大黄、络泰对鱼胆毒致MODS治疗作用的实验研究

目的 探讨鱼胆毒对大耳白兔心、肝、肾、肠的损伤所致多器官功能障碍综合征 (MODS)的机理以及大黄、络泰对MODS的治疗作用。方法 采用鲜草鱼胆汁灌胃法制作动物MODS模型 ,分别测定治疗前后不同时段动物血清超氧化物歧化酶 (SOD)及血清、尿液中 β2 微球蛋白 (β2 -MG)含量 ;并取各组动物心、肝、肾、肠四种组织观察病理及超微结构变化。结果 治疗前对照组及各治疗组SOD均呈进行性降低 ,治疗后逐渐恢复 ;对照组与大黄、络泰两治疗组差异显著 (P <0 0 5 ) ,与大黄、络泰联合治疗组差异非常显著 (P <0 0 1) ;血及尿液 β2 -MG治疗前均进行性升高 ,治疗后逐渐恢复。对照组与大黄、络泰两治疗组差异显著 (P <0 0 5 ) ;与大黄、络泰联合治疗组差异显著 (P <0 0 1)。心、肝、肠组织细胞均有不同程度的病理结构改变 ,而各治疗组较对照组病理改变轻。结论 大黄、络泰具有抗氧自由基及保护心、肝、肾、肠组织细胞及黏膜作用 ,两药联合使用作用更佳 。

血液透析治疗抢救鱼胆中毒所致急性肾功衰6例

民间常用口服鱼胆来治疗慢性支气管炎及眼病、高血压等,但由此可发生中毒,甚至导致死亡。我院于1994年来用血液透析治疗抢救6例服用鱼胆致急性肾功能衰竭患者,现报导如下:

鱼胆中毒1例报告

鱼胆中毒临床少见，本院近年曾收治1例，现报告如下：

Multiple organ dysfunction syndrome due to ingestion of fish gall bladder

OBJECTIVE: To investigate changes in renal function, urine N-acetyl-beta-D-glucosaminidase enzyme (N-AG),liver function, myocardial enzymes, the pathology of renal damage and the mechanism of acute renal failure (ARF) associated with fish gall bladder poisoning. METHODS: Eleven patients with acute fish gall bladder poisoning were consecutively admitted to our hospital from September 1997 to October 1999. Renal function, urine N-AG enzyme, liver function, and myocardial enzymes were assayed before and after treatment. One patient consented to a kidney biopsy and the pathology of renal damage was observed under light and electron microscopes. RESULTS: All patients had multiple organ dysfunction syndrome (MODS) and 11 patients suffered from ARF. Ten patients had liver dysfunction, ten patients had poisonous myocarditis, and 8 patients had gastrointestinal dysfunction. Renal function, urine N-AG enzyme, liver function, and myocardial enzymes were significantly improved after treatment compared with those of before treatment (P