目的 :观察体内注射阳离子脂质体包裹的小鼠白细胞介素 12 (m IL - 12 )基因对小鼠黑色素细胞瘤的治疗作用。方法 :C5 7BL / 6小鼠在接种 B16黑色素细胞后 3、5、7、9d分别给予 lipofectin包裹的 p Cm IL- 12质粒治疗 ,观察小鼠的肿瘤...目的 :观察体内注射阳离子脂质体包裹的小鼠白细胞介素 12 (m IL - 12 )基因对小鼠黑色素细胞瘤的治疗作用。方法 :C5 7BL / 6小鼠在接种 B16黑色素细胞后 3、5、7、9d分别给予 lipofectin包裹的 p Cm IL- 12质粒治疗 ,观察小鼠的肿瘤生长速度、生存期以及 NK细胞活性的变化。结果 :阳离子脂质体明显增强 p Cm IL - 12质粒在体内的抗肿瘤生长活性 ,并延长荷瘤小鼠的存活期。此外 ,p Cm IL - 12 /阳离子脂质体还能显著增强荷瘤小鼠的 NK细胞活性。结论 :阳离子脂质体介导的 IL - 12基因对小鼠黑色素瘤有明显的治疗效果。展开更多
Background. Loss of appetite and nausea can reduce the quality of life of patients with malignant melanoma and liver metastases. Often established antiemetic drugs fail to bring relief.Tetrahy drocannabinol (THC, Mari...Background. Loss of appetite and nausea can reduce the quality of life of patients with malignant melanoma and liver metastases. Often established antiemetic drugs fail to bring relief.Tetrahy drocannabinol (THC, Marinol TM), which is the active agent of Indian hemp, has been used successfully in this situation for other malignant tumors. Patients and methods. We treated 7 patients with hematogenous metastatic melanoma and liver metastases suffering from extensive loss of appetite and nausea supportively with dronabinol (Marinol ). All of these patients had previously received standard antiemetic therapy without adequate relief. Dronabinol is a synthetic △ - tetrahydrocannabinol. The drug was administered in capsule form. We evaluated the palliative effects of dronabinol with a special patient evaluation form, which was filled out at the beginning of the therapy and again after 4 weeks. Results. The majority of patients described a significant increase in appetite and decrease in nausea. These effects remained for some weeks, but then decreased as metastases progressed and the general condition worsened. All of the patients experienced slight to moderate dizziness, but it was not sufficiently troubling to cause interruption or termination of therapy. Conclusion. Loss of appetite and nausea due to liver metastases of malignant melanoma can be treated in individual cases supportively with Dronabinol.展开更多
文摘目的 :观察体内注射阳离子脂质体包裹的小鼠白细胞介素 12 (m IL - 12 )基因对小鼠黑色素细胞瘤的治疗作用。方法 :C5 7BL / 6小鼠在接种 B16黑色素细胞后 3、5、7、9d分别给予 lipofectin包裹的 p Cm IL- 12质粒治疗 ,观察小鼠的肿瘤生长速度、生存期以及 NK细胞活性的变化。结果 :阳离子脂质体明显增强 p Cm IL - 12质粒在体内的抗肿瘤生长活性 ,并延长荷瘤小鼠的存活期。此外 ,p Cm IL - 12 /阳离子脂质体还能显著增强荷瘤小鼠的 NK细胞活性。结论 :阳离子脂质体介导的 IL - 12基因对小鼠黑色素瘤有明显的治疗效果。
文摘Background. Loss of appetite and nausea can reduce the quality of life of patients with malignant melanoma and liver metastases. Often established antiemetic drugs fail to bring relief.Tetrahy drocannabinol (THC, Marinol TM), which is the active agent of Indian hemp, has been used successfully in this situation for other malignant tumors. Patients and methods. We treated 7 patients with hematogenous metastatic melanoma and liver metastases suffering from extensive loss of appetite and nausea supportively with dronabinol (Marinol ). All of these patients had previously received standard antiemetic therapy without adequate relief. Dronabinol is a synthetic △ - tetrahydrocannabinol. The drug was administered in capsule form. We evaluated the palliative effects of dronabinol with a special patient evaluation form, which was filled out at the beginning of the therapy and again after 4 weeks. Results. The majority of patients described a significant increase in appetite and decrease in nausea. These effects remained for some weeks, but then decreased as metastases progressed and the general condition worsened. All of the patients experienced slight to moderate dizziness, but it was not sufficiently troubling to cause interruption or termination of therapy. Conclusion. Loss of appetite and nausea due to liver metastases of malignant melanoma can be treated in individual cases supportively with Dronabinol.
