楂精降脂片治疗原发性高脂蛋白血症的临床观察 被引量:12
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作者 常小荣 严洁 +2 位作者 林亚萍 易受乡 章威 《湖南中医学院学报》 1998年第4期36-37,共2页
观察口服山楂精降脂片对高脂蛋白血症患者血清总胆固醇(TCH)、甘油三脂(TG),高密度脂蛋白胆固醇(HDL-C),低密度脂蛋白胆固醇(LDL-C)的影响,结果表明:山楂精降脂片可明显降低血清TCH、TG,升高HDL—... 观察口服山楂精降脂片对高脂蛋白血症患者血清总胆固醇(TCH)、甘油三脂(TG),高密度脂蛋白胆固醇(HDL-C),低密度脂蛋白胆固醇(LDL-C)的影响,结果表明:山楂精降脂片可明显降低血清TCH、TG,升高HDL—C及APoA,对A/B比值具有良好的调节作用。说明山楂精降脂片能降低血脂,调节体内脂质代谢。 展开更多
关键词 山楂精降脂片 高脂高蛋白血症 中医药疗法
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假性低钠血症 被引量:4
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作者 卞善述 《中国危重病急救医学》 CSCD 1990年第4期231-233,共3页
目前,实验室报告的血清钠是指血清水中的钠浓度,而血清由水和非水成份组成,前者一般占血清容量的93%,后者占血清容量的7%。当血清中非水成份增加时,由于实验室检查方法的关系。
关键词 清钠 低钠 钠浓度 高蛋白血症 甘油三醋 类皮质激素 浆渗透压 细胞内液 脂性
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特殊电泳图形1例
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作者 隋少玉 郭朝阳 张睿 《黑龙江医药科学》 2003年第3期19-19,共1页
关键词 蛋白电泳 γ后高蛋白血症
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Hyperhomocysteinemia independently causes and promotes atherosclerosis in LDL receptor-deficient mice 被引量:23
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作者 Hang-Yuan GUO Fu-Kang XU Hai-Tao LV Long-Bin LIU Zheng JI Xiao-Ya ZHAI Wei-Liang TANG Ju-Fang CH 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2014年第1期74-78,共5页
Background Hyperhomocysteine is an independent risk factor of coronary heart disease (CHD). However, whether hyperhomocys teine affects the progression of atherosclerosis is unclear. In the present study, we examine... Background Hyperhomocysteine is an independent risk factor of coronary heart disease (CHD). However, whether hyperhomocys teine affects the progression of atherosclerosis is unclear. In the present study, we examined the effect of hyperhomocysteine on the forma tion of atherosclerosis in low-density lipoprotein receptor-deficient (LDLr ) mice. Methods Forty-eight 7-week-old LDLr/ mice were assigned to the following groups: mice fed a standard rodent diet (control group), mice fed a high-methionine diet (high-methionine group), mice fed a high-fat diet (high-fat group), and mice fed a diet high in both methionine and fat (high-methionine and high-fat group). At the age of 19, 23, and 27 weeks, four mice at each interval in every group were sacrificed. Results At the end of the study, mice did not show atherosclerotic lesions in the aortic sinus and aortic surface until 27 weeks old in the control group. However, atherosclerotic lesions developed in the other three groups at 19 weeks. The amount of atherosclerotic lesions on the aortic surface was lower in the high-methionine group than in the high-fat group (P 〈 0.001). Atherosclerotic lesions on the aortic surface in the high-methionine and high-fat group were the most severe. The mean area of atherosclerotic lesions in the aortic sinus compared with atherosclerotic lesions on the aortic surface was lower in the high-methionine group than in the high-fat group (P 〈 0.001). Atherosclerotic lesions in the aortic sinus in the high-methionine and high-fat group were the most severe. Conclusions Homocysteinemia accelerates atherosclerotic lesions and induces early atherosclerosis independently in LDLrmice. Reducing the level of homocysteinemia may be beneficial for prevention and treatment of CHD. 展开更多
关键词 ATHEROSCLEROSIS HOMOCYSTEINE Low-density lipoprotein HYPERHOMOCYSTEINEMIA
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Prevalence of Abnormity of Blood Lipid and Associated Factors in Health Examination Population in Beijing 被引量:2
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作者 Wei-ming Kang Jie-shi Zhang Xin-xin Liu Min-shan Wang Ming-li Zhao Jian-chun Yu 《Chinese Medical Sciences Journal》 CAS CSCD 2009年第3期142-146,共5页
Objective To investigate the prevalence of abnormity of blood lipid and associated factors in healthy population in Beijing. Methods Totally, 38 462 individuals who received health examination were enrolled in our stu... Objective To investigate the prevalence of abnormity of blood lipid and associated factors in healthy population in Beijing. Methods Totally, 38 462 individuals who received health examination were enrolled in our study. We divided them into eight groups according to their ages. The levels of serum total cholesterol, triglyceride, high density lipoprotein cholesterol, and low density lipoprotein cholesterol were tested, and the relationship of blood lipid abnormity with body mass index (BMI) and fasting blood glucose was analyzed. Results The incidences of hypercholesterolemia, hyperglyceridemia, low high-density lipoprotein cholesterolemia, and hyper low-density lipoprotein cholesterolemia presented increasing trend in this population. The incidence rate of abnormity of blood lipid in health examination population increased with BMI increase. The incidence of abnormity of blood lipid in overweight and obesity population was significantly higher than that in low weight and normal weight populations (P<0.05). Meanwhile, the trend of abnormal blood lipid incidence coincided with that of abnormal fasting blood glucose. Conclusions The prevalence of overweight, obesity, and abnormity of blood lipid in Beijing presents increasing trend. The incidence of abnormity of blood lipid increases with BMI increase, in coincidence with that of fasting blood glucose. 展开更多
关键词 body mass index total cholesterol TRIGLYCERIDE high density lipoprotein cholesterol low density lipoprotein cholesterol fasting blood glucose
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EFFECT OF HERB-MEDICINE-CAKE-SEPARATED MOXIBUSTION ON SERUM LIPOPROTEIN CONTENTS IN HYPERLIPEMIA RABBITS
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作者 严洁 常小荣 +4 位作者 岳增辉 林亚平 易受乡 沈菁 曹湘平 《World Journal of Acupuncture-Moxibustion》 2004年第1期10-13,共4页
Objective: To study the effect of medicinal herb-cake-separated moxibustion on serum lipoprotein levels in hyperlipemia rabbits. Methods: A total of 55 New-Zealand rabbits were randomly divided into control group (n=1... Objective: To study the effect of medicinal herb-cake-separated moxibustion on serum lipoprotein levels in hyperlipemia rabbits. Methods: A total of 55 New-Zealand rabbits were randomly divided into control group (n=13), model group (n=14), direct moxibustion group (n=14) and medicinal herb-cake-separated moxibustion (indirect moxibustion) group (n=14). Hyperlipemia model was established by feeding the animals with specialized forage (15% vitellus powder, 5% lard, 0.5% cholesterol and common forage) for 6 weeks. Moxibustion was applied to “Juque”(CV 14), “Tianshu”(ST 25), “Fenglong”(ST 40), etc., 4 moxa-cones for every acupoint, once daily and continuously for 40 days. Serum triglyceride (TG) and total cholesterol (TCh) contents were assayed with colorimentric method. Results: Compared with control group, TCh and TG levels of model group increased significantly (P< 0.01). TCh and TG contents of direct moxibustion and indirect moxibustion groups were significantly lower than those of model group (P<0.01). Comparison between two moxibustion groups showed that serum TCh level of indirect moxibustion group was strikingly lower than that of direct moxibustion group (P<0.01). It indicated that both direct and indirect moxibustion could effectively lower hyperlipemia and the therapeutic effect of indirect moxibustion was significantly superior to that of direct moxibustion in lowering serum TCh level. Conclusion: Both direct and indirect moxibustion can regulate lipid metabolism and the therapeutic effect of medicinal herb-cake-separated moxibustion is superior to that of direction moxibustion in hyperlipemia rabbits. 展开更多
关键词 Hyperlipemia Herb-medicine-cake-separated moxibustion Direct moxibustion
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The function of T-lymphocyte subtypes of blood in patients with hyper-IgE syndrome
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作者 雷小兵 谭升顺 +3 位作者 曾维惠 王俊民 张磐谏 袁媛 《Journal of Medical Colleges of PLA(China)》 CAS 2005年第2期106-109,共4页
Objective: To study the function in cellular immunity of patients with hyper-IgE syndrome (HIE). Methods: T-lymphocyte subtypes of the peripheral blood and cutaneous delayed-type hypersensitivity (DTH) to two recall a... Objective: To study the function in cellular immunity of patients with hyper-IgE syndrome (HIE). Methods: T-lymphocyte subtypes of the peripheral blood and cutaneous delayed-type hypersensitivity (DTH) to two recall antigens, tetanus toxoid (TT) and purified protein derivative(PPD), were measured in 5 patients with HIE and 15 healthy controls, respectively. Results: The CD4 + cell counts in HIE group were significantly lower than those in the control group (P<0.01). In contrast, CD8 + cells were significantly higher in HIE group than those in the controls. The induration sizes of DTH to two recall antigens were smaller in HIE group than those in controls (P<0.01). Conclusion: There is an immunologic dysfunction of T lymphocytes in the patients with HIE and T cells play an important role in the pathogenesis. 展开更多
关键词 hyper-IgE syndrome T-lymphocyte subtypes delayed-type hypersensitivity
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Effects of purified herbal extract of Salvia miltiorrhiza on lipid profile in hyperlipidemic patients 被引量:2
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作者 Zuchang Li Ling Zhu Bin Huang 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2009年第2期99-101,共3页
Background and Objective Hyperlipidemia is one of the most potent and best substantiated risk factors for coronary heart disease (CHD). Purified Salvia miltiorrhiza extract (PSME) had been shown to have hypolipide... Background and Objective Hyperlipidemia is one of the most potent and best substantiated risk factors for coronary heart disease (CHD). Purified Salvia miltiorrhiza extract (PSME) had been shown to have hypolipidemic effect in animal experiments. This study aimed to evaluate its lipids modulating effects in hyperlipidemic patients. Methods In this single-blind, placebo cantrolled study, lipid profiles of 80 hyperlipidemic patients were checked at same conditions. They were divided into two equal groups randomly (each composing of 40 patients). They were given PSME tablet (800 mg) three times per day, or placebo tablet. All patients were put on NCEP type II diet and six weeks later, lipid profiles were checked. Results In PSME group, total cholesterol decreased by 27.32 mg/dl (12.3% reduction), LDL-cholesterol decreased by 23.13 mg/dl (16.8% reduction) and HDL-cholesterol increased by 9.06 mg/dl (11.1%), all were statistically significant. Although triglyceride dropped by 12.12 mg/dl (5.1%) but this was not significant statistically (P=0.34). There were no significant changes oflipids levels in the placebo group. Conclusions PSME has significant favorable effect on total cholesterol, LDL-cholesterol, and HDL-cholesterol and may be a potential agent for the treatment ofatherogenic dyslipidemia. 展开更多
关键词 Hypcrlipidemia Salvia miltiorrhiza randomized trial
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托伐普坦治疗严重心力衰竭伴乙型肝炎肝硬化腹水的疗效评价 被引量:1
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作者 刘斌 《实用老年医学》 CAS 2016年第8期697-698,共2页
2006年3月至2014年12月,我科共收治临床资料较为完整的重度心力衰竭伴乙型肝炎肝硬化大量腹水的患者18例,其中有8例病人在常规治疗基础上同时加用托伐普坦治疗,与常规治疗相比,临床疗效非常显著,现报道如下。
关键词 乙型肝炎肝硬化 重度心力衰竭 严重心力衰竭 肝硬化腹水 临床疗效 临床资料 体液潴留 钠浓度 心功能 高蛋白血症
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慢性肾炎患者的饮食问题
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作者 刘天山 《祝您健康》 1994年第8期32-32,共1页
得了慢性肾炎后,在饮食方面要注意些什么,我的临床体会是:食盐方面:患者有明显水肿或伴有高血压时,应禁一切含盐过高的食物,等水肿消退、血压降下来之后.才可以适当地吃一些如咸鸭蛋。
关键词 慢性肾炎患者 饮食问题 咸鸭蛋 少食多餐 急性肾功能衰竭 进食量 高蛋白血症 食物过敏 海螺肉
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Intermittent protein restriction protects isletβcells and improves glucose homeostasis in diabetic mice 被引量:3
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作者 Siying Wei Chenchen Li +6 位作者 Xuemei Luo Lanzexin Yang Long Yu Qintao Wang Zhuo-Xian Meng Tao Wang Yan Chen 《Science Bulletin》 SCIE EI CSCD 2022年第7期733-747,共15页
Diabetes is caused by the interplay between genetics and environmental factors, tightly linked to lifestyle and dietary patterns. In this study, we explored the effectiveness of intermittent protein restriction(IPR)in... Diabetes is caused by the interplay between genetics and environmental factors, tightly linked to lifestyle and dietary patterns. In this study, we explored the effectiveness of intermittent protein restriction(IPR)in diabetes control. IPR drastically reduced hyperglycemia in both streptozotocin-treated and leptin receptor-deficient db/db mouse models. IPR improved the number, proliferation, and function of β cells in pancreatic islets. IPR reduced glucose production in the liver and elevated insulin signaling in the skeletal muscle. IPR elevated serum level of FGF21, and deletion of the Fgf21 gene in the liver abrogated the hypoglycemic effect of IPR without affecting β cells. IPR caused less lipid accumulation and damage in the liver than that caused by continuous protein restriction in streptozotocin-treated mice. Single-cell RNA sequencing using mouse islets revealed that IPR reversed diabetes-associated β cell reduction and immune cell accumulation. As IPR is not based on calorie restriction and is highly effective in glycemic control and β cell protection, it has promising translational potential in the future. 展开更多
关键词 Nutritional intervention Diabetes intervention Protein restriction ISLETS scRNA-seq
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Association between moderately oxidized low-density lipoprotein and high-density lipoprotein particle subclass distribution in hemodialyzed and post-renal transplant patients 被引量:5
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作者 Elzbieta KIMAK Magdalena HALABI +2 位作者 Iwona BARANOWICZ-GASZCZYK Janusz SOLSKI Andrzej KSIAZEK 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2011年第5期365-371,共7页
Disturbances in the metabolism of lipoprotein profiles and oxidative stress in hemodialyzed (HD) and post-renal transplant (Tx) patients are proatherogenic, but elevated concentrations of plasma high-density lipop... Disturbances in the metabolism of lipoprotein profiles and oxidative stress in hemodialyzed (HD) and post-renal transplant (Tx) patients are proatherogenic, but elevated concentrations of plasma high-density lipoprotein (HDL) reduce the risk of cardiovascular disease. We investigated the concentrations of lipid, lipoprotein, HDL particle, oxidized low-density lipoprotein (ox-LDL) and anti-ox-LDL, and paraoxonase-1 (PON-1) activity in HD (n=33) and Tx (n=71) patients who were non-smokers without active inflammatory disease, liver disease, diabetes, or malignancy. HD patients had moderate hypertriglyceridemia, normocholesterolemia, low HDL-C, apolipoprotein A-I (apoA-I) and HDL particle concentrations as well as PON-1 activity, and increased ox-LDL and anti-ox-LDL levels. Tx patients had hypertriglyceridemia, hypercholesterolemia, moderately decreased HDL-C and HDL particle concentrations and PON-1 activity, and moderately increased ox-LDL and anti-ox-LDL levels as compared to the reference, but ox-LDL and anti-ox-LDL levels and PON-1 activity were more disturbed in HD patients. However, in both patient groups, lipid and lipoprotein ratios (total cholesterol (TC)/HDL-C, LDL-C/HDL-C, triglyceride (TG)/HDL-C, HDL-C/non-HDL-C, apoA-I/apoB, HDL-C/apoA-I, TG/HDL) were atherogenic. The Spearman's rank coefficient test showed that the concentration of ox-LDL correlated positively with HDL particle level (R=0.363, P=0.004), and negatively with TC (R=-0.306, P=0.012), LDL-C (R=-0.283, P=0.020), and non-HDL-C (R=-0.263, P=0.030) levels in Tx patients. Multiple stepwise forward regression analysis in Tx patients demonstrated that ox-LDL concentration, as an independent variable, was associated significantly positively with HDL particle level. The results indicated that ox-LDL and de- creased PON-1 activity in Tx patients may give rise to more mildly-oxidized HDLs, which are less stable, easily undergo metabolic remodeling, generate a greater number of smaller pre-13-HDL particles, and thus accelerate reverse cholesterol transport, which may be beneficial for Tx patients. Further studies are necessary to confirm this. 展开更多
关键词 Lipids LIPOPROTEINS Paraoxonase-1 (PON-1) activity Oxidized low-density lipoprotein (ox-LDL) High-density lipoprotein (HDL) particles Post-renal transplant HEMODIALYSIS
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