播散性黄瘤（xanthoma disseminatum,XD）,是一种临床少见的非朗汉斯组织细胞增生性疾病,特征性表现有皮肤、黏膜黄瘤和尿崩症三联征。我院近年收治1例表现为鼻咽部肿物、鞍鼻畸形、皮肤病变、骨关节损害、尿崩症、睾丸鞘膜积液等多器...播散性黄瘤（xanthoma disseminatum,XD）,是一种临床少见的非朗汉斯组织细胞增生性疾病,特征性表现有皮肤、黏膜黄瘤和尿崩症三联征。我院近年收治1例表现为鼻咽部肿物、鞍鼻畸形、皮肤病变、骨关节损害、尿崩症、睾丸鞘膜积液等多器官或系统损害的XD,因酷似肉芽肿性多血管炎（granulomatosis with polyangiitis,GPA）于我院首诊时而误诊。展开更多
AIM： To investigate the relationship among gastric xanthomatosis （GX）, Hpylori, dyslipidemia, and gastritis in Korea, a well-known Hpylori endemic area.METHODS： A total of 771 patients who had undergone gastroduod...AIM： To investigate the relationship among gastric xanthomatosis （GX）, Hpylori, dyslipidemia, and gastritis in Korea, a well-known Hpylori endemic area.METHODS： A total of 771 patients who had undergone gastroduodenoscopy by one endoscopist were included in this study. Among them, 54 patients with GX were assessed for Hpylori infection and their endoscopic characteristics and serum lipid profiles. The findings were compared with 54 age- and sex-matched control subjects without GX.RESULTS： The prevalence of GX was 7% （54/771） with no sex difference. GX was mainly single （64.8%） and located in the antrum （53.7%）. The mean diameter was 7 ± 3 mm. Mean body mass index （BMI） of patients with GX was 23.1 ± 2.8 and no one was above 30. Compared with the controls, lipid profiles of GX group showed significantly lower HDL-cholesterol （48.8 ± 12.3 vs 62.9 ± 40.5, P = 0.028） and higher LDL-cholesterol （112.9 ± 29.9 vs 95.9 ± 22.4, P = 0.032）. The level of total serum cholesterol, triglyceride and the existence of dyslipoproteinemia were not related to the presence of GX. However, GX showed a close relationship with endoscopically determined atrophic gastritis and histologic severity （24/53, 44.4% vs 8/54, 14.8%, P = 0.0082）. H pylori infection and bile reflux gastritis were not significantly related with GX.CONCLUSION： The prevalence of GX is 7% and it may be an increasing entity in Korea. Moreover, dyslipidemia and atrophic gastritis are found to be related to GX, but lip, H pylori infection is not.展开更多
文摘播散性黄瘤（xanthoma disseminatum,XD）,是一种临床少见的非朗汉斯组织细胞增生性疾病,特征性表现有皮肤、黏膜黄瘤和尿崩症三联征。我院近年收治1例表现为鼻咽部肿物、鞍鼻畸形、皮肤病变、骨关节损害、尿崩症、睾丸鞘膜积液等多器官或系统损害的XD,因酷似肉芽肿性多血管炎（granulomatosis with polyangiitis,GPA）于我院首诊时而误诊。
文摘AIM： To investigate the relationship among gastric xanthomatosis （GX）, Hpylori, dyslipidemia, and gastritis in Korea, a well-known Hpylori endemic area.METHODS： A total of 771 patients who had undergone gastroduodenoscopy by one endoscopist were included in this study. Among them, 54 patients with GX were assessed for Hpylori infection and their endoscopic characteristics and serum lipid profiles. The findings were compared with 54 age- and sex-matched control subjects without GX.RESULTS： The prevalence of GX was 7% （54/771） with no sex difference. GX was mainly single （64.8%） and located in the antrum （53.7%）. The mean diameter was 7 ± 3 mm. Mean body mass index （BMI） of patients with GX was 23.1 ± 2.8 and no one was above 30. Compared with the controls, lipid profiles of GX group showed significantly lower HDL-cholesterol （48.8 ± 12.3 vs 62.9 ± 40.5, P = 0.028） and higher LDL-cholesterol （112.9 ± 29.9 vs 95.9 ± 22.4, P = 0.032）. The level of total serum cholesterol, triglyceride and the existence of dyslipoproteinemia were not related to the presence of GX. However, GX showed a close relationship with endoscopically determined atrophic gastritis and histologic severity （24/53, 44.4% vs 8/54, 14.8%, P = 0.0082）. H pylori infection and bile reflux gastritis were not significantly related with GX.CONCLUSION： The prevalence of GX is 7% and it may be an increasing entity in Korea. Moreover, dyslipidemia and atrophic gastritis are found to be related to GX, but lip, H pylori infection is not.
