Introduction. Squamous cell carcinoma is a malignant epithelial tumor of the skin, rarely observed in "black"skin. It often complicates an acquired or congenital pre-neoplastic dermatosis. We report on 80 ca...Introduction. Squamous cell carcinoma is a malignant epithelial tumor of the skin, rarely observed in "black"skin. It often complicates an acquired or congenital pre-neoplastic dermatosis. We report on 80 cases of squamous cell carcinoma having occurred in black African patients from Senegal. Patients and methods. We retrospectively analyzed all the medical files of patients followed-up in the department for histologically confirmed squamous cell carcinoma from 1980 to 1999. Results. Eighty cases of carcinoma were collected. The mean age of the patients was of 47 years (range: 1 to 85) and the sex ratio was of 1.35 (46 men and 34 women). A pre-neoplastic dermatosis was identified in 65%of the patients. Acquired pre-neoplastic dermatosis was: heat burn scars (15 cases), chronic discoid lupus erythematosus (6 cases) and chronic phagedenic ulcer (4 cases). Pre-neoplastic genodermatoses were: albinism (6 cases), xeroderma pigmentosum (5 cases) and epidermodysplasia verruciformis (1 case). Lesions were multiple and cephalic in patients with genodermatosis. Death due to carcinoma occurred in 8 patients. Comments. This large series of squamous cell carcinoma emphasizes: the rarity of squamous cell carcinomas in black patients and the frequency of its occurrence on acquired pre-existing dermatosis. For many years phagedenic ulcers predominated. Our results show the regression of the latter and its increase on post-burn scars and chronic lupus erythematosus. Pre-neoplastic genodermatoses thatdeterminemultiplecancers,usuallylocatedonsun-exposed areas and occurring in young patients, are particularly severe.展开更多
Background: Black race affords some protection from retinopathy of prematurity (ROP), but more ROP was previously found in another darkly pigmented race, the Alaskan natives. Design: From fall 1989 through summer 2003...Background: Black race affords some protection from retinopathy of prematurity (ROP), but more ROP was previously found in another darkly pigmented race, the Alaskan natives. Design: From fall 1989 through summer 2003, all Alaskan infants with a birth weight of 1500 g or less were examined, documenting mother’ s stated race, prenatal care, and neonatal intensive care unit course. Results: Retinopathy of prematurity was classified as to predefined threshold for peripheral ablative treatment (region of avascular retina and fibrovascular ridge and vessel tortuosity) in 873 infants. Threshold ROP was more prevalent in Alaskan natives (24.9% ) and Asians (15.9% ) (10% overall),with no significant difference between Alaskan natives and Asians (P=.24). Alaskan native males had more threshold ROP (69% ) compared with non-Alaskan native males (51% ). Compared with threshold nonnatives, Alaskan native threshold infants had greater birth weights (829± 222 vs 704± 186 g), required less time on ventilation (46± 22 vs 70± 75 days), and progressed to treatment at a younger age (35.5± 2.2 vs 36.2± 2.6 weeks’ gestational age) (data are given as mean± SD). Conclusions: In this limited study, we find increased risk of threshold ROP in 2 northern Pacific races. Threshold Alaskan natives had similar or better prenatal and neonatal intensive care unit variables than did threshold nonnatives; however, Alaskan native males were still at a greater risk.展开更多
文摘Introduction. Squamous cell carcinoma is a malignant epithelial tumor of the skin, rarely observed in "black"skin. It often complicates an acquired or congenital pre-neoplastic dermatosis. We report on 80 cases of squamous cell carcinoma having occurred in black African patients from Senegal. Patients and methods. We retrospectively analyzed all the medical files of patients followed-up in the department for histologically confirmed squamous cell carcinoma from 1980 to 1999. Results. Eighty cases of carcinoma were collected. The mean age of the patients was of 47 years (range: 1 to 85) and the sex ratio was of 1.35 (46 men and 34 women). A pre-neoplastic dermatosis was identified in 65%of the patients. Acquired pre-neoplastic dermatosis was: heat burn scars (15 cases), chronic discoid lupus erythematosus (6 cases) and chronic phagedenic ulcer (4 cases). Pre-neoplastic genodermatoses were: albinism (6 cases), xeroderma pigmentosum (5 cases) and epidermodysplasia verruciformis (1 case). Lesions were multiple and cephalic in patients with genodermatosis. Death due to carcinoma occurred in 8 patients. Comments. This large series of squamous cell carcinoma emphasizes: the rarity of squamous cell carcinomas in black patients and the frequency of its occurrence on acquired pre-existing dermatosis. For many years phagedenic ulcers predominated. Our results show the regression of the latter and its increase on post-burn scars and chronic lupus erythematosus. Pre-neoplastic genodermatoses thatdeterminemultiplecancers,usuallylocatedonsun-exposed areas and occurring in young patients, are particularly severe.
文摘Background: Black race affords some protection from retinopathy of prematurity (ROP), but more ROP was previously found in another darkly pigmented race, the Alaskan natives. Design: From fall 1989 through summer 2003, all Alaskan infants with a birth weight of 1500 g or less were examined, documenting mother’ s stated race, prenatal care, and neonatal intensive care unit course. Results: Retinopathy of prematurity was classified as to predefined threshold for peripheral ablative treatment (region of avascular retina and fibrovascular ridge and vessel tortuosity) in 873 infants. Threshold ROP was more prevalent in Alaskan natives (24.9% ) and Asians (15.9% ) (10% overall),with no significant difference between Alaskan natives and Asians (P=.24). Alaskan native males had more threshold ROP (69% ) compared with non-Alaskan native males (51% ). Compared with threshold nonnatives, Alaskan native threshold infants had greater birth weights (829± 222 vs 704± 186 g), required less time on ventilation (46± 22 vs 70± 75 days), and progressed to treatment at a younger age (35.5± 2.2 vs 36.2± 2.6 weeks’ gestational age) (data are given as mean± SD). Conclusions: In this limited study, we find increased risk of threshold ROP in 2 northern Pacific races. Threshold Alaskan natives had similar or better prenatal and neonatal intensive care unit variables than did threshold nonnatives; however, Alaskan native males were still at a greater risk.
