目的观察天晴甘美治疗各种慢性肝炎高转氨酶血症的临床疗效。方法选择我院住院或门诊慢性肝炎高转氨酶血症患者260例,随机分为治疗组和对照组,治疗组131例,对照组129例。治疗组在常规保肝治疗的基础上加用天晴甘美每日1次,20 m l静脉滴...目的观察天晴甘美治疗各种慢性肝炎高转氨酶血症的临床疗效。方法选择我院住院或门诊慢性肝炎高转氨酶血症患者260例,随机分为治疗组和对照组,治疗组131例,对照组129例。治疗组在常规保肝治疗的基础上加用天晴甘美每日1次,20 m l静脉滴注,对照组在常规保肝治疗的基础上加用甘利欣每日1次,30 m l静脉滴注。疗程均为4周。治疗前后每周详细记录患者症状、体征、肝功能、肾功能、电解质及血尿常规,同时记录治疗过程中的不良反应及停药后随访3个月。结果2组疗效均显著,肝功能生化指标与治疗前相比有统计学意义(治疗组P<0.01,对照组P<0.05),治疗结束后生化指标下降程度2组也有统计学意义(P<0.05),治疗组明显优于对照组,且治疗组出现的不良反应明显少于对照组。结论天晴甘美治疗各种慢性肝炎高转氨酶血症不仅疗效好,而且不良反应少,值得临床推广。展开更多
It is controversial whether steroid therapy should be continued to prevent the recurrence of autoimmune hepatitis （AIH） in patients who have undergone liver transplantation （LTx） due to AIH. We report a case of re...It is controversial whether steroid therapy should be continued to prevent the recurrence of autoimmune hepatitis （AIH） in patients who have undergone liver transplantation （LTx） due to AIH. We report a case of recurrent autoimmune hepatitis after LTx despite a persistently normal range of alanine aminotransferase （ALT）. A S0-year-old woman was admitted to our hospital because of jaundice and severe liver dysfunction, where she was diagnosed with liver failure due to AIH. Steroid therapy was not effective enough and the patient received living-donor LTx in 1999. Following the operation, the level of ALT was maintained within a normal range and anti-nuclear antibody （ANA） became negative, however, the serum level of IgG gradually elevated and ANA became positive, while platelets decreased. A liver biopsy performed 6 years after LTx showed histological findings of AIH and she was diagnosed with recurrent AIH. A recurrence of AIH may occur after LTx even if the level of ALT remains within a normal range. We consider that a protocol liver biopsy should be performed in patients who undergo LTx due to AIH to decide the indication for steroid therapy.展开更多
As a common urea-cycle disorder, ornithine transcarbamylase deficiency(OTCD) disables the conversion of ammonia into non-toxic urea, and its subsequent excretion results in hyperammonemia. We reported a 28-year-old wo...As a common urea-cycle disorder, ornithine transcarbamylase deficiency(OTCD) disables the conversion of ammonia into non-toxic urea, and its subsequent excretion results in hyperammonemia. We reported a 28-year-old woman who was diagnosed with OTCD during her first pregnancy. She was treated with arginine, citrulline and sodium benzoate for complications associated with hyperammonemia, and her protein intake was restricted. The patient’s condition was stabilized, and she delivered a baby boy via cesarean section. However, the baby died 2d later. During her second pregnancy, prenatal screening suggested that the fetus had OTCD, and an induced abortion was performed. During her third pregnancy, fetal OTCD was ruled out, and the patient was treated with oral sodium benzoate. Her blood ammonia level was stabilized, and a baby boy was successfully delivered via cesarean section. This case described the treatment process of the pregnant patient with OTCD, and the safety and efficacy of sodium benzoate were evaluated. Collectively, our findings provided the experience and evidence for the drug selection and treatment of these rare diseases.展开更多
文摘目的观察天晴甘美治疗各种慢性肝炎高转氨酶血症的临床疗效。方法选择我院住院或门诊慢性肝炎高转氨酶血症患者260例,随机分为治疗组和对照组,治疗组131例,对照组129例。治疗组在常规保肝治疗的基础上加用天晴甘美每日1次,20 m l静脉滴注,对照组在常规保肝治疗的基础上加用甘利欣每日1次,30 m l静脉滴注。疗程均为4周。治疗前后每周详细记录患者症状、体征、肝功能、肾功能、电解质及血尿常规,同时记录治疗过程中的不良反应及停药后随访3个月。结果2组疗效均显著,肝功能生化指标与治疗前相比有统计学意义(治疗组P<0.01,对照组P<0.05),治疗结束后生化指标下降程度2组也有统计学意义(P<0.05),治疗组明显优于对照组,且治疗组出现的不良反应明显少于对照组。结论天晴甘美治疗各种慢性肝炎高转氨酶血症不仅疗效好,而且不良反应少,值得临床推广。
文摘It is controversial whether steroid therapy should be continued to prevent the recurrence of autoimmune hepatitis （AIH） in patients who have undergone liver transplantation （LTx） due to AIH. We report a case of recurrent autoimmune hepatitis after LTx despite a persistently normal range of alanine aminotransferase （ALT）. A S0-year-old woman was admitted to our hospital because of jaundice and severe liver dysfunction, where she was diagnosed with liver failure due to AIH. Steroid therapy was not effective enough and the patient received living-donor LTx in 1999. Following the operation, the level of ALT was maintained within a normal range and anti-nuclear antibody （ANA） became negative, however, the serum level of IgG gradually elevated and ANA became positive, while platelets decreased. A liver biopsy performed 6 years after LTx showed histological findings of AIH and she was diagnosed with recurrent AIH. A recurrence of AIH may occur after LTx even if the level of ALT remains within a normal range. We consider that a protocol liver biopsy should be performed in patients who undergo LTx due to AIH to decide the indication for steroid therapy.
基金Clinical Trial of Xinhua Hospital(Grant No.15LC11)。
文摘As a common urea-cycle disorder, ornithine transcarbamylase deficiency(OTCD) disables the conversion of ammonia into non-toxic urea, and its subsequent excretion results in hyperammonemia. We reported a 28-year-old woman who was diagnosed with OTCD during her first pregnancy. She was treated with arginine, citrulline and sodium benzoate for complications associated with hyperammonemia, and her protein intake was restricted. The patient’s condition was stabilized, and she delivered a baby boy via cesarean section. However, the baby died 2d later. During her second pregnancy, prenatal screening suggested that the fetus had OTCD, and an induced abortion was performed. During her third pregnancy, fetal OTCD was ruled out, and the patient was treated with oral sodium benzoate. Her blood ammonia level was stabilized, and a baby boy was successfully delivered via cesarean section. This case described the treatment process of the pregnant patient with OTCD, and the safety and efficacy of sodium benzoate were evaluated. Collectively, our findings provided the experience and evidence for the drug selection and treatment of these rare diseases.
