鼻注生大黄液辅助治疗重症急性胰腺炎的临床观察

目的:观察生大黄辅助治疗重症急性胰腺炎(severe acute pancreatitis,SAP)的临床疗效。方法:将57例SAP患者随机分为两组,生大黄水辅助治疗组29例,在综合治疗的基础上经鼻胃管给药,另外28例单纯用西药综合治疗为对照,比较两组病人腹痛、腹胀缓解时间、压痛消失时间、住院天数,血、尿淀粉酶、C反应蛋白恢复正常时间,合并肝肾功能障碍的比率和病死率。结果:生大黄辅助治疗组腹痛、腹胀缓解时间、压痛消失时间、住院天数,血、尿淀粉酶、CRP恢复正常时间均少于对照组(P<0.05,P<0.01);生大黄辅助治疗组合并肾功能障碍的比率低于对照组(P<0.05);合并肝功能障碍的比率及病死率,两组比较无统计学差异(P>0.05)。结论:生大黄辅助治疗能有效地改善SAP患者的病情,而加强给药前后护理,按时从鼻胃管注入生大黄水并严密观察很重要。

鼻注生大黄液辅助治疗重症急性胰腺炎的临床观察

目的:观察生大黄辅助治疗重症急性胰腺炎(severe acute pancreatitis,SAP)的临床疗效。方法:将57例SAP患者分为两组,生大黄水辅助治疗组29例,在综合治疗的基础上经鼻胃管给药,另外28例单纯用西药综合治疗为对照,比较两组病人腹痛、腹胀缓解时间、压痛消失时间、住院天数,血、尿淀粉酶、C反应蛋白恢复正常时间,合并肝肾功能障碍的比率和病死率。结果:生大黄辅助治疗组腹痛、腹胀缓解时间、压痛消失时间、住院天数,血、尿淀粉酶、CRP恢复正常时间均少于对照组(P<0.05,P<0.01);生大黄辅助治疗组合并肾功能障碍的比率低于对照组(P<0.05);合并肝功能障碍的比率及病死率,两组比较无统计学差异(P>0.05)。结论:生大黄辅助治疗能有效地改善SAP患者的病情,而加强给药前后护理,按时从鼻胃管注入生大黄水并严密观察很重要。

不同途径营养支持对老年重症患者营养代谢的影响

目的 本文旨在观察老年重症患者营养代谢受不同途径营养支持产生的影响,以为此类患者营养代谢优质调整提供支持。方法 选我院收治于2020年8月至2021年12月82例老年重症患者为研究观察对象,将患者依据随机数字表法分组,常规组(给予常规鼻肠管注食支持治疗41例)、结合组(给予常规鼻肠管注食支持治疗+静脉高价营养支持治疗41例)。所有患者支持治疗后观察患者血清白蛋白(ALB)、前白蛋白(PA)、转铁蛋白(TRF)情况及营养不良发生率、并发症发生率、治疗满意度。结果 支持治疗前,常规组、结合组ALB、PA、TRF水平对比,差异无统计学意义(P>0.05);支持治疗后,常规组、结合组ALB、PA、TRF水平明显升高,结合组高于常规组,差异有统计学意义(P<0.05)。支持治疗后,结合组营养不良发生率、并发症发生率低于常规组,差异有统计学意义(P<0.05)。结合组治疗满意度高于常规组,差异有统计学意义(P<0.05)。结论针对重症老年患者,不同途径营养支持效果存在一定差异,常规鼻肠管注食支持治疗+静脉高价营养支持治疗可以有效调整老年患者营养代谢情况,降低患者并发症、营养不良的发生率,使得患者对治疗服务更满意,可推广应用。

Effect of percutaneous endoscopic gastrostomy on gastroesophageal reflux in mechanically-ventilated patients

AIM： To investigate the effect of percutaneous endoscopic gastrostomy （PEG） on gastroesophageal reflux （GER） in mechanically-ventilated patients. METHODS ： In a prospective, randomized, controlled study 36 patients with recurrent or persistent ventilatorassociated pneumonia （VAP） and GER 〉 6% were divided into PEG group （n=16） or non-PEG group （n = 20）. Another 11 ventilated patients without reflux （GER 〈 3%） served as control group. Esophageal pH-metry was performed by the ＂pull through＂ method at baseline, 2 and 7 d after PEG. Patients were strictly followed up for semi-recumbent position and control of gastric nutrient residue. RESULTS： A significant decrease of median （range） reflux was observed in PEG group from 7.8 （6.2-15.6） at baseline to 2.7 （0-10.4） on d 7 post-gastrostomy （P 〈 0.01）, while the reflux increased from 9 （6.2-22） to 10.8 （6.3-36.6） （P〈 0.01） in non-PEG group. A significant correlation between GER （%） and the stay of nasogastric tube was detected （r= 0.56, P〈 0.01）. CONCLUSION： Gastrostomy when combined with semi- recumbent position and absence of nutrient gastric residue reduces the gastroesophageal reflux in ventilated patients.

Clinical observation of nedaplatin concurrent with radiotherapy for mid-advanced nasopharyngeal carcinoma and esophageal carcinoma

Objective: The aim of our study was to evaluate the short-term efficacy and the toxic reaction of nedaplatin concurrent with radiotherapy for mid-advanced nasopharyngeal carcinoma and esophageal carcinoma. Methods: Thirty-four patients were confirmed diagnosis with cancer by pathologic results. All patients were given 6MV X-ray for radiotherapy, Dt 66-70 Gy/33-35 f/6-7 w, concurrently administrated nedaplatin (30 mg/m2) once a week (6 times). Results: A total 34 patients were enrolled, of whom 33 patients were available for objective response, 1 patient of esophageal cancer quit for allergic reaction. The response rate (RR) of nedaplatin-contained therapy for nasopharyngeal carcinoma and esophageal carcinoma were 90.0% and 76.9%, respectively. The major toxic reaction was bone marrow suppression observed in 25 patients (73.5%), in which grade III aleukocytosis was observed in 3 patients (8.8%), grade III + IV thrombocytopenia in 3 patients (8.8%). And 6 patients (17.6%) showed gastrointestinal tract reaction. There were 4 patients with radiation esophagitis in the 13 patients with esophageal carcinoma. Conclusion: Nedaplatin can increase the therapeutic effect of radiation. Its incidence rate of bone marrow suppression is high, but the gastrointestinal tract reaction and renal toxicity is low and mild.

A novel technique to insert nasogastric tube for the anesthetized patients during cervical esophageal reconstruction

We are describing a novel technique to insert nasogastric tube （NGT） in the anesthetized patients dur- ing cervical esophageal reconstruction. Methods： Forty patients with mid and upper esophageal tumor enrolled into this study were randomly allocated into two groups （the control group, group C and the novel method group, group N）. All the patients were applied mechanical anastomosis to finish the cervical esophageal reconstruction. The procedure of NGT insertion for group C use the conventional method; well, the group N use the novel technique. Results： All the patients in group N had been finished the NGT insertion in the first attempt, and the total time for insertion was （5.05 ＋ 1.15） mins; on the contrary, for the group C, duration of insertion （min） was （24.45 ± 5.23） mins, and the successful rate of NGT insertion in the first attempt was 40% （P〈 0.05）; no one in group N had coiling/kinking, and 6/20 （30%） in group C had it （P= 0.020）. The complication rate of bleeding between the two group had no significant difference. Conclusion： For the patient with mid and upper esophageal tumor who need cervical esophageal reconstruction, this novel method can save the NGT insertion time, and make it easier with higher successful rate.