目的:观察干支耳位贴敷联合疏肝健脾化斑汤治疗女性肝郁脾虚型黄褐斑的疗效。方法:将80例女性患者采用随机数字表法随机分为治疗组和对照组。对照组中途退出1例,入组39例;治疗组失访脱落1例、未遵医嘱用药1例,入组38例。对照组给予疏肝...目的:观察干支耳位贴敷联合疏肝健脾化斑汤治疗女性肝郁脾虚型黄褐斑的疗效。方法:将80例女性患者采用随机数字表法随机分为治疗组和对照组。对照组中途退出1例,入组39例;治疗组失访脱落1例、未遵医嘱用药1例,入组38例。对照组给予疏肝健脾化斑汤治疗(药物组成:柴胡、白芍、白术、茯苓、当归、川芎、枳壳、泽泻、白蒺藜、菟丝子、僵蚕、甘草片),1剂/d,200 mL/次,早晚温服。治疗组在对照组治疗基础上加用干支耳位贴敷。采用王不留行籽贴于耳穴丑时位、巳时位、辰时位、子时位和寅时位,按压,5 min/次,3次/d,1周更换1次耳穴贴。两组均以4周为1个疗程,治疗3个疗程判定疗效。观察两组治疗前后的临床疗效、黄褐斑面积和严重程度指数(melasma area and severity index,MASI)评分、中医证候积分、黄褐斑生活质量评分(melasma quality of life score,MELASQOL)、VISIA皮肤图像检测仪评分、皮肤镜评分及患者满意度。结果:治疗组基本治愈5例,显效23例,有效7例,无效3例,有效率为92.11%(35/38);对照组基本治愈2例,显效10例,有效16例,无效11例,有效率为71.79%(28/39)。两组疗效对比,差异有统计学意义(P<0.01)。治疗后,两组MASI评分、中医证候积分、MELASQOL评分、面部VISIA皮肤图像检测仪评分、皮肤镜评分较治疗前均下降(P<0.01),且治疗组低于对照组(P<0.01),治疗组患者满意度高于对照组(P<0.05)。结论:干支耳位贴敷联合疏肝健脾化斑汤治疗女性肝郁脾虚型黄褐斑能提高临床疗效,提升患者生活质量。展开更多
We developed and validated a measurement instrument (CLASI-Cutaneous Lupus Erythematosus Disease Area and Severity Index) for lupus erythematosus that could be used in clinical trials. The instrument has separate scor...We developed and validated a measurement instrument (CLASI-Cutaneous Lupus Erythematosus Disease Area and Severity Index) for lupus erythematosus that could be used in clinical trials. The instrument has separate scores for damage and activity. A group of seven American Dermato-Rheumatologists and the “ American College of Rheumatology Response Criteria Committee on SLE (systemic lupus erythematosus)” assessed content validity. After a preliminary session, we conducted standardized interviews with the raters and made slight changes to the instrument. The final instrument was evaluated by five dermatologists and six residents who scored nine patients to estimate inter- and intra-rater reliability in two sessions. Consultation with experts has established content validity of the instrument. Reliability studies demonstrated an intra-class correlation coefficient (ICC) for inter-rater reliability of 0.86 for the activity score (95% confidence interval (CI) = 0.73- 0.99)- and of 0.92 for the damage score (95% CI = 0.85- 1.00). The Spearman’ s ρ (Sp) for intra-rater reliability for the activity score was 0.96 (95% CI = 0.89 to 1.00) and for the damage score Sp was 0.99 (95% CI = 0.97- 1.00). Clinical responsiveness needs to be evaluated in a prospective clinical trial, which is ongoing.展开更多
目的:探讨六味地黄汤加减联合超皮秒激光治疗稳定期黄褐斑临床效果观察。方法:将笔者医院2021年2月-2022年1月收治的86例稳定期肝肾阴虚型黄褐斑患者,按数字表法随机分为对照组42例和研究组44例。对照组给予口服维生素C、E和Q开关Nd∶YA...目的:探讨六味地黄汤加减联合超皮秒激光治疗稳定期黄褐斑临床效果观察。方法:将笔者医院2021年2月-2022年1月收治的86例稳定期肝肾阴虚型黄褐斑患者,按数字表法随机分为对照组42例和研究组44例。对照组给予口服维生素C、E和Q开关Nd∶YAG激光治疗,观察组给予六味地黄汤加减联合超皮秒激光治疗,比较两组治疗3个月后的治疗有效率、黄褐斑面积和严重指数评分(Melasma area severity index,MASI)、中医证候积分、生活质量及安全性。结果:治疗3个月后,研究组治疗有效率86.36%,显著高于对照组的66.67%(P<0.05);治疗1个月后、治疗3个月后,两组MASI评分均较治疗前明显降低,且研究组MASI评分均显著低于对照组(P<0.05);治疗3个月后,两组各项中医证候积分均较治疗前明显降低,且研究组各项中医证候积分均显著低于对照组(P<0.05);治疗3个月后,两组黄褐斑生活质量评分(MELA-subjective quality of life,MELA-SQOL)、皮肤病生活质量指数(Dermatology life quality index,DLQI)均较治疗前明显降低,且研究组MELASQOL、DLQI评分均显著低于对照组(P<0.05);两组不良反应发生情况差异无统计学意义。结论:六味地黄汤加减联合超皮秒激光治疗稳定期黄褐斑疗效显著,该联合疗法能有效改善患者的皮损程度和生活质量,安全性高,值得临床推广应用。展开更多
文摘目的:观察干支耳位贴敷联合疏肝健脾化斑汤治疗女性肝郁脾虚型黄褐斑的疗效。方法:将80例女性患者采用随机数字表法随机分为治疗组和对照组。对照组中途退出1例,入组39例;治疗组失访脱落1例、未遵医嘱用药1例,入组38例。对照组给予疏肝健脾化斑汤治疗(药物组成:柴胡、白芍、白术、茯苓、当归、川芎、枳壳、泽泻、白蒺藜、菟丝子、僵蚕、甘草片),1剂/d,200 mL/次,早晚温服。治疗组在对照组治疗基础上加用干支耳位贴敷。采用王不留行籽贴于耳穴丑时位、巳时位、辰时位、子时位和寅时位,按压,5 min/次,3次/d,1周更换1次耳穴贴。两组均以4周为1个疗程,治疗3个疗程判定疗效。观察两组治疗前后的临床疗效、黄褐斑面积和严重程度指数(melasma area and severity index,MASI)评分、中医证候积分、黄褐斑生活质量评分(melasma quality of life score,MELASQOL)、VISIA皮肤图像检测仪评分、皮肤镜评分及患者满意度。结果:治疗组基本治愈5例,显效23例,有效7例,无效3例,有效率为92.11%(35/38);对照组基本治愈2例,显效10例,有效16例,无效11例,有效率为71.79%(28/39)。两组疗效对比,差异有统计学意义(P<0.01)。治疗后,两组MASI评分、中医证候积分、MELASQOL评分、面部VISIA皮肤图像检测仪评分、皮肤镜评分较治疗前均下降(P<0.01),且治疗组低于对照组(P<0.01),治疗组患者满意度高于对照组(P<0.05)。结论:干支耳位贴敷联合疏肝健脾化斑汤治疗女性肝郁脾虚型黄褐斑能提高临床疗效,提升患者生活质量。
文摘We developed and validated a measurement instrument (CLASI-Cutaneous Lupus Erythematosus Disease Area and Severity Index) for lupus erythematosus that could be used in clinical trials. The instrument has separate scores for damage and activity. A group of seven American Dermato-Rheumatologists and the “ American College of Rheumatology Response Criteria Committee on SLE (systemic lupus erythematosus)” assessed content validity. After a preliminary session, we conducted standardized interviews with the raters and made slight changes to the instrument. The final instrument was evaluated by five dermatologists and six residents who scored nine patients to estimate inter- and intra-rater reliability in two sessions. Consultation with experts has established content validity of the instrument. Reliability studies demonstrated an intra-class correlation coefficient (ICC) for inter-rater reliability of 0.86 for the activity score (95% confidence interval (CI) = 0.73- 0.99)- and of 0.92 for the damage score (95% CI = 0.85- 1.00). The Spearman’ s ρ (Sp) for intra-rater reliability for the activity score was 0.96 (95% CI = 0.89 to 1.00) and for the damage score Sp was 0.99 (95% CI = 0.97- 1.00). Clinical responsiveness needs to be evaluated in a prospective clinical trial, which is ongoing.
文摘目的:探讨六味地黄汤加减联合超皮秒激光治疗稳定期黄褐斑临床效果观察。方法:将笔者医院2021年2月-2022年1月收治的86例稳定期肝肾阴虚型黄褐斑患者,按数字表法随机分为对照组42例和研究组44例。对照组给予口服维生素C、E和Q开关Nd∶YAG激光治疗,观察组给予六味地黄汤加减联合超皮秒激光治疗,比较两组治疗3个月后的治疗有效率、黄褐斑面积和严重指数评分(Melasma area severity index,MASI)、中医证候积分、生活质量及安全性。结果:治疗3个月后,研究组治疗有效率86.36%,显著高于对照组的66.67%(P<0.05);治疗1个月后、治疗3个月后,两组MASI评分均较治疗前明显降低,且研究组MASI评分均显著低于对照组(P<0.05);治疗3个月后,两组各项中医证候积分均较治疗前明显降低,且研究组各项中医证候积分均显著低于对照组(P<0.05);治疗3个月后,两组黄褐斑生活质量评分(MELA-subjective quality of life,MELA-SQOL)、皮肤病生活质量指数(Dermatology life quality index,DLQI)均较治疗前明显降低,且研究组MELASQOL、DLQI评分均显著低于对照组(P<0.05);两组不良反应发生情况差异无统计学意义。结论:六味地黄汤加减联合超皮秒激光治疗稳定期黄褐斑疗效显著,该联合疗法能有效改善患者的皮损程度和生活质量,安全性高,值得临床推广应用。
