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来源肌腱的多发黄色素瘤1例 被引量:1
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作者 都芳涛 都芳鹃 +1 位作者 赵家庆 黄永禄 《现代中西医结合杂志》 CAS 2005年第6期792-792,共1页
关键词 肌腱 黄色素瘤
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胃蛋白酶原1、G-17、HP-IgG检测,结合胃黄色素瘤对诊断萎缩性胃炎准确性分析 被引量:4
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作者 陈亚军 罗俊 韩怡 《分子诊断与治疗杂志》 2021年第4期547-550,共4页
目的探究胃蛋白酶原1(PG1)、胃泌素17(G-17)、幽门螺杆菌IgG抗体(HP-IgG)检测,结合胃黄色素瘤对诊断萎縮性胃炎准确性。方法选择并分析2017年8月到2020年12月来本院消化科就诊的102例萎縮性胃炎患者作为实验组,并选取同期来体检的健康... 目的探究胃蛋白酶原1(PG1)、胃泌素17(G-17)、幽门螺杆菌IgG抗体(HP-IgG)检测,结合胃黄色素瘤对诊断萎縮性胃炎准确性。方法选择并分析2017年8月到2020年12月来本院消化科就诊的102例萎縮性胃炎患者作为实验组,并选取同期来体检的健康者50例作为对照组、住院后胃镜诊断为慢性非萎缩性胃炎患者50例作为非萎缩性胃炎组,检测并比较三组患者PG1、G-17、HP-IgG水平,并采用内镜检查患者是否带有胃黄色素瘤,并采用Roc曲线分析其对萎縮性胃炎的诊断价值。结果实验组的PG1、G-17水平小于非萎缩性胃炎组、对照组(P<0.05),HP-IgG、胃黄色素瘤检测率大于非萎缩性胃炎组、对照组,差异均有统计学意义(P<0.05)。PG1、G17、胃黄色素瘤检测率、HP-IgG、诊断萎缩性胃炎的价值的AUC分别为0.707、0.975、0.64、0.896,四项联合诊断萎缩性胃炎的价值的AUC为0.991,诊断萎缩性胃炎的价值准确性高,根据最佳临界值,PG1敏感度为63.7%,特异度为74%;G17敏感度为89.2%,特异度为100%;胃黄色素瘤检测率敏感度为46.1%,特异度为82%;HP-IgG敏感度为80.4%,特异度为94%;联合敏感度为100%,特异度为96%。结论PG1、G17、HP-IgG检测,结合胃黄色素瘤对诊断萎縮性胃炎有较高的准确性。 展开更多
关键词 胃蛋白酶原1 胃泌素17 幽门螺杆菌IgG抗体 黄色素瘤 萎縮性胃炎
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肝素钠皮内注射治疗黄色素瘤的临床治疗与护理
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作者 韩秀英 王春莲 《医学信息(中旬刊)》 2010年第10期2949-2949,共1页
黄色素瘤好发于中老年女性,也有男性发病。多发生在上眼睑的内眦部,局部皮肤呈橘皮样改变。发病原因与脂代谢在局部功能紊乱,造成脂肪堆积在眼睑内眦部形成大小不等的黄色隆起。影响美观,严重影响人们的身心健康。现将我科2006-2008年... 黄色素瘤好发于中老年女性,也有男性发病。多发生在上眼睑的内眦部,局部皮肤呈橘皮样改变。发病原因与脂代谢在局部功能紊乱,造成脂肪堆积在眼睑内眦部形成大小不等的黄色隆起。影响美观,严重影响人们的身心健康。现将我科2006-2008年共收治45例黄色素瘤病人皮内注射肝素钠治疗效果满意,现将护理总结如下。 展开更多
关键词 肝素钠 黄色素瘤
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86例胃黏膜黄色素瘤的临床分析
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作者 高艳萍 《中国民康医学》 2012年第21期2595-2596,共2页
目的:观察胃黏膜黄色素瘤与相关疾病之间的关系,以及治疗情况。方法:选自2001~2010年赤峰市巴林左旗医院内窥镜下确诊"胃黏膜黄色素瘤"113例,其中86例患者复查2~3次,根据病理检查分为3组:(1)无炎细胞及腺体萎缩组5例患者未... 目的:观察胃黏膜黄色素瘤与相关疾病之间的关系,以及治疗情况。方法:选自2001~2010年赤峰市巴林左旗医院内窥镜下确诊"胃黏膜黄色素瘤"113例,其中86例患者复查2~3次,根据病理检查分为3组:(1)无炎细胞及腺体萎缩组5例患者未予治疗;(2)有腺体萎缩及炎细胞组19例患者按萎缩性胃炎治疗;(3)炎细胞组62例给予杀菌及抑酸治疗。在治疗基础疾病以后,2次胃镜复查。结果:在第1次行胃镜检查6个月后,再次复查胃镜,炎细胞组有1例未发现胃黏膜黄色素瘤。1.5年后复查发现无炎细胞及腺体萎缩组有1例未再见到胃黏膜黄色素瘤。腺体萎缩的19例患者中,有2例胃黏膜黄色素瘤消失,其余62例患者中1例胃黏膜黄色素瘤消失。结论:胃黏膜胃黄色素瘤是一种良性瘤,一般无需治疗。 展开更多
关键词 黄色素瘤 胃镜 泡沫细胞 基础疾病
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家族性高胆固醇血症1例
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作者 黄晓华 《心脏杂志》 CAS 2013年第5期630-631,共2页
家族性高胆固醇血症(familial hypercholesterolemia,FH)是一种常染色体显性遗传性疾病,其特点为患者血浆中低密度脂蛋白胆固醇(LDL-C)水平明显增高,临床表现为黄色素瘤及早发动脉粥样硬化,如不尽早发现及合理治疗,易导致冠心... 家族性高胆固醇血症(familial hypercholesterolemia,FH)是一种常染色体显性遗传性疾病,其特点为患者血浆中低密度脂蛋白胆固醇(LDL-C)水平明显增高,临床表现为黄色素瘤及早发动脉粥样硬化,如不尽早发现及合理治疗,易导致冠心病、脑血管栓塞等,易猝死。现报道我院心外科收治的1例典型家族性高胆固醇血症患者。 展开更多
关键词 家族性高胆固醇血症 黄色素瘤 降脂
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Antiproliferation Effects of Curcumin on the STAT5 Signaling Parthway in K562 Cells
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作者 Yan Chen Hongli Liu Weihong Chen 《Chinese Journal of Clinical Oncology》 CSCD 2005年第4期685-692,共8页
OBJECTIVE Curcumin is the major component of the spice turmeric and the yellow pigment in curry powder. Many studies have shown that curcumin (diferuloylmethane) has significant antiproliferative and apoptotic effec... OBJECTIVE Curcumin is the major component of the spice turmeric and the yellow pigment in curry powder. Many studies have shown that curcumin (diferuloylmethane) has significant antiproliferative and apoptotic effects in cancer cells by several mechanisms. Signal transducers and activators of transcription (STAT) proteins are critical in mediating a response in hematopoietic cells. This study was designed to investigate whether curcumin is associated with proteins involved in signal transduction and activation of transcription (STAT) and to investigate the expression of signal transducers and activators of transcription and the significance of the STAT5 signaling pathway of by treating k562 cells and cells from CML patients with curcumin. METHODS The study was divided into the following groups: normal control cells (human bone marrow cells), untreated K562 cells, curcumin treated K562 cells, IFN-γ treated K562 cells, curcumin plus IFN-γ treated K562 cells, and CML patient cells with and without curcumin treatment. Cell proliferation was measured by the MTT assay. The expression of STAT5 mRNA was determined by RT-PCR. The expression of the STAT5 protein was assayed by Western-blotting and the expression of STAT5 in K562 cells was examined under confocal laser-scanning microscopy. The expression of STAT5 mRNA of K562 cells was determined with in situ hybridization. EMSA was used to assess the change in binding of STAT5 with DNA in CML patient cells. RESULTS The proliferation of the K562 cells and CML primary cells was decreased in the curcumin-treated group and/or IFN-γ group. The expression of STAT5 mRNA and protein were decreased the curcumin-treated group as compared with the K562 untreated group (P〈0.01). STAT5 mRNA and protein expression was decreased in the IFN-γ group compared to the untreated K562 group (P〈0.01). Combined use of curcumin with IFN-γ inhibited the proliferation of K562 cells and decreased the expression of STAT5 mRNA and protein of the K562 cells. For the CML patient cells, the OD value of STAT5-DNA binding in the curcumin treated cells was less than that compared to untreated cells. CONCLUSION The antiproliferation effects of curcumin may partly be mediated through signal transduction and activation of transcription and may involve the STAT5 signaling pathway. 展开更多
关键词 CURCUMIN STAT5 signaling pathway K562 cells
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公众对高血脂认识的9大误区
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作者 胡大一 《中国老年》 2020年第18期48-49,共2页
误区(1):高血脂的人有症状在通常情况下,高血脂的人没有明显症状和异常体征。诊断高血脂主要通过血液生化检验。仅少数有家族性高胆固醇血症的患者可见到皮肤黄色素瘤。误区(2):甘油三酯高危害最大低密度脂蛋白胆固醇(LDL-C)与动脉粥样... 误区(1):高血脂的人有症状在通常情况下,高血脂的人没有明显症状和异常体征。诊断高血脂主要通过血液生化检验。仅少数有家族性高胆固醇血症的患者可见到皮肤黄色素瘤。误区(2):甘油三酯高危害最大低密度脂蛋白胆固醇(LDL-C)与动脉粥样硬化的关系最密切,危害最大。 展开更多
关键词 家族性高胆固醇血症 异常体征 血液生化检验 动脉粥样硬化 低密度脂蛋白胆固醇 高血脂 黄色素瘤 甘油三酯
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Effects of hydroxy safflower Yellow-A on tumor capillary angiogenesis in transplanted human gastric adenocarcinoma BGC-823 tumors in nude mice 被引量:22
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作者 奚胜艳 张前 +3 位作者 刘朝阳 解华 岳利峰 高学敏 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2012年第2期243-248,共6页
OBJECTIVE:To study the effects of hydroxy safflower yellow A(HSYA) on tumor capillary angiogenesis in transplanted human gastric adenocarcinoma BGC-823 tumors in nude mice.METHODS:BGC-823 cells were injected subcutane... OBJECTIVE:To study the effects of hydroxy safflower yellow A(HSYA) on tumor capillary angiogenesis in transplanted human gastric adenocarcinoma BGC-823 tumors in nude mice.METHODS:BGC-823 cells were injected subcutaneously into the right anterior armpit of nude mice to establish an animal model of transplanted tumors.After 24 h,18 nude mice injected with tumor cells were randomized into model,control,and HSYA 0.028 g/L groups,with six mice in each group.Transplanted tumors were excised on day 20.Tumor inhibition ratios were calculated for the transplanted tumors.Pathological changes and capillary angiogenesis in the tumors were observed by light microscopy.RESULTS:Tumors in the model group grew more quickly than those in the control and HSYA groups,with inhibition ratios of 48% and 30%,respectively.The microvessel count in the HSYA group was lower than in the model group(P<0.01),and microvessel density was also lower in the HSYA group(P<0.05).Pathological changes were more obvious in tumors in the model group compared to the HSYA group.CONCLUSION:HSYA inhibits the growth of transplanted BGC-823 tumors,and its effects on tumor capillary angiogenesis may represent one of the mechanisms responsible for this antineoplastic effect. 展开更多
关键词 Hydroxy safflower yellow-A(HSYA) Transplantation tumor BGC-823 CD34 MVD Tumor capillary angiogenesis
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