A 45-year-old male cook was seen for the evaluation and removal of a "mole o n my eye" of steady growth during the previous 6 months. The patient stated that he had had a "brown spot" above his lef...A 45-year-old male cook was seen for the evaluation and removal of a "mole o n my eye" of steady growth during the previous 6 months. The patient stated that he had had a "brown spot" above his left eye for 17 years prior to its recent e nlargement; it was now partly blocking the vision in his left eye. He denied a h istory or family history of cutaneous tumors, including skin cancer. On examinat ion, a 2.5-cm ×.0.5-cm ×.0.8-cm, horn-like, darkly pigmented, cutaneous no dule was evident extending from the left upper eyelid downwards to below the low er eyelid (Figs 1 and 2). He also had scattered, skin-colored, 2-3-mm cystic papules on his anterior mid-chest. A shave excision specimen was obtained from the eyelid nodule. Microscopic examination demonstrated acanthosis, hyperkeratos is, and papillomatosis (Fig. 3). Large dendritic cells with abundant melanin gra nules were spread throughout the epidermis. In addition, small basaloid or spino us keratinocytes were present in the malpighian layer.展开更多
文摘A 45-year-old male cook was seen for the evaluation and removal of a "mole o n my eye" of steady growth during the previous 6 months. The patient stated that he had had a "brown spot" above his left eye for 17 years prior to its recent e nlargement; it was now partly blocking the vision in his left eye. He denied a h istory or family history of cutaneous tumors, including skin cancer. On examinat ion, a 2.5-cm ×.0.5-cm ×.0.8-cm, horn-like, darkly pigmented, cutaneous no dule was evident extending from the left upper eyelid downwards to below the low er eyelid (Figs 1 and 2). He also had scattered, skin-colored, 2-3-mm cystic papules on his anterior mid-chest. A shave excision specimen was obtained from the eyelid nodule. Microscopic examination demonstrated acanthosis, hyperkeratos is, and papillomatosis (Fig. 3). Large dendritic cells with abundant melanin gra nules were spread throughout the epidermis. In addition, small basaloid or spino us keratinocytes were present in the malpighian layer.
