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血压、血脂、血糖及肾功能不同水平对老年高血压心血管事件的影响分析
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作者 向涛 《医学食疗与健康》 2019年第6期275-275,共1页
目的:分析探究血压、血脂、血糖及肾功能不同水平对老年高血压心血管事件的影响。方法:随机选取2017年2月~2018年2月在我院接受过治疗的老年高血压患者286例,将所有老年高血压患者,根据老年患者的血压、血脂、血糖及肾功能的高低分为两... 目的:分析探究血压、血脂、血糖及肾功能不同水平对老年高血压心血管事件的影响。方法:随机选取2017年2月~2018年2月在我院接受过治疗的老年高血压患者286例,将所有老年高血压患者,根据老年患者的血压、血脂、血糖及肾功能的高低分为两组。血糖以收缩压SBP140mmHg,舒张压DBP80mmHg,脉压60mmHg分界值,血脂以总胆固醇TC5.72mmpl/L为分界值,血糖以空腹血糖为FPG70mmol/L,肾功能以估算肾小球滤过率eGFR60ml.min-1.1.73-2为分界值。对两组老年患者经行为期1年的随访工作,记录高低两组老年患者的心血管事件,比较血压、血脂、血糖级肾功能对老年高血压心血管事件的影响。结果:经过为期1年的随访记录显示,老年高血压患者出现脑卒中事件67例,冠心病事件141例,心血管死亡事件11例。比较两组老年患者出现的心血管死亡率、脑卒中和冠心病事件,高SBP、DBP、PP、TC、FPG组老年高血压患者明显高于低SBP、DBP、PP、TC、FPG组老年高血压患者,且(p<0.05)存在明显差异具有统计学意义。比较两组老年患者出现的心血管死亡率、脑卒中和冠心病事件,低eGFR组明显高于高于eGFR组,且(p<0.05)存在明显差异具有统计学意义。讨论:老年高血压患者出现心血管事件与老年患者的血压、血脂、血糖及肾功能的正常指标密切相关。 展开更多
关键词 血压 血糖 血脂 肾功能 老年高血压心血管事件
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老年高血压心血管预后危险因素相关性分析
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作者 李丽娟 《现代医学与健康研究电子杂志》 2017年第9期170-170,共1页
目的探讨分析高血压心血管病老年患者预后存在的危险因素。方法选取我院2016年8月~2017年7月期间收治的高血压心血管症患者50例作为研究组,另抽取来我院正常体检正常人员50名作为对照组,行对比参照分析,了解两组人员不良生活习惯、家庭... 目的探讨分析高血压心血管病老年患者预后存在的危险因素。方法选取我院2016年8月~2017年7月期间收治的高血压心血管症患者50例作为研究组,另抽取来我院正常体检正常人员50名作为对照组,行对比参照分析,了解两组人员不良生活习惯、家庭史情况以及自身甘油三酯、总胆固醇、空腹血糖、体质量指数和高密度脂蛋白胆固醇、低密度脂蛋白胆固醇含量,判断病症患者预后危险因素。结果除高密度脂蛋白胆固醇与空腹血糖含量组间差异不显著(P>0.05),其它危险因素组间均存在显著差异(P<0.05)。结论老年高血压患者预后不良生活习惯、家族史、甘油三酯、总胆固醇、低密度脂蛋白胆固醇含量均为危险因素,需要重点关注。 展开更多
关键词 高血压心血管 预后 危险因素
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血清补体1q、同型半胱氨酸及脂联素水平在老年原发性高血压并发心血管疾病风险评估中的价值 被引量:4
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作者 汤祥瑞 程德均 +2 位作者 王科程 郭宏毅 张勇 《分子诊断与治疗杂志》 2023年第4期602-605,609,共5页
目的 通过分析血清补体1q(C1q)、同型半胱氨酸(Hcy)及脂联素(APN)的水平,探讨这些指标在老年原发性高血压并发心血管疾病风险评估中的价值。方法 选择2020年3月至2022年3月西安交通大学附属三二〇一医院收治的原发性高血压并发心血管疾... 目的 通过分析血清补体1q(C1q)、同型半胱氨酸(Hcy)及脂联素(APN)的水平,探讨这些指标在老年原发性高血压并发心血管疾病风险评估中的价值。方法 选择2020年3月至2022年3月西安交通大学附属三二〇一医院收治的原发性高血压并发心血管疾病患者154名作为高血压并心血管疾病组,另选取同期于本院收治的高血压患者151例为单纯高血压组,同期体检健康者152例为对照组,观察三组及原发性高血压并发心血管疾病患者高风险与低风险组血清Hcy、APN、C1q水平,分析影响老年原发性高血压并发心血管疾病风险的相关因素。结果 APN、C1q水平:高血压并心血管疾病组<单纯高血压组<对照组μg/mL,Hcy水平:高血压并心血管疾病组>单纯高血压组>对照组,差异有统计学意义(P<0.05);高风险组的血清APN、C1q水平分别为(12.34±2.87)mg/L、(164.47±8.65)μg/mL,低于低风险组的(25.69±1.25)mg/L、(171.39±9.26)μg/mL,Hcy水平为(24.78±4.74)mg/L,高于低风险组的(17.54±2.85)mg/L,差异有统计学意义(P<0.05);收集所有研究者基线资料、生化指标,经非条件多因素logistic回归模型分析得,吸烟史、糖尿病史、高血压史、体重指数、病理分级、危险度的分层、Hcy、APN、C1q为原发性高血压并发心血管疾病风险的独立危险因素(P<0.05)。结论 血清Hcy、APN、C1q水平在评估老年原发性高血压并发心血管疾病风险方面具有较高的价值,有望作为老年原发性高血压并发心血管疾病中的生物标志物。 展开更多
关键词 血清补体1q 同型半胱氨酸 脂联素 原发性高血压并发心血管疾病
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不同联合降压方式对维持性血液透析合并高血压患者心血管并发症的影响
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作者 李友河 黄瑞玲 李芬芬 《医学食疗与健康》 2021年第23期41-42,共2页
目的:本项目3种不同联合降压方式对维持性血液透析患者合并高血压患者降压效果以及心血管并发症的影响。方法:从本院长期血液透析的患者中随机抽取60人,再将60人按随机数字表法分为三组,每组20人,每组患者采用不同的联合降压方式,经过1... 目的:本项目3种不同联合降压方式对维持性血液透析患者合并高血压患者降压效果以及心血管并发症的影响。方法:从本院长期血液透析的患者中随机抽取60人,再将60人按随机数字表法分为三组,每组20人,每组患者采用不同的联合降压方式,经过1年的随访,观察不同联合降压方案对MHD合并高血压患者的降压效果、心血管事件发生情况、心脏结构及血管结构异常情况。对结果进行统计学分析。结果:三种降压方案均能达到降压目的,但降压效果无显著差异(P>0.05);C组采用CCB(左旋氨氯地平)+ARB(缬沙坦)联合降压后,MHD合并高血压患者的心血管事件发生率较低(P<0.01);C组采用CCB(左旋氨氯地平)+ARB(缬沙坦)联合降压后,MHD合并高血压患者的心脏及血管结构异常率较低(P<0.01)。结论:CCB(左旋氨氯地平)+ARB(缬沙坦)联合用药,能显著降低患者出现心脏及血管结构异常的概率和心血管事件的发生率。 展开更多
关键词 联合降压 血液透析 高血压心血管
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高血压继发心血管疾病的超声诊断价值探讨 被引量:1
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作者 郑华 《中国现代药物应用》 2021年第20期23-25,共3页
目的探讨高血压继发心血管疾病的超声诊断价值。方法选择100例高血压继发心血管疾病患者作为观察组,接受超声与心电图检查;选择同期体检健康者100例作为对照组,接受超声检查。比较观察组左室肥大、左房增大、左室增大、心室缺血、主动... 目的探讨高血压继发心血管疾病的超声诊断价值。方法选择100例高血压继发心血管疾病患者作为观察组,接受超声与心电图检查;选择同期体检健康者100例作为对照组,接受超声检查。比较观察组左室肥大、左房增大、左室增大、心室缺血、主动脉扩张、ST-T改变的超声、心电图检出率;比较观察组和对照组心脏结构与心脏功能指标。结果观察组左室肥大、左房增大、左室增大、心室缺血、主动脉扩张、ST-T改变的超声检出率分别为69.00%、58.00%、22.00%、37.00%、6.00%、10.00%,均显著高于心电图的41.00%、40.00%、7.00%、21.00%、0、3.00%,差异具有统计学意义(P<0.05)。两组左心室舒张末期内径、左室后壁厚度、室间隔厚度比较差异无统计学意义(P>0.05);观察组左心室射血分数(58.69±9.78)%低于对照组的(71.06±10.85)%,左心房内径(57.69±11.48)mm长于对照组的(45.02±9.79)mm,差异具有统计学意义(P<0.05)。结论超声可准确检出高血压继发心血管疾病,还可分析患者的心脏结构与心脏功能变化,辅助临床早期采用有效方案进行对症治疗。 展开更多
关键词 高血压继发心血管疾病 超声 心电图
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高血压并冠心病患者发生心血管事件相关因素分析 被引量:5
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作者 王惠敏 《基层医学论坛》 2013年第32期4257-4258,共2页
目的研究高血压合并冠心病患者的血压变化情况以及发生心血管事件的相关因素。方法将120例高血压合并冠心病患者分为有心血管事件组和无心血管事件组,对2组患者的各项指标进行对比分析。结果高血压合并冠心病患者中出现心血管事件组的... 目的研究高血压合并冠心病患者的血压变化情况以及发生心血管事件的相关因素。方法将120例高血压合并冠心病患者分为有心血管事件组和无心血管事件组,对2组患者的各项指标进行对比分析。结果高血压合并冠心病患者中出现心血管事件组的冠脉病变积分、患者年龄、24 h动态收缩压(SBP)、夜间动态SBP、日间动态SBP、24 h动态脉压(PP)、夜间动态PP、日间动态PP均比无心血管事件组的数值高(P<0.01)。结论高血压合并冠心病患者发生心血管事件的危险因素很多,对其进行有效的控制能够有效降低高血压合并冠心病患者发生心血管事件的概率。 展开更多
关键词 高血压冠心病心血管事件相关因素
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波依定治疗原发性高血压的临床疗效观察
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作者 刘利君 何元军 贺集贤 《齐齐哈尔医学院学报》 2011年第4期550-551,共2页
目的探讨波依定治疗原发性高血压的临床效果。方法选择81例原发性高血压患者,按入院先后分为:A组(41例),B组(40例)。A组口服波依定5~10 mg/d;B组口服硝苯地平缓释片20~40 mg/d,两组的疗程均为4周;观察比较两组的临床疗效。结果 A组的... 目的探讨波依定治疗原发性高血压的临床效果。方法选择81例原发性高血压患者,按入院先后分为:A组(41例),B组(40例)。A组口服波依定5~10 mg/d;B组口服硝苯地平缓释片20~40 mg/d,两组的疗程均为4周;观察比较两组的临床疗效。结果 A组的总有效率95.1%;B组的总有效率82.5%,两组有效率比较差异具有显著性(P<0.05);A组不良反应率14.6%,B组不良反应率42.5%,两组之间差异具有显著性(P<0.05)。结论波依定具有高效、剂量小、安全、患者依从性好等的优点,是治疗原发性高土压疗兹较好的药物之一。 展开更多
关键词 波依定高血压治疗高血压是临床上最常见的心血管疾病之一 血压长期升
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妊娠期高血压疾病与免疫 被引量:1
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作者 张阳 苟文丽 《现代妇产科进展》 CSCD 北大核心 2009年第3期229-231,共3页
免疫机制贯穿于妊娠始终,免疫失调在妊娠期高血压疾病的发病中起重要的作用,现对该病的免疫学发病机制及治疗进展作一综述。
关键词 妊娠并发症 心血管 高血压 免疫 综述文献
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妊娠高血压综合征并发子痫、左心室衰竭、肺水肿及昏迷1例麻醉管理
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作者 王恩斌 《齐鲁医学杂志》 2005年第2期182-182,共1页
关键词 妊娠高血压综合征 心血管 子痫 肺水肿 麻醉和镇痛
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严格管控危险因素,提高心血管病防治水平:解读2021版ESC心血管病预防临床实践指南 被引量:2
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作者 郭艺芳 《中华心血管病杂志》 CAS CSCD 北大核心 2021年第12期1244-1246,共3页
欧洲心脏病学会(ESC)更新并颁布了2021版心血管病预防临床实践指南。结合近年来最新研究证据,新指南在降胆固醇、降压、降糖与抗血小板治疗等方面提出了新的推荐建议,对我国临床实践具有一定的借鉴价值。本文对该指南的部分要点做了简... 欧洲心脏病学会(ESC)更新并颁布了2021版心血管病预防临床实践指南。结合近年来最新研究证据,新指南在降胆固醇、降压、降糖与抗血小板治疗等方面提出了新的推荐建议,对我国临床实践具有一定的借鉴价值。本文对该指南的部分要点做了简要介绍与解析。 展开更多
关键词 动脉粥样硬化性心血管疾病 心血管疾病预防 高血压 胆固醇 糖尿病
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滋养细胞侵入过浅与PIH 被引量:7
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作者 杨娜娜 孙丽洲 《现代妇产科进展》 CSCD 2004年第6期455-458,共4页
胚泡植入蜕膜化的子宫内膜和随后发生的血管重铸是建立正常妊娠的关键步骤。滋养细胞浅侵入和子宫螺旋动脉重铸障碍可能是导致妊娠高血压综合征 (PIH)和胎儿宫内生长受限 (FGR)的主要原因 ,研究绒毛外细胞滋养细胞浸润能力现已成为PIH... 胚泡植入蜕膜化的子宫内膜和随后发生的血管重铸是建立正常妊娠的关键步骤。滋养细胞浅侵入和子宫螺旋动脉重铸障碍可能是导致妊娠高血压综合征 (PIH)和胎儿宫内生长受限 (FGR)的主要原因 ,研究绒毛外细胞滋养细胞浸润能力现已成为PIH发病机制研究的热点 ,现就胎盘滋养层细胞过度凋亡和细胞因子MMPs、IGFBP 1、TGF 展开更多
关键词 滋养层 细胞因子类 细胞凋亡 妊娠并发征 心血管 高血压
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A continued study on the bisoprolol and isosorbide dinitrate transdermal patches:cardiovascular protection in spontaneously hypertensive rats 被引量:1
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作者 魏巍 傅继华 +7 位作者 苏长海 单英 王渊 孔树佳 赵继会 吕万良 王树明 王丽 《Journal of Chinese Pharmaceutical Sciences》 CAS 2008年第3期241-248,共8页
The objective of the present study is to examine cardiovascular protective action of a newly developed transdermal patch by incorporating bisoprolol and isosorbide dinitrate in spontaneously hypertensive rats. As the ... The objective of the present study is to examine cardiovascular protective action of a newly developed transdermal patch by incorporating bisoprolol and isosorbide dinitrate in spontaneously hypertensive rats. As the combination therapy with these two synergistic drugs at low doses through a suitable form of administration could provide optimal therapeutic benefit, we further evaluated the effects of a 42 d period of anti-hypertensive treatment in spontaneously hypertensive rats. Rats were divided into the following five groups: control (blank patch), bisoprolol fumarate tablets (BP-FT, 20.0 mg/kg, i.g.), bisoprolol transdermal patch (BP-TP, 20.0 mg/kg), isosorbide dinitrate transdermal patch (ISDN-TP, 20.0 mg/kg), and the combination of BP and ISDN in a transdermal patch at low doses (8 and 12 mg/kg, respectively). The effects of treatment were evaluated via biochemical indicators related to cardiovascular protection, structure and function. The combination therapy had synergistic anti-hypertensive effects and significantly reduced blood pressure with the benefit of controlling blood pressure variability compared to BP-FT and BP-TP. The combined treatment also reduced heart rate as well as BP-FT and BP-TP, while ISDN-TP had no evident effects on blood pressure, heart rate, and cardiovascular protection. Combination therapy was superior to BP-TP and BP-FT at increasing blood atrial natriuretic peptide and nitric oxide, while also reducing cardiac hydroxyproline and endothelin-1 with no difference in blood endothelin-1 and cardiac malondialdehyde levels. Cardiovascular remodeling differed among the groups, with the combination therapy reducing cardiac hypertrophy and the aortic media/lumen ratio. The consequential improvements in relaxation in response to cumulative concentrations of acetylcholine may explain the associated improvement in endothelial function. Combi- nation treatment with a transdermal patch exhibited a synergistic therapeutic effect. Such favorable cardiovascular effects with nitric oxide donors and β-blockade combination through a transdermal patch may provide long-term cardiovascular protection during anti-hypertensive treatment. 展开更多
关键词 Transdermal patch HYPERTENSION Isosorbide dinitrate BISOPROLOL Cardiovascular protection
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COX-2、E-cadherin和β-catenin在妊娠期高血压疾病中的表达及意义
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作者 张秀芬 魏振杰 +3 位作者 张玉华 陈玲 李志红 霍高翔 《中国妇幼保健》 CAS 北大核心 2009年第24期3423-3425,共3页
目的:探讨COX-2、E-cadherin和β-catenin在妊娠期高血压疾病中的表达及其相关性。方法:采用免疫组化SP法检测妊娠期高血压组21例、子痫前期组17例和正常妊娠组20例胎盘组织中E-cadherin、β-catenin及COX-2的表达情况。结果:子痫前期组... 目的:探讨COX-2、E-cadherin和β-catenin在妊娠期高血压疾病中的表达及其相关性。方法:采用免疫组化SP法检测妊娠期高血压组21例、子痫前期组17例和正常妊娠组20例胎盘组织中E-cadherin、β-catenin及COX-2的表达情况。结果:子痫前期组COX-2的表达较正常妊娠组显著降低,E-cadherin的表达较正常妊娠组显著升高;妊娠期高血压组、子痫前期组β-catenin的表达均较正常妊娠组升高;E-cadherin和COX-2、COX-2和β-catenin表达均呈负相关,E-cadher-in和β-catenin的表达呈正相关。结论:胎盘局部E-cadherin、β-catenin及COX-2的改变与子痫前期的发生有关,3种因子表达的改变可能存在相互调节。 展开更多
关键词 妊娠合并症 心血管高血压胎盘COX-2 E—cadherin Β-CATENIN
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张仲景与预防医学
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作者 沈开金 《家庭医学(上半月)》 1998年第10期32-32,共1页
张仲景是汉代杰出的医学家,所著《金匮要略》一书,不仅历来被誉为“医方之祖、杂病之宗”,理论与实践相结合辨证论治的经典著作;也对预防学作了精辟的阐述。 上工治未病 治未病即是治未病之脏。人体是有机的统一体,一脏有病,必然影响它... 张仲景是汉代杰出的医学家,所著《金匮要略》一书,不仅历来被誉为“医方之祖、杂病之宗”,理论与实践相结合辨证论治的经典著作;也对预防学作了精辟的阐述。 上工治未病 治未病即是治未病之脏。人体是有机的统一体,一脏有病,必然影响它脏。医者能把握这种规律。 展开更多
关键词 张仲景 上工治未病 辨证论治 预防疾病 《金匮要略》 中医治疗 玉屏风散 高血压心血管 预防学 农药中毒
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Association of resting heart rate and hypertension stages on all-cause and car- diovascular mortality among elderly Koreans: the Kangwha Cohort Study 被引量:7
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作者 Mikyung Ryu Gombojav Bayasgalan +2 位作者 Heejin Kimm Chung Mo Nam Heechoul Ohrr 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2016年第7期573-579,共7页
Background Elevated resting heart rate and hypertension independently increase the risk of mortality. However, their combined ef- fect on mortality in stages of hypertension according to updated clinical guidelines am... Background Elevated resting heart rate and hypertension independently increase the risk of mortality. However, their combined ef- fect on mortality in stages of hypertension according to updated clinical guidelines among dderly population is unclear. Methods We fol- lowed a cohort of 6100 residents (2600 males and 3500 females) of Kangwha County, Korea, ranging from 55 to 99 year-olds as of March 1985, for all-cause and cardiovascular mortality for 20.8 years until December 31, 2005. Mortality data were collected through telephone calls and visits (to 1991), and were confirmed by death record matching with the National Statistical Office (1992-2005). Hazard ratios were calculated for all-cause and cardiovascular mortality by resting heart rate and hypertension defined by Eighth Joint National Committee crite- ria using the Cox proportional hazard model after controlling for confounding factors. Results The hazard ratios associated with resting heart rate 〉 80 beats/min were higher in hypertensive men compared with normotensives with heart rate of 61-79 beats/rain, with hazard ratios values of 1.43 (95% CI: 1.00-1.92) on all-cause mortality for prehypertension, 3.01 (95% CI: 1.07-8.28) on cardiovascular mortality for prehypertension, and 8.34 (95% CI: 2.52-28.19) for stage 2 hypertension. Increased risk (HR: 3.54, 95% CI: 1.16-9.21) was observed among those with both a resting heart rate 〉 80 beats/rain and prehypertension on cardiovascular mortality in women. Conclusions Indi- viduals with coexisting elevated resting heart rate and hypertension, even in prehypertension, have a greater risk for all-cause and cardiovas- cular mortality compared to those with elevated resting heart rate or hypertension alone. These findings suggest that elevated resting heart rate should not be regarded as a less serious risk factor in elderly hypertensive patients. 展开更多
关键词 Cardiovascular diseases Heart rate HYPERTENSION MORTALITY PREHYPERTENSION
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Study on the Effect of Simvastatin on Left Ventricular Mass and Endothelial Function and the Relationship between Their Changes in the Patients with Essential Hypertension 被引量:2
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作者 ZHANGPing-yang DENGYou-bin YANGHao-yi BIXiao-jun PANMin 《Journal of Nanjing Medical University》 2004年第3期163-166,共4页
Objective:To study the effect of Simvastatin on the left ventricular mass and endothelial function and to investigate the relationship between their changes in the patients with essential hypertension(EH). Methods: 5... Objective:To study the effect of Simvastatin on the left ventricular mass and endothelial function and to investigate the relationship between their changes in the patients with essential hypertension(EH). Methods: 50 patients with hypertension without severe complication were divided into two groups in a randomized,controlled and single blind trial.Group I(n=25)were given Simvastatin and hydragogue for 12 weeks while Group Ⅱ were given hydragogue during the same time.We detected the left ventricular mass and the brachial artery dilatation induced by reactive hyperemia(DIRH)or nitroglycerin(DING)respectively with ultrasonography in all patients before and after treatment.25 normal subjects without any treatment were taken as the control. Results:The left ventricular mass index(LVMI)was higher in the two groups of patients[(133.61±31.02)g/m 2;(118.04±39.62)g/m 2]than that in the control(88.79±22.73)g/m 2 before treatment(P<0.01,0.000 1,respectively)while the blood pressure was higher.The DIRH was lower in the two groups of patients(5.93±2.24)%;(6.54±3.16)%than that in the control(13.09±2.99)%,P<0.000 1.There was no significantly differences in age,serum concentrations of total cholesterol,triglyceride,sugar,blood pressure or the DING between two groups of patients and the control(P>0.05).And there was no significant difference in the all variables between group Ⅰ and group Ⅱ before treatment.After treatment the LVMI decreased[(133.61±31.02)g/m 2 VS(91.07±16.01)g/m 2,P<0.01]and the DTRH increased[(5.93±2.24)% VS(13.53±2.38)%,P<0.01]in the patients of group Ⅰ while there was no significant change in LVMI and DIRH in the patients of group Ⅱ.The blood pressure in the two groups of patients was decreased to the normal.Compared with group Ⅱ,the changes of LVMI and DIRH was higher in patients of group Ⅰ though the serum concentrations of total cholesterol,triglyceride or sugar were not significantly different.No significant change in serum concentrations oftotal cholesterol,triglyceride or sugar was found during treatment in the two groups of patients.Analysis showed that the LVMI correlated with DIRH and the change of LVMI correlated better with the change of DIRH(r=-0.56;0.69,P<0.000 1,respectly). Conclusions: The increase of left ventricular mass was related with endothelial dysfunction in essential hypertension.Being independent of the changes of serum concentrations of total cholesterol,triglyceride or sugar and blood pressure,Simvastatin could inhibit the increase of left ventricular mass and improve endothelial function. 展开更多
关键词 essential hypertension SIMVASTATIN left ventricular mass endothelial function
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Cardiovascular and cerebrovascular outcomes in elderly hypertensive patients treated with either ARB or ACEI 被引量:5
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作者 Cong Ma Jian Cao +4 位作者 Xue-Chun Lu Xin-Hong Guo Yan Gao Xian-Feng Liu Li Fan 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2012年第3期252-257,共6页
Background Although angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) are equally important in the treatment of hypertension, there is less evidence whether they have equal ca... Background Although angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) are equally important in the treatment of hypertension, there is less evidence whether they have equal cardiovascular and cerebrovascular protective effects, especially in elder hypertensive patients. This study aims to clarify this unresolved issue. Methods This cross-sectional study included clinical data on 933 aged male patients with hypertension who received either an ARB or ACEI for more than two months between January 2007 and May 2011. The primary outcome was the composite of cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke. The secondary endpoints were unstable angina, new atrial fibrillation, and transient ischemic attack. Results The median follow-up time was 24 months. Age, drug types, cerebral infarction history, renal dysfunction history were the independent predictors of the primary endpoint. The risk of an occurrence of a primary endpoint event was higher in the ARB group than the ACEI group [P = 0.037, hazard ratios (HR): 2.124, 95% confidence interval (95% CI): 1.048-4.306]. The Kaplan-Meier method also suggests that the rate of primary endpoint occurrence was higher in the ARB group than the ACEI group (P = 0.04). In regard to the secondary endpoints, there were no significant differences between the two treatment arms (P = 0.137, HR: 1.454, 95% CI: 0.888-2.380). Patient age and coronary heart disease history were independent predictors of the secondary endpoint. Conclusion ACEI were more effective than ARB in reducing cardiovascular and cerebrovascular morbidity and mortality in aged patients with hypertension. 展开更多
关键词 Angiotensin receptor blocker Angiotensin converting enzyme inhibitor Renin-angiotensin-aldosterone system Angiotensintype 2 receptor
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Cardiovascular care for older adults: hypertension and stroke in the older adult 被引量:1
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作者 Andrew P Miller Ann M Navar +1 位作者 Gary S Roubin Suzanne Oparil 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2016年第5期373-379,共7页
1 Introduction Hypertension and cerebrovascular disease incidence and prevalence rise dramatically with age, owing to longer exposure time to age-associated alterations in vascular function and structure and cardiova... 1 Introduction Hypertension and cerebrovascular disease incidence and prevalence rise dramatically with age, owing to longer exposure time to age-associated alterations in vascular function and structure and cardiovascular risk factors. This chapter is aimed at connecting age-related alterations in vascular function and structure to the resultant target organ damage, and to raise awareness of unique presentations and treatment strategies for hypertension and stroke in older adults. 展开更多
关键词 Aging Cerebrovascular disease Clinical trials HYPERTENSION STROKE
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Association between serum homocysteine and arterial stiffness:role of anti-hypertensive drugs 被引量:8
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作者 Ercan Varol 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2014年第2期175-175,共1页
To the Editor I read the article of Zhang, et al. with great interest. They investigated the association of homocysteine with arterial stiffness in Chinese community-based elderly persons. The carotid-femoral pulse wa... To the Editor I read the article of Zhang, et al. with great interest. They investigated the association of homocysteine with arterial stiffness in Chinese community-based elderly persons. The carotid-femoral pulse wave velocity (PWV) was significantly higher in the high homocyteine group than in the normal one, however, there was no differences in carotid-radial PWV between the high homocyteine group and the normal one. Homocysteine levels were strongly associated with the carotidfemoral PWV even after adjustment for classical risk factors of cardiovascular disease. I congratulate the authors for this important study. However, I want to make minor criticism for this study from the methodological aspect. 展开更多
关键词 HOMOCYSTEINE Arterial stiffness HYPERTENSION Antihypertensive drugs
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Relationship between lipoprotein (a) and micro/macro complications in type 2 diabetes mellitus: a forgotten target 被引量:10
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作者 Rocio Toro Eduardo Segura +3 位作者 Jesfis Millan Nunez-Cortes Juan Carlos Pedro-Botet Maribel Quezada-Feijoo Alipio Mangas 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2015年第2期93-99,共7页
Objectives Increased lipoprotein (a) serum concentration seems to be a cardiovascular risk factor; this has not been confirmed in extracoronary atherosclerosis complications. We therefore wished to gain a deeper ins... Objectives Increased lipoprotein (a) serum concentration seems to be a cardiovascular risk factor; this has not been confirmed in extracoronary atherosclerosis complications. We therefore wished to gain a deeper insight into relationship between the plasma concentrations of lipoprotein (a) and the micro- and macro-vascular complications of type 2 diabetes mellitus and to identify possible differences in this association. Methods This is a descriptive observational cross-sectional study. Two-hundred and seventeen elderly patients with type 2 diabetes mellitus were included from the internal medicine outclinic. Anthropometric data, analytical data (insulin reserve, basal and postprandial peptide C, glycosylated hemoglobin, renal parameters, lipid profile and clinical data as hypertension, obesity, micro and macrovascular complications were collected. Results Patients were grouped according to the type 2 diabetes mellitus time of evolution. The mean plasma concentration of lipoprotein (a) was 22.2± 17.3 mg/dL (22.1± 15.9 mg/dL for males, and 22.1 ± 18.4 mg/dL for females). Patients with hypertension, coronary heart disease, cerebrovascular accident, microalbuminuria and proteinuria presented a statistically significant increased level of lipoprotein (a). Similarly, the patients with hyperlipoprotein (a) (≥30 mg/dL) presented significantly increased levels of urea and total cholesterol. In the multivariate regression model, the level of lipoprotein (a) is positively correlated with coronary heart disease and diabetic nephropathy (P 〈 0.01 and P 〈 0.005, respectively). Conclusions The elevation of plasma levels of lipoprotein (a) are associ- ated with the development of coronary heart disease and diabe tic nephropathy. Therefore, we consider that the determination of lipoprotein (a) may be a prognostic marker of vascular complications in patients with type 2 diabetes mellitus. 展开更多
关键词 Lipoprotein (a) Macrovascular complications Type 2 diabetes Risk factors
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