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鼻敏清药理作用的实验研究 被引量:1
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作者 张英华 吴波 《中国中医药科技》 CAS 2004年第3期155-155,共1页
关键词 鼻敏清 药理作用 免疫器官 中医
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HPLC法测定鼻敏清丸胶囊中木兰脂素的含量
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作者 李坚 周杰 +2 位作者 刘志雄 许冬冬 赖科英 《广东药学院学报》 CAS 2009年第5期486-488,共3页
目的建立鼻敏清丸胶囊中木兰脂素的含量测定方法。方法采用HPLC法:色谱柱为DiamonsilC18(250 mm×4.6 mm,5μm);流动相为乙腈-四氢呋喃-水(体积比42∶2∶56);流速为1.0 mL/min;柱温为35℃;检测波长为278 nm。结果木兰脂素的质... 目的建立鼻敏清丸胶囊中木兰脂素的含量测定方法。方法采用HPLC法:色谱柱为DiamonsilC18(250 mm×4.6 mm,5μm);流动相为乙腈-四氢呋喃-水(体积比42∶2∶56);流速为1.0 mL/min;柱温为35℃;检测波长为278 nm。结果木兰脂素的质量浓度在1.856-46.40μg/mL范围内呈良好线性关系,平均回收率为98.34%,RSD为1.53%。结论本方法准确可靠、重现性好,可用于鼻敏清丸胶囊的质量控制。 展开更多
关键词 HPLC法 鼻敏清丸胶囊 木兰脂素 含量测定
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HPLC法测定鼻敏清丸胶囊中辛夷脂素的含量
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作者 李坚 石莹 +3 位作者 冼婉筠 周建因 郭亮洪 吴敏霞 《郧阳医学院学报》 2010年第3期259-260,共2页
关键词 HPLC 鼻敏清丸胶囊 辛夷脂素 含量测定
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基于中医病因病机的敏鼻清滴鼻液治疗过敏性鼻炎临床研究 被引量:7
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作者 孙蓉 钱晓路 +2 位作者 刘持年 李晓宇 王玉明 《中国药物评价》 2012年第5期323-329,共7页
目的:通过总结中医理论对于过敏性鼻炎病因病机认识与源流发展,依据本病证临床症候规律,观察敏鼻清滴鼻液的临床疗效。方法:通过查阅国内外相关文献,整理、分析、归纳过敏性鼻炎的源流,并且对行敏鼻清滴鼻液进行治疗的临床实验研究。90... 目的:通过总结中医理论对于过敏性鼻炎病因病机认识与源流发展,依据本病证临床症候规律,观察敏鼻清滴鼻液的临床疗效。方法:通过查阅国内外相关文献,整理、分析、归纳过敏性鼻炎的源流,并且对行敏鼻清滴鼻液进行治疗的临床实验研究。90例患者随机分为敏鼻清滴鼻液1号组、敏鼻清滴鼻液2号组和博科鼻炎水组,进行7日的疗效观察,并观测了三组治疗前后对鼻塞、鼻痒、喷嚏、留清涕症状和嗅觉迟钝、鼻黏膜色淡苍白和下鼻甲肿胀的体征方面以及局部镜下病变、鼻气道阻力等方面和鼻分泌物嗜酸性粒细胞的影响。结果:敏鼻清滴鼻液1号和2号治疗过敏性鼻炎,经过临床前后的观察对照,均有明显的临床疗效,敏鼻清滴鼻液1号治愈率60%、显效率23.3%、有效率10%、总有效率93.3%;敏鼻清滴鼻液2号治愈率46.3%、显效率20%、有效率20%、总有效率86.7%。其中敏鼻清滴鼻液1号治疗作用更为突出,表现在改善鼻塞、鼻痒、喷嚏、留清涕症状和改善嗅觉迟钝、鼻黏膜色淡苍白和下鼻甲肿胀的体征方面以及改善局部镜下病变、降低鼻气道阻力等方面,进行给药前后的自身对照和给药后的组间对照,经过Raddit分析和t检验,分别有极显著性差异、非常显著性差异和显著性差异。三者在使用过程中均未发现有毒副作用出现,表现在血液学WBC计数、尿常规、肝功能(ALT)、肾功能(BUN)的指标在给药前后自身对照和给药后组间对照方面,无统计学差异。结论:敏鼻清滴鼻液1号和2号对变应性鼻炎具有明显的治疗作用,尤其以敏鼻清滴鼻液1号疗效更佳。 展开更多
关键词 中医 病因病机 临床研究
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敏鼻清滴鼻液治疗过敏性鼻炎的主要药效学研究
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作者 孙蓉 吕莉莉 +1 位作者 钱晓路 郑跃 《中国药物评价》 2012年第4期277-280,283,共5页
目的:考察敏鼻清滴鼻液治疗过敏性鼻炎的主要药效学作用。方法:观察敏鼻清滴鼻液对豚鼠过敏性鼻炎模型的治疗和预防作用,对大鼠过敏性鼻炎模型的预防作用。结果:敏鼻清滴鼻液能有效对抗豚鼠过敏性鼻炎模型所产生的鼻痒、喷嚏、流涕的症... 目的:考察敏鼻清滴鼻液治疗过敏性鼻炎的主要药效学作用。方法:观察敏鼻清滴鼻液对豚鼠过敏性鼻炎模型的治疗和预防作用,对大鼠过敏性鼻炎模型的预防作用。结果:敏鼻清滴鼻液能有效对抗豚鼠过敏性鼻炎模型所产生的鼻痒、喷嚏、流涕的症状,降低血中嗜酸粒细胞和IgE抗体含量,抑制鼻黏膜和鼻分泌物中嗜酸粒细胞(EOS)浸润和鼻黏膜肥大细胞(MC)浸润,明显改善大鼠过敏性鼻炎血中嗜酸性粒细胞和IgE抗体含量的增加。结论:敏鼻清滴鼻液具有抗过敏作用,其机制与抑制嗜酸粒细胞(EOS)浸润和鼻黏膜肥大细胞(MC)浸润有关。 展开更多
关键词 辛夷酯素 豚鼠过炎模型 大鼠过炎模型 药效作用
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Treatment of “itching symptom” of allergic rhinitis from the perspective of “wind” 被引量:1
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作者 冯罡 《World Journal of Acupuncture-Moxibustion》 CSCD 2017年第4期60-64,共5页
Objective To observe the clinical efficacy of "itching symptom" of allergic rhinitis treated from the perspective of "wind". Methods Forty patients were given acupuncture therapy, Fengchf (风池 GB 20, bilaterally... Objective To observe the clinical efficacy of "itching symptom" of allergic rhinitis treated from the perspective of "wind". Methods Forty patients were given acupuncture therapy, Fengchf (风池 GB 20, bilaterally), Dazhui (大椎 GV 14), Fengmen (风门 BL 12, bilaterally), Feishu (肺俞 BL 13, bilaterally) and Shangyingxiang (上迎香 EX-HN8, bilaterally) were selected. After needle withdrawal, a fire cup was applied between GV 14 and BL 13, and the cup was retained for 10 min. Treatment for 15 times was considered as 1 course of treatment. Three days were free from treatment between 2 courses, and 3 courses were needed. The curative effect was evaluated after treatment ends, and follow-up visit was performed one year after treatment. Results The scores of nasal symptom and itching symptom after treatment ends and one year after treatment significantly reduced when compared with that before treatment (all P〈0.05), the difference was not statistically significant when compared the scores of nasal symptom and itching symptom one year after treatment with that after treatment ends (both P〉O.O5).According to the follow-up visit performed one year after treatment, the markedly effective and effective cases reduced, ineffective cases increased, and the total effective rate declined slightly. The serum IgE levels, after treatment ends I-(164.79±44.29) IU/mL and one year after treatment [(180.71±52.81)IU/ mL] , both significantly reduced when compared with that before treatment [(380.12±61.45) IU/mL, both P〈0.05] , the serum igE level one year after treatment increased when compared with that after treatment ends, but the difference was not statistically significant (P〉O.05). Conclusion (1) Significant short-term and long-term curative effects have been obtained during the treatment of "itching symptom" of allergic rhinitis from the perspective of "wind", (2) the mechanism of action may be related with the decrease of serum IgE level, (3) it is indicated that there are correlations between allergic rhinitis and atopic diseases such as atopic dermatitis and allergic conjunctivitis, etc. 展开更多
关键词 allergic rhinitis itching symptom wind-evil serum IgE
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