Synthetic dyes are commonly used for graphite depression in poly-metallic flotation circuits; however,these dyes can be very expensive. The aim of this study is to evaluate performance of certain low-cost alternative ...Synthetic dyes are commonly used for graphite depression in poly-metallic flotation circuits; however,these dyes can be very expensive. The aim of this study is to evaluate performance of certain low-cost alternative depressants for a complex lead-zinc(Pb-Zn) ore rich in graphite(Gr-C) on a conventional mini pilot-scale flotation circuit. The reagents used were commercial and industrial grade starch; agro-based waste-sugarcane bagasse and charred(burnt) bagasse powder. The primary evaluation criteria were quality(grades) of lead and zinc concentrates, their recoveries(%), and graphite rejection(%) in the tails.Benchmark tests using nigrosine as graphite depressant showed 94.3% rejection of Gr-C. The results with commercial starch were found as effective with 93.8% graphite rejection. Furthermore, bagasse powder showed potential in improving product quality(36.4% and 65.6% Pb grade and recovery) with an intermediate effectiveness in graphite rejection(85.6%). The order of effectiveness in Gr-C rejection follows nigrosine % commercial starch > bagasse > industrial starch > charred bagasse. In addition, the effect these depressants on silver(byproduct) grade and recovery was also investigated.展开更多
基金The author is grateful to the management and staff of Center Research Development laboratory(HZL,Debari),India for their support with this research and permitting to publish the work.
文摘Synthetic dyes are commonly used for graphite depression in poly-metallic flotation circuits; however,these dyes can be very expensive. The aim of this study is to evaluate performance of certain low-cost alternative depressants for a complex lead-zinc(Pb-Zn) ore rich in graphite(Gr-C) on a conventional mini pilot-scale flotation circuit. The reagents used were commercial and industrial grade starch; agro-based waste-sugarcane bagasse and charred(burnt) bagasse powder. The primary evaluation criteria were quality(grades) of lead and zinc concentrates, their recoveries(%), and graphite rejection(%) in the tails.Benchmark tests using nigrosine as graphite depressant showed 94.3% rejection of Gr-C. The results with commercial starch were found as effective with 93.8% graphite rejection. Furthermore, bagasse powder showed potential in improving product quality(36.4% and 65.6% Pb grade and recovery) with an intermediate effectiveness in graphite rejection(85.6%). The order of effectiveness in Gr-C rejection follows nigrosine % commercial starch > bagasse > industrial starch > charred bagasse. In addition, the effect these depressants on silver(byproduct) grade and recovery was also investigated.
文摘Binimetinib是Array BioPharma开发的丝裂原活化细胞外信号调节蛋白激酶(mitogen-activated extracellular signal regulated kinase,MEK)1/2抑制剂,2018年6月在美国获批上市。本品联合康奈非尼用于治疗具有BRAF V600E或V600K突变的不可切除或转移性黑色素瘤患者。2018年7月后,欧盟、澳大利亚、瑞士和日本也提交了binimetinib和康奈非尼组合用于治疗BRAF突变阳性晚期黑色素瘤的登记申请。Binimetinib可抑制MEK和细胞外信号调节蛋白激酶(extracellular regulated protein kinases,ERK)磷酸化,从而抑制肿瘤生长,对于BRAF、NRAS和KRAS基因突变的肿瘤尤其有效。目前世界各地正在进行binimetinib对于转移性结直肠癌、非小细胞肺癌、晚期胆道癌、神经纤维瘤等治疗的临床试验。本文以binimetinib为关键词进行文献检索,并对其药理作用、药动学、临床评价、用法用量、安全性和药物相互作用等进行综述。
