An ishemic ventricular tachyarrhythmias canine model was established in open-chest dogs subjected to programmed electrical stimulation (PES)for 5-8 days after acute myocardial infarction. The electrophysiologic effect...An ishemic ventricular tachyarrhythmias canine model was established in open-chest dogs subjected to programmed electrical stimulation (PES)for 5-8 days after acute myocardial infarction. The electrophysiologic effects of neferine (Nef) and procainamide (PA) were observed in this model. With routine methods of PES,ventricular tachycardia (VT)and ventricular fibrillation (VF) could be reproducibly initiated. Both drugs lengthened the QTc interval (P【0.01) and effective refractory period(ERP)of normal and ischemic ventricular myocardia (NERP and IERP) respectively (P【0.01), decreased the dispersion of ERP in ischemic myocardium and the dispersion of ERP in left ventricle (P【0.01), and increased the diastolic excitability threshold of normal and ischemic ventricular myocardia (P【0.01). The two compounds prevented the PES-induced VT or VF (Nef group P【0.01, PA group P【0.05) and ischemia-induced VF (P【0.05). The results indicated that neferine and procainamide may be effective in preventing the onset of reentrant ventricular tachyarrhythmias after myocardial ischemic damage in dogs.展开更多
The work deals with analysis of geographical factor as one of the main factor determining the historical change of a border on the example of Georgia. The research was conducted in two main directions: the evaluation...The work deals with analysis of geographical factor as one of the main factor determining the historical change of a border on the example of Georgia. The research was conducted in two main directions: the evaluation of historical transformations of state borders of Georgia throughout of XIX-XX centuries and identification the leading geographical factors. Special emphasis has been made on geographical and cartometric analysis of modern state border of Georgia. In order to identify the historical transformations of state border that have used different methods as well as GIS-technologies, the research is based on the historical, cartographical and statistical data. On the base of a lot of cartographic sources, it is concluded that the borderline in modem topographic maps is often plotted by ignoring the international practice related to plotting the state borders across the physical-geographical objects. This is why the geographical factor seems important in the historical transformations of the state border creating similarly a negative perspective in the future. The main results of research are: (1) classification of geographical factors causing the transformations of the state borders; (2) Evaluation of sensitivity of state border; and (3) creation of DB of the state border of Georgia, allowing continuing the studies in the future.展开更多
According to ancient Georgian traditional winemaking technology, the crushed grape is placed in a clay vessel (qvevri) dug in the ground, and alcoholic fermentation is carried out together with solid parts of grape ...According to ancient Georgian traditional winemaking technology, the crushed grape is placed in a clay vessel (qvevri) dug in the ground, and alcoholic fermentation is carried out together with solid parts of grape cluster (stem, skin, seeds). Quantitative content of phenolic compounds and antiradical efficiency of Kakhethian wines were studied and findings are compared to the appropriate data of the European wines. Analysis showed Kakhethian wines to considerably surpass the European wines with regard to total phenolics compounds: 1,330-2,430 mg/L (Kakhethian white wines), 210-468 mg/L (European white wines), 2,898-4,416 mg/L (Kakhethian red wines), 1,630-2,340 mg/L (European red wines). Average value of antiradical efficiency of white and red wines of Kakhethian type was found to exceed the average value of antiradical efficiency of white and red wines of European type, by 2.3 and 1.7 times, respectively. Georgian wines in the world market are submitted in an insufficient measure, and the purpose of this work is r^v~alino their naritiv~ a,nlitie~展开更多
The purpose of this study is to analyze the robust performance of equity-based sukuk in Malaysia, that is, Musharakah and Mudharabah contract. Accounting and Auditing Organization for Islamic Financial Institutions (...The purpose of this study is to analyze the robust performance of equity-based sukuk in Malaysia, that is, Musharakah and Mudharabah contract. Accounting and Auditing Organization for Islamic Financial Institutions (AAOIFI), as an international standard-setting organization for Islamic finance, raised an issue that 85% issuances of Musharakah and Mudharabah sukuk have breached the shariah rulings and do not comply with Islamic principles (AAOIFI, 2002). Consequently, the performance of equity-based sukuk in Malaysia was affected. This study used a secondary data for size of issuances which are gathered from Bank Negara Malaysia (BNM)'s Bond Info website and Securities Commission (SC) website. The performance of equity-based sukuk, either Musharakah or Mudarabah, is robust in the study year period of 2000-2012 as regards their sizes of issuances.展开更多
The research analyzed the expression and difference of MSTN/Smad signal path genes(MSTN, Smad2, Smad3,Smad4, TGFBR1, TGFBR2) in Turpan black sheep muscle tissue, as well as the correlation with some growth indices. Be...The research analyzed the expression and difference of MSTN/Smad signal path genes(MSTN, Smad2, Smad3,Smad4, TGFBR1, TGFBR2) in Turpan black sheep muscle tissue, as well as the correlation with some growth indices. Besides,the research used the fluorescence quantitative PCR technique to detect the expression level of MSTN, Smad2, Smad3, Smad4,TGFBR1 and TGFBR2 genes in m RNA of Turpan black sheep muscle. The research also used conventional and histological methods to determine the muscle growth and meat producibility indices, discussed the relationship between MSTN/Smad signal path and muscle growth and meat production. The result shows that these genes are expressed in Turpan black sheep muscle tissues, and have some relationship with body weight, height, length, chest circumference, hoof circumference, carcass and dressing percentage. The MSTN gene is negatively correlated with body weight(r = 0.993, P < 0.05), and hoof circumference(r= 0.957, p < 0.01), but has no significant correlation with body height, length, carcass weight, dressing percentages(P > 0.05);Smad2 gene shows significantly negative correlation the with dressing percentage(r = 0.918, p < 0.05), but no significant correlation with body weight, height, length, chest circumference, hoof circumference and carcass(P > 0.05); Smad3 gene shows no significant correlation with any of them(P > 0.05); Smad4, TGFBR1, TGFBR2 did not show any significant relationship with body height, length, chest circumference, weight and dressing percentage(P > 0.05).展开更多
This study focuses on the characters of public perceptions on climate and cryosphere change,which are based on a questionnaire survey in the(U|¨)r(u|¨)mqi River Basin.In comparison with scientific observatio...This study focuses on the characters of public perceptions on climate and cryosphere change,which are based on a questionnaire survey in the(U|¨)r(u|¨)mqi River Basin.In comparison with scientific observation results of climate and cryosphere change,this paper analyzes the possible impact of the change on water resources and agriculture production in the area.Perceptions of most respondents on climate and cryosphere changes confirm the main objective facts.For the selection of adaptation measures addressing the shortage of water resource,the results are as follows:most people preferred to choose the measures like "policy change" and "basic facility construction" which are mostly implemented by the government and the policy-making department;some people showed more preference to the measures of avoiding unfavorable natural environment,such as finding job in or migrating to other places.The urgency of personal participation in the adaptation measures is still inadequate.Some adaptation measures should be implemented in line with local conditions and require the organic combination of "resource-development" with "water-saving".展开更多
To meet the current energy needs of society,the highly efficient and continuous production of clean energy is required.One of the key issues facing the green hydrogen evolution is the construction of efficient,low-cos...To meet the current energy needs of society,the highly efficient and continuous production of clean energy is required.One of the key issues facing the green hydrogen evolution is the construction of efficient,low-cost electrocatalysts.Prussian blue(PB),Prussian blue analogs(PBAs),and their derivatives have tunable metal centers and have attracted significant interest as novel photo-and electrochemical catalysts.In this review,recent research progress into PB/PBA-based hollow structures,substrate-supported nanostructures,and their derivatives for green water splitting is discussed and summarized.First,several remarkable examples of nanostructured PB/PBAs supported on substrates(copper foil,carbon cloth,and nickel foam)and hollow structures(such as single-shelled hollow boxes,open hollow cages,and intricate hollow structures(multi-shell and yolk-shell))are discussed in detail,including their synthesis and formation mechanisms.Subsequently,the applications of PB/PBA derivatives((hydr)oxides,phosphides,chalcogenides,and carbides)for water splitting are discussed.Finally,the limitations in this research area and the most urgent challenges are summarized.We hope that this review will stimulate more researchers to develop technologies based on these intricate PB/PBA structures and their derivatives for highly efficient,green water splitting.展开更多
Robust Clustering methods are aimed at avoiding unsatisfactory results resulting from the presence of certain amount of outlying observations in the input data of many practical applications such as biological sequenc...Robust Clustering methods are aimed at avoiding unsatisfactory results resulting from the presence of certain amount of outlying observations in the input data of many practical applications such as biological sequences analysis or gene expressions analysis. This paper presents a fuzzy clustering algorithm based on average link and possibilistic clustering paradigm termed as AVLINK. It minimizes the average dissimilarity between pairs of patterns within the same cluster and at the same time the size of a cluster is maximized by computing the zeros of the derivative of proposed objective function. AVLINK along with the proposed initialization procedure show a high outliers rejection capability as it makes their membership very low furthermore it does not requires the number of clusters to be known in advance and it can discover clusters of non convex shape. The effectiveness and robustness of the proposed algorithms have been demonstrated on different types of protein data sets.展开更多
In 1329-1334, George the Brilliant took advantage of the situation created in the llkhanate, eliminated his political opponents and restored the territorial integrity of Georgia. He created a solid legal basis for the...In 1329-1334, George the Brilliant took advantage of the situation created in the llkhanate, eliminated his political opponents and restored the territorial integrity of Georgia. He created a solid legal basis for the country and regulated the ecclesiastic area. He was in West Georgia in 1329-1332/1333. The llkhanid coin was not minted in Georgia during that period; yet, soon the king of Georgia, which had already been united by that time, restored relations with llkhanids and returned to Tbilisi, which implied making the already united Georgia subject to Mongols. Ilkhanid coins and later, coins of Chobanids, the Golden Horde and Jalayirids circulated during the reign of George the Brdhant. In 1338-1339 George the Brilliant conquered Ossetia and Ilkhanid coins were disseminated on the territory of the Golden Horde after that. Formally, Georgia remained under the control of Ilkhanids, which was replaced by Chobanids in 1338 and the governors of the Golden Horde in 757/1356; and in parallel and afterwards by Jalayirids, which is evidenced by written sources as well as numismatic data; Despite formal dependence on the foreign power, which is evidenced by the deployment of 10,000 troops at the border of Georgia as well, the country enjoyed a rather wide internal autonomy. Participation of George the Brilliant in sending envoys for the purpose of the redemption of the Jvari (Cross) Monastery in Palestine in 1316/7, 1320 cannot be assumed. It seems that in those years envoys were sent by Constantine, the king of West Georgia. All the above do not diminish the merits of George V to the Georgian nation and his historic role in terms of the political unification of the country, the creation of a legal basis for it and the regulation of ecclesiastic affairs--the accomplishments of the king, who deservedly bears the name "the Brilliant".展开更多
A mathematical model of management of a social insurance fund with exponential insurance reimburse and financing determined social programs is represented and analyzed; A probability density function and fund's funct...A mathematical model of management of a social insurance fund with exponential insurance reimburse and financing determined social programs is represented and analyzed; A probability density function and fund's functioning probabilistic characteristics are obtained, that makes it possible to determine the sufficiency of fund capital at all levels of its management. With the help of conclusion it is possible for particular period of time determine in insurance fund change of cash flow movement speed, on what basis in determined from state tax revenues assigns acceptance necessity and capacity.展开更多
文摘An ishemic ventricular tachyarrhythmias canine model was established in open-chest dogs subjected to programmed electrical stimulation (PES)for 5-8 days after acute myocardial infarction. The electrophysiologic effects of neferine (Nef) and procainamide (PA) were observed in this model. With routine methods of PES,ventricular tachycardia (VT)and ventricular fibrillation (VF) could be reproducibly initiated. Both drugs lengthened the QTc interval (P【0.01) and effective refractory period(ERP)of normal and ischemic ventricular myocardia (NERP and IERP) respectively (P【0.01), decreased the dispersion of ERP in ischemic myocardium and the dispersion of ERP in left ventricle (P【0.01), and increased the diastolic excitability threshold of normal and ischemic ventricular myocardia (P【0.01). The two compounds prevented the PES-induced VT or VF (Nef group P【0.01, PA group P【0.05) and ischemia-induced VF (P【0.05). The results indicated that neferine and procainamide may be effective in preventing the onset of reentrant ventricular tachyarrhythmias after myocardial ischemic damage in dogs.
文摘The work deals with analysis of geographical factor as one of the main factor determining the historical change of a border on the example of Georgia. The research was conducted in two main directions: the evaluation of historical transformations of state borders of Georgia throughout of XIX-XX centuries and identification the leading geographical factors. Special emphasis has been made on geographical and cartometric analysis of modern state border of Georgia. In order to identify the historical transformations of state border that have used different methods as well as GIS-technologies, the research is based on the historical, cartographical and statistical data. On the base of a lot of cartographic sources, it is concluded that the borderline in modem topographic maps is often plotted by ignoring the international practice related to plotting the state borders across the physical-geographical objects. This is why the geographical factor seems important in the historical transformations of the state border creating similarly a negative perspective in the future. The main results of research are: (1) classification of geographical factors causing the transformations of the state borders; (2) Evaluation of sensitivity of state border; and (3) creation of DB of the state border of Georgia, allowing continuing the studies in the future.
文摘According to ancient Georgian traditional winemaking technology, the crushed grape is placed in a clay vessel (qvevri) dug in the ground, and alcoholic fermentation is carried out together with solid parts of grape cluster (stem, skin, seeds). Quantitative content of phenolic compounds and antiradical efficiency of Kakhethian wines were studied and findings are compared to the appropriate data of the European wines. Analysis showed Kakhethian wines to considerably surpass the European wines with regard to total phenolics compounds: 1,330-2,430 mg/L (Kakhethian white wines), 210-468 mg/L (European white wines), 2,898-4,416 mg/L (Kakhethian red wines), 1,630-2,340 mg/L (European red wines). Average value of antiradical efficiency of white and red wines of Kakhethian type was found to exceed the average value of antiradical efficiency of white and red wines of European type, by 2.3 and 1.7 times, respectively. Georgian wines in the world market are submitted in an insufficient measure, and the purpose of this work is r^v~alino their naritiv~ a,nlitie~
文摘The purpose of this study is to analyze the robust performance of equity-based sukuk in Malaysia, that is, Musharakah and Mudharabah contract. Accounting and Auditing Organization for Islamic Financial Institutions (AAOIFI), as an international standard-setting organization for Islamic finance, raised an issue that 85% issuances of Musharakah and Mudharabah sukuk have breached the shariah rulings and do not comply with Islamic principles (AAOIFI, 2002). Consequently, the performance of equity-based sukuk in Malaysia was affected. This study used a secondary data for size of issuances which are gathered from Bank Negara Malaysia (BNM)'s Bond Info website and Securities Commission (SC) website. The performance of equity-based sukuk, either Musharakah or Mudarabah, is robust in the study year period of 2000-2012 as regards their sizes of issuances.
文摘The research analyzed the expression and difference of MSTN/Smad signal path genes(MSTN, Smad2, Smad3,Smad4, TGFBR1, TGFBR2) in Turpan black sheep muscle tissue, as well as the correlation with some growth indices. Besides,the research used the fluorescence quantitative PCR technique to detect the expression level of MSTN, Smad2, Smad3, Smad4,TGFBR1 and TGFBR2 genes in m RNA of Turpan black sheep muscle. The research also used conventional and histological methods to determine the muscle growth and meat producibility indices, discussed the relationship between MSTN/Smad signal path and muscle growth and meat production. The result shows that these genes are expressed in Turpan black sheep muscle tissues, and have some relationship with body weight, height, length, chest circumference, hoof circumference, carcass and dressing percentage. The MSTN gene is negatively correlated with body weight(r = 0.993, P < 0.05), and hoof circumference(r= 0.957, p < 0.01), but has no significant correlation with body height, length, carcass weight, dressing percentages(P > 0.05);Smad2 gene shows significantly negative correlation the with dressing percentage(r = 0.918, p < 0.05), but no significant correlation with body weight, height, length, chest circumference, hoof circumference and carcass(P > 0.05); Smad3 gene shows no significant correlation with any of them(P > 0.05); Smad4, TGFBR1, TGFBR2 did not show any significant relationship with body height, length, chest circumference, weight and dressing percentage(P > 0.05).
基金funded by the "973" National Social Development Research Program "Dynamic process of cryosphere,the mechanism of cryospheric impacts on climate, hydrology and ecologyadaptation measures" (Grant No.2007CB411507)Science of state key laboratory open fund of "The research of typical basin of cryosphere change and its threshold level,adaptation and strategy"(SKLCS08-04)
文摘This study focuses on the characters of public perceptions on climate and cryosphere change,which are based on a questionnaire survey in the(U|¨)r(u|¨)mqi River Basin.In comparison with scientific observation results of climate and cryosphere change,this paper analyzes the possible impact of the change on water resources and agriculture production in the area.Perceptions of most respondents on climate and cryosphere changes confirm the main objective facts.For the selection of adaptation measures addressing the shortage of water resource,the results are as follows:most people preferred to choose the measures like "policy change" and "basic facility construction" which are mostly implemented by the government and the policy-making department;some people showed more preference to the measures of avoiding unfavorable natural environment,such as finding job in or migrating to other places.The urgency of personal participation in the adaptation measures is still inadequate.Some adaptation measures should be implemented in line with local conditions and require the organic combination of "resource-development" with "water-saving".
文摘To meet the current energy needs of society,the highly efficient and continuous production of clean energy is required.One of the key issues facing the green hydrogen evolution is the construction of efficient,low-cost electrocatalysts.Prussian blue(PB),Prussian blue analogs(PBAs),and their derivatives have tunable metal centers and have attracted significant interest as novel photo-and electrochemical catalysts.In this review,recent research progress into PB/PBA-based hollow structures,substrate-supported nanostructures,and their derivatives for green water splitting is discussed and summarized.First,several remarkable examples of nanostructured PB/PBAs supported on substrates(copper foil,carbon cloth,and nickel foam)and hollow structures(such as single-shelled hollow boxes,open hollow cages,and intricate hollow structures(multi-shell and yolk-shell))are discussed in detail,including their synthesis and formation mechanisms.Subsequently,the applications of PB/PBA derivatives((hydr)oxides,phosphides,chalcogenides,and carbides)for water splitting are discussed.Finally,the limitations in this research area and the most urgent challenges are summarized.We hope that this review will stimulate more researchers to develop technologies based on these intricate PB/PBA structures and their derivatives for highly efficient,green water splitting.
文摘Robust Clustering methods are aimed at avoiding unsatisfactory results resulting from the presence of certain amount of outlying observations in the input data of many practical applications such as biological sequences analysis or gene expressions analysis. This paper presents a fuzzy clustering algorithm based on average link and possibilistic clustering paradigm termed as AVLINK. It minimizes the average dissimilarity between pairs of patterns within the same cluster and at the same time the size of a cluster is maximized by computing the zeros of the derivative of proposed objective function. AVLINK along with the proposed initialization procedure show a high outliers rejection capability as it makes their membership very low furthermore it does not requires the number of clusters to be known in advance and it can discover clusters of non convex shape. The effectiveness and robustness of the proposed algorithms have been demonstrated on different types of protein data sets.
文摘In 1329-1334, George the Brilliant took advantage of the situation created in the llkhanate, eliminated his political opponents and restored the territorial integrity of Georgia. He created a solid legal basis for the country and regulated the ecclesiastic area. He was in West Georgia in 1329-1332/1333. The llkhanid coin was not minted in Georgia during that period; yet, soon the king of Georgia, which had already been united by that time, restored relations with llkhanids and returned to Tbilisi, which implied making the already united Georgia subject to Mongols. Ilkhanid coins and later, coins of Chobanids, the Golden Horde and Jalayirids circulated during the reign of George the Brdhant. In 1338-1339 George the Brilliant conquered Ossetia and Ilkhanid coins were disseminated on the territory of the Golden Horde after that. Formally, Georgia remained under the control of Ilkhanids, which was replaced by Chobanids in 1338 and the governors of the Golden Horde in 757/1356; and in parallel and afterwards by Jalayirids, which is evidenced by written sources as well as numismatic data; Despite formal dependence on the foreign power, which is evidenced by the deployment of 10,000 troops at the border of Georgia as well, the country enjoyed a rather wide internal autonomy. Participation of George the Brilliant in sending envoys for the purpose of the redemption of the Jvari (Cross) Monastery in Palestine in 1316/7, 1320 cannot be assumed. It seems that in those years envoys were sent by Constantine, the king of West Georgia. All the above do not diminish the merits of George V to the Georgian nation and his historic role in terms of the political unification of the country, the creation of a legal basis for it and the regulation of ecclesiastic affairs--the accomplishments of the king, who deservedly bears the name "the Brilliant".
文摘A mathematical model of management of a social insurance fund with exponential insurance reimburse and financing determined social programs is represented and analyzed; A probability density function and fund's functioning probabilistic characteristics are obtained, that makes it possible to determine the sufficiency of fund capital at all levels of its management. With the help of conclusion it is possible for particular period of time determine in insurance fund change of cash flow movement speed, on what basis in determined from state tax revenues assigns acceptance necessity and capacity.