Objective: To explore effects of Shenmai Injection(参麦注射液) combined with Meglumine Adenosine Cyclophosphate Injection on cardiac function and peripheral serum levels of tumor necrosis factor-α(TNF-α), transformi...Objective: To explore effects of Shenmai Injection(参麦注射液) combined with Meglumine Adenosine Cyclophosphate Injection on cardiac function and peripheral serum levels of tumor necrosis factor-α(TNF-α), transforming growth factor-β1(TGF-β1) and interferon-γ(IFN-γ) in patients with viral myocarditis.Methods: A total of 70 patients with viral myocarditis admitted in Cardiovascular Medicine Department of our hospital from June 2016 to June 2018 were selected and divided into a control group(treated with Meglumine Adenosine Cyclophosphate Injection) and an observation group(additionally treated with Shenmai Injection(参麦注射液) on the treatment basis of the control group) according to random number method, with 35 cases in each group.Before and after the treatment, cardiac functional indexes like cardiac index(CI), left ventricular ejection fraction(LVEF) and left ventricular shortening fraction(FS), serum levels of TNF-α, TGF-β1 and IFN-γ, clinical efficacy and adverse reactions occurred in the 2 groups were recorded and compared.Results: Therapeutic effective rate in the observation group was 88.57%, higher than 68.57% in the control group(P < 0.05).After the treatment, cardiac functional indexes like CI, LVEF and FS were higher than those in the control group(P < 0.05).After the treatment, the serum expression levels of TNF-α and TGF-β1 were lower than those in the control group(P < 0.05), while the serum expression level of IFN-γ was higher than that in the control group(P < 0.05).There was no statistically significant difference in the adverse reaction rates between the 2 groups(P > 0.05).Conclusion: The treatment of patients with viral myocarditis by Shenmai Injection(参麦注射液) combined with Meglumine Adenosine Cyclophosphate Injection is more effective, reducing inflammation and restoring cardiac function.展开更多
目的探讨鼓室内注射曲安奈德(triamcinolone acetonide,TA)和盐酸氨溴索(ambroxol)治疗分泌性中耳炎(otitis media with effusion,OME)的临床疗效。方法将120例(148耳)OME患者随机分为治疗组(60例,73耳)和对照组(60例,75耳),治疗组先行...目的探讨鼓室内注射曲安奈德(triamcinolone acetonide,TA)和盐酸氨溴索(ambroxol)治疗分泌性中耳炎(otitis media with effusion,OME)的临床疗效。方法将120例(148耳)OME患者随机分为治疗组(60例,73耳)和对照组(60例,75耳),治疗组先行鼓室穿刺抽液,再注入曲安奈德40 mg和盐酸氨溴索30 mg;对照组在鼓室穿刺抽液后注入地塞米松5 mg。两组患者每周治疗一次,4周为一疗程,观察两组的治疗效果并作统计学分析。结果治疗后随访3个月,治疗组痊愈31例(38耳),有效20例(24耳),总有效率为84.9%(62/73);对照组痊愈11例(14耳),有效25例(31耳),总有效率为60%(45/75),治疗组总有效率高于对照组,差异有统计学意义(P<0.05)。对于OME导致的骨导听阈提高的疗效治疗组优于对照组。两组患者均未出现毒副作用。结论鼓室内注射曲安奈德和盐酸氨溴索对治疗OME安全有效,且无毒副作用。展开更多
目的探讨前列地尔联合鼓室注射地塞米松治疗突发性耳聋的临床疗效及对血液流变学的影响。方法选取2016年1~11月我院收治的88例突发性耳聋患者,将其按照随机数字法随机分为观察组和对照组,每组44例,两组均给予常规治疗,对照组在常规治疗...目的探讨前列地尔联合鼓室注射地塞米松治疗突发性耳聋的临床疗效及对血液流变学的影响。方法选取2016年1~11月我院收治的88例突发性耳聋患者,将其按照随机数字法随机分为观察组和对照组,每组44例,两组均给予常规治疗,对照组在常规治疗基础上给予前列地尔进行治疗,观察组在常规治疗基础上给予前列地尔联合鼓室注射地塞米松进行治疗,观察比较两组治疗前后纯音听阈(pure tone audiometry,PTA)的变化,检测比较治疗前后血液流变学指标(全血高切黏度、全血低切黏度、血浆黏度),并对治疗前后两组的临床疗效及安全性进行评价。结果治疗后两组PTA均显著下降(t=2.874、6.695,P均<0.05),但观察组下降更为明显(t=3.981,P<0.05)。治疗后两组全血高切黏度、全血低切黏度、血浆黏度均显著下降(P<0.05),但观察组下降更为明显(t=18.511、17.823、8.145,P均<0.05)。治疗后观察组总有效率高于对照组。两组治疗期间均未出现眩晕、短暂性眩晕等不良反应。结论前列地尔联合鼓室注射地塞米松治疗突发性耳聋临床疗效显著,安全性高,可促进患者听力恢复,并改善患者血液流变学指标,值得临床推广。展开更多
文摘Objective: To explore effects of Shenmai Injection(参麦注射液) combined with Meglumine Adenosine Cyclophosphate Injection on cardiac function and peripheral serum levels of tumor necrosis factor-α(TNF-α), transforming growth factor-β1(TGF-β1) and interferon-γ(IFN-γ) in patients with viral myocarditis.Methods: A total of 70 patients with viral myocarditis admitted in Cardiovascular Medicine Department of our hospital from June 2016 to June 2018 were selected and divided into a control group(treated with Meglumine Adenosine Cyclophosphate Injection) and an observation group(additionally treated with Shenmai Injection(参麦注射液) on the treatment basis of the control group) according to random number method, with 35 cases in each group.Before and after the treatment, cardiac functional indexes like cardiac index(CI), left ventricular ejection fraction(LVEF) and left ventricular shortening fraction(FS), serum levels of TNF-α, TGF-β1 and IFN-γ, clinical efficacy and adverse reactions occurred in the 2 groups were recorded and compared.Results: Therapeutic effective rate in the observation group was 88.57%, higher than 68.57% in the control group(P < 0.05).After the treatment, cardiac functional indexes like CI, LVEF and FS were higher than those in the control group(P < 0.05).After the treatment, the serum expression levels of TNF-α and TGF-β1 were lower than those in the control group(P < 0.05), while the serum expression level of IFN-γ was higher than that in the control group(P < 0.05).There was no statistically significant difference in the adverse reaction rates between the 2 groups(P > 0.05).Conclusion: The treatment of patients with viral myocarditis by Shenmai Injection(参麦注射液) combined with Meglumine Adenosine Cyclophosphate Injection is more effective, reducing inflammation and restoring cardiac function.
文摘目的探讨鼓室内注射曲安奈德(triamcinolone acetonide,TA)和盐酸氨溴索(ambroxol)治疗分泌性中耳炎(otitis media with effusion,OME)的临床疗效。方法将120例(148耳)OME患者随机分为治疗组(60例,73耳)和对照组(60例,75耳),治疗组先行鼓室穿刺抽液,再注入曲安奈德40 mg和盐酸氨溴索30 mg;对照组在鼓室穿刺抽液后注入地塞米松5 mg。两组患者每周治疗一次,4周为一疗程,观察两组的治疗效果并作统计学分析。结果治疗后随访3个月,治疗组痊愈31例(38耳),有效20例(24耳),总有效率为84.9%(62/73);对照组痊愈11例(14耳),有效25例(31耳),总有效率为60%(45/75),治疗组总有效率高于对照组,差异有统计学意义(P<0.05)。对于OME导致的骨导听阈提高的疗效治疗组优于对照组。两组患者均未出现毒副作用。结论鼓室内注射曲安奈德和盐酸氨溴索对治疗OME安全有效,且无毒副作用。
文摘目的探讨前列地尔联合鼓室注射地塞米松治疗突发性耳聋的临床疗效及对血液流变学的影响。方法选取2016年1~11月我院收治的88例突发性耳聋患者,将其按照随机数字法随机分为观察组和对照组,每组44例,两组均给予常规治疗,对照组在常规治疗基础上给予前列地尔进行治疗,观察组在常规治疗基础上给予前列地尔联合鼓室注射地塞米松进行治疗,观察比较两组治疗前后纯音听阈(pure tone audiometry,PTA)的变化,检测比较治疗前后血液流变学指标(全血高切黏度、全血低切黏度、血浆黏度),并对治疗前后两组的临床疗效及安全性进行评价。结果治疗后两组PTA均显著下降(t=2.874、6.695,P均<0.05),但观察组下降更为明显(t=3.981,P<0.05)。治疗后两组全血高切黏度、全血低切黏度、血浆黏度均显著下降(P<0.05),但观察组下降更为明显(t=18.511、17.823、8.145,P均<0.05)。治疗后观察组总有效率高于对照组。两组治疗期间均未出现眩晕、短暂性眩晕等不良反应。结论前列地尔联合鼓室注射地塞米松治疗突发性耳聋临床疗效显著,安全性高,可促进患者听力恢复,并改善患者血液流变学指标,值得临床推广。