Wind speed forecasting is of great importance for wind farm management and plays an important role in grid integration. Wind speed is volatile in nature and therefore it is difficult to predict with a single model. In...Wind speed forecasting is of great importance for wind farm management and plays an important role in grid integration. Wind speed is volatile in nature and therefore it is difficult to predict with a single model. In this study, three hybrid multi-step wind speed forecasting models are developed and compared — with each other and with earlier proposed wind speed forecasting models. The three models are based on wavelet decomposition(WD), the Cuckoo search(CS) optimization algorithm, and a wavelet neural network(WNN). They are referred to as CS-WD-ANN(artificial neural network), CS-WNN, and CS-WD-WNN, respectively. Wind speed data from two wind farms located in Shandong, eastern China, are used in this study. The simulation result indicates that CS-WD-WNN outperforms the other two models, with minimum statistical errors. Comparison with earlier models shows that CS-WD-WNN still performs best, with the smallest statistical errors. The employment of the CS optimization algorithm in the models shows improvement compared with the earlier models.展开更多
The purpose of this study was to examine the behavioral impact of varying LED （light emitting diode） spectral emissions on avian species. A novel oculo-neuro-motor response to monochromatic LEDs has been identified....The purpose of this study was to examine the behavioral impact of varying LED （light emitting diode） spectral emissions on avian species. A novel oculo-neuro-motor response to monochromatic LEDs has been identified. LED colored light of sufficient intensity matched to the short-wavelength cones of avian species can efficiently diminish overall visual perception leading to an augmented behavioral response. The study method involved monitoring the change in behavioral response after exposure to high brightness monochromatic LED light to wild Osprey （Pandion haliaetus） foraging and nesting in their natural environment. Our results demonstrated a statistically significant change in foraging behaviors with wild Osprey （p = 0.005） and in nesting behavior as a result of exposure to high brightness monochromatic LED light. An augmented behavioral responses was observed which is believed to be analogous to human reaction to solar glare and glint. The neuroimaging mechanism of avian species is discussed. This novel augmented behavioral response provides a new technique of studying the neuroscience of temporal and spatial light stimulus. A non-lethal deterrence technique involving the augmented behavioral response could mitigate mortality and morbidity of avian-human conflict in areas such as airports, airplane bird strikes, and wind turbines.展开更多
Objective:This phase II study aimed at investigating the correlation between O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and protein expression,together with Ki-67 labeling index (LI),to respons...Objective:This phase II study aimed at investigating the correlation between O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and protein expression,together with Ki-67 labeling index (LI),to response,time to progression (TTP),and overall survival (OS) in newly diagnosed glioblastoma multiforme (GBM) patients treated with temozolomide (TMZ) concomitant with and adjuvant to radiotherapy (RT).Methods:From June 2005 to August 2008,34 adult patients (18-65 years),PS ≥70,with newly diagnosed GBM received TMZ 75 mg/m2 plus RT up to 60 Gy,followed by TMZ 175 mg/m2 5 days every 4 weeks for 12 doses.MGMT Methylation-specific PCR assay,MGMT protein expression,and Ki-67 expression using immunohistochemistry (IHC) were performed on the tissue blocks.The patients were followed by MRI while MR spectroscopy (MRS) was performed for the stable cases or to confirm progression and accordingly Bevacizumab 10 mg/kg every 2 weeks was added to 7 patients till further progression was proved.Results:31 cases were evaluable,12 (38.7%) had unmethylated MGMT,while 19 (61.3%) were methylated.Seventeen cases (55%) were MGMT immunonegative while 14 cases (45%) were immunopositive.The cut off value of Ki-67 LI in relation to survival was 17%,where 15 were < 17% (48.4%),and 16 were ≥ 17% (51.6%).Response evaluation started after the second dose of the adjuvant TMZ and was repeated every 2 months.The overall disease control rate (ODC) was 74.2%,where 2 patients had complete response (CR),14 had partial response (PR),and 7 had stable disease (SD),while 8 (25.8%) had progressive disease (PD).The ODC was significantly higher among methylated patients and in those with Ki-67 < 17% (P=0.0003).The median overall TTP was 12 months and the median OS was 20 months for all the patients including those who received Bevacizumab for some stable cases or as a salvage treatment in patients with good PS,the MGMT-methylated patients had a higher median TTP of 13 months (range 8 to 18 months,95% CI of 9.36 to 12.9),and OS of 24 months (range 12 to 31 months,95% CI of 16.1 to 21.32),while the unmethylated patients had a median TTP of 6.5 months and a median OS of 12 months,such correlations were highly significant (P=0.0001).MGMT immunoexpression failed to show significant correlation with MGMT promotor methylation or the outcome of the patients.Patients with Ki-67 < 17% had a median TTP of 16 months and median OS of 24 months compared to 7 and 12.5 months respectively for the patients with Ki-67 ≥17%.Significant correlation was found between the ODC,TTP,and OS with age < 52,near total excision,and TMZ doses received ≥ 10.The commonest grade 3 and 4 toxicities was neutropenia recorded in 3 patients (9.67%),thrombocytopenia in 4 patients (12.9%),and one patient with G3 nausea,vomiting,and constipations (3%),all were medically manageable.Conclusion:MGMT promotor methylation status and Ki-67 LI (but not the MGMT protein expression),could serve as prognostic markers for survival,also MGMT could identify the newly diagnosed GBM patients who will have better response to TMZ.展开更多
基金supported by the National Key Research and Development Program of China [grant number2017YFA0604500]
文摘Wind speed forecasting is of great importance for wind farm management and plays an important role in grid integration. Wind speed is volatile in nature and therefore it is difficult to predict with a single model. In this study, three hybrid multi-step wind speed forecasting models are developed and compared — with each other and with earlier proposed wind speed forecasting models. The three models are based on wavelet decomposition(WD), the Cuckoo search(CS) optimization algorithm, and a wavelet neural network(WNN). They are referred to as CS-WD-ANN(artificial neural network), CS-WNN, and CS-WD-WNN, respectively. Wind speed data from two wind farms located in Shandong, eastern China, are used in this study. The simulation result indicates that CS-WD-WNN outperforms the other two models, with minimum statistical errors. Comparison with earlier models shows that CS-WD-WNN still performs best, with the smallest statistical errors. The employment of the CS optimization algorithm in the models shows improvement compared with the earlier models.
基金This work was supported by grant No. IIP-1350562 from the National Science Foundation. NH Audubon Society provided assistance in tabulating the field results. Support at the test sites was provided by US Cellular, and NH Fish and Game Department--Milford Fish Hatchery.
文摘The purpose of this study was to examine the behavioral impact of varying LED （light emitting diode） spectral emissions on avian species. A novel oculo-neuro-motor response to monochromatic LEDs has been identified. LED colored light of sufficient intensity matched to the short-wavelength cones of avian species can efficiently diminish overall visual perception leading to an augmented behavioral response. The study method involved monitoring the change in behavioral response after exposure to high brightness monochromatic LED light to wild Osprey （Pandion haliaetus） foraging and nesting in their natural environment. Our results demonstrated a statistically significant change in foraging behaviors with wild Osprey （p = 0.005） and in nesting behavior as a result of exposure to high brightness monochromatic LED light. An augmented behavioral responses was observed which is believed to be analogous to human reaction to solar glare and glint. The neuroimaging mechanism of avian species is discussed. This novel augmented behavioral response provides a new technique of studying the neuroscience of temporal and spatial light stimulus. A non-lethal deterrence technique involving the augmented behavioral response could mitigate mortality and morbidity of avian-human conflict in areas such as airports, airplane bird strikes, and wind turbines.
文摘Objective:This phase II study aimed at investigating the correlation between O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and protein expression,together with Ki-67 labeling index (LI),to response,time to progression (TTP),and overall survival (OS) in newly diagnosed glioblastoma multiforme (GBM) patients treated with temozolomide (TMZ) concomitant with and adjuvant to radiotherapy (RT).Methods:From June 2005 to August 2008,34 adult patients (18-65 years),PS ≥70,with newly diagnosed GBM received TMZ 75 mg/m2 plus RT up to 60 Gy,followed by TMZ 175 mg/m2 5 days every 4 weeks for 12 doses.MGMT Methylation-specific PCR assay,MGMT protein expression,and Ki-67 expression using immunohistochemistry (IHC) were performed on the tissue blocks.The patients were followed by MRI while MR spectroscopy (MRS) was performed for the stable cases or to confirm progression and accordingly Bevacizumab 10 mg/kg every 2 weeks was added to 7 patients till further progression was proved.Results:31 cases were evaluable,12 (38.7%) had unmethylated MGMT,while 19 (61.3%) were methylated.Seventeen cases (55%) were MGMT immunonegative while 14 cases (45%) were immunopositive.The cut off value of Ki-67 LI in relation to survival was 17%,where 15 were < 17% (48.4%),and 16 were ≥ 17% (51.6%).Response evaluation started after the second dose of the adjuvant TMZ and was repeated every 2 months.The overall disease control rate (ODC) was 74.2%,where 2 patients had complete response (CR),14 had partial response (PR),and 7 had stable disease (SD),while 8 (25.8%) had progressive disease (PD).The ODC was significantly higher among methylated patients and in those with Ki-67 < 17% (P=0.0003).The median overall TTP was 12 months and the median OS was 20 months for all the patients including those who received Bevacizumab for some stable cases or as a salvage treatment in patients with good PS,the MGMT-methylated patients had a higher median TTP of 13 months (range 8 to 18 months,95% CI of 9.36 to 12.9),and OS of 24 months (range 12 to 31 months,95% CI of 16.1 to 21.32),while the unmethylated patients had a median TTP of 6.5 months and a median OS of 12 months,such correlations were highly significant (P=0.0001).MGMT immunoexpression failed to show significant correlation with MGMT promotor methylation or the outcome of the patients.Patients with Ki-67 < 17% had a median TTP of 16 months and median OS of 24 months compared to 7 and 12.5 months respectively for the patients with Ki-67 ≥17%.Significant correlation was found between the ODC,TTP,and OS with age < 52,near total excision,and TMZ doses received ≥ 10.The commonest grade 3 and 4 toxicities was neutropenia recorded in 3 patients (9.67%),thrombocytopenia in 4 patients (12.9%),and one patient with G3 nausea,vomiting,and constipations (3%),all were medically manageable.Conclusion:MGMT promotor methylation status and Ki-67 LI (but not the MGMT protein expression),could serve as prognostic markers for survival,also MGMT could identify the newly diagnosed GBM patients who will have better response to TMZ.
