目的研究垂直生长型安氏Ⅱ类1分类拔牙病例矫治前后鼻唇角的变化及其改变的相关性分析,为临床对错畸形的诊断与分析以及预测矫治后的疗效提供依据。方法选取38例垂直生长型安氏Ⅱ类1分类拔牙病例,矫治前后拍摄头颅侧位片,对18个软硬组...目的研究垂直生长型安氏Ⅱ类1分类拔牙病例矫治前后鼻唇角的变化及其改变的相关性分析,为临床对错畸形的诊断与分析以及预测矫治后的疗效提供依据。方法选取38例垂直生长型安氏Ⅱ类1分类拔牙病例,矫治前后拍摄头颅侧位片,对18个软硬组织测量指标进行测量,对青少年与成人治疗前后变化量进行比较,并分析鼻唇角改变的相关性。结果青少年组与成人组鼻唇角均增大,但成人组鼻唇角改变更显著;U1 to FH、U1 to NA、U1-NA、Spr-Ptm在矫治后均减小,成人组减小更显著;青少年组上唇凹点厚度、上唇凸缘厚度、A’-Ptm、上唇长度以及鼻突度矫治后均增加,而成人均有一定程度的减小,差异有统计学意义。鼻唇角改变的相关性分析显示,两组U1 to FH、U1 to NA、U1-NA均有显著性的负相关,上唇倾角均有显著的正相关,并且成人相关性更显著;青少年组上唇凸缘厚度与鼻唇角呈负相关,而上唇凹点厚度与鼻唇角呈正相关,成人组这两项则无明显相关性。结论垂直生长型安氏Ⅱ类1分类青少年拔牙矫治后鼻唇角改变与上前牙硬组织以及上唇软组织均有相关性,而成人则只与上前牙硬组织相关。展开更多
Congenital central hypoventilation syndrome (CCHS) is caused by mutations in PHOX2B,which is essential for maturation of the neural crest into the autonomic nervous system and is expressed in the dorsal rhombencephalo...Congenital central hypoventilation syndrome (CCHS) is caused by mutations in PHOX2B,which is essential for maturation of the neural crest into the autonomic nervous system and is expressed in the dorsal rhombencephalon,a region that gives rise to facial structures. Digital photographs of 45 individuals with PHOX2B-confirmed CCHS,and 45 matched controls were analyzed for 17 linear and 6 angular measurements,and 9 derived indices. Paired t tests were used to compare group means,correlation was calculated between PHOX2B polyalanine expansion number and facial measures,and stepwise logistic regression was used to predict case-control and genotype status. CCHS cases differed significantly from controls on 13 variables (6 after p value correction:nasolabial angle,upper lip height,lateral lip height,facial index,upper facial index,and presence of inferior inflection of the lateral segment of the upper lip vermillion border). Five variables were able to predict correctly 85.7%of CCHS cases and 82.2%of controls:upper lip height,binocular width,upper facial height,nasal tip protrusion,and inferior inflection of the upper lip vermillion border. A negative relationship between number of repeats and four anthropometric measures was observed:mandible breadth,nasolabial angle,lateral lip height,and mandible-face width index. These results suggest a characteristic facial phenotype in children and young adults with CCHS,due to an expansion mutation in PHOX2B.展开更多
文摘目的研究垂直生长型安氏Ⅱ类1分类拔牙病例矫治前后鼻唇角的变化及其改变的相关性分析,为临床对错畸形的诊断与分析以及预测矫治后的疗效提供依据。方法选取38例垂直生长型安氏Ⅱ类1分类拔牙病例,矫治前后拍摄头颅侧位片,对18个软硬组织测量指标进行测量,对青少年与成人治疗前后变化量进行比较,并分析鼻唇角改变的相关性。结果青少年组与成人组鼻唇角均增大,但成人组鼻唇角改变更显著;U1 to FH、U1 to NA、U1-NA、Spr-Ptm在矫治后均减小,成人组减小更显著;青少年组上唇凹点厚度、上唇凸缘厚度、A’-Ptm、上唇长度以及鼻突度矫治后均增加,而成人均有一定程度的减小,差异有统计学意义。鼻唇角改变的相关性分析显示,两组U1 to FH、U1 to NA、U1-NA均有显著性的负相关,上唇倾角均有显著的正相关,并且成人相关性更显著;青少年组上唇凸缘厚度与鼻唇角呈负相关,而上唇凹点厚度与鼻唇角呈正相关,成人组这两项则无明显相关性。结论垂直生长型安氏Ⅱ类1分类青少年拔牙矫治后鼻唇角改变与上前牙硬组织以及上唇软组织均有相关性,而成人则只与上前牙硬组织相关。
文摘Congenital central hypoventilation syndrome (CCHS) is caused by mutations in PHOX2B,which is essential for maturation of the neural crest into the autonomic nervous system and is expressed in the dorsal rhombencephalon,a region that gives rise to facial structures. Digital photographs of 45 individuals with PHOX2B-confirmed CCHS,and 45 matched controls were analyzed for 17 linear and 6 angular measurements,and 9 derived indices. Paired t tests were used to compare group means,correlation was calculated between PHOX2B polyalanine expansion number and facial measures,and stepwise logistic regression was used to predict case-control and genotype status. CCHS cases differed significantly from controls on 13 variables (6 after p value correction:nasolabial angle,upper lip height,lateral lip height,facial index,upper facial index,and presence of inferior inflection of the lateral segment of the upper lip vermillion border). Five variables were able to predict correctly 85.7%of CCHS cases and 82.2%of controls:upper lip height,binocular width,upper facial height,nasal tip protrusion,and inferior inflection of the upper lip vermillion border. A negative relationship between number of repeats and four anthropometric measures was observed:mandible breadth,nasolabial angle,lateral lip height,and mandible-face width index. These results suggest a characteristic facial phenotype in children and young adults with CCHS,due to an expansion mutation in PHOX2B.
