This study works on setting a scientific standard for Polygonatum Cyrtonema Hua regarding its growth site condition,seed-stem choice,cultivation technique,field management,harvest,processing and storage.It aims at sta...This study works on setting a scientific standard for Polygonatum Cyrtonema Hua regarding its growth site condition,seed-stem choice,cultivation technique,field management,harvest,processing and storage.It aims at standardizing the cultivation of Polygonatum Cyrtonema Hua and providing technical support for the sustainable development of Polygonatum Cyrtonema Hua in Hunan Province.展开更多
Artemisinin, also known as qinghaosu, a sesquiterpene endoperoxide lactone isolated from the Chinese medicinal plant Artemisia annua L., is the most effective antimalarial drug which has saved millions of lives.Due to...Artemisinin, also known as qinghaosu, a sesquiterpene endoperoxide lactone isolated from the Chinese medicinal plant Artemisia annua L., is the most effective antimalarial drug which has saved millions of lives.Due to its great antimalarial activity and low content in wild A. annua plants, researches focused on enhancing the artemisin yield in plants became a hotspot. Several families of transcription factors have been reported to participate in regulating the biosynthesis and accumulation of artemisinin.In this review, we summarize recent investigations in these fields, with emphasis on newly identified transcription factors and their functions in artemisinin biosynthesis regulation, and provide new insight for further research.展开更多
As an effective component of safflower,hydroxysafflor yellow A(HSYA)has the effect of promoting blood circulation,removing blood stasis,and relieving pain,and it has a certain effect on blood stasis and wind-induced P...As an effective component of safflower,hydroxysafflor yellow A(HSYA)has the effect of promoting blood circulation,removing blood stasis,and relieving pain,and it has a certain effect on blood stasis and wind-induced Parkinson‘s disease(PD).However,the current research mostly involves a single intervention mechanism,which is not conducive to the clinical transformation of this type of drugs.In the present study,rotenone was used to construct a PD cell model,and the protective effect of HSYA on the PD cell model was evaluated by cell viability and mitochondrial membrane potential.TTD database was used to query PD-related therapeutic targets,Swiss Target Prediction database to query HSYA-related targets,STRING database was used to search the gene interaction relationship of common targets,and ClueGO pathway was adopted to enrich and analyze common targets and their interaction targets,as well as to explore the comprehensive intervention mechanism.The results showed that rotenone could successfully establish the PD cell model,and HSYA had significant protective effect on PD cell model.Through the network pharmacological analysis,36 PD-related therapeutic targets and 88 HSYA-related targets were queried.The common targets of PD and HSYA were FKBP1A,HTR1A,SLC6A4 and SLC6A3.To enrich four common targets and their interaction targets through REACTOME pathway,eight cell signal pathways were obtained,and six cell biological processes were obtained through biological process pathway enrichment.展开更多
基金Supported by Special Fund for National Modern Industrial Technology System Construction(CARS-21)Display and Science Popularization of the Planting Techiques of High-quality and Well-known Chinese Medical Herbs of Hunan(2017ZK3132)+1 种基金Germplasm Bank Construction and Genetic Diversity of Polygonatum Cyrtonema Hua Genus in Hunan(2017JC58)Research,Development and Demonstration of Polygonatum Cyrtonema Hua food products in Xinhua Lvyuan(2016SK3058)~~
文摘This study works on setting a scientific standard for Polygonatum Cyrtonema Hua regarding its growth site condition,seed-stem choice,cultivation technique,field management,harvest,processing and storage.It aims at standardizing the cultivation of Polygonatum Cyrtonema Hua and providing technical support for the sustainable development of Polygonatum Cyrtonema Hua in Hunan Province.
基金supported by National High Technology Research and Development Program(2011AA100605)Shanghai Key Discipline Cultivation and Construction Project(Horticulture+1 种基金ZXDF150005)Shanghai Jiao Tong University Agri-Engineering Program(AF1500028)
文摘Artemisinin, also known as qinghaosu, a sesquiterpene endoperoxide lactone isolated from the Chinese medicinal plant Artemisia annua L., is the most effective antimalarial drug which has saved millions of lives.Due to its great antimalarial activity and low content in wild A. annua plants, researches focused on enhancing the artemisin yield in plants became a hotspot. Several families of transcription factors have been reported to participate in regulating the biosynthesis and accumulation of artemisinin.In this review, we summarize recent investigations in these fields, with emphasis on newly identified transcription factors and their functions in artemisinin biosynthesis regulation, and provide new insight for further research.
基金Education Department of Hebei Province(Grant No.ZD2019107)。
文摘As an effective component of safflower,hydroxysafflor yellow A(HSYA)has the effect of promoting blood circulation,removing blood stasis,and relieving pain,and it has a certain effect on blood stasis and wind-induced Parkinson‘s disease(PD).However,the current research mostly involves a single intervention mechanism,which is not conducive to the clinical transformation of this type of drugs.In the present study,rotenone was used to construct a PD cell model,and the protective effect of HSYA on the PD cell model was evaluated by cell viability and mitochondrial membrane potential.TTD database was used to query PD-related therapeutic targets,Swiss Target Prediction database to query HSYA-related targets,STRING database was used to search the gene interaction relationship of common targets,and ClueGO pathway was adopted to enrich and analyze common targets and their interaction targets,as well as to explore the comprehensive intervention mechanism.The results showed that rotenone could successfully establish the PD cell model,and HSYA had significant protective effect on PD cell model.Through the network pharmacological analysis,36 PD-related therapeutic targets and 88 HSYA-related targets were queried.The common targets of PD and HSYA were FKBP1A,HTR1A,SLC6A4 and SLC6A3.To enrich four common targets and their interaction targets through REACTOME pathway,eight cell signal pathways were obtained,and six cell biological processes were obtained through biological process pathway enrichment.
