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脑出血并发高钠血症的病因与治疗 被引量:6
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作者 费世早 陈观保 庞洪波 《华北煤炭医学院学报》 2007年第2期157-158,共2页
①目的探讨脑出血并发高钠血症的病因、临床特点及其治疗和预防。②方法对神经内科收治的206例脑出血患者资料完整者进行回顾性分析。③结果206例脑出血患者中并发高钠血症25例,其中死亡19例,病死率明显高于对照组(P<0.01)。④结论... ①目的探讨脑出血并发高钠血症的病因、临床特点及其治疗和预防。②方法对神经内科收治的206例脑出血患者资料完整者进行回顾性分析。③结果206例脑出血患者中并发高钠血症25例,其中死亡19例,病死率明显高于对照组(P<0.01)。④结论下丘脑损伤是脑出血并发高钠血症的主要原因,是脑出血的严重并发症之一,也是脑出血预后不良的重要指标,可作为脑出血死亡的独立危险因素。 展开更多
关键词 脑出 高钠血 症病因
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应用血仿膜肝素吸附法低钠透析抢救特大面积烧伤后高钠血症
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作者 王淑芬 杜娟 +2 位作者 吕恒华 钦军 龚平 《透析与人工器官》 1998年第3期25-25,共1页
关键词 仿膜肝素吸附法 特大面积烧伤 高钠血 液透析 烧伤后 小板计数 透析液 透析治疗 低钠 烧伤患者
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治愈特重度烧伤合并高钠高氯血症1例 被引量:3
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作者 刘江月 李智 +1 位作者 王建强 李捆 《临床医药实践》 2004年第5期388-388,共1页
关键词 特重度烧伤 合并症 高钠高氯 治疗
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采用临床路径治疗重度烧伤并发高钠高氯血症 被引量:1
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作者 章荣涛 赵遵江 +2 位作者 张保德 刘勇 梁启国 《中国医药指南》 2013年第12期647-648,共2页
目的了解合并高钠高氯血症的重度烧伤的特点,研究临床治疗的优良方法。方法我院在2006年3月至2011年12月收治了64例并发高钠高氯血症的重度烧伤患者,采用临床路径对这些患者进行治疗。选取这几年前的同样病情的患者进行对照,分析比对。... 目的了解合并高钠高氯血症的重度烧伤的特点,研究临床治疗的优良方法。方法我院在2006年3月至2011年12月收治了64例并发高钠高氯血症的重度烧伤患者,采用临床路径对这些患者进行治疗。选取这几年前的同样病情的患者进行对照,分析比对。结果烧伤程度越重,烧伤面积越大,并发高钠高氯血症的可能性越大。结论重度烧伤常并发高钠高氯血症,对患者的健康危害大。在临床治疗过程中,注意机体水电解质代谢的变化,采取相应的治疗方法,才能使患者尽快恢复健康。 展开更多
关键词 重度烧伤 高钠高氯 临床治疗
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连续血液净化治疗重度烧伤并发高钠高氯血症疗效评估 被引量:1
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作者 莫伟胜 卜会驹 郭发良 《现代诊断与治疗》 CAS 2014年第6期1210-1211,共2页
目的连续血液净化治疗重度烧伤并发高钠高氯血症的临床疗效及意义,为临床治疗重度烧伤并发高钠高氯血症提供理论依据。方法选取我院2010年3月-2013年3月收治的30例采用连续血液净化治疗重度烧伤并发高钠高氯血症的病例为观察组,选取同... 目的连续血液净化治疗重度烧伤并发高钠高氯血症的临床疗效及意义,为临床治疗重度烧伤并发高钠高氯血症提供理论依据。方法选取我院2010年3月-2013年3月收治的30例采用连续血液净化治疗重度烧伤并发高钠高氯血症的病例为观察组,选取同期收治的采用常规治疗方法治疗的患者30例为对照组,对两组患者疗效进行评估分析。结果观察组的治疗效果更具有优越性,观察组总有效率明显高于对照组(P〈0.05)。结论连续血液净化治疗重度烧伤并发高钠高氯血症副作用低,病人回复快,不良反应少。 展开更多
关键词 连续液净化 重度烧伤 高钠高氯
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恶性肿瘤脑转移合并高钠高氯血症二例报告
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作者 宁晓红 陈书长 《北京医学》 CAS 2006年第11期702-702,共1页
关键词 高钠高氯 肿瘤脑转移 Β2-微球蛋白 纵隔淋巴结肿大 非霍奇金淋巴瘤 恶性 CT引导 肿大淋巴结
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复方氨基酸注射液联合小剂量垂体后叶素治疗重症颅脑损伤合并高钠高氯血症的临床效果 被引量:1
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作者 彭晓红 卢有亮 +1 位作者 黎卉 李文慧 《临床合理用药杂志》 2022年第16期79-81,共3页
目的观察复方氨基酸注射液联合小剂量垂体后叶素治疗重症颅脑损伤合并高钠高氯血症的临床效果。方法选取2018年12月—2021年2月广州中医药大学第一附属医院白云医院收治的重症颅脑损伤合并高钠高氯血症患者70例,以随机数字表法分为研究... 目的观察复方氨基酸注射液联合小剂量垂体后叶素治疗重症颅脑损伤合并高钠高氯血症的临床效果。方法选取2018年12月—2021年2月广州中医药大学第一附属医院白云医院收治的重症颅脑损伤合并高钠高氯血症患者70例,以随机数字表法分为研究组与对照组各35例。研究组采用复方氨基酸注射液联合小剂量垂体后叶素治疗,对照组采用小剂量垂体后叶素治疗。比较2组患者疾病预后情况,治疗前后血清钠、血清氯水平,入住ICU时间、治疗前后急性生理与慢性健康评分(APACHEⅡ评分)及28 d生存率。结果研究组患者预后良好率为77.14%,高于对照组的54.29%(χ^(2)=4.058,P=0.044)。治疗后,2组患者的血清钠及血清氯水平均显著低于治疗前,且研究组均低于对照组(P<0.05)。治疗后,2组患者的APACHEⅡ评分均显著低于治疗前,且研究组低于对照组(P<0.05);研究组患者入住ICU时间短于对照组,28 d生存率高于对照组(P<0.05)。结论采取复方氨基酸注射液联合小剂量垂体后叶素治疗重症颅脑损伤合并高钠高氯血症,可显著降低血清钠及血清氯水平,改善预后,提升生存率,缩短住院时间,值得应用与推广。 展开更多
关键词 重症颅脑损伤 高钠高氯 复方氨基酸注射液 垂体后叶素 小剂量
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脑出血后高钠高氯血症的临床研究 被引量:7
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作者 张学军 陈志琴 李华 《中风与神经疾病杂志》 CAS CSCD 北大核心 2007年第5期609-611,共3页
目的研究脑出血后高钠高氯血症的发生原因及预后。方法对431例脑出血患者进行入院常规电解质检查并复查,对高钠高氯血症组和非高钠高氯血症组的预后、出血部位、高热情况、合并症、糖尿病史、入院时意识情况和甘露醇使用剂量等进行对照... 目的研究脑出血后高钠高氯血症的发生原因及预后。方法对431例脑出血患者进行入院常规电解质检查并复查,对高钠高氯血症组和非高钠高氯血症组的预后、出血部位、高热情况、合并症、糖尿病史、入院时意识情况和甘露醇使用剂量等进行对照研究。结果高钠高氯血症发生率为7.42%,病死率68.75%,其中高钠高氯血症组在丘脑出血、高热、合并症、合并糖尿病、意识障碍程度和甘露醇使用剂量等方面高于非高钠高氯血症组。结论脑出血后的高钠高氯血症的发生原因是多方面的,不但有中枢性原因,也有治疗方面的原因,病死率较高。 展开更多
关键词 脑出 高钠高氯
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螺内酯治疗大面积烧伤合并高钠高氯血症的临床研究 被引量:1
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作者 董士华 曲狄 +2 位作者 王雪莹 刘铭然 张大威 《中国医药指南》 2012年第13期130-131,共2页
目的就螺内酯治疗大面积烧伤合并高钠高氯血症进行临床研究。方法选择2005年3月至2010年7月大庆油田总医院烧伤科收治的大面积烧伤合并高钠高氯血症患者25例,对其进行有效治疗,在治疗的同时,采用螺内酯120mg/d,分3次口服。结果 25例大... 目的就螺内酯治疗大面积烧伤合并高钠高氯血症进行临床研究。方法选择2005年3月至2010年7月大庆油田总医院烧伤科收治的大面积烧伤合并高钠高氯血症患者25例,对其进行有效治疗,在治疗的同时,采用螺内酯120mg/d,分3次口服。结果 25例大面积烧伤合并高钠高氯血症患者经过上述治疗之后,显效(症状较治疗前明显减轻)18例(72%),有效(症状有所减轻)6例(24%),无效(治疗前后临床症状无改善)1例(4%),总有效率96%。高钠高氯血症的病死率明显下降,25例大面积烧伤合并高钠高氯血症患者中只有1例因严重脓毒血症死于多器官功能衰竭外,其余24例均治愈,治愈率明显上升,可见治疗效果良好。结论螺内酯对于改善大面积烧伤合并高钠高氯血症患者的预后和恢复等方面均具有重要意义。 展开更多
关键词 螺内酯 大面积烧伤 高钠高氯 临床研究
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金水宝胶囊在重症脑卒中患者高氯血症中的应用
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作者 曾瀛 高琳 +1 位作者 陈勇 朱秋艳 《中国当代医药》 CAS 2021年第34期61-64,68,共5页
目的探讨金水宝胶囊治疗重症脑卒中合并高钠高氯血症对患者肾功能的影响。方法选取2018年3月至2020年12月于宜春市人民医院就诊的148例重症脑卒中患者作为研究对象,其中高钠高氯血症72例,非高钠高氯血症76例。另将高钠高氯血症72例患者... 目的探讨金水宝胶囊治疗重症脑卒中合并高钠高氯血症对患者肾功能的影响。方法选取2018年3月至2020年12月于宜春市人民医院就诊的148例重症脑卒中患者作为研究对象,其中高钠高氯血症72例,非高钠高氯血症76例。另将高钠高氯血症72例患者按随机数字表法分为A组(36例)和B组(36例);非高钠高氯血症76例按随机数字表法分为C组(38例)和D组(38例)。A组和C组采用常规综合治疗,B组和D组加用金水宝胶囊治疗。比较四组患者的神经功能、肾功能。结果治疗前,B组与A组、D组与C组、B组与D组、A组与C组患者的神经功能比较,差异无统计学意义(P>0.05);治疗后,四组患者的美国国立卫生研究所卒中量表(NIHSS)评分、改良Rankin量表(mRS)评分低于治疗前,格拉斯哥昏迷(GCS)评分高于治疗前,差异有统计学意义(P<0.05);治疗后,B组患者的NIHSS评分、mRS评分低于A组,GCS评分高于A组,差异有统计学意义(P<0.05);治疗后,D组患者的NIHSS评分、mRS评分低于C组,GCS评分高于C组,差异有统计学意义(P<0.05);治疗后,B组患者的NIHSS评分、mRS评分高于D组,GCS评分低于D组,A组患者的NIHSS评分、mRS评分高于C组,GCS评分低于C组,差异有统计学意义(P<0.05)。治疗前,四组患者的肾功能比较,差异无统计学意义(P>0.05);治疗后,四组患者的血尿素氮(BUN)、肌酐(Cr)水平低于治疗前,差异有统计学意义(P<0.05);治疗后,B组患者的BUN、Cr水平低于A组,差异有统计学意义(P<0.05);治疗后,D组患者的BUN、Cr水平低于C组,差异有统计学意义(P<0.05);治疗后,B组患者的BUN、Cr高于D组,A组患者的BUN、Cr高于C组,差异有统计学意义(P<0.05)。结论金水宝胶囊可增强重症脑卒中合并高钠高氯血症患者的治疗效果,加快患者神经功能恢复,减轻肾功能损害,利于患者尽早康复。 展开更多
关键词 重症脑卒中 高钠高氯 金水宝胶囊 肾功能 神经功能
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采用临床路径治疗重度烧伤并发高钠高氯血症 被引量:2
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作者 马驰 石富胜 《中国基层医药》 CAS 2012年第11期1722-1723,共2页
2005年3月至2010年12月共收治特重度烧伤并发高钠高氯血症患者18例,对其按照临床医疗路径实施治疗,针对其发生的病因相关因素、临床特点进行实施治疗,回顾性选取12例特重度烧伤并发高钠高氯血症患者作为对照进行对比研究。现报告如下。
关键词 高钠高氯 特重度烧伤 临床路径 并发 治疗 临床医疗 相关因素 临床特点
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Associations between serum potassium and sodium levels and risk of hypertension: a community-based cohort study 被引量:4
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作者 Lu XI Yong-Chen HAO Jing LIU Wei WANG Miao WANG Guo-Qi LI Yue QI Fan ZHAO Wu-Xiang XIE Yan LI Jia-Yi SUN Jun LIU Lan-Ping QIN Dong ZHAO 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2015年第2期119-126,共8页
Objective Several studies have examined the relationships between dietary potassium and sodium and hypertension, but few have evaluated the association between serum potassium or sodium and risk of incident hypertensi... Objective Several studies have examined the relationships between dietary potassium and sodium and hypertension, but few have evaluated the association between serum potassium or sodium and risk of incident hypertension. We therefore investigated the associations between serum potassium and sodium and risk of incident hypertension in a Chinese community-based population. Methods A total of 839 normotensive individuals without cardiovascular disease from the Chinese Multi-Provincial Cohort Study who took part in the baseline examination in 2007-2008 and the follow-up survey in 2012-2013 were included in this study. Odds ratios (OR) and 95% confidence intervals (95%CI) for baseline serum potassium and sodium in relation to the risk of new-onset hypertension were evaluated using multivari- ate logistic regression models. Results During five years of follow-up, 218 (26.0%) individuals progressed to hypertension. Logistic re- gression adjusting for multiple confounders showed that every 1 mEq/L increment in baseline serum potassium level was associated with a 75% increased risk of hypertension (OR: 1.75; 95%CI: 1.01-3.04; P = 0.04). Compared with adults with serum potassium level of 4.20-4.79 mEq/L, adults with level 〉 4.80 mEq/L had an 84% increased risk of hypertension (OR: 1.84; 95%CI: 1.14-2.96; P = 0.01). There was no significant association between serum sodium and risk of hypertension (OR: 0.96; 95%CI: 0.89-1.04; P = 0.33). Conclusions Base- line serum potassium level, but not baseline serum sodium level, was positively related to the risk of incident hypertension in the Chinese population. 展开更多
关键词 HYPERTENSION POTASSIUM SERUM SODIUM
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Lower body weight and female gender:Hyperphosphatemia risk factors after sodium phosphate preparations
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作者 Parakkal Deepak Eli D Ehrenpreis 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第21期2681-2682,共2页
Casals et al have reported an inverse correlation between serum phosphate and body weight after administration of sodium phosphate at a dose of 60 g. Our group has already described the relationship between body weigh... Casals et al have reported an inverse correlation between serum phosphate and body weight after administration of sodium phosphate at a dose of 60 g. Our group has already described the relationship between body weight and hyperphosphatemia with these preparations, although our study was not quoted by Casals. We performed a pharmacokinetic study involving 13 volunteers who were divided into two groups on the basis of body weight: group I consisting of seven women with a median weight of 60 kg and group Ⅱ consisting of five men and one woman with a median weight of 119.2 kg. Group Ⅰdeveloped higher peak phosphate levels and maintained these levels above the subjects in Group Ⅱ for a prolonged time period despite adequate hydration being ensured with frequent monitoring of weight, fluid intake and total body weight. Our studydemonstrated that adequate hydration does not protect against the secondary effects of hyperphosphatemia. In the study by Casais et al, 66% of the study subjects were women, the correlation between serum phosphate and gender in their data also appears to be important. Women are at higher risk of acute phosphate nephropathy due to a diminished volume of distribution of the high dose of ingested phosphate. Decreased volume of distribution in women is due to diminished body weight. This is further compounded by decreased creatinine clearance in females. 展开更多
关键词 Colonoscopy bowel preparation Lower body weight HYPERPHOSPHATEMIA Sodium phosphate FEMALE
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Effect of Allocryptopine on Late sodium current of atrial myocytes in spontaneously hypertensive rats
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作者 Ying ZHAO Xiao-Ting XIE +7 位作者 Yan-Mei SUN Zhong-Qi CAI Ying DONG Chao ZHU Xi CHEN Hong-Lin WU Jian-Cheng ZHANG Yang LI 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2017年第4期280-286,共7页
Objective To explore the effect of allocryptopine (All) on the Late sodium current (INa,Late) of atrial myocytes in spontaneously hyper- tensive rats (SHR). Method The enzyme digestion method was used to separat... Objective To explore the effect of allocryptopine (All) on the Late sodium current (INa,Late) of atrial myocytes in spontaneously hyper- tensive rats (SHR). Method The enzyme digestion method was used to separate single atrial myocytes from SHR and Wistar-Kyoto rat (WKY) rats. INa,Late was record by patch-clamp technique and the effect of All on the current was evaluated. Results Comparing with WKY cells, markedly increasing of INa,Late current in SHR myocytes was found from 0.24 ± 0.02 pA/pF of WKY cells to 1.73± 0.04 pA/pF of SHR cells (P 〈 0.01, n = 15). After treament with 30 μmol/L All; the current densities was reduced to 0.92 ± 0.03 pA/pF. The ratio of INa,Late/INa,peak of WKY and SHR were 0.09% ± 0.01% and 0.71% ± 0.02%, INa, Late/INa,peak of SHR was reduced to 0.37% ± 0.02% by 30 μmol/L All (P 〈 0.01, n = 15). We also determined the effect of All on the gating mechanism of the INa,Late in the SHR cells. It was found that All decreased the INa,Late by alleviating the inactivation of the channels and increasing the window current of sodium channel. Conclusion Increased INa,Late in SHR atrial myocytes and the prolonged APD were inhibited by All coming from Chinese herb medicine. 展开更多
关键词 Action potential ALLOCRYPTOPINE Atrial myocytes Late sodium current Spontaneously hypertensive rats
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重型颅脑损伤患者常见并发症的监测及护理 被引量:167
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作者 缪建平 茹卫芳 《中华护理杂志》 CSCD 北大核心 2003年第6期435-437,共3页
目的 :探讨影响重型颅脑损伤患者预后的常见严重并发症及其监护措施。方法 :将 2 6 4例患者收入NICU ,进行多系统综合监护 :动态颅内压 ,脑灌注压 ,动脉血氧分压 ,心电、脉搏氧饱和度 ,血气分析 ,血液生化检查和生命体征等 ,对可能继发... 目的 :探讨影响重型颅脑损伤患者预后的常见严重并发症及其监护措施。方法 :将 2 6 4例患者收入NICU ,进行多系统综合监护 :动态颅内压 ,脑灌注压 ,动脉血氧分压 ,心电、脉搏氧饱和度 ,血气分析 ,血液生化检查和生命体征等 ,对可能继发的并发症采取相应的护理措施。结果 :影响重型颅脑损伤预后的严重并发症主要有重度颅高压、低氧血症、高钠高糖血症、肺部感染、消化道出血和癫痫持续状态。经严密监测与护理提高了抢救成功率 ,死亡率为 2 5 .4%。结论 :对重型颅脑损伤的常见严重并发症只要监护措施得当是可以预防的 ,并可降低其死亡率和致残程度。 展开更多
关键词 重型颅脑损伤 并发症 护理 颅内高压 低氧 高钠高糖 肺部感染 消化道出 癫痫持续状态
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Ascites, refractory ascites and hyponatremia in cirrhosis 被引量:2
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作者 Brett Fortune Andres Cardenas 《Gastroenterology Report》 SCIE EI 2017年第2期104-112,I0001,共10页
Ascites is the most common complication related to cirrhosis and is associated with increased morbidity and mortality.Ascites is a consequence of the loss of compensatory mechanisms to maintain the overall effective a... Ascites is the most common complication related to cirrhosis and is associated with increased morbidity and mortality.Ascites is a consequence of the loss of compensatory mechanisms to maintain the overall effective arterial blood volume due to worsening splanchnic arterial vasodilation as a result of clinically significant portal hypertension.In order to maintain effective arterial blood volume,vasoconstrictor and antinatriuretic pathways are activated,which increase overall sodiumand fluid retention.As a result of progressive splanchnic arterial vasodilation,intestinal capillary pressure increases and results in the formation of protein-poor fluid within the abdominal cavity due to increased capillary permeability from the hepatic sinusoidal hypertension.In some patients,the fluid can translocate across diaphragmatic fenestrations into the pleural space,leading to hepatic hydrothorax.In addition,infectious complications such as spontaneous bacterial peritonitis can occur.Eventually,as the liver disease progresses related to higher portal pressures,loss of a compensatory cardiac output and further splanchnic vasodilation,kidney function becomes compromised fromworsening renal vasoconstriction as well as the development of impaired solute-free water excretion and severe sodium retention.Thesemechanisms then translate into significant clinical complications,such as refractory ascites,hepatorenal syndrome and hyponatremia,and all are linked to increased short-termmortality.Currently,liver transplantation is the only curative option for this spectrumof clinical manifestations but ongoing research has led to further insight on alternative approaches.This review will further explore the current understanding on the pathophysiology andmanagement of ascites as well as expand on two advanced clinical consequences of advanced liver disease,refractory ascites and hyponatremia. 展开更多
关键词 ASCITES portal hypertension CIRRHOSIS HYPONATREMIA
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0.9% saline is neither normal nor physiological 被引量:1
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作者 Heng LI Shi-ren SUN +2 位作者 John Q.YAP Jiang-hua CHEN Qi QIAN 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2016年第3期181-187,共7页
The purpose of this review is to objectively evaluate the biochemical and pathophysiological properties of 0.9% saline (henceforth: saline) and to discuss the impact of saline infusion, specifically on systemic aci... The purpose of this review is to objectively evaluate the biochemical and pathophysiological properties of 0.9% saline (henceforth: saline) and to discuss the impact of saline infusion, specifically on systemic acid-base bal- ance and renal hemodynamics. Studies have shown that electrolyte balance, including effects of saline infusion on serum electrolytes, is often poorly understood among practicing physicians and inappropriate saline prescribing can cause increased morbidity and mortality. Large-volume (〉2 L) saline infusion in healthy adults induces hyperohloremia which is associated with metabolic acidosis, hyperkalemia, and negative protein balance. Saline overload (80 ml/kg) in rodents can cause intestinal edema and contractile dysfunction associated with activation of sodium-proton exchanger (NHE) and decrease in myosin light chain phosphorylation. Saline infusion can also adversely affect renal hemody- namics. Microperfusion experiments and real-time imaging studies have demonstrated a reduction in renal perfusion and an expansion in kidney volume, compromising 02 delivery to the renal perenchyma following saline infusion. Clinically, saline infusion for patients post abdominal and cardiovascular surgery is associated with a greater number of adverse effects including more frequent blood product transfusion and bicarbonate therapy, reduced gastric blood flow, delayed recovery of gut function, impaired cardiac contractility in response to inotropes, prolonged hospital stay, and possibly increased mortality. In critically ill patients, saline infusion, compared to balanced fluid infusions, in- creases the occurrence of acute kidney injury. In summary, saline is a highly acidic fluid. With the exception of saline infusion for patients with hypochloremic metabolic alkalosis and volume depletion due to vomiting or upper gastroin- testinal suction, indiscriminate use, especially for acutely ill patients, may cause unnecessary complications and should be avoided. More education regarding saline-related effects and adequate electrolyte management is needed. 展开更多
关键词 0.9% saline Hyperchloremia ACIDOSIS HYPERKALEMIA Balanced fluids Renal hemodynamics
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Analysis of treatment regimen in a pregnant patient with ornithine transcarbamylase deficiency
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作者 Lixia Li Yingxiu Liu Junming Du 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2020年第9期666-670,共5页
As a common urea-cycle disorder, ornithine transcarbamylase deficiency(OTCD) disables the conversion of ammonia into non-toxic urea, and its subsequent excretion results in hyperammonemia. We reported a 28-year-old wo... As a common urea-cycle disorder, ornithine transcarbamylase deficiency(OTCD) disables the conversion of ammonia into non-toxic urea, and its subsequent excretion results in hyperammonemia. We reported a 28-year-old woman who was diagnosed with OTCD during her first pregnancy. She was treated with arginine, citrulline and sodium benzoate for complications associated with hyperammonemia, and her protein intake was restricted. The patient’s condition was stabilized, and she delivered a baby boy via cesarean section. However, the baby died 2d later. During her second pregnancy, prenatal screening suggested that the fetus had OTCD, and an induced abortion was performed. During her third pregnancy, fetal OTCD was ruled out, and the patient was treated with oral sodium benzoate. Her blood ammonia level was stabilized, and a baby boy was successfully delivered via cesarean section. This case described the treatment process of the pregnant patient with OTCD, and the safety and efficacy of sodium benzoate were evaluated. Collectively, our findings provided the experience and evidence for the drug selection and treatment of these rare diseases. 展开更多
关键词 Ornithine transcarbamylase deficiency PREGNANCY HYPERAMMONEMIA Sodium benzoate
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