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补脾法辅助治疗腹型肥胖性高血压的临床观察 被引量:4
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作者 邹静 郑梅生 《广西医学》 CAS 2020年第4期496-498,共3页
目的观察补脾法辅助治疗腹型肥胖性高血压的临床疗效。方法将60例腹型肥胖性高血压痰湿壅盛型患者随机分为对照组和治疗组,每组30例。两组均接受常规西药降压治疗,治疗组在此基础上,运用补脾法治疗,方选半夏白术天麻汤合归脾汤加减。两... 目的观察补脾法辅助治疗腹型肥胖性高血压的临床疗效。方法将60例腹型肥胖性高血压痰湿壅盛型患者随机分为对照组和治疗组,每组30例。两组均接受常规西药降压治疗,治疗组在此基础上,运用补脾法治疗,方选半夏白术天麻汤合归脾汤加减。两组疗程均4周。比较两组治疗前后中医证候积分、血压、腹围、血浆肾素活性(PRA)、血管紧张素Ⅱ(AngⅡ)及醛固酮水平。结果治疗后两组中医证候积分、收缩压、舒张压、腹围、血浆PRA、AngⅡ及醛固酮均低于治疗前,且治疗组低于对照组(P<0.05)。结论补脾法辅助治疗腹型肥胖性高血压的临床疗效显著。 展开更多
关键词 型肥胖性高血压 补脾法 痰湿壅盛证
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氯沙坦、依那普利及其合用对腹主动脉缩窄型高血压大鼠的影响
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作者 张高星 张康信 +1 位作者 刘培庆 陈国伟 《中国心血管杂志》 2002年第4期235-237,共3页
目的 探讨依那普利、氯沙坦及其合用对腹主动脉缩窄型高血压大鼠血压、心肌肥厚程度和心肌组织丝裂原活化蛋白激酶 (MAPK)的活性及表达的影响。方法 采用腹主动脉缩窄型高血压大鼠模型 ,然后将动物随机分为 7组 (n均 =6 )。分别为氯沙... 目的 探讨依那普利、氯沙坦及其合用对腹主动脉缩窄型高血压大鼠血压、心肌肥厚程度和心肌组织丝裂原活化蛋白激酶 (MAPK)的活性及表达的影响。方法 采用腹主动脉缩窄型高血压大鼠模型 ,然后将动物随机分为 7组 (n均 =6 )。分别为氯沙坦 (10 mg· kg- 1 · d- 1 )组 ,氯沙坦 (30 mg· kg- 1 · d- 1 )组 ,依那普利 (4mg· kg- 1 · d- 1 )组 ,依那普利 (12 mg· kg- 1· d- 1 )组 ,依那普利合用氯沙坦 (4m g· kg- 1· d- 1和 10 m g· kg- 1· d- 1 )组和安慰剂组。以假手术组作对照。给药 5周后测定左心室重量与体重比值、平滑肌肌动蛋白表达和 MAPK蛋白表达变化。结果 与假手术组比较 ,大鼠腹主动脉缩窄术后 6周血压明显升高 ,心肌组织发生明显肥厚 ,平滑肌肌动蛋白和 MAPK蛋白表达增高 (P<0 .0 1)。与安慰剂组比较 ,氯沙坦、依那普利及其合用可降低平均动脉血压 ,减轻心肌肥厚 ,同时降低平滑肌肌动蛋白和 MAPK蛋白表达 (P<0 .0 1) ,且氯沙坦、依那普利的作用呈剂量依赖性。与单用氯沙坦或依那普利比较 ,氯沙坦和依那普利合用可进一步降低平均动脉血压、减轻心肌肥厚和 MAPK蛋白表达 (P <0 .0 5 )。结论  MAPK是介导高血压心肌肥厚的重要信号分子。氯沙坦、依那普利均能减轻心肌肥厚和 MAPK蛋白? 展开更多
关键词 氯沙坦 依那普利 丝裂原活化蛋白激酶 心肌肥厚 主动脉缩窄型高血压
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卡托普利防治腹主动脉狭窄性高血压大鼠心肌肥厚的形态定量研究
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作者 陈云 吴扬 沙宝熙 《中国体视学与图像分析》 2000年第1期18-26,共9页
方法选用腹主动脉狭窄的大鼠实验性心肌肥厚模型,采用光镜、电镜形态计量手段,定量观察了血管紧张素转换酶抑制剂卡托普利防治心肌肥厚的作用,并比较了倍他乐克对心肌肥厚的作用。结果卡托普利组大鼠的全心/体重比、心肌组织/间质... 方法选用腹主动脉狭窄的大鼠实验性心肌肥厚模型,采用光镜、电镜形态计量手段,定量观察了血管紧张素转换酶抑制剂卡托普利防治心肌肥厚的作用,并比较了倍他乐克对心肌肥厚的作用。结果卡托普利组大鼠的全心/体重比、心肌组织/间质比、心肌细胞横径及心肌细胞线粒体体密度与对照组类似(p>0.05),明显不同于心肌肥厚组(p<0.05),而倍他乐克组上述多指标与心肌肥厚组相似(p>0.05)。本实验表明卡托普利通过保护心肌细胞及间质而使心肌组织免遭损伤因素刺激发生肥厚的作用,即对大鼠高血压性。心肌肥厚具有良好的防治作用。 展开更多
关键词 防治 卡托普利 形态计量 心肌肥厚 主动脉狭窄性高血压
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多形式的健康教育模式对腹型肥胖型高血压患者腹围及体重指数的干预效果
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作者 王红霞 《首都食品与医药》 2023年第2期85-87,共3页
目的探究多形式的健康教育模式对腹型肥胖型高血压患者腹围及体重指数(Body Mass Index,BMI)的干预效果.方法回顾性选取2019年1月-2022年7月丰台区宛平社区卫生服务中心管理慢病病例中100例腹型肥胖型高血压患者作为此次研究对象,根据... 目的探究多形式的健康教育模式对腹型肥胖型高血压患者腹围及体重指数(Body Mass Index,BMI)的干预效果.方法回顾性选取2019年1月-2022年7月丰台区宛平社区卫生服务中心管理慢病病例中100例腹型肥胖型高血压患者作为此次研究对象,根据不同健康教育方法将其分为观察组50例与对照组50例.观察组实施多形式的健康教育模式干预,对照组实施常规健康教育模式干预.比较两组患者干预前后腹围变化情况、BMI、血压变化情况及治疗依从性情况.结果观察组干预后男性腹围(89.25±1.31)cm、女性腹围(84.48±1.31)cm,均短于对照组男性腹围(91.53±1.54)cm、女性腹围(86.67±1.42)cm(t=7.974、8.381,P均<0.05);观察组干预后男性BMI(23.45±0.44)kg/m^(2)、女性BMI(23.38±0.31)kg/m^(2),均小于对照组男性BMI(24.32±0.58)kg/m^(2)、女性BMI(24.15±0.53)kg/m^(2)(t=8.450、8.867,P均<0.05);观察组干预后SBP(131.25±5.71)mmHg、DBP(79.48±6.22)mmHg,低于对照组SBP(142.53±5.64)mmHg、DBP(86.65±6.35)mmHg(t=9.938、5.704,P均<0.05);观察组治疗依从率96.00%(48/50)显著高于对照组的84.00%(42/50)(χ^(2)=4.000,P=0.046).结论多形式的健康教育模式应用于腹型肥胖型高血压患者中能有效缩短患者腹围与降低BMI,控制血压,提升患者治疗依从性,值得临床推广. 展开更多
关键词 多形式的健康教育模式 型肥胖型高血压 体重指数 血压 治疗依从性
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硝苯地平联合二甲双胍治疗腹型肥胖性高血压98例 被引量:5
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作者 陈福生 邵亚珺 《中华全科医学》 2012年第4期571-572,共2页
目的观察硝苯地平缓释片联合二甲双胍治疗腹型肥胖性高血压病的临床疗效及其安全性。方法将98例腹型肥胖性高血压病患者随机分为两组:硝苯地平缓释片、二甲双胍联合应用治疗组(A组)49例以及单独应用硝苯地平缓释片治疗组(B组)49例,于治... 目的观察硝苯地平缓释片联合二甲双胍治疗腹型肥胖性高血压病的临床疗效及其安全性。方法将98例腹型肥胖性高血压病患者随机分为两组:硝苯地平缓释片、二甲双胍联合应用治疗组(A组)49例以及单独应用硝苯地平缓释片治疗组(B组)49例,于治疗12周分别测量体重、身高、血压、空腹血清葡萄糖(FPG)、HbA1c及血脂、肝肾功能等,观察降压疗效以及对心率、血脂、血糖、肾功能的影响。结果 A组显效40例,有效7例,无效2例,总有效率95.9%;B组显效31例,有效8例,无效10例,总有效率80.0%。A组总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL-C)水平均显著降低(P<0.05),高密度脂蛋白(HDL-C)水平增高(P<0.05)而B组无明显变化(P>0.05)。结论硝苯地平缓释片、二甲双胍合用对腹型肥胖性高血压治疗疗效理想,对心率、血糖、肾功能无明显影响且有明显降脂和减轻体重作用,是治疗腹型肥胖性高血压病较理想的治疗方案。 展开更多
关键词 硝苯地平缓释片 二甲双胍 型肥胖性高血压
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西藏地区女性绝经与左心室舒张功能障碍风险分析 被引量:1
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作者 蒋琳琳 陈祚 +7 位作者 张林峰 王馨 杨瑛 郑聪毅 亢玉婷 邵澜 田野 王增武 《医学研究杂志》 2020年第8期33-37,23,共6页
目的探讨我国西藏地区女性不同绝经时期左心室舒张功能障碍(LVDD)的患病风险。方法2015-2016年采用分层多阶段随机抽样的方法对西藏地区常住居民进行慢性心肺疾病调查,最终获得40~60岁女性的有效样本853例。计算各绝经时期的构成比和LVD... 目的探讨我国西藏地区女性不同绝经时期左心室舒张功能障碍(LVDD)的患病风险。方法2015-2016年采用分层多阶段随机抽样的方法对西藏地区常住居民进行慢性心肺疾病调查,最终获得40~60岁女性的有效样本853例。计算各绝经时期的构成比和LVDD发生率,用多因索Logistic回归模型计算女性不同绝经时期的LVDD患病风险。结果未绝经、绝经早期和绝经晚期女性比例分别是56.0%.21.8%和22.2%,相应LVDD发生率分别为16.3%.35.5%和47.1%。伴有高血压或腹型肥胖的女性LVDD发生率显著高于无上述症状的女性。以未绝经女性为参照,调整年龄等混杂因素后的Logistic回归分析显示,绝经早期女性的LVDD患病风险增加(OR=1.881,95%6 CI:1.186-2.982),绝经晚期女性风险进一步升高(OR=2.877,95%CI:1.650-5.017);在高血压对象中,绝经早期与绝经晚期女性LVDD患病风险OR值分别为2.399(95%CI:1.220~4.719)和2.940(95%CI:1.226~7.048);在腹型肥胖对象中,OR值则分别为2.124(95%CI:1.222~3.690)和2.974(95%CI:1.451~6.095)。但在非高血压和非腹型肥胖的女性中,绝经早期LVDD患病风险的升高无统计学意义。结论西藏地区女性绝经后LVDD患病风险增高,高血压和腹型肥胖对象更显著,应针对这类人群进行尽早干预。 展开更多
关键词 绝经左心室舒张功能障碍 高血压腹 型肥胖
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复方丹参滴丸对高血压模型大鼠血流动力学的影响 被引量:18
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作者 唐瑭 陈德森 +1 位作者 刘兴林 安庆宝 《国际中医中药杂志》 2014年第1期40-42,共3页
目的 观察复方丹参滴丸对腹主动脉狭窄高血压模型大鼠血流动力学的影响.方法 大鼠于左肾动脉上0.5 cm处行腹主动脉环扎缩窄术,造成心脏后负荷增加而复制大鼠腹主动脉狭窄型高血压动物模型,8周以后采用直接测压法测大鼠灌胃复方丹参滴丸... 目的 观察复方丹参滴丸对腹主动脉狭窄高血压模型大鼠血流动力学的影响.方法 大鼠于左肾动脉上0.5 cm处行腹主动脉环扎缩窄术,造成心脏后负荷增加而复制大鼠腹主动脉狭窄型高血压动物模型,8周以后采用直接测压法测大鼠灌胃复方丹参滴丸前及给药后0.5 h、1、2、4 h的左室内压峰值(LVSP)、左心室舒张末压(LVEDP),左室内压最大上升/下降速率(±dp/dtmax)、动脉收缩压(SBP)及脉压差(PP),评价复方丹参滴丸对腹主动脉狭窄高血压模型大鼠血流动力学的影响.结果 给药后2 h、4 h复方丹参滴丸可提高高血压大鼠LVSP及LVEDP下降百分率、降低±dp/dtmax、SBP,但对PP没有明显影响.其中LVSP在2 h、4 h分别为(18.21±1.36)%、(14.52±0.95)%;LVEDP 分别为(10.21±2.31%、(8.58±0.91)%;+dp/dtmax分别为(4730±211)mmHg/s、(3932±170)mmHg/s;-dp/dtmax分别为(2997±128)mmHg/s、(2781±120)mmHg/s;SBP为(161.1±11.9)mmHg(1 mmHg=0.133 Kpa)、(159.4±11.5)mmHg;与给药前及模型组比较,差异均有统计学意义(P均<0.05).结论 复方丹参滴丸对腹主动脉狭窄高血压模型大鼠有降压作用,其降压机制可与复方丹参滴丸具有扩张冠状动脉、增加冠脉血流量并降低心肌收缩力进而改善心功能有关. 展开更多
关键词 大鼠 主动脉狭窄高血压 复方丹参滴丸 血流动力学
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Early recognition of abdominal compartment syndrome in patients with acute pancreatitis 被引量:32
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作者 Zilvinas Dambrauskas Audrius Parseliunas +2 位作者 Antanas Gulbinas Juozas Pundzius Giedrius Barauskas 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第6期717-721,共5页
AIM: To assess the value of widely used clinical scores in the early identification of acute pancreatitis (AP) patients who are likely to suffer from intra-abdominal hypertension (IAH) and abdominal compartment s... AIM: To assess the value of widely used clinical scores in the early identification of acute pancreatitis (AP) patients who are likely to suffer from intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS).METHODS: Patients (η = 44) with AP recruited in this study were divided into two groups (ACS and non-ACS) according to intra-abdominal pressure (IAP) determined by indirect measurement using the transvesical route via Foley bladder catheter. On admission and at regular intervals, the severity of the AP and presence of organ dysfunction were assessed utilizing different multifactorial prognostic systems: Glasgow-Imrie score, Acute Physiology and Chronic Health Evaluation Ⅱ (APACHE-Ⅱ) score, and Multiorgan Dysfunction Score (MODS). The diagnostic performance of scores predicting ACS development, cut-off values and specificity and sensitivity were established using receiver operating characteristic (ROC) curve analysis.RESULTS: The incidence of ACS in our study population was 19.35%. IAP at admission in the ACS group was 22.0 (18.5-25.0) mmHg and 9.25 (3.0-12.4) mmHg in the non-ACS group (P 〈 0.01). Univariate statistical analysis revealed that patients in the ACS group had significantly higher multifactorial clinical scores (APACHE Ⅱ, Glasgow-Imrie and MODS) on admission and higher maximal scores during hospitalization (P 〈 0.01). ROC curve analysis revealed that APACHE Ⅱ, Glasgow-Imrie, and MODS are valuable tools for early prediction of ACS with high sensitivity and specificity, and that cut-off values are similar to those used for stratification of patients with severe acute pancreatitis (SAP).CONCLUSION: IAH and ACS are rare findings in patients with mild AR Based on the results of our study we recommend measuring the IAP in cases when patients present with SAP (APACHE Ⅱ 〉 7; MODS 〉 2 or Glasgow-Imrie score 〉 3). 展开更多
关键词 Acute pancreatitis Abdominal compartment syndrome Intra-abdominal pressure Intra-abdominal hypertension Organ dysfunction
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Current recognition and management of intra-abdominal hypertension and abdominal compartment syndrome among tertiary Chinese intensive care physicians 被引量:20
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作者 Jian-cang ZHOU Hong-chen ZHAO Kong-han PAN Qiu-ping XU 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2011年第2期156-162,共7页
This survey was designed to clarify the current understanding and clinical management of intra-abdominal hypertension (IAH)/abdominal compartment syndrome (ACS) among intensive care physicians in tertiary Chinese ... This survey was designed to clarify the current understanding and clinical management of intra-abdominal hypertension (IAH)/abdominal compartment syndrome (ACS) among intensive care physicians in tertiary Chinese hospitals. A postal twenty-question questionnaire was sent to 141 physicians in different intensive care units (ICUs). A total of 108 (76.6%) questionnaires were returned. Among these, three quarters worked in combined medical-surgical ICUs and nearly 80% had primary training in internal or emergency medicine. Average ICU beds, annual admission, ICU length of stay, acute physiology and chronic health evaluation (APACHE)II score, and mortality were 18.2 beds, 764.5 cases, 8.3 d, 19.4, and 21.1%, respectively. Of the respondents, 30.6% never measured intra-abdominal pressure (IAP). Although the vast majority of the ICUs adopted the exclusively transvesicular method, the over- whelming majority (88.0%) only measured lAP when there was a clinical suspicion of IAH/ACS and only 29.3% measured either often or routinely. Moreover, 84.0% used the wrong priming saline volume while 88.0% zeroed at reference points which were not in consistence with the standard method for lAP monitoring recommended by the World Society of Abdominal Compartment Syndrome. ACS was suspected mainly when there was a distended ab- domen (92%), worsening oliguria (80%), and increased ventilatory support requirement (68%). Common causes for IAH/ACS were "third-spacing from massive volume resuscitation in different settings" (88%), "intra-abdominal bleeding", and "liver failure with ascites" (52% for both). Though 60% respondents would recommend surgical decompression when the lAP exceeded 25 mmHg, accompanied by signs of organ dysfunction, nearly three quarters of re- spondents preferred diuresis and dialysis. A total of 68% of respondents would recommend paracentesis in the treatment for ACS. In conclusion, urgent systematic education is absolutely necessary for most intensive care physicians in China to help to establish clear diagnostic criteria and appropriate management for these common, but life-threatening, diseases. 展开更多
关键词 QUESTIONNAIRE Intra-abdominal pressure Intra-abdominal hypertension Decompression laparotomy Abdominal compartment syndrome
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Effect of increased intra-abdominal pressure and decompressive laparotomy on aerated lung volume distribution 被引量:6
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作者 Jian-cang ZHOU Qiu-ping XU +2 位作者 Kong-han PAN Chen MAO Chong-wu JIN 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2010年第5期378-385,共8页
Increased intra-abdominal pressure(IAP) is common in intensive care patients,affecting aerated lung volume distribution.The current study deals with the effect of increased IAP and decompressive laparotomy on aerated ... Increased intra-abdominal pressure(IAP) is common in intensive care patients,affecting aerated lung volume distribution.The current study deals with the effect of increased IAP and decompressive laparotomy on aerated lung volume distribution.The serial whole-lung computed tomography scans of 16 patients with increased IAP were retrospectively analyzed between July 2006 and July 2008 and compared to controls.The IAP increased from(12.1±2.3) mmHg on admission to(25.2±3.6) mmHg(P<0.01) before decompressive laparotomy and decreased to(14.7±2.8) mmHg after decompressive laparotomy.Mean time from admission to decompressive laparotomy and length of intensive-care unit(ICU) stay were 26 h and 16.2 d,respectively.The percentage of normally aerated lung volume on admission was significantly lower than that of controls(P<0.01).Prior to decompressive laparotomy,the total lung volume and percentage of normally aerated lung were significantly less in patients compared to controls(P<0.01),and the absolute volume of non-aerated lung and percentage of non-aerated lung were significantly higher in patients(P<0.01).Peak inspiratory pressure,partial pressure of carbon dioxide in arterial blood,and central venous pressure were higher in patients,while the ratio of partial pressure of arterial O2 to the fraction of inspired O2(PaO2/FIO2) was decreased relative to controls prior to laparotomy.An approximately 1.8 cm greater cranial displacement of the diaphragm in patients versus controls was observed before laparotomy.The sagittal diameter of the lung at the T6 level was significantly increased compared to controls on admission(P<0.01).After laparotomy,the volume and percentage of non-aerated lung decreased significantly while the percentage of normally aerated lung volume increased significantly(P<0.01).In conclusion,increased IAP decreases total lung volume while increasing non-aerated lung volume.Decompressive laparotomy is associated with resolution of these effects on lung volumes. 展开更多
关键词 Intra-abdominal pressure Intra-abdominal hypertension Lung volume Decompressive laparotomy Computed tomography
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