胎儿期营养受限与其成年高血压病关系的研究进展

胎儿起源假说源于20世纪初,假说假定胎儿期营养受限影响其成年后的血压。已有大量研究通过胎儿出生时的体重来作为胎儿期营养的指标来研究其成年后的血压状况。近十几年来大量研究通过研究饥荒作为一个自然试验来探讨胎儿期暴露于饥荒与其成年后的血压关系。然而研究结果并非始终如一,本文将会对胎儿期营养受限和成年高血压关系的研究进展作一综述。

基因在泄密

控制饮食,检测血糖,饭前注射胰岛素,朴怀宇74岁的母亲每天只能靠此才能正常地生活,而朴怀宇8岁的外甥女,甚至还得随时有人陪着,为她在发病时做急救注射。她们在2007年被先后查出糖尿病。

Genetic Association Study of KCNB1 Gene with the Susceptibility of Hypertension Related LVH （Left Ventricular Hypertrophy） Patients in Malaysia

LVH （Left ventricular hypertrophy） is an independent risk factor for the development of heart failure, cardiac arrhythmias and stroke. A recent genome-wide association study reported the involvement of a candidate gene namely KCNBI in mechanism for development of LVH in hypertension. This study aimed to replicate the finding by investigating the genetic association of KCNBI gene among the hypertensive LVH patients from Malaysia. We genotyped a SNP （single nucleotide polymorphism） located in KCNBI namely, rs6063397 among 200 subjects consisting of61 LVH and 139 non LVH patients using Sanger sequencing method. Statistical analysis revealed no significant association between the L VH susceptibility between the allele and genotype frequencies （P = 0.2719 and 0.4768, respectively）. This finding suggests that KCNBI may not playa role in LVH susceptibility in hypertensive patients in Southeast Asian populations.