Objective: To reveal the action mechanism and efficacy of electroacupuncture(EA) plus external application of Wei Ling Xian(Radix Clematidis) extract in treating knee osteoarthritis(KOA), for providing theoreti...Objective: To reveal the action mechanism and efficacy of electroacupuncture(EA) plus external application of Wei Ling Xian(Radix Clematidis) extract in treating knee osteoarthritis(KOA), for providing theoretical evidence and novel plan for the treatment of KOA. Methods: Totally 284 inpatients were divided into an EA group and an observation group by the random number table, 142 cases in each group. The EA group was intervened by EA, ultrashort waves, and oral administration of Glucosamine Hydrochloride capsules; while the observation group was by external application of Wei Ling Xian(Radix Clematidis) extract at topical area in addition to the treatment given to the EA group. The intervention lasted 14 d in both groups. X-ray examination of knee joint was ordered before and after treatment, as well as the detection of positive expression of matrix metalloproteinase-1(MMP-1) in cartilage of knee joint, hyaluronic acid(HA) and interleukin-1β(IL-1β) in the inflammatory effusion; the Western Ontario and McM aster Universities osteoarthritis index(WOMAC) and visual analogue scale(VAS) were adopted to evaluate the clinical efficacy. Results: In the observation group, the X-ray examination result of knee joint was significantly improved, the positive expressions of MMP-1 and IL-1β content were significantly decreased, the level of HA was increased, WOMAC and VAS scores dropped, and the total effective rate was 91.5%, which were significantly different from those in the EA group(P〈0.05). Conclusion: EA plus external application of Wei Ling Xian(Radix Clematidis) extract can produce a more significant efficacy in treating KOA compared to ordinary EA treatment.展开更多
Objective:To observe the clinical efficacy of triple needling plus moxibustion and Tanbo-plucking tender points in treating the third lumbar vertebra transverse process syndrome. Methods: Totally 108 patients with t...Objective:To observe the clinical efficacy of triple needling plus moxibustion and Tanbo-plucking tender points in treating the third lumbar vertebra transverse process syndrome. Methods: Totally 108 patients with the third lumbar vertebra transverse process syndrome were randomized into two groups, 56 cases in the observation group were intervened by triple needling method plus moxibustion and Tanbo-plucking tender points; 52 cases in the control group were by acupuncture plus moxibustion. The pain rating index(PRI), visual analogue scale (VAS), and present pain intensity (PPI) from the short-form McGill pain questionnaire (SF-MPQ) were observed before and after intervention for comparing the therapeutic efficacy. Results: The total effective rate was 96.4% in the observation group versus 76.9% in the control group, and the difference was statistically significant (P〈0.05). After intervention, the sensory-PRI, affective-PRI, totaI-PRI, VAS, and PPI scores were markedly changed in both groups (P〈0.05). The difference in comparing the change of clinical sign score was statistically significant between the two groups (P〈0.05). The follow-ups performed 4 weeks and 8 weeks after treatment showed that there were significant differences in comparing the relapse rate between the two groups (P〈0.05). Conclusion: Triple needling plus moxibustion and Tanbo-plucking tender points can produce a better efficacy in treating the third lumbar vertebra transverse process syndrome than acupuncture plus moxibustion alone, and the relapse rate is relatively low.展开更多
基金supported by Project of Science and Technology Department of Hubei Province~~
文摘Objective: To reveal the action mechanism and efficacy of electroacupuncture(EA) plus external application of Wei Ling Xian(Radix Clematidis) extract in treating knee osteoarthritis(KOA), for providing theoretical evidence and novel plan for the treatment of KOA. Methods: Totally 284 inpatients were divided into an EA group and an observation group by the random number table, 142 cases in each group. The EA group was intervened by EA, ultrashort waves, and oral administration of Glucosamine Hydrochloride capsules; while the observation group was by external application of Wei Ling Xian(Radix Clematidis) extract at topical area in addition to the treatment given to the EA group. The intervention lasted 14 d in both groups. X-ray examination of knee joint was ordered before and after treatment, as well as the detection of positive expression of matrix metalloproteinase-1(MMP-1) in cartilage of knee joint, hyaluronic acid(HA) and interleukin-1β(IL-1β) in the inflammatory effusion; the Western Ontario and McM aster Universities osteoarthritis index(WOMAC) and visual analogue scale(VAS) were adopted to evaluate the clinical efficacy. Results: In the observation group, the X-ray examination result of knee joint was significantly improved, the positive expressions of MMP-1 and IL-1β content were significantly decreased, the level of HA was increased, WOMAC and VAS scores dropped, and the total effective rate was 91.5%, which were significantly different from those in the EA group(P〈0.05). Conclusion: EA plus external application of Wei Ling Xian(Radix Clematidis) extract can produce a more significant efficacy in treating KOA compared to ordinary EA treatment.
基金supported by Shanghai Community Project of Traditional Chinese Medicine,No:SHJCZYYNLTS-SQZYYTS-21~~
文摘Objective:To observe the clinical efficacy of triple needling plus moxibustion and Tanbo-plucking tender points in treating the third lumbar vertebra transverse process syndrome. Methods: Totally 108 patients with the third lumbar vertebra transverse process syndrome were randomized into two groups, 56 cases in the observation group were intervened by triple needling method plus moxibustion and Tanbo-plucking tender points; 52 cases in the control group were by acupuncture plus moxibustion. The pain rating index(PRI), visual analogue scale (VAS), and present pain intensity (PPI) from the short-form McGill pain questionnaire (SF-MPQ) were observed before and after intervention for comparing the therapeutic efficacy. Results: The total effective rate was 96.4% in the observation group versus 76.9% in the control group, and the difference was statistically significant (P〈0.05). After intervention, the sensory-PRI, affective-PRI, totaI-PRI, VAS, and PPI scores were markedly changed in both groups (P〈0.05). The difference in comparing the change of clinical sign score was statistically significant between the two groups (P〈0.05). The follow-ups performed 4 weeks and 8 weeks after treatment showed that there were significant differences in comparing the relapse rate between the two groups (P〈0.05). Conclusion: Triple needling plus moxibustion and Tanbo-plucking tender points can produce a better efficacy in treating the third lumbar vertebra transverse process syndrome than acupuncture plus moxibustion alone, and the relapse rate is relatively low.